IL11

Summary

IL11 (interleukin 11, HGNC:5966) is a protein-coding gene on chromosome 19q13.42, encoding Interleukin-11 (P20809). Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production.

The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Source: NCBI Gene 3589 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 46 total
• Druggable target: yes
• MANE Select transcript: NM_000641

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:5966
Approved symbol	IL11
Name	interleukin 11
Location	19q13.42
Locus type	gene with protein product
Status	Approved
Aliases	IL-11, AGIF
Ensembl gene	ENSG00000095752
Ensembl biotype	protein_coding
OMIM	147681
Entrez	3589

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000264563, ENST00000585513, ENST00000587093, ENST00000590625

RefSeq mRNA: 2 — MANE Select: NM_000641 NM_000641, NM_001267718

CCDS: CCDS12923, CCDS59423

Canonical transcript exons

ENST00000264563 — 5 exons

Exon	Start	End
ENSE00000699660	55368210	55368371
ENSE00000816517	55368769	55368941
ENSE00001179094	55364382	55366177
ENSE00003470978	55370304	55370463
ENSE00003553595	55368483	55368569

Expression profiles

Bgee: expression breadth ubiquitous, 152 present calls, max score 92.62.

FANTOM5 (CAGE): breadth broad, TPM avg 2.4388 / max 107.7400, expressed in 526 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
182797	2.4388	526

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	92.62	gold quality
cartilage tissue	UBERON:0002418	92.59	gold quality
stromal cell of endometrium	CL:0002255	80.81	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	80.42	gold quality
metanephros cortex	UBERON:0010533	75.51	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.14	gold quality
cerebellar hemisphere	UBERON:0002245	74.48	gold quality
cerebellar cortex	UBERON:0002129	74.45	gold quality
cerebellum	UBERON:0002037	73.03	gold quality
mucosa of urinary bladder	UBERON:0001259	70.16	gold quality
vena cava	UBERON:0004087	69.83	gold quality
subthalamic nucleus	UBERON:0001906	69.77	gold quality
lower esophagus mucosa	UBERON:0035834	68.98	gold quality
inferior vagus X ganglion	UBERON:0005363	68.85	gold quality
dorsal plus ventral thalamus	UBERON:0001897	68.79	gold quality
medulla oblongata	UBERON:0001896	68.69	gold quality
ventral tegmental area	UBERON:0002691	68.58	gold quality
lateral nuclear group of thalamus	UBERON:0002736	68.51	gold quality
inferior olivary complex	UBERON:0002127	68.35	gold quality
cardia of stomach	UBERON:0001162	68.21	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	68.20	gold quality
superior vestibular nucleus	UBERON:0007227	68.15	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	68.12	gold quality
body of tongue	UBERON:0011876	68.10	gold quality
olfactory bulb	UBERON:0002264	68.05	gold quality
saphenous vein	UBERON:0007318	68.04	gold quality
nipple	UBERON:0002030	67.96	gold quality
pharyngeal mucosa	UBERON:0000355	67.85	gold quality
pericardium	UBERON:0002407	67.75	gold quality
substantia nigra pars reticulata	UBERON:0001966	67.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.44

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AP1, ATF2, FOS, FOSB, FOSL1, FOSL2, FOXL2, HIF1A, HMGA2, HOXA10, JUN, JUNB, JUND, NR3C1, RUNX2, SMAD1, STAT3, TXK

miRNA regulators (miRDB)

55 targeting IL11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-6845-3P	99.94	66.88	1439
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-4799-5P	99.82	70.60	2663
HSA-MIR-3681-5P	99.82	66.88	387
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-651-5P	99.64	68.49	1104
HSA-MIR-6849-5P	99.64	66.00	352
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-425-5P	99.59	67.67	900
HSA-MIR-154-3P	99.50	70.05	831
HSA-MIR-487A-3P	99.50	69.95	840

Literature-anchored findings (GeneRIF, showing 40)

• Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1). (PMID:11940481)
• Administration of recombinant human IL11 after supralethal radiation exposure promotes survival in mice: interactive effect with thrombopoietin. (PMID:12005542)
• IL-11 is involved in the endogenous cytokine response to sepsis or NEC in preterm neonates. (PMID:12032273)
• Respiratory syncytial virus induces IL-11 generation in antigen presenting cells (PMID:12197884)
• Dinucleotide repeat frequencies of the IL11.A1 allele and of IL11.A1 homozygous individuals is significantly increased among patients with ulcerative colitis. (PMID:12486609)
• expression and function in human endometrium (PMID:12569176)
• Recombinant human IL-11 induces from peripheral blood mononuclear cells the formation of osteoclastic cells, which are positive for tartrate-resistant acid phosphatase, vitronectin receptor and calcitonin receptor, and capable of lacunar resorption. (PMID:12584029)
• Immunoreactive IL-11 & IL-11Ralpha were studied in human first trimester decidua & distinct spatial & temporal patterns were defined. IL-11 has a role during decidualization & placentation in primates. (PMID:12740032)
• Upregulation of IL-11 mRNA by additive IL-1beta- and TGF-beta1, mediated by p38 MAP kinase-mediated mRNA stabilization. (PMID:12760902)
• Data suggest that interleukin-6 activation of gp130 promoted cell division in fibroblasts from patients with idiopathic pulmonary fibrosis (IPF), while IL-11 was mitogenic in both normal and IPF cells. (PMID:12819039)
• IL-11 exerts a cytoprotectve effect in a model of human T-cell mediated allograft rejection that is dependent on induction of survivin in graft endothelial cells. (PMID:14734714)
• could have a significant role in the progression of gingivitis to periodontitis (PMID:15025215)
• may participate in the pathogenesis of temporomandibular disorders and induce osseous changes in the condyle (PMID:15121272)
• IL-11 produced by blastic cells from a patient with acute megakaryocytic leukemia enhanced expression of osteoprotegerin, causing the osteosclerosis observed in this patient. (PMID:15307108)
• RANKL treatment induced a significant increase of IL-11 secretion by both bone marrow stromal & endothelial cells. (PMID:15377473)
• production of IL-11 does not increase in response to thrombocytopenia in most children with SAA (PMID:15381181)
• activation of three major signaling pathways and support a role for IL-11 in the regulation of both transcription and protein synthesis in fully differentiated adipocytes. (PMID:15389536)
• HGF maintains the hematopoietic microenvironment through stimulating proliferation and adhesion to the extracellular matrix and promoting hematopoiesis through inducing constitutive production of IL-11, SDF-1 alpha, and SCF by stromal cells themselves (PMID:15504551)
• LCH represents a cytokine-driven condition partially mediated by TNF, IL-11, and LIF. These three cytokines are all osteoclastogenic, suggesting a pathogenetic pathway for the osteolytic lesions in LCH. (PMID:15543003)
• IL-11 expression is critically important during decidualization in the human endometrium (PMID:15613426)
• in contrast to IL-6, IL-11 in plasma does not correlate with trauma severity (PMID:15614128)
• Blocking IL-11 signaling reduced RLrelaxin and medoxyprogesterone or PGE(2)+P-induced decidualization. (PMID:15784719)
• in human lung fibroblasts ET-1 exerts a profibrogenic action via an ET(A) receptor-dependent, MAPK-mediated induction of IL-11 release and cell proliferation (PMID:16149067)
• High interleukin 11 is associated with breast cancer (PMID:16614887)
• role for IL-11 via pSTAT3 and SOCS3 in initiating and progressing decidualization (PMID:16709613)
• thrombocytopenia in dengue disease is associated with changes in the serum levels of thrombopoietin, but not interleukin-11 (PMID:16759877)
• IL-11/IL-11R pathway plays an important role in the progression of colorectal adenocarcinoma. (PMID:16964382)
• There is no receptivity defect with regard to LIF and IL-11 secretions by eutopic endometrium in infertile women with endometriosis. (PMID:17000646)
• Increased IL-11 in premature senescence of fetal lung fibroblasts induced by both tert-butylhydroperoxide and ethanol. (PMID:17295091)
• Role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia. (PMID:17325843)
• The objectives of this study were to clarify the role of IL-11 and IL-11Ralpha in human gastric carcinoma. (PMID:17332920)
• An important role for IL-11 in placentation. (PMID:17702845)
• dysregulated production of IL-11 by polycythemia vera (PV) T cells, contributes to the in vitro formation of erythroid colonies in the absence of exogenous cytokines by PV CD34+ cells and likely plays a role in sustaining hematopoiesis in PV (PMID:17713553)
• IL-11, but not IL-6 levels are increased in AD and FTLD, and the highest peaks were observed in patients with a less severe degree of cognitive deterioration, therefore suggesting a role of this cytokine in early phases of neurodegeneration. (PMID:18204920)
• levels are significantly decreased in gingival crevicular fluid from sites with periodontitis compared with gingivitis and healthy sites (PMID:18433382)
• activation of protein kinase A elicits an immediate response through induction of genes such as ID2 and FosB, followed by sustained secretion of bone-related cytokines such as BMP-2, IGF-1, and IL-11 (PMID:18490653)
• binding site of il-11 to IL-11R alpha is characterized (PMID:18941632)
• IL11 inhibits human extravillous trophoblast invasion via STAT3, indicating a likely role for IL11 in the decidual restraint of EVT invasion during normal pregnancy. (PMID:18987331)
• Increased gastric IL-11 alters expression of proliferative and cytoprotective genes and promotes pretumorigenic cellular changes (PMID:19121317)
• IL-11 and LIF regulated endometrial epithelial cell adhesion, suggesting that targeting IL-11 and LIF may be useful in regulating fertility by either enhancing or blocking implantation. (PMID:19213836)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	il11a	ENSDARG00000037859
danio_rerio	il11b	ENSDARG00000058557
mus_musculus	Il11	ENSMUSG00000004371
rattus_norvegicus	Il11	ENSRNOG00000017386

Protein

Protein identifiers

Interleukin-11 — P20809 (reviewed: P20809)

Alternative names: Adipogenesis inhibitory factor

All UniProt accessions (3): P20809, A8K3F7, K7ESD5

UniProt curated annotations — full annotation on UniProt →

Function. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates ‘classic signaling’, whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates ’trans-signaling’.

Subunit / interactions. Interacts with IL11RA to associate with IL6ST, giving rise to a multimeric signaling complex.

Subcellular location. Secreted.

Similarity. Belongs to the IL-6 superfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
P20809-1	1	yes
P20809-2	2

RefSeq proteins (2): NP_000632, NP_001254647 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009079	4_helix_cytokine-like_core	Homologous_superfamily
IPR020412	IL-11_mml	Family
IPR020438	IL-11	Family

Pfam: PF07400

UniProt features (19 total): helix 8, mutagenesis site 3, sequence variant 2, signal peptide 1, chain 1, sequence conflict 1, region of interest 1, site 1, splice variant 1

Structure

Experimental structures (PDB)

8 structures.

PDB	Method	Resolution (Å)
8DPV	X-RAY DIFFRACTION	1.48
6O4O	X-RAY DIFFRACTION	1.62
8DPW	X-RAY DIFFRACTION	1.8
4MHL	X-RAY DIFFRACTION	2.09
8QY4	ELECTRON MICROSCOPY	3.06
8DPS	ELECTRON MICROSCOPY	3.47
8DPU	X-RAY DIFFRACTION	3.78
8DPT	ELECTRON MICROSCOPY	4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P20809-F1	83.46	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 168 (important for interaction with il6st and for the stimulation of cell proliferation)

Mutagenesis-validated functional residues (3):

Position	Phenotype
182	increases affinity for il11ra and stimulation of cell proliferation.
186	strongly increases affinity for il11ra and stimulation of cell proliferation.
186	increases affinity for il11ra and stimulation of cell proliferation.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-6788467	IL-6-type cytokine receptor ligand interactions

MSigDB gene sets: 265 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN, GOBP_MYELOID_CELL_DIFFERENTIATION, GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_DN, BROWNE_HCMV_INFECTION_4HR_UP, MODULE_92, AP1_01, GOBP_REGULATION_OF_PROTEIN_BINDING, BENPORATH_ES_WITH_H3K27ME3, MCLACHLAN_DENTAL_CARIES_UP, GOBP_REGULATION_OF_PHOSPHORYLATION, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, GOBP_RESPONSE_TO_PEPTIDE, GOBP_B_CELL_ACTIVATION, MODULE_64, GOBP_PEPTIDYL_SERINE_MODIFICATION

GO Biological Process (12): cell population proliferation (GO:0008283), positive regulation of cell population proliferation (GO:0008284), B cell differentiation (GO:0030183), megakaryocyte differentiation (GO:0030219), positive regulation of peptidyl-serine phosphorylation (GO:0033138), interleukin-11-mediated signaling pathway (GO:0038154), positive regulation of MAPK cascade (GO:0043410), fat cell differentiation (GO:0045444), positive regulation of transcription by RNA polymerase II (GO:0045944), negative regulation of hormone secretion (GO:0046888), positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731), signal transduction (GO:0007165)

GO Molecular Function (4): cytokine activity (GO:0005125), interleukin-11 receptor binding (GO:0005142), growth factor activity (GO:0008083), protein binding (GO:0005515)

GO Cellular Component (3): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Interleukin-6 family signaling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular process	2
positive regulation of protein phosphorylation	2
receptor ligand activity	2
cellular anatomical structure	2
cell population proliferation	1
regulation of cell population proliferation	1
positive regulation of cellular process	1
lymphocyte differentiation	1
B cell activation	1
myeloid cell differentiation	1
peptidyl-serine phosphorylation	1
regulation of peptidyl-serine phosphorylation	1
cytokine-mediated signaling pathway	1
MAPK cascade	1
regulation of MAPK cascade	1
positive regulation of intracellular signal transduction	1
cell differentiation	1
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
negative regulation of cell communication	1
negative regulation of signaling	1
hormone secretion	1
regulation of hormone secretion	1
negative regulation of secretion by cell	1
peptidyl-tyrosine phosphorylation	1
regulation of peptidyl-tyrosine phosphorylation	1
cell communication	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
cytokine receptor binding	1
growth factor receptor binding	1
binding	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2016 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
IL11	IL11RA	Q14626	998
IL11	IL6R	P08887	983
IL11	IL6ST	P40189	972
IL11	IL6	P05231	957
IL11	OSM	P13725	934
IL11	CNTF	P26441	927
IL11	LIF	P15018	918
IL11	CTF1	Q16619	846
IL11	OSMR	Q99650	845
IL11	LIFR	P42702	834
IL11	CNTFR	P26992	829
IL11	IL3	P08700	813
IL11	CXCL8	P10145	807
IL11	IL1A	P01583	806
IL11	IL10	P22301	789

IntAct

15 interactions, top by confidence:

A	B	Type	Score
IL11	MAGEA11	psi-mi:“MI:0915”(physical association)	0.670
MAGEA11	IL11	psi-mi:“MI:0915”(physical association)	0.560
IL11	S100P	psi-mi:“MI:0407”(direct interaction)	0.560
	IL11	psi-mi:“MI:0407”(direct interaction)	0.560
IL11	UBQLN2	psi-mi:“MI:0915”(physical association)	0.560
IL11	IL11RA	psi-mi:“MI:0407”(direct interaction)	0.440
IL11	MAGEA11	psi-mi:“MI:0915”(physical association)	0.000
IL11	UBQLN2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (18): MAGEA11 (Two-hybrid), MAGEA11 (Two-hybrid), IL11 (Affinity Capture-RNA), IL11 (Co-localization), IL11 (Co-localization), MAGEA11 (Two-hybrid), UBQLN2 (Two-hybrid), S100P (Reconstituted Complex), S100A1 (Reconstituted Complex), S100B (Reconstituted Complex), S100A6 (Reconstituted Complex), NCS1 (Reconstituted Complex), GUCA1A (Reconstituted Complex), GUCA1B (Reconstituted Complex), CALM1 (Reconstituted Complex)

ESM2 similar proteins: A2A9Q0, A2VDH3, B0BNK7, C9JI98, D2HFT7, D4A2Q0, D4ABX8, E7ERA6, E9Q7T7, F2Z333, O94819, P0C6S8, P0DKB5, P13224, P20809, P56400, Q04785, Q17QZ8, Q1RMS4, Q2I0M4, Q32NY4, Q50LG9, Q5VT99, Q684M3, Q6GQU6, Q6NUI6, Q6PJG9, Q6UKI2, Q6UX72, Q6ZMC9, Q7M6Z0, Q7Z736, Q80WD1, Q80XU8, Q86UN3, Q8BHA1, Q8BLY3, Q8BQB4, Q8IZ52, Q8NE01

Diamond homologs: P20808, P20809, P47873, Q99MF5

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
IL11	“up-regulates activity”	IL6ST	binding
“Activated PSC”	up-regulates	IL11
IL11	up-regulates	IL6ST	binding
IL11	up-regulates	IL11RA	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

605 predictions. Top by Δscore:

Variant	Effect	Δscore
19:55368205:CATA:C	donor_loss	1.0000
19:55368206:ATAC:A	donor_loss	1.0000
19:55368207:TACCA:T	donor_loss	1.0000
19:55368208:A:AC	donor_gain	1.0000
19:55368209:C:CC	donor_gain	1.0000
19:55368209:C:CT	donor_loss	1.0000
19:55368368:GGAG:G	acceptor_gain	1.0000
19:55368370:AG:A	acceptor_gain	1.0000
19:55368372:C:CC	acceptor_gain	1.0000
19:55368477:CCTTA:C	donor_loss	1.0000
19:55368478:CTTA:C	donor_loss	1.0000
19:55368479:TTACC:T	donor_loss	1.0000
19:55368481:A:AT	donor_loss	1.0000
19:55368565:TCCCT:T	acceptor_gain	1.0000
19:55368566:CCCT:C	acceptor_gain	1.0000
19:55368566:CCCTC:C	acceptor_gain	1.0000
19:55368567:CCTC:C	acceptor_gain	1.0000
19:55368568:CT:C	acceptor_gain	1.0000
19:55368570:C:CC	acceptor_gain	1.0000
19:55368570:CTGGC:C	acceptor_loss	1.0000
19:55368765:CTA:C	donor_loss	1.0000
19:55368768:CCAG:C	donor_gain	1.0000
19:55370302:A:AC	donor_gain	1.0000
19:55370303:C:CC	donor_gain	1.0000
19:55366174:ACATC:A	acceptor_loss	0.9900
19:55366175:CAT:C	acceptor_gain	0.9900
19:55366177:TCTGT:T	acceptor_loss	0.9900
19:55366178:C:CC	acceptor_gain	0.9900
19:55366178:C:CG	acceptor_loss	0.9900
19:55366179:T:A	acceptor_loss	0.9900

AlphaMissense

1206 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:55366038:C:A	R190M	0.996
19:55366045:C:G	A188P	0.992
19:55366046:C:A	W187C	0.992
19:55366046:C:G	W187C	0.992
19:55368337:A:G	L101P	0.992
19:55366048:A:G	W187R	0.991
19:55366048:A:T	W187R	0.991
19:55366037:C:A	R190S	0.990
19:55366037:C:G	R190S	0.990
19:55368311:A:G	W110R	0.990
19:55368311:A:T	W110R	0.990
19:55366036:C:G	G191R	0.989
19:55366036:C:T	G191R	0.989
19:55366038:C:G	R190T	0.988
19:55366086:G:T	A174D	0.988
19:55368307:A:G	L111P	0.988
19:55368309:C:A	W110C	0.988
19:55368309:C:G	W110C	0.988
19:55366032:A:G	L192P	0.987
19:55366077:A:T	I177N	0.987
19:55368523:G:T	P76H	0.987
19:55368803:A:G	L49P	0.987
19:55366050:T:A	D186V	0.986
19:55368558:G:C	F64L	0.986
19:55368558:G:T	F64L	0.986
19:55368560:A:G	F64L	0.986
19:55368803:A:T	L49H	0.986
19:55366044:G:T	A188D	0.985
19:55366051:C:G	D186H	0.984
19:55366065:A:G	L181P	0.984

dbSNP variants (sampled 300 via entrez): RS1000277349 (19:55372067 C>T), RS1000519792 (19:55369100 G>A), RS1000627847 (19:55371707 C>T), RS1001385968 (19:55364029 C>G), RS1001437778 (19:55369337 A>C,T), RS1001667459 (19:55364295 C>A,T), RS1001682416 (19:55369324 C>A,T), RS1001895217 (19:55363949 G>A), RS1002394330 (19:55368042 G>A), RS1003164805 (19:55365117 ATCACCTGAGG>A), RS1003529616 (19:55370783 G>T), RS1003580518 (19:55371045 C>T), RS1004092841 (19:55365223 A>C), RS1004744088 (19:55371415 G>A), RS1005220676 (19:55370506 C>G,T)

Disease associations

OMIM: gene MIM:147681 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST000643_1	Response to antidepressants	3.000000e-06
GCST006926_11	Osteoarthritis (hip)	2.000000e-11
GCST90000025_574	Appendicular lean mass	5.000000e-35
GCST90000026_28	Appendicular lean mass	8.000000e-18
GCST90000027_2	Appendicular lean mass	7.000000e-19

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6196073 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs1126757	Efficacy	3	escitalopram	Depression

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs1126757	IL11	3	1.50	1	escitalopram

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.85	Kd	140	nM	CHEMBL6162758
5.58	Kd	2600	nM	CHEMBL6160522

CTD chemical–gene interactions

130 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases secretion, affects methylation, increases expression	6
Tetrachlorodibenzodioxin	affects cotreatment, increases expression, decreases expression	4
Estradiol	decreases secretion, increases expression, increases reaction, increases secretion, affects expression (+1 more)	3
Cyclosporine	increases expression	3
tert-Butylhydroperoxide	affects expression, increases expression	3
sodium arsenite	increases expression	2
potassium chromate(VI)	decreases expression, affects cotreatment, increases expression	2
entinostat	increases expression, affects cotreatment	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases reaction, increases secretion, affects cotreatment, increases expression	2
(+)-JQ1 compound	increases expression	2
Air Pollutants	increases expression, increases abundance	2
Ethanol	decreases expression, increases expression	2
Cisplatin	decreases expression, increases reaction, increases expression	2
Folic Acid	affects expression, affects response to substance, affects cotreatment, increases expression	2
Formaldehyde	decreases reaction, increases expression, increases secretion, decreases expression	2
Hydrogen Peroxide	affects expression, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Silver	increases expression	2
Dronabinol	decreases expression	2
Triclosan	decreases reaction, increases expression	2
Valproic Acid	increases expression, increases methylation	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression, increases expression	2
Cadmium Chloride	increases expression	2
Particulate Matter	increases expression, affects expression, increases reaction, increases abundance	2
aristolochic acid I	increases expression	1
Glupearl 19S	increases expression	1
aminomethylphosphonic acid (AMPA)	increases expression	1
methylmercuric chloride	increases expression	1
lasiocarpine	increases expression	1
triphenyl phosphate	increases abundance, increases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL6115567	Binding	Binding affinity to CAP chip-immobilized IL-11 (unknown origin) assessed as dissociation constant by SPR analysis	De novo discovery of cyclic peptide inhibitors of IL-11 signaling. — Bioorg Med Chem

Cellosaurus cell lines

3 cell lines: 2 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D7RZ	Ubigene A-549 IL11 KO	Cancer cell line	Male
CVCL_D9GY	Ubigene HEK293 IL11 KO	Transformed cell line	Female
CVCL_E0EV	Ubigene HeLa IL11 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.