INE2

Summary

INE2 (inactivation escape 2, HGNC:6061) is a long non-coding RNA gene on chromosome Xp22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6061
Approved symbol	INE2
Name	inactivation escape 2
Location	Xp22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00011
Ensembl gene	ENSG00000281371
Ensembl biotype	lncRNA
OMIM	300165
Entrez	8551
RNAcentral	URS000075E0D3 — lncRNA, 1874 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000630399

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000630399 — 1 exons

Exon	Start	End
ENSE00003762301	15785716	15787589

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 76.82.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	76.82	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.54	gold quality
colonic epithelium	UBERON:0000397	69.67	silver quality
bone marrow cell	CL:0002092	67.17	silver quality
stromal cell of endometrium	CL:0002255	65.39	gold quality
right coronary artery	UBERON:0001625	65.36	gold quality
ascending aorta	UBERON:0001496	65.11	gold quality
substantia nigra	UBERON:0002038	65.08	gold quality
thoracic aorta	UBERON:0001515	65.02	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.66	gold quality
leukocyte	CL:0000738	64.22	gold quality
descending thoracic aorta	UBERON:0002345	63.97	gold quality
ganglionic eminence	UBERON:0004023	63.90	gold quality
mucosa of stomach	UBERON:0001199	63.63	gold quality
tonsil	UBERON:0002372	63.38	silver quality
ventricular zone	UBERON:0003053	63.31	gold quality
cortical plate	UBERON:0005343	62.98	gold quality
hypothalamus	UBERON:0001898	62.83	gold quality
uterine cervix	UBERON:0000002	62.54	gold quality
blood	UBERON:0000178	62.32	gold quality
endocervix	UBERON:0000458	62.17	gold quality
temporal lobe	UBERON:0001871	62.02	gold quality
amygdala	UBERON:0001876	61.94	gold quality
ectocervix	UBERON:0012249	61.65	gold quality
left coronary artery	UBERON:0001626	61.12	gold quality
right ovary	UBERON:0002118	61.06	gold quality
lower esophagus mucosa	UBERON:0035834	60.79	gold quality
putamen	UBERON:0001874	60.77	gold quality
nucleus accumbens	UBERON:0001882	60.72	gold quality
popliteal artery	UBERON:0002250	60.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ESR1, NCOR1, NCOR2, NFKB, SP1

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.