IL21-AS1

Summary

IL21-AS1 (IL21 antisense RNA 1, HGNC:40299) is a long non-coding RNA gene on chromosome 4q27.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40299
Approved symbol	IL21-AS1
Name	IL21 antisense RNA 1
Location	4q27
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227145
Ensembl biotype	lncRNA
Entrez	100996941
RNAcentral	URS00003DF5B4 — lncRNA, 3748 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000417927, ENST00000660809, ENST00000667001, ENST00000668520, ENST00000775025

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000417927 — 11 exons

Exon	Start	End
ENSE00001613029	122618983	122619492
ENSE00001656409	122619968	122620165
ENSE00001669827	122648101	122648228
ENSE00001671527	122648728	122648842
ENSE00001685954	122621195	122621321
ENSE00001694910	122628885	122628996
ENSE00001729891	122688537	122689156
ENSE00001745267	122624670	122624717
ENSE00001754749	122625216	122626813
ENSE00001773767	122649624	122649711
ENSE00001787763	122620868	122621071

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 81.55.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.55	gold quality
bone marrow cell	CL:0002092	75.87	gold quality
tonsil	UBERON:0002372	69.76	gold quality
lymph node	UBERON:0000029	68.91	gold quality
cortex of kidney	UBERON:0001225	65.23	gold quality
vermiform appendix	UBERON:0001154	64.83	gold quality
right testis	UBERON:0004534	62.44	gold quality
testis	UBERON:0000473	62.40	gold quality
left testis	UBERON:0004533	62.37	gold quality
bone marrow	UBERON:0002371	59.74	gold quality
urinary bladder	UBERON:0001255	58.41	gold quality
prefrontal cortex	UBERON:0000451	54.81	gold quality
sural nerve	UBERON:0015488	54.23	silver quality
right atrium auricular region	UBERON:0006631	53.79	gold quality
leukocyte	CL:0000738	53.61	silver quality
vagina	UBERON:0000996	53.39	gold quality
multicellular organism	UBERON:0000468	52.57	gold quality
muscle layer of sigmoid colon	UBERON:0035805	52.14	gold quality
myometrium	UBERON:0001296	51.83	gold quality
putamen	UBERON:0001874	50.87	gold quality
blood	UBERON:0000178	50.62	gold quality
smooth muscle tissue	UBERON:0001135	50.31	gold quality
pancreas	UBERON:0001264	49.56	gold quality
adrenal gland	UBERON:0002369	49.30	silver quality
duodenum	UBERON:0002114	49.15	gold quality
heart	UBERON:0000948	48.92	gold quality
body of uterus	UBERON:0009853	48.72	gold quality
colon	UBERON:0001155	48.51	gold quality
monocyte	CL:0000576	47.81	silver quality
left ovary	UBERON:0002119	47.81	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Involvement of lncRNA IL21-AS1 in interleukin-2 and T follicular regulatory cell activation in systemic lupus erythematosus. (PMID:34895341)
• LncRNA IL21-AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosus. (PMID:36447054)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.