IL6-AS1

Summary

IL6-AS1 (IL6 antisense RNA 1, HGNC:40301) is a long non-coding RNA gene on chromosome 7p15.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40301
Approved symbol	IL6-AS1
Name	IL6 antisense RNA 1
Location	7p15.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000179428
Ensembl biotype	lncRNA
Entrez	541472
RNAcentral	URS00008E39B4 — lncRNA, 1374 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000325042

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000325042 — 2 exons

Exon	Start	End
ENSE00001228191	22727568	22727620
ENSE00001228200	22725395	22726705

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 78.96.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1023 / max 4.5583, expressed in 53 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
83086	0.2286	90
83087	0.1023	53

Top tissues by expression

223 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	78.96	gold quality
bone marrow cell	CL:0002092	68.92	silver quality
lymph node	UBERON:0000029	63.65	gold quality
nasal cavity epithelium	UBERON:0005384	62.60	gold quality
sperm	CL:0000019	62.02	gold quality
vermiform appendix	UBERON:0001154	60.54	gold quality
leukocyte	CL:0000738	59.73	gold quality
caecum	UBERON:0001153	59.46	gold quality
tonsil	UBERON:0002372	59.11	gold quality
omental fat pad	UBERON:0010414	58.87	gold quality
peritoneum	UBERON:0002358	58.85	gold quality
gall bladder	UBERON:0002110	58.65	gold quality
spleen	UBERON:0002106	58.03	gold quality
adipose tissue of abdominal region	UBERON:0007808	57.79	gold quality
cerebellar vermis	UBERON:0004720	57.68	gold quality
vena cava	UBERON:0004087	57.23	gold quality
cardia of stomach	UBERON:0001162	57.18	gold quality
thymus	UBERON:0002370	56.88	gold quality
smooth muscle tissue	UBERON:0001135	56.32	gold quality
inferior vagus X ganglion	UBERON:0005363	56.32	gold quality
nipple	UBERON:0002030	55.93	gold quality
mucosa of paranasal sinus	UBERON:0005030	55.62	gold quality
gingival epithelium	UBERON:0001949	55.42	gold quality
saphenous vein	UBERON:0007318	55.27	gold quality
urethra	UBERON:0000057	55.18	gold quality
pericardium	UBERON:0002407	55.16	gold quality
layer of synovial tissue	UBERON:0007616	55.10	gold quality
right coronary artery	UBERON:0001625	55.08	gold quality
corpus callosum	UBERON:0002336	54.98	gold quality
pharyngeal mucosa	UBERON:0000355	54.96	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA IL6-AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR-149-5p and early B-cell factor 1. (PMID:34323408)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.