IGIP

Summary

IGIP (IgA inducing protein, HGNC:33847) is a protein-coding gene on chromosome 5q31.3, encoding IgA-inducing protein homolog (A6NJ69). Enhances IgA secretion from B-cells stimulated via CD40.

Predicted to be located in extracellular region.

Source: NCBI Gene 492311 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 4 total
• MANE Select transcript: NM_001007189

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33847
Approved symbol	IGIP
Name	IgA inducing protein
Location	5q31.3
Locus type	gene with protein product
Status	Approved
Aliases	LOC492311
Ensembl gene	ENSG00000182700
Ensembl biotype	protein_coding
Entrez	492311

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000333305

RefSeq mRNA: 1 — MANE Select: NM_001007189 NM_001007189

CCDS: CCDS34244

Canonical transcript exons

ENST00000333305 — 1 exons

Exon	Start	End
ENSE00001321228	140125937	140129392

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 94.26.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2951 / max 217.0966, expressed in 72 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58883	0.2951	72

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hypothalamus	UBERON:0001898	94.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.07	gold quality
substantia nigra	UBERON:0002038	94.05	gold quality
amygdala	UBERON:0001876	93.90	gold quality
temporal lobe	UBERON:0001871	93.75	gold quality
primary visual cortex	UBERON:0002436	93.48	gold quality
Ammon’s horn	UBERON:0001954	93.38	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	93.25	gold quality
nucleus accumbens	UBERON:0001882	93.22	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.16	gold quality
putamen	UBERON:0001874	93.08	gold quality
superior frontal gyrus	UBERON:0002661	92.96	gold quality
cerebellar hemisphere	UBERON:0002245	92.93	gold quality
cerebellar cortex	UBERON:0002129	92.92	gold quality
corpus callosum	UBERON:0002336	92.84	gold quality
cerebellum	UBERON:0002037	92.83	gold quality
anterior cingulate cortex	UBERON:0009835	92.80	gold quality
caudate nucleus	UBERON:0001873	92.55	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.24	gold quality
brain	UBERON:0000955	91.96	gold quality
cerebral cortex	UBERON:0000956	91.93	gold quality
right frontal lobe	UBERON:0002810	91.57	gold quality
frontal cortex	UBERON:0001870	91.25	gold quality
prefrontal cortex	UBERON:0000451	91.06	gold quality
tibial nerve	UBERON:0001323	87.46	gold quality
calcaneal tendon	UBERON:0003701	87.41	gold quality
adenohypophysis	UBERON:0002196	87.17	gold quality
pituitary gland	UBERON:0000007	87.01	gold quality
right coronary artery	UBERON:0001625	86.26	gold quality
ascending aorta	UBERON:0001496	85.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.41

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

31 targeting IGIP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-452-5P	99.65	69.63	1762
HSA-MIR-4676-3P	99.65	69.31	1733
HSA-MIR-892C-3P	99.65	69.38	1745
HSA-MIR-582-5P	99.47	70.79	2635
HSA-MIR-3973	99.20	69.19	1990
HSA-MIR-548L	99.06	70.90	2560
HSA-MIR-4717-3P	99.06	66.34	1072
HSA-MIR-4774-3P	98.90	67.82	737
HSA-MIR-6792-5P	98.39	68.16	1330
HSA-MIR-24-1-5P	95.57	65.85	492

Literature-anchored findings (GeneRIF, showing 1)

• IgA-inducing protein stimulation drives the production of mu-alpha switch circles from IgM(+)IgD(+) naive human B cells, indicating its role as an IgA switch factor. (PMID:19201837)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Igip	ENSMUSG00000110185

Protein

Protein identifiers

IgA-inducing protein homolog — A6NJ69 (reviewed: A6NJ69)

All UniProt accessions (2): A6NJ69, A0A158RFU4

UniProt curated annotations — full annotation on UniProt →

Function. Enhances IgA secretion from B-cells stimulated via CD40.

Subcellular location. Secreted.

RefSeq proteins (1): NP_001007190* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR038815	IGIP	Family

UniProt features (2 total): signal peptide 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NJ69-F1	44.33	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 58 (showing top): MILI_PSEUDOPODIA_CHEMOTAXIS_UP, CUI_TCF21_TARGETS_2_DN, CTTTGTA_MIR524, NUYTTEN_EZH2_TARGETS_DN, chr5q31, ATACTGT_MIR144, LI_INDUCED_T_TO_NATURAL_KILLER_DN, MIR153_5P, MIR607, MIR3671, MIR9983_3P, MIR144_3P, GCAAAAA_MIR129, MIR129_5P, MIR452_5P

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

238 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
IGIP	HOOK3	Q86VS8	481
IGIP	SEPTIN7	Q16181	450
IGIP	CD3D	P04234	363
IGIP	CYSTM1	Q9H1C7	357
IGIP	GIPR	P48546	350
IGIP	HSPA4	P34932	323
IGIP	RWDD4	Q6NW29	300
IGIP	LRRIQ1	Q96JM4	299
IGIP	ZNF839	A8K0R7	296
IGIP	H2AP	O75409	277
IGIP	PGBD4	Q96DM1	276
IGIP	GPR15LG	Q6UWK7	261
IGIP	SEC61B	P38390	250
IGIP	LIME1	Q9H400	250
IGIP	PPP2R5D	Q14738	249

IntAct

3 interactions, top by confidence:

A	B	Type	Score
IGIP	MAPK8IP2	psi-mi:“MI:0915”(physical association)	0.490
MAPK8IP2	IGIP	psi-mi:“MI:0915”(physical association)	0.490

BioGRID (2): IGIP (Two-hybrid), IGIP (Affinity Capture-RNA)

ESM2 similar proteins: A0A0B7P221, A0A385XJK5, A4D0Y5, A6NJ69, C0H444, G2TRL8, G2TRQ5, K7LSB9, O13536, O83886, P03086, P03164, P0C272, P0C5L7, P0C5N7, P0C5Q7, P0C8B7, P0DPN5, P0DSH6, P0DUM4, P0DXX6, P19282, P19755, P38194, P38468, P39566, P40326, P41953, P54429, P60236, P75692, P92540, Q10927, Q32063, Q3B7S5, Q3E767, Q3E7Y9, Q3E808, Q6GZN3, Q6IM82

Diamond homologs: A6NJ69, P0C7I2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

4 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

71 predictions. Top by Δscore:

Variant	Effect	Δscore
5:140126038:ATT:A	donor_gain	0.8800
5:140126005:T:G	donor_gain	0.8400
5:140126005:T:TG	donor_gain	0.7900
5:140126035:T:G	donor_gain	0.7400
5:140128558:A:AG	acceptor_gain	0.7100
5:140128559:G:GG	acceptor_gain	0.7100
5:140125994:G:GT	donor_gain	0.6500
5:140126033:C:T	donor_gain	0.6500
5:140126009:G:GG	donor_gain	0.6100
5:140125938:A:T	donor_gain	0.6000
5:140126039:T:TG	donor_gain	0.5900
5:140125946:T:G	donor_gain	0.5700
5:140125946:T:TG	donor_gain	0.5600
5:140125990:T:G	donor_gain	0.5600
5:140126008:A:AG	donor_gain	0.5500
5:140126099:A:T	donor_gain	0.5500
5:140125990:T:TG	donor_gain	0.5200
5:140128553:ATCT:A	acceptor_gain	0.4900
5:140125937:G:T	donor_gain	0.4800
5:140128555:C:T	acceptor_gain	0.4800
5:140126295:G:GT	donor_gain	0.4400
5:140128556:T:TA	acceptor_gain	0.4400
5:140128527:T:TA	acceptor_gain	0.4300
5:140128528:A:AA	acceptor_gain	0.4300
5:140126296:A:T	donor_gain	0.4000
5:140128559:GT:G	acceptor_gain	0.3800
5:140125967:T:G	donor_gain	0.3600
5:140125937:G:GT	donor_gain	0.3400
5:140125989:A:G	donor_gain	0.3400
5:140126152:T:G	donor_gain	0.3400

AlphaMissense

353 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:140128618:T:C	F48L	0.914
5:140128620:T:A	F48L	0.914
5:140128620:T:G	F48L	0.914
5:140128602:C:G	C42W	0.904
5:140128600:T:C	C42R	0.862
5:140128546:T:C	F24L	0.853
5:140128548:C:A	F24L	0.853
5:140128548:C:G	F24L	0.853
5:140128532:T:A	I19K	0.834
5:140128600:T:A	C42S	0.821
5:140128601:G:C	C42S	0.821
5:140128538:C:A	A21D	0.820
5:140128578:T:G	C34W	0.814
5:140128532:T:G	I19R	0.772
5:140128613:T:C	L46P	0.765
5:140128541:T:A	V22D	0.762
5:140128601:G:A	C42Y	0.762
5:140128606:A:C	S44R	0.750
5:140128608:C:A	S44R	0.750
5:140128608:C:G	S44R	0.750
5:140128613:T:A	L46H	0.749
5:140128633:A:C	S53R	0.740
5:140128635:C:A	S53R	0.740
5:140128635:C:G	S53R	0.740
5:140128622:T:A	V49D	0.738
5:140128500:G:C	K8N	0.729
5:140128500:G:T	K8N	0.729
5:140128604:T:C	I43T	0.722
5:140128607:G:T	S44I	0.721
5:140128576:T:C	C34R	0.719

dbSNP variants (sampled 300 via entrez): RS1001398135 (5:140127274 T>A,C), RS1001703725 (5:140126738 T>C), RS1002617515 (5:140128249 A>G), RS1004126275 (5:140127633 G>A), RS1004168819 (5:140127058 T>A), RS1005645569 (5:140129062 A>G), RS1006229357 (5:140125437 C>G), RS1006512693 (5:140125149 C>G), RS1007520117 (5:140128087 T>G), RS1007578424 (5:140124325 A>T), RS1007630563 (5:140124555 T>C), RS1008109355 (5:140125763 C>A,T), RS1008191086 (5:140129199 T>G), RS1008578164 (5:140126254 A>G), RS1009620809 (5:140125250 T>C,G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST005951_151	Body mass index	6.000000e-07
GCST011768_4	Schizophrenia	2.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol F	affects cotreatment, decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, decreases expression	1
methylparaben	increases expression	1
butyraldehyde	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
bisphenol S	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Leflunomide	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Lead	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Silicon Dioxide	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	increases expression	1
Valproic Acid	decreases expression	1
1-Methyl-3-isobutylxanthine	decreases expression, affects cotreatment	1
Cyclosporine	decreases expression	1
Aflatoxin B1	decreases methylation	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.