IL10RB-DT

Summary

IL10RB-DT (IL10RB divergent transcript, HGNC:44303) is a long non-coding RNA gene on chromosome 21q22.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44303
Approved symbol	IL10RB-DT
Name	IL10RB divergent transcript
Location	21q22.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	IFNAR2-AS1
Ensembl gene	ENSG00000223799
Ensembl biotype	lncRNA
Entrez	100288432
RNAcentral	URS000075CF5F — lncRNA, 474 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000411998

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000411998 — 2 exons

Exon	Start	End
ENSE00004208608	33263873	33265902
ENSE00004208609	33266063	33266301

Expression profiles

Bgee: expression breadth ubiquitous, 166 present calls, max score 85.67.

FANTOM5 (CAGE): breadth broad, TPM avg 2.5001 / max 212.8839, expressed in 294 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190230	2.3180	285
190232	0.1373	37
190231	0.0449	13

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	85.67	gold quality
granulocyte	CL:0000094	85.66	gold quality
leukocyte	CL:0000738	85.48	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.69	gold quality
blood	UBERON:0000178	80.51	gold quality
spleen	UBERON:0002106	79.58	gold quality
tendon of biceps brachii	UBERON:0008188	79.47	gold quality
sural nerve	UBERON:0015488	79.32	gold quality
amniotic fluid	UBERON:0000173	78.46	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.39	gold quality
apex of heart	UBERON:0002098	75.23	gold quality
vermiform appendix	UBERON:0001154	75.01	gold quality
right lobe of liver	UBERON:0001114	75.00	gold quality
islet of Langerhans	UBERON:0000006	74.41	gold quality
bone marrow cell	CL:0002092	74.25	gold quality
bone marrow	UBERON:0002371	74.10	gold quality
medial globus pallidus	UBERON:0002477	73.36	gold quality
mucosa of transverse colon	UBERON:0004991	72.98	gold quality
oviduct epithelium	UBERON:0004804	72.63	gold quality
upper lobe of left lung	UBERON:0008952	72.60	gold quality
colonic epithelium	UBERON:0000397	72.10	silver quality
tibial nerve	UBERON:0001323	71.18	gold quality
upper lobe of lung	UBERON:0008948	70.75	gold quality
omental fat pad	UBERON:0010414	70.66	gold quality
stromal cell of endometrium	CL:0002255	70.58	gold quality
peritoneum	UBERON:0002358	70.58	gold quality
hindlimb stylopod muscle	UBERON:0004252	70.45	gold quality
right lung	UBERON:0002167	70.40	gold quality
right coronary artery	UBERON:0001625	70.11	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.24

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.