IFNG-AS1

Summary

IFNG-AS1 (IFNG regulatory antisense RNA 1, HGNC:43910) is a long non-coding RNA gene on chromosome 12q15.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43910
Approved symbol	IFNG-AS1
Name	IFNG regulatory antisense RNA 1
Location	12q15
Locus type	RNA, long non-coding
Status	Approved
Aliases	Tmevpg1, LincR-Ifng-3’AS, NEST
Ensembl gene	ENSG00000255733
Ensembl biotype	lncRNA
Entrez	100885789
RNAcentral	URS0002853A80 — lncRNA, 1893 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000536914, ENST00000538665, ENST00000541715, ENST00000674322, ENST00000717999, ENST00000718000, ENST00000718001, ENST00000718002, ENST00000718003, ENST00000718004

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000536914 — 6 exons

Exon	Start	End
ENSE00002224253	67995941	67996073
ENSE00002234532	68234529	68234686
ENSE00002236302	67989529	67989579
ENSE00002256385	68026651	68026708
ENSE00004033864	68006090	68006146
ENSE00004033873	68019862	68019898

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 86.45.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.5236 / max 191.3228, expressed in 120 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
126576	1.4504	120
126575	0.0732	31

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	86.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.77	silver quality
lymph node	UBERON:0000029	81.58	gold quality
colonic epithelium	UBERON:0000397	77.14	gold quality
tonsil	UBERON:0002372	74.77	gold quality
vermiform appendix	UBERON:0001154	73.57	gold quality
bone marrow	UBERON:0002371	71.82	gold quality
sural nerve	UBERON:0015488	71.71	gold quality
granulocyte	CL:0000094	70.12	gold quality
urinary bladder	UBERON:0001255	69.81	gold quality
skeletal muscle tissue	UBERON:0001134	66.90	gold quality
spleen	UBERON:0002106	66.49	gold quality
muscle tissue	UBERON:0002385	65.17	gold quality
rectum	UBERON:0001052	65.08	gold quality
duodenum	UBERON:0002114	64.34	gold quality
blood	UBERON:0000178	63.12	gold quality
leukocyte	CL:0000738	60.42	gold quality
calcaneal tendon	UBERON:0003701	59.81	gold quality
ventricular zone	UBERON:0003053	59.78	silver quality
ganglionic eminence	UBERON:0004023	59.63	silver quality
monocyte	CL:0000576	59.07	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.49	gold quality
small intestine	UBERON:0002108	57.09	gold quality
gall bladder	UBERON:0002110	56.99	gold quality
tibial artery	UBERON:0007610	56.68	gold quality
popliteal artery	UBERON:0002250	56.66	gold quality
small intestine Peyer’s patch	UBERON:0003454	56.23	gold quality
mucosa of transverse colon	UBERON:0004991	55.68	gold quality
right atrium auricular region	UBERON:0006631	55.62	gold quality
adrenal tissue	UBERON:0018303	55.31	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.43
E-HCAD-35	yes	8.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• Long intergenic noncoding (linc)RNA TMEVPG1 belongs to the general class of lincRNAs that positively regulate gene transcription in human and mouse; TMEVPG1 expression contributes to driving T helper (Th)1 cell-dependent interferon (IFN)gamma expression. (PMID:22851706)
• IFNG-AS1 regulated the expression of IFNG at both transcriptional and translational level in human CD4(+) T cells. (PMID:26634912)
• we speculated that TMEVPG1 could promote IFNG transcription, and IFNG over-expression negative feedback regulated on TMEVPG1 expression, which resulted in decreased TMEVPG1 in ITP patients. (PMID:27050808)
• IFNG-AS1 may be involved in CD4(+)T cell-mediated immune responses in myasthenia gravis. (PMID:28822831)
• In conclusion, our findings suggested that IFNG-AS1 may function as an oncogene in pituitary adenoma by interacting with ESRP2. (PMID:30322807)
• High expression of IFNG-AS1 is associated with breast cancer. (PMID:30336781)
• LncRNAs encoded by AC007278.2 and IFNG-AS1-001 showed significantly higher expression in relapsing Phase multiple sclerosis patients whereas IFNG-AS1-003 was elevated in patients in the remitting phase compared with relapsing patients. (PMID:31066039)
• These results establish Ifng-as1 as an important regulator of Ifng expression, as a DNA element and transcribed RNA, involved in dynamic and cell state-specific responses to infection. (PMID:31377117)
• The ulcerative colitis -associated long noncoding RNA IFNG-AS1 regulates the balance between inflammatory and anti-inflammatory cytokine production after T-cell stimulation. (PMID:31545920)
• The expression level of LncRNA IFNG-AS1 and IFN-gamma increased significantly in all patient groups with brucellosis compared to healthy subjects. Its effective role in many protective actions, including enhancing the expression of IFN-gamma in the immune response in brucellosis patients, suggest a new molecular interaction response to brucella infection. (PMID:31595441)
• Effects of IFNG-AS1 and ANRIL on intestinal epithelial cells and their relationship with colitis. (PMID:32706073)
• Investigation of NEAT1, IFNG-AS1, and NRIR expression in Crimean-Congo hemorrhagic fever. (PMID:33064349)
• Significance of long non-coding RNA IFNG-AS1 in the progression and clinical prognosis in colon adenocarcinoma. (PMID:34872454)
• Exosome lncRNA IFNG-AS1 derived from mesenchymal stem cells of human adipose ameliorates neurogenesis and ASD-like behavior in BTBR mice. (PMID:38368393)
• Long noncoding RNAs (CTC-471J1.2, NeST) as epigenetic risk factors of active juvenile lupus nephritis: a case-control study. (PMID:38678299)
• The function of long non-coding RNA IFNG-AS1 in autoimmune diseases. (PMID:39004663)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.