IGFBP7-AS1

Summary

IGFBP7-AS1 (IGFBP7 antisense RNA 1, HGNC:40296) is a long non-coding RNA gene on chromosome 4q12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40296
Approved symbol	IGFBP7-AS1
Name	IGFBP7 antisense RNA 1
Location	4q12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245067
Ensembl biotype	lncRNA
Entrez	255130
RNAcentral	URS000075ED46 — lncRNA, 1418 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000499667, ENST00000508328, ENST00000515865, ENST00000687443, ENST00000777009, ENST00000777010, ENST00000777011, ENST00000777012, ENST00000777013, ENST00000777014, ENST00000777015, ENST00000777016, ENST00000777017, ENST00000777019, ENST00000777021, ENST00000777022, ENST00000777023, ENST00000777024

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499667 — 5 exons

Exon	Start	End
ENSE00001965593	57109762	57109970
ENSE00001969567	57188170	57188319
ENSE00001975776	57204478	57204593
ENSE00001982110	57205074	57205299
ENSE00001990683	57201133	57201820

Expression profiles

Bgee: expression breadth ubiquitous, 151 present calls, max score 90.16.

FANTOM5 (CAGE): breadth broad, TPM avg 3.8421 / max 152.5053, expressed in 680 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
47764	2.4910	524
47763	1.3511	422

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.16	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.32	gold quality
stromal cell of endometrium	CL:0002255	72.95	gold quality
bone marrow cell	CL:0002092	71.80	silver quality
tibial artery	UBERON:0007610	70.66	gold quality
popliteal artery	UBERON:0002250	70.65	gold quality
ascending aorta	UBERON:0001496	70.17	gold quality
aorta	UBERON:0000947	70.16	gold quality
thoracic aorta	UBERON:0001515	69.92	gold quality
descending thoracic aorta	UBERON:0002345	69.64	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.52	gold quality
left coronary artery	UBERON:0001626	68.13	gold quality
colonic epithelium	UBERON:0000397	67.19	silver quality
coronary artery	UBERON:0001621	66.42	gold quality
pituitary gland	UBERON:0000007	66.30	gold quality
amygdala	UBERON:0001876	65.98	gold quality
adenohypophysis	UBERON:0002196	65.98	gold quality
cortex of kidney	UBERON:0001225	65.94	gold quality
right coronary artery	UBERON:0001625	65.58	gold quality
hypothalamus	UBERON:0001898	64.91	gold quality
cortical plate	UBERON:0005343	64.15	gold quality
sural nerve	UBERON:0015488	64.04	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	63.39	gold quality
caudate nucleus	UBERON:0001873	62.83	gold quality
corpus callosum	UBERON:0002336	62.21	gold quality
nucleus accumbens	UBERON:0001882	61.85	gold quality
ganglionic eminence	UBERON:0004023	61.71	gold quality
spinal cord	UBERON:0002240	61.63	gold quality
Ammon’s horn	UBERON:0001954	61.09	gold quality
metanephros cortex	UBERON:0010533	60.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.94

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis. (PMID:34634383)
• Long non-coding RNA IGFBP7-AS1 promotes odontogenic differentiation of stem cells from human exfoliated deciduous teeth through autophagy: An in vitro study. (PMID:35772254)
• Long non-coding RNA IGFBP7-AS1 accelerates the odontogenic differentiation of stem cells from human exfoliated deciduous teeth by regulating IGFBP7 expression. (PMID:36038801)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.