IL6R-AS1

Summary

IL6R-AS1 (IL6R antisense RNA 1, HGNC:53716) is a long non-coding RNA gene on chromosome 1q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53716
Approved symbol	IL6R-AS1
Name	IL6R antisense RNA 1
Location	1q21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-350G8.5
Ensembl gene	ENSG00000228013
Ensembl biotype	lncRNA
Entrez	101928101
RNAcentral	URS0000BC4567 — lncRNA, 1791 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000424435, ENST00000789562

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000424435 — 2 exons

Exon	Start	End
ENSE00001759085	154402328	154403957
ENSE00001782149	154406439	154406564

Expression profiles

Bgee: expression breadth ubiquitous, 140 present calls, max score 65.52.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.8774 / max 80.9831, expressed in 152 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14803	0.6743	134
14802	0.1038	50
14804	0.0993	49

Top tissues by expression

229 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.52	gold quality
islet of Langerhans	UBERON:0000006	63.73	gold quality
bone marrow cell	CL:0002092	63.23	silver quality
hindlimb stylopod muscle	UBERON:0004252	63.04	gold quality
gastrocnemius	UBERON:0001388	62.73	gold quality
muscle of leg	UBERON:0001383	62.51	gold quality
pancreas	UBERON:0001264	56.07	gold quality
right hemisphere of cerebellum	UBERON:0014890	55.96	gold quality
ganglionic eminence	UBERON:0004023	55.74	gold quality
lymph node	UBERON:0000029	55.59	gold quality
gall bladder	UBERON:0002110	54.00	gold quality
vermiform appendix	UBERON:0001154	53.95	gold quality
prefrontal cortex	UBERON:0000451	53.65	gold quality
calcaneal tendon	UBERON:0003701	53.25	silver quality
cerebellar hemisphere	UBERON:0002245	52.35	gold quality
right lobe of liver	UBERON:0001114	52.32	gold quality
leukocyte	CL:0000738	51.44	silver quality
adenohypophysis	UBERON:0002196	50.79	gold quality
blood	UBERON:0000178	50.60	silver quality
monocyte	CL:0000576	50.06	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	49.46	gold quality
liver	UBERON:0002107	49.40	silver quality
left ovary	UBERON:0002119	49.31	gold quality
left adrenal gland cortex	UBERON:0035825	48.93	gold quality
pituitary gland	UBERON:0000007	48.91	gold quality
muscle tissue	UBERON:0002385	48.88	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	48.72	gold quality
tibial artery	UBERON:0007610	48.70	gold quality
popliteal artery	UBERON:0002250	48.68	gold quality
spinal cord	UBERON:0002240	48.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.97

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.