IGFBP-AS1

Summary

IGFBP-AS1 (IGFBP5 antisense RNA 1, HGNC:55655) is a long non-coding RNA gene on chromosome 2q35.

At a glance

• Clinical variants (ClinVar): 17 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55655
Approved symbol	IGFBP-AS1
Name	IGFBP5 antisense RNA 1
Location	2q35
Locus type	RNA, long non-coding
Status	Approved
Entrez	101928278
RNAcentral	URS00026A2813 — lncRNA, 1999 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

17 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	13
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000002114 (2:216712956 C>G,T), RS1000010662 (2:217248592 G>A,C), RS1000016285 (2:216934824 C>T), RS1000017312 (2:217053891 A>G,T), RS1000019128 (2:216829201 G>A), RS1000020299 (2:217059891 G>T), RS1000037220 (2:216814007 G>T), RS1000052483 (2:216754441 G>A), RS1000056353 (2:217024815 C>T), RS1000060405 (2:216713908 G>A,T), RS1000064335 (2:216743447 T>C), RS1000071289 (2:216829007 A>G), RS1000072220 (2:216787077 A>G), RS1000086318 (2:217119815 C>A,T), RS1000087323 (2:216875082 G>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.