ILF3-DT

Summary

ILF3-DT (ILF3 divergent transcript, HGNC:27115) is a long non-coding RNA gene on chromosome 19p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27115
Approved symbol	ILF3-DT
Name	ILF3 divergent transcript
Location	19p13.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000267100
Ensembl biotype	lncRNA
Entrez	147727
RNAcentral	URS000075B993 — lncRNA, 2032 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000591501, ENST00000790961, ENST00000790962

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000591501 — 1 exons

Exon	Start	End
ENSE00004171711	10651859	10653879

Expression profiles

Bgee: expression breadth ubiquitous, 231 present calls, max score 90.26.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.2061 / max 111.6692, expressed in 1753 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179172	10.5559	1752
179170	0.5136	98
179171	0.1365	52

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	90.26	gold quality
gastrocnemius	UBERON:0001388	90.22	gold quality
muscle of leg	UBERON:0001383	89.74	gold quality
pituitary gland	UBERON:0000007	89.48	gold quality
left lobe of thyroid gland	UBERON:0001120	89.23	gold quality
left ovary	UBERON:0002119	89.21	gold quality
nucleus accumbens	UBERON:0001882	88.96	gold quality
right lobe of thyroid gland	UBERON:0001119	88.93	gold quality
right uterine tube	UBERON:0001302	88.76	gold quality
thyroid gland	UBERON:0002046	88.67	gold quality
body of uterus	UBERON:0009853	87.80	gold quality
mucosa of stomach	UBERON:0001199	87.72	gold quality
endocervix	UBERON:0000458	87.59	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.55	gold quality
cerebellar hemisphere	UBERON:0002245	87.44	gold quality
cerebellar cortex	UBERON:0002129	87.34	gold quality
putamen	UBERON:0001874	87.30	gold quality
apex of heart	UBERON:0002098	87.24	gold quality
cerebellar vermis	UBERON:0004720	87.21	gold quality
tibial nerve	UBERON:0001323	87.06	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.06	gold quality
hypothalamus	UBERON:0001898	86.90	gold quality
right ovary	UBERON:0002118	86.88	gold quality
skin of leg	UBERON:0001511	86.76	gold quality
ectocervix	UBERON:0012249	86.76	gold quality
right lung	UBERON:0002167	86.66	gold quality
cerebellum	UBERON:0002037	86.58	gold quality
caudate nucleus	UBERON:0001873	86.47	gold quality
lower esophagus muscularis layer	UBERON:0035833	86.47	gold quality
lower esophagus	UBERON:0013473	86.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.37

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Long noncoding RNA ILF3-AS1 promotes EZH2-mediated cell proliferation, migration, and invasion via negatively regulating miR-200b/a/429 in melanoma. (PMID:28935763)
• The expression levels of lncRNA ILF3-AS1 was up-regulated in osteosarcoma tissues and cell lines, and was modulated by SP1. LncRNA ILF3-AS1 promoted osteosarcoma cells proliferation and metastasis via modulation of miR-212-SOX5 pathway. (PMID:30819403)
• LncRNA ILF3-AS1 mediated the occurrence of epilepsy through suppressing hippocampal miR-212 expression. (PMID:32404536)
• Up-regulated long non-coding RNA ILF3-AS1 indicates poor prognosis of nasopharyngeal carcinoma and promoted cell metastasis. (PMID:32962500)
• Mechanism underlying long noncoding RNA ILF3AS1mediated inhibition of cervical cancer cell proliferation, invasion and migration, and promotion of apoptosis. (PMID:34080029)
• LncRNA ILF3-AS1 mediates oxidative stress and inflammation through miR-504-3p/HMGB1 axis in a cellular model of temporal lobe epilepsy. (PMID:39135276)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.