IGF2-AS

Summary

IGF2-AS (IGF2 antisense RNA, HGNC:14062) is a long non-coding RNA gene on chromosome 11p15.5.

This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 51214 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14062
Approved symbol	IGF2-AS
Name	IGF2 antisense RNA
Location	11p15.5
Locus type	RNA, long non-coding
Status	Approved
Aliases	PEG8, IGF2-AS1
Ensembl gene	ENSG00000099869
Ensembl biotype	lncRNA
OMIM	610146
Entrez	51214
RNAcentral	URS0000A76E5D — lncRNA, 2107 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000381361, ENST00000381363, ENST00000445504

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000381361 — 3 exons

Exon	Start	End
ENSE00001287225	2147318	2148666
ENSE00001488413	2146245	2146527
ENSE00001926448	2140517	2140947

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 83.76.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0786 / max 13.4976, expressed in 41 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
112671	0.0518	34
112670	0.0269	15

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	83.76	silver quality
triceps brachii	UBERON:0001509	80.53	gold quality
gluteal muscle	UBERON:0002000	80.26	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	79.77	gold quality
gingival epithelium	UBERON:0001949	79.05	gold quality
adrenal tissue	UBERON:0018303	76.23	gold quality
gingiva	UBERON:0001828	75.88	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	74.39	silver quality
diaphragm	UBERON:0001103	73.08	gold quality
tonsil	UBERON:0002372	72.28	gold quality
inferior olivary complex	UBERON:0002127	71.71	gold quality
tongue squamous epithelium	UBERON:0006919	71.57	gold quality
vena cava	UBERON:0004087	71.56	gold quality
cartilage tissue	UBERON:0002418	70.16	silver quality
secondary oocyte	CL:0000655	69.84	gold quality
placenta	UBERON:0001987	68.75	gold quality
amniotic fluid	UBERON:0000173	68.62	gold quality
decidua	UBERON:0002450	68.31	silver quality
right lobe of liver	UBERON:0001114	68.30	gold quality
stromal cell of endometrium	CL:0002255	68.17	gold quality
vastus lateralis	UBERON:0001379	68.08	gold quality
islet of Langerhans	UBERON:0000006	67.97	gold quality
body of tongue	UBERON:0011876	67.77	gold quality
biceps brachii	UBERON:0001507	67.75	gold quality
epithelial cell of pancreas	CL:0000083	67.70	gold quality
heart right ventricle	UBERON:0002080	67.52	gold quality
pharyngeal mucosa	UBERON:0000355	67.51	gold quality
quadriceps femoris	UBERON:0001377	67.48	gold quality
saphenous vein	UBERON:0007318	67.32	gold quality
pons	UBERON:0000988	67.19	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): DNMT3B, POU5F1

Literature-anchored findings (GeneRIF, showing 12)

• IGF-IR and IGF-IIR antisense genes could significantly restrain the malignant behavior of human hepatoma cells and might be useful in investigating a potential route for hepatocellular carcinoma gene therapy. (PMID:12603530)
• The strongest evidence for altered methylation patterns in shiftworkers was observed for IGF2AS gene. (PMID:23193016)
• Germline variations in IGF2-AS gene were associated with prostate cancer mortality, independent of stage and Gleason score and specific to prostate cancer. (PMID:24824313)
• IGF2-AS takes important regulatory parts in the gastric adenocarcinoma development by regulating SHOX2 via sponging miR-503.IGF2-AS is up-regulated in gastric adenocarcinoma tissues and correlated with poor prognosis. (PMID:31183590)
• We demonstrated that inhibiting IGF2-AS, possibly also through activation of AKT signaling pathway, has a protective function in high-glucose-induced apoptosis in human retinal pigment epithelial cells in diabetic retinopathy. (PMID:31317640)
• Data suggest that serum long non-coding RNA IGF2-AS (IGF2AS) may be a potential biomarker for the diagnosis of HBV-related hepatocellular carcinoma (HCC). (PMID:31850718)
• Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2. (PMID:33175607)
• lncRNA IGF2-AS promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR-3,126-5p to upregulate KLK4. (PMID:34101307)
• Long non-coding RNA IGF2-AS promotes trophoblast cell proliferation, migration, and invasion by regulating miR-520g/N-cadherin axis. (PMID:34109707)
• Downregulation of lncRNA IGF2-AS-encoded peptide induces trophoblast - cycle arrest. (PMID:34474977)
• Over-expression of long non-coding RNA insulin-like growth factor 2-antisense suppressed hepatocellular carcinoma cell proliferation and metastasis by regulating the microRNA-520h/cyclin-dependent kinase inhibitor 1A signaling pathway. (PMID:34516353)
• LncRNA IGF2-AS promotes endometriosis progression through targeting miR-370-3p/IGF2 axis and activating PI3K/AKT/mTOR signaling pathway. (PMID:36508036)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.