IGLL1

Summary

IGLL1 (immunoglobulin lambda like polypeptide 1, HGNC:5870) is a protein-coding gene on chromosome 22q11.23, encoding Immunoglobulin lambda-like polypeptide 1 (P15814). Critical for B-cell development.

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 3543 — RefSeq curated summary.

At a glance

• Gene–disease (curated): agammaglobulinemia 2, autosomal recessive (Strong, GenCC) — +1 more curated relationship
• GWAS associations: 5
• Clinical variants (ClinVar): 271 total
• Phenotypes (HPO): 38
• Dosage sensitivity (ClinGen): haploinsufficiency autosomal recessive, triplosensitivity no evidence
• MANE Select transcript: NM_020070

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5870
Approved symbol	IGLL1
Name	immunoglobulin lambda like polypeptide 1
Location	22q11.23
Locus type	gene with protein product
Status	Approved
Aliases	IGVPB, IGL5, 14.1, CD179B
Ensembl gene	ENSG00000128322
Ensembl biotype	protein_coding
OMIM	146770
Entrez	3543

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 protein_coding

ENST00000249053, ENST00000330377, ENST00000438703

RefSeq mRNA: 3 — MANE Select: NM_020070 NM_001369906, NM_020070, NM_152855

CCDS: CCDS13809, CCDS13810

Canonical transcript exons

ENST00000330377 — 3 exons

Exon	Start	End
ENSE00000879461	23574967	23575082
ENSE00001313083	23579985	23580290
ENSE00003586626	23573125	23573585

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 91.67.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 13.5294 / max 4710.0035, expressed in 67 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193316	7.6297	54
193315	3.7384	45
193317	1.1518	34
193314	0.6265	23
193313	0.1544	10
193318	0.1459	20
209418	0.0827	15

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	91.67	gold quality
bone marrow cell	CL:0002092	87.94	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.88	gold quality
left testis	UBERON:0004533	84.90	gold quality
right testis	UBERON:0004534	83.75	gold quality
testis	UBERON:0000473	81.77	gold quality
trabecular bone tissue	UBERON:0002483	81.64	gold quality
tendon of biceps brachii	UBERON:0008188	72.79	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	70.81	gold quality
thymus	UBERON:0002370	68.82	silver quality
buccal mucosa cell	CL:0002336	66.16	gold quality
gluteal muscle	UBERON:0002000	65.61	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	64.92	gold quality
vena cava	UBERON:0004087	63.63	gold quality
male germ cell	CL:0000015	63.52	gold quality
triceps brachii	UBERON:0001509	62.91	gold quality
sperm	CL:0000019	62.57	gold quality
monocyte	CL:0000576	62.53	gold quality
mononuclear cell	CL:0000842	62.41	gold quality
biceps brachii	UBERON:0001507	62.41	gold quality
leukocyte	CL:0000738	62.12	gold quality
adult organism	UBERON:0007023	61.24	gold quality
tongue squamous epithelium	UBERON:0006919	60.69	gold quality
endothelial cell	CL:0000115	60.11	gold quality
jejunal mucosa	UBERON:0000399	57.83	gold quality
oral cavity	UBERON:0000167	57.70	gold quality
lymph node	UBERON:0000029	57.49	gold quality
myocardium	UBERON:0002349	57.28	gold quality
gingiva	UBERON:0001828	55.78	gold quality
quadriceps femoris	UBERON:0001377	55.60	gold quality

Single-cell (SCXA)

Detected in 15 experiment(s), a significant marker in 15.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	3905.92
E-CURD-112	yes	3411.65
E-MTAB-7407	yes	3193.07
E-MTAB-9067	yes	3102.31
E-MTAB-10432	yes	2497.42
E-CURD-79	yes	1811.15
E-MTAB-8884	yes	1472.08
E-GEOD-100618	yes	1214.98
E-ANND-5	yes	704.07
E-GEOD-76312	yes	686.83
E-HCAD-6	yes	72.25
E-HCAD-10	yes	15.27
E-MTAB-10042	yes	11.67
E-CURD-122	yes	7.18
E-ANND-3	yes	7.06

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): EBF1, IKZF1, IKZF3, MYB, PAX5, PREB, RUNX1, SOX4, SSRP1, TCF3

miRNA regulators (miRDB)

10 targeting IGLL1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-762	99.58	66.61	1994
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-4498	99.47	67.42	2360
HSA-MIR-5001-5P	99.05	66.76	1972
HSA-MIR-4270	99.02	66.26	1987
HSA-MIR-6754-5P	98.60	65.54	1627
HSA-MIR-563	96.26	66.13	450
HSA-MIR-380-5P	95.68	67.32	512
HSA-MIR-503-3P	92.89	66.09	537

Functional genomics

ClinGen dosage: haploinsufficiency 30 (autosomal recessive), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Literature-anchored findings (GeneRIF, showing 3)

• Hhydrophobic residues from the lambda5-UR is crucial for the interaction with GAL1 and for pre-BCR clustering. (PMID:23124203)
• in autosomal recessive agammaglobulinemia a homozygous missense mutation at codon 142 (CCG>with CTG) resulting in a Pro>Leu substitution was identified in exon 3 of the IGLL1 gene; 2 additional silent homozygous substitutions were identified at codons 131 (T>C) and 140 (T>C); sequencing also revealed 2 homozygous single-nucleotide polymorphisms in the noncoding region of exon 3 (PMID:27576013)
• Irrespective of subtype, Acute Lymphoblastic Leukemia with high levels of IGHM, IGLL1 and VPREB1 are arrested at the pre-B stage and correlate with good prognosis in high-risk pediatric B-cell precursor acute lymphoblastic leukemia. (PMID:27611867)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
mus_musculus	Iglc2	ENSMUSG00000076937
mus_musculus	Iglc3	ENSMUSG00000105547
mus_musculus	Iglc1	ENSMUSG00000105906
mus_musculus	Iglc4	ENSMUSG00000106039
rattus_norvegicus	Iglc1	ENSRNOG00000058590
rattus_norvegicus		ENSRNOG00000077205
rattus_norvegicus		ENSRNOG00000079313
rattus_norvegicus		ENSRNOG00000086508

Paralogs (82): IGHV1OR15-9 (ENSG00000188403), IGKC (ENSG00000211592), IGLC1 (ENSG00000211675), IGLC2 (ENSG00000211677), IGLC3 (ENSG00000211679), IGLC7 (ENSG00000211685), TRDC (ENSG00000211829), IGHA2 (ENSG00000211890), IGHE (ENSG00000211891), IGHG4 (ENSG00000211892), IGHG2 (ENSG00000211893), IGHA1 (ENSG00000211895), IGHG1 (ENSG00000211896), IGHG3 (ENSG00000211897), IGHD (ENSG00000211898), IGHM (ENSG00000211899), IGHV6-1 (ENSG00000211933), IGHV1-2 (ENSG00000211934), IGHV1-3 (ENSG00000211935), IGHV2-5 (ENSG00000211937), IGHV3-7 (ENSG00000211938), IGHV3-11 (ENSG00000211941), IGHV3-13 (ENSG00000211942), IGHV3-15 (ENSG00000211943), IGHV3-16 (ENSG00000211944), IGHV1-18 (ENSG00000211945), IGHV3-20 (ENSG00000211946), IGHV3-21 (ENSG00000211947), IGHV3-23 (ENSG00000211949), IGHV1-24 (ENSG00000211950), IGHV2-26 (ENSG00000211951), IGHV4-28 (ENSG00000211952), IGHV3-33 (ENSG00000211955), IGHV4-34 (ENSG00000211956), IGHV3-35 (ENSG00000211957), IGHV3-38 (ENSG00000211958), IGHV4-39 (ENSG00000211959), IGHV1-45 (ENSG00000211961), IGHV1-46 (ENSG00000211962), IGHV3-48 (ENSG00000211964)

Protein

Protein identifiers

Immunoglobulin lambda-like polypeptide 1 — P15814 (reviewed: P15814)

Alternative names: CD179 antigen-like family member B, Ig lambda-5, Immunoglobulin omega polypeptide, Immunoglobulin-related protein 14.1

All UniProt accessions (2): P15814, C9JEE0

UniProt curated annotations — full annotation on UniProt →

Function. Critical for B-cell development.

Subunit / interactions. Associates non-covalently with VPREB1. Interacts with SYNV1/HRD1 (via N-terminus); this interaction leads to increased IGLL1 ubiquitination and degradation in pre-B cells, possibly through a lysosomal, not proteasomal, pathway.

Subcellular location. Endoplasmic reticulum. Secreted.

Tissue specificity. Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).

Disease relevance. Agammaglobulinemia 2, autosomal recessive (AGM2) [MIM:613500] A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. The disease is caused by variants affecting the gene represented in this entry.

Isoforms (2)

UniProt ID	Names	Canonical?
P15814-1	1	yes
P15814-2	2

RefSeq proteins (3): NP_001356835, NP_064455, NP_690594 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003006	Ig/MHC_CS	Conserved_site
IPR003597	Ig_C1-set	Domain
IPR007110	Ig-like_dom	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR050160	MHC/Immunoglobulin	Family

Pfam: PF07654

UniProt features (24 total): strand 8, helix 4, turn 2, region of interest 2, disulfide bond 2, sequence variant 2, signal peptide 1, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
2H3N	X-RAY DIFFRACTION	2.3
2H32	X-RAY DIFFRACTION	2.7
2LKQ	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P15814-F1	75.19	0.53

Antibody-complex structures (SAbDab): 2 — 2H32, 2H3N

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (2): 135–194, 212

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-202733	Cell surface interactions at the vascular wall

MSigDB gene sets: 213 (showing top): MODULE_478, GOBP_LEUKOCYTE_MEDIATED_IMMUNITY, GOBP_B_CELL_MEDIATED_IMMUNITY, MODULE_75, GOBP_LYMPHOCYTE_MEDIATED_IMMUNITY, TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_10D_UP, GOBP_ADAPTIVE_IMMUNE_RESPONSE, GOBP_IMMUNE_EFFECTOR_PROCESS, JAATINEN_HEMATOPOIETIC_STEM_CELL_UP, MCCABE_HOXC6_TARGETS_CANCER_UP, MODULE_46, REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL, GOBP_ADAPTIVE_IMMUNE_RESPONSE_BASED_ON_SOMATIC_RECOMBINATION_OF_IMMUNE_RECEPTORS_BUILT_FROM_IMMUNOGLOBULIN_SUPERFAMILY_DOMAINS, WILCOX_RESPONSE_TO_PROGESTERONE_DN, TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_8D_UP

GO Biological Process (2): immune response (GO:0006955), immunoglobulin mediated immune response (GO:0016064)

GO Molecular Function (2): antigen binding (GO:0003823), protein binding (GO:0005515)

GO Cellular Component (4): extracellular region (GO:0005576), endoplasmic reticulum (GO:0005783), membrane (GO:0016020), IgG immunoglobulin complex (GO:0071735)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Hemostasis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
cellular anatomical structure	2
immune system process	1
response to stimulus	1
B cell mediated immunity	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
immunoglobulin complex	1

Protein interactions and networks

STRING

1318 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
IGLL1	VPREB1	P12018	999
IGLL1	CD79A	P11912	992
IGLL1	CD79B	P40259	991
IGLL1	IGHV4-38-2	P0DP08	935
IGLL1	VPREB3	Q9UKI3	890
IGLL1	PGM3	O95394	879
IGLL1	BLNK	Q8WV28	815
IGLL1	RAG1	P15918	749
IGLL1	RAG2	P55895	737
IGLL1	LRRC8A	Q8IWT6	733
IGLL1	BTK	Q06187	724
IGLL1	CD19	P15391	698
IGLL1	EBF1	Q9UH73	651
IGLL1	JCHAIN	P01591	647
IGLL1	DNTT	P04053	642

IntAct

18 interactions, top by confidence:

A	B	Type	Score
CD9	ADAM10	psi-mi:“MI:0914”(association)	0.750
IGLL1	FAM25C	psi-mi:“MI:0915”(physical association)	0.560
IGLL1	UBQLN2	psi-mi:“MI:0915”(physical association)	0.560
FAM25C	IGLL1	psi-mi:“MI:0915”(physical association)	0.560
IGLL5	IGLC7	psi-mi:“MI:0914”(association)	0.530
	IGLL1	psi-mi:“MI:0915”(physical association)	0.510
IGLL1		psi-mi:“MI:0915”(physical association)	0.510
IGLL1		psi-mi:“MI:0915”(physical association)	0.370
	IGLL1	psi-mi:“MI:0915”(physical association)	0.370
IGHG1	PDPK1	psi-mi:“MI:0914”(association)	0.350
IGLL5	POTEF	psi-mi:“MI:0914”(association)	0.350
GPC3	PXDNL	psi-mi:“MI:0914”(association)	0.350
MME	HLA-A	psi-mi:“MI:0914”(association)	0.350
IGLL1	UBQLN2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (13): IGLL1 (Affinity Capture-MS), IGLL1 (Two-hybrid), IGLL1 (Affinity Capture-MS), IGLL1 (Affinity Capture-MS), UBQLN2 (Two-hybrid), FAM25A (Two-hybrid), FAM25G (Two-hybrid), FAM25C (Two-hybrid), IGLL1 (Affinity Capture-MS), IGLL1 (Affinity Capture-MS), IGLL1 (Co-fractionation), IGLL1 (Affinity Capture-RNA), IGLL1 (Two-hybrid)

ESM2 similar proteins: A4D1S0, A4K2S4, A6NMD0, B9A064, F8WCM5, H7C350, O00220, O14931, O15533, O70146, O73895, O75298, O76081, P01854, P01883, P14138, P15692, P15814, P16382, P20764, P24394, P49763, P61484, P83743, Q00731, Q0VCS0, Q15569, Q3UM83, Q5R8H1, Q5RFR2, Q5TJE4, Q63257, Q63572, Q68D85, Q6P050, Q6PZD2, Q6WG24, Q7TQM3, Q863Z5, Q8MJ02

Diamond homologs: A0A0A0MT76, B9A064, P15814, A0A5B9, A0M8Q6, P01834, P01835, P01836, P01837, P01838, P01839, P01840, P01841, P01843, P01844, P01845, P01846, P01847, P01850, P01851, P01852, P01854, P01855, P01857, P01859, P01860, P01861, P01862, P01863, P01865, P01867, P01868, P01869, P01871, P01872, P01874, P01921, P03984, P03987, P03988

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

271 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	153
Likely benign	76
Benign	21

Top pathogenic / likely-pathogenic (0)

SpliceAI

254 predictions. Top by Δscore:

Variant	Effect	Δscore
22:23574965:A:AC	donor_gain	1.0000
22:23574966:C:CC	donor_gain	1.0000
22:23573582:TGAC:T	acceptor_gain	0.9900
22:23573585:CCT:C	acceptor_loss	0.9900
22:23573586:C:CA	acceptor_loss	0.9900
22:23573587:T:A	acceptor_loss	0.9900
22:23579979:CCTTA:C	donor_loss	0.9900
22:23579980:CTTA:C	donor_loss	0.9900
22:23579981:TTACC:T	donor_loss	0.9900
22:23579982:TACCT:T	donor_loss	0.9900
22:23579983:A:C	donor_loss	0.9900
22:23579984:C:T	donor_loss	0.9900
22:23573581:CTGAC:C	acceptor_gain	0.9800
22:23573586:C:CC	acceptor_gain	0.9800
22:23573588:G:C	acceptor_gain	0.9800
22:23573588:G:GC	acceptor_gain	0.9800
22:23573595:C:CT	acceptor_gain	0.9800
22:23579987:G:A	donor_gain	0.9800
22:23573583:GAC:G	acceptor_gain	0.9700
22:23573590:G:C	acceptor_gain	0.9700
22:23573596:A:T	acceptor_gain	0.9700
22:23574959:CCACT:C	donor_loss	0.9700
22:23574960:CACTT:C	donor_loss	0.9700
22:23574961:ACTT:A	donor_loss	0.9700
22:23574962:CTTAC:C	donor_loss	0.9700
22:23574963:TTA:T	donor_loss	0.9700
22:23574964:TACT:T	donor_loss	0.9700
22:23574965:ACTT:A	donor_loss	0.9700
22:23573583:GACC:G	acceptor_gain	0.9600
22:23573584:AC:A	acceptor_gain	0.9600

AlphaMissense

1362 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:23573461:C:A	W149C	0.982
22:23573461:C:G	W149C	0.982
22:23573488:A:C	F140L	0.981
22:23573488:A:T	F140L	0.981
22:23573490:A:G	F140L	0.981
22:23573350:C:A	W186C	0.967
22:23573350:C:G	W186C	0.967
22:23573463:A:G	W149R	0.967
22:23573463:A:T	W149R	0.967
22:23573504:C:G	C135S	0.960
22:23573505:A:T	C135S	0.960
22:23573377:G:C	S177R	0.949
22:23573377:G:T	S177R	0.949
22:23573379:T:G	S177R	0.949
22:23573505:A:G	C135R	0.949
22:23573327:C:G	C194S	0.944
22:23573328:A:T	C194S	0.944
22:23574995:A:C	F98L	0.939
22:23574995:A:T	F98L	0.939
22:23574997:A:G	F98L	0.939
22:23573380:G:C	S176R	0.931
22:23573380:G:T	S176R	0.931
22:23573382:T:G	S176R	0.931
22:23573352:A:G	W186R	0.928
22:23573352:A:T	W186R	0.928
22:23573551:G:C	F119L	0.927
22:23573551:G:T	F119L	0.927
22:23573553:A:G	F119L	0.927
22:23573327:C:T	C194Y	0.909
22:23573328:A:G	C194R	0.909

dbSNP variants (sampled 300 via entrez): RS1000046947 (22:23576192 C>T), RS1000453116 (22:23582139 C>G,T), RS1000508939 (22:23581194 C>A), RS1001402001 (22:23580787 A>G), RS1001454428 (22:23581050 A>G), RS1001566096 (22:23580392 C>A), RS1001604188 (22:23577753 C>T), RS1002400303 (22:23579718 G>A), RS1002776535 (22:23575165 G>T), RS1003327368 (22:23579061 C>T), RS1004808166 (22:23574788 T>TG), RS1004956328 (22:23579925 C>A), RS1004968479 (22:23579899 A>C,G), RS1005417044 (22:23580118 G>A,T), RS1005472970 (22:23577125 G>C,T)

Disease associations

OMIM: gene MIM:146770 | disease phenotypes: MIM:613500

GenCC curated gene-disease

Disease	Classification	Inheritance
agammaglobulinemia 2, autosomal recessive	Strong	Autosomal recessive
autosomal agammaglobulinemia	Supportive	Autosomal dominant

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
agammaglobulinemia 2, autosomal recessive	Moderate	AR

Mondo (2): agammaglobulinemia 2, autosomal recessive (MONDO:0013287), autosomal agammaglobulinemia (MONDO:0011096)

Orphanet (0):

HPO phenotypes

38 total (30 of 38 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000218	High palate
HP:0000246	Sinusitis
HP:0000286	Epicanthus
HP:0000316	Hypertelorism
HP:0000377	Abnormal pinna morphology
HP:0000389	Chronic otitis media
HP:0000403	Recurrent otitis media
HP:0000509	Conjunctivitis
HP:0000988	Skin rash
HP:0001287	Meningitis
HP:0001369	Arthritis
HP:0001508	Failure to thrive
HP:0001581	Recurrent skin infections
HP:0001875	Decreased total neutrophil count
HP:0001944	Dehydration
HP:0001945	Fever
HP:0002014	Diarrhea
HP:0002024	Malabsorption
HP:0002110	Bronchiectasis
HP:0002205	Recurrent respiratory infections
HP:0002718	Recurrent bacterial infections
HP:0002719	Recurrent infections
HP:0002720	Decreased circulating IgA concentration
HP:0002721	Immunodeficiency
HP:0002754	Osteomyelitis
HP:0002843	Abnormal T cell morphology
HP:0002850	Decreased circulating total IgM
HP:0003593	Infantile onset
HP:0004432	Agammaglobulinemia

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST000175_34	Height	6.000000e-06
GCST001019_2	Migraine	8.000000e-06
GCST002504_3	Peripheral artery disease	6.000000e-06
GCST006585_916	Blood protein levels	4.000000e-25
GCST010724_28	HOMA-B (corrected for HOMA-IR)	3.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004469	HOMA-B

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C538056	Agammaglobulinemia, non-Bruton type (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, affects methylation	2
Valproic Acid	increases expression, increases methylation, affects cotreatment	2
Zinc	affects expression, affects cotreatment, increases expression	2
sulforaphane	decreases expression	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	decreases expression	1
aflatoxin B2	increases methylation	1
Bortezomib	decreases expression	1
Air Pollutants	increases abundance, increases expression	1
Air Pollutants, Occupational	affects expression	1
Cisplatin	decreases expression	1
Curcumin	decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Hydralazine	affects cotreatment, increases expression	1
Progesterone	decreases expression	1
Tetradecanoylphorbol Acetate	affects cotreatment, affects expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.