IGFL2-AS1

Summary

IGFL2-AS1 (IGFL2 antisense RNA 1, HGNC:52559) is a long non-coding RNA gene on chromosome 19q13.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52559
Approved symbol	IGFL2-AS1
Name	IGFL2 antisense RNA 1
Location	19q13.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC006262.5
Ensembl gene	ENSG00000268621
Ensembl biotype	lncRNA
Entrez	645553
RNAcentral	URS0000A76D1B — lncRNA, 1665 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000594027, ENST00000595673, ENST00000598518, ENST00000598754, ENST00000599817, ENST00000601263, ENST00000663593, ENST00000663652, ENST00000664765, ENST00000666136, ENST00000667831, ENST00000668528, ENST00000669846, ENST00000670157, ENST00000819124, ENST00000819125, ENST00000819126, ENST00000819127

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000594027 — 3 exons

Exon	Start	End
ENSE00003072844	46198408	46198442
ENSE00003156112	46202840	46203083
ENSE00003220332	46189029	46189229

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 83.88.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2510 / max 33.0738, expressed in 65 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
181620	0.1854	57
181621	0.0656	37

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of leg	UBERON:0001511	83.88	gold quality
zone of skin	UBERON:0000014	83.26	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.82	gold quality
skin of abdomen	UBERON:0001416	82.48	gold quality
lower esophagus mucosa	UBERON:0035834	81.28	gold quality
esophagus mucosa	UBERON:0002469	77.88	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.77	silver quality
sural nerve	UBERON:0015488	72.87	gold quality
placenta	UBERON:0001987	70.41	gold quality
esophagus	UBERON:0001043	66.71	gold quality
ganglionic eminence	UBERON:0004023	66.10	gold quality
vagina	UBERON:0000996	65.82	gold quality
pituitary gland	UBERON:0000007	65.33	gold quality
testis	UBERON:0000473	65.11	gold quality
cortical plate	UBERON:0005343	65.11	gold quality
right testis	UBERON:0004534	64.60	gold quality
left testis	UBERON:0004533	64.54	gold quality
corpus callosum	UBERON:0002336	63.36	gold quality
primary visual cortex	UBERON:0002436	63.26	gold quality
tonsil	UBERON:0002372	63.15	gold quality
skeletal muscle tissue	UBERON:0001134	62.55	gold quality
ectocervix	UBERON:0012249	61.67	gold quality
body of uterus	UBERON:0009853	61.56	gold quality
minor salivary gland	UBERON:0001830	61.43	gold quality
saliva-secreting gland	UBERON:0001044	61.34	gold quality
muscle tissue	UBERON:0002385	61.19	gold quality
adenohypophysis	UBERON:0002196	60.66	gold quality
myometrium	UBERON:0001296	60.57	gold quality
uterine cervix	UBERON:0000002	60.02	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	59.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Knockdown of IGFL2-AS1 suppressed gastric cancer cell proliferation, migration, and invasion in vitro. IGFL2-AS1 exerted its function as a molecular sponge of miR-802. (PMID:31943339)
• IGFL2-AS1 facilitates tongue squamous cell carcinoma progression via Wnt/beta-catenin signaling pathway. (PMID:34085359)
• IGFL2-AS1, a Long Non-Coding RNA, Is Associated with Radioresistance in Colorectal Cancer. (PMID:36674495)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.