INE1

Summary

INE1 (inactivation escape 1, HGNC:6060) is a long non-coding RNA gene on chromosome Xp11.3.

X chromosome inactivation provides dosage compensation for the expression level of X-linked genes from the single X in males and the two in females. This X chromosome gene is intronless and was identified because its transcription escapes X inactivation in females. This gene does not make a protein.

Source: NCBI Gene 8552 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6060
Approved symbol	INE1
Name	inactivation escape 1
Location	Xp11.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00010
Ensembl gene	ENSG00000224975
Ensembl biotype	lncRNA
OMIM	300164
Entrez	8552
RNAcentral	URS000075C6CE — lncRNA, 1014 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000456273

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000456273 — 1 exons

Exon	Start	End
ENSE00001786014	47204921	47205865

Expression profiles

Bgee: expression breadth ubiquitous, 172 present calls, max score 81.02.

Top tissues by expression

276 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.02	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.78	gold quality
granulocyte	CL:0000094	78.36	gold quality
right ovary	UBERON:0002118	78.11	gold quality
right lobe of thyroid gland	UBERON:0001119	78.01	gold quality
left ovary	UBERON:0002119	77.76	gold quality
stromal cell of endometrium	CL:0002255	77.41	gold quality
left uterine tube	UBERON:0001303	77.03	gold quality
skin of abdomen	UBERON:0001416	76.48	gold quality
left lobe of thyroid gland	UBERON:0001120	76.10	gold quality
monocyte	CL:0000576	75.74	gold quality
mononuclear cell	CL:0000842	75.38	gold quality
body of uterus	UBERON:0009853	75.37	gold quality
mucosa of stomach	UBERON:0001199	75.27	gold quality
skin of leg	UBERON:0001511	75.16	gold quality
leukocyte	CL:0000738	75.02	gold quality
thyroid gland	UBERON:0002046	74.86	gold quality
blood	UBERON:0000178	74.77	gold quality
ectocervix	UBERON:0012249	74.03	gold quality
endocervix	UBERON:0000458	73.97	gold quality
minor salivary gland	UBERON:0001830	73.70	gold quality
right uterine tube	UBERON:0001302	73.69	gold quality
apex of heart	UBERON:0002098	73.43	gold quality
descending thoracic aorta	UBERON:0002345	73.42	gold quality
transverse colon	UBERON:0001157	73.36	gold quality
upper lobe of left lung	UBERON:0008952	73.28	gold quality
small intestine Peyer’s patch	UBERON:0003454	73.27	gold quality
right coronary artery	UBERON:0001625	73.13	gold quality
sural nerve	UBERON:0015488	73.08	gold quality
right lung	UBERON:0002167	72.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.19

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AP1, NFKB

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.