IL12A-AS1

Summary

IL12A-AS1 (IL12A antisense RNA 1, HGNC:49094) is a long non-coding RNA gene on chromosome 3q25.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49094
Approved symbol	IL12A-AS1
Name	IL12A antisense RNA 1
Location	3q25.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	ILAS1-AS1
Ensembl gene	ENSG00000244040
Ensembl biotype	lncRNA
Entrez	101928376
RNAcentral	URS0000521E93 — lncRNA, 2425 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 34 — 34 lncRNA

ENST00000462431, ENST00000486168, ENST00000497452, ENST00000642756, ENST00000654530, ENST00000656481, ENST00000659957, ENST00000660728, ENST00000661085, ENST00000662594, ENST00000663549, ENST00000664175, ENST00000666425, ENST00000671614, ENST00000726628, ENST00000726629, ENST00000740375, ENST00000740376, ENST00000740377, ENST00000740378, ENST00000740379, ENST00000740380, ENST00000740381, ENST00000740382, ENST00000740383, ENST00000740384, ENST00000740385, ENST00000740386, ENST00000740387, ENST00000740388, ENST00000740389, ENST00000740390, ENST00000740391, ENST00000740392

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000462431 — 5 exons

Exon	Start	End
ENSE00001824162	160011665	160012110
ENSE00001853925	160009112	160009257
ENSE00001885972	160015696	160015861
ENSE00001918089	159998174	159998317
ENSE00001921158	160011466	160011551

Expression profiles

Bgee: expression breadth ubiquitous, 144 present calls, max score 92.65.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0320 / max 6.6892, expressed in 16 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
45343	0.0320	16

Top tissues by expression

235 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	92.65	gold quality
buccal mucosa cell	CL:0002336	76.73	silver quality
esophagus mucosa	UBERON:0002469	76.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.67	gold quality
prefrontal cortex	UBERON:0000451	67.88	gold quality
right frontal lobe	UBERON:0002810	67.06	gold quality
left testis	UBERON:0004533	66.86	gold quality
cortical plate	UBERON:0005343	66.83	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	66.77	silver quality
muscle layer of sigmoid colon	UBERON:0035805	66.50	gold quality
right testis	UBERON:0004534	65.22	gold quality
testis	UBERON:0000473	64.68	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.41	gold quality
anterior cingulate cortex	UBERON:0009835	64.39	gold quality
esophagus	UBERON:0001043	62.93	gold quality
frontal cortex	UBERON:0001870	62.76	gold quality
neocortex	UBERON:0001950	62.48	gold quality
stromal cell of endometrium	CL:0002255	61.71	gold quality
smooth muscle tissue	UBERON:0001135	60.52	gold quality
monocyte	CL:0000576	60.01	gold quality
ventricular zone	UBERON:0003053	58.92	silver quality
hindlimb stylopod muscle	UBERON:0004252	58.68	gold quality
cerebral cortex	UBERON:0000956	58.63	gold quality
islet of Langerhans	UBERON:0000006	57.67	gold quality
vagina	UBERON:0000996	57.41	gold quality
ganglionic eminence	UBERON:0004023	57.11	silver quality
sural nerve	UBERON:0015488	57.09	silver quality
colon	UBERON:0001155	56.81	gold quality
large intestine	UBERON:0000059	56.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 are bona fide susceptibility genes for Behcet’s disease. (PMID:26097239)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.