INO80C

Summary

INO80C (INO80 complex subunit C, HGNC:26994) is a protein-coding gene on chromosome 18q12.2, encoding INO80 complex subunit C (Q6PI98). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in cytosol; fibrillar center; and nucleoplasm. Part of Ino80 complex and MLL1 complex.

Source: NCBI Gene 125476 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 52 total
• Druggable target: yes — 1 molecules with ChEMBL bioactivity
• MANE Select transcript: NM_194281

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26994
Approved symbol	INO80C
Name	INO80 complex subunit C
Location	18q12.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ38183, hIes6, IES6
Ensembl gene	ENSG00000153391
Ensembl biotype	protein_coding
Entrez	125476

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 12 protein_coding, 3 retained_intron, 1 nonsense_mediated_decay

ENST00000283410, ENST00000334598, ENST00000441607, ENST00000585971, ENST00000586449, ENST00000586489, ENST00000587450, ENST00000589053, ENST00000589273, ENST00000590757, ENST00000591139, ENST00000592173, ENST00000934274, ENST00000934275, ENST00000934276, ENST00000934277

RefSeq mRNA: 3 — MANE Select: NM_194281 NM_001098817, NM_001308064, NM_194281

CCDS: CCDS11914, CCDS45853, CCDS77177

Canonical transcript exons

ENST00000334598 — 5 exons

Exon	Start	End
ENSE00002859403	35468333	35468742
ENSE00003171906	35479300	35479411
ENSE00003461422	35497719	35497960
ENSE00003473299	35478282	35478349
ENSE00003584990	35480453	35480563

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 97.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.3250 / max 102.8474, expressed in 1786 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
171660	8.0706	1779
171659	0.5856	267
171662	0.5426	282
171661	0.1262	36

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	97.58	gold quality
right testis	UBERON:0004534	97.31	gold quality
testis	UBERON:0000473	95.90	gold quality
amniotic fluid	UBERON:0000173	95.70	gold quality
pharyngeal mucosa	UBERON:0000355	95.70	gold quality
esophagus squamous epithelium	UBERON:0006920	95.36	gold quality
lower esophagus mucosa	UBERON:0035834	95.00	gold quality
esophagus mucosa	UBERON:0002469	94.34	gold quality
buccal mucosa cell	CL:0002336	93.65	gold quality
adult organism	UBERON:0007023	92.97	gold quality
epithelial cell of pancreas	CL:0000083	92.91	silver quality
ileal mucosa	UBERON:0000331	92.83	gold quality
skin of abdomen	UBERON:0001416	92.13	gold quality
adenohypophysis	UBERON:0002196	92.08	gold quality
pituitary gland	UBERON:0000007	92.07	gold quality
oral cavity	UBERON:0000167	91.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	91.73	gold quality
sperm	CL:0000019	91.55	gold quality
spleen	UBERON:0002106	91.39	gold quality
mucosa of stomach	UBERON:0001199	91.22	gold quality
esophagus	UBERON:0001043	90.74	gold quality
body of stomach	UBERON:0001161	90.65	gold quality
cardiac muscle of right atrium	UBERON:0003379	90.59	silver quality
zone of skin	UBERON:0000014	90.53	gold quality
palpebral conjunctiva	UBERON:0001812	90.52	gold quality
skin of leg	UBERON:0001511	90.44	gold quality
left ventricle myocardium	UBERON:0006566	90.39	silver quality
monocyte	CL:0000576	90.24	gold quality
placenta	UBERON:0001987	90.15	gold quality
granulocyte	CL:0000094	90.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.71

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

26 targeting INO80C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-32-3P	99.36	68.20	2517
HSA-MIR-3614-5P	99.30	65.25	837
HSA-MIR-4291	99.20	68.88	2969
HSA-MIR-196A-3P	99.19	67.34	1204
HSA-MIR-548AS-3P	99.12	69.12	2294
HSA-MIR-922	99.02	67.23	1838
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-214-3P	98.71	68.12	2128
HSA-MIR-761	98.71	68.07	2051
HSA-MIR-603	98.58	68.28	1603
HSA-MIR-216B-3P	98.55	67.19	1223
HSA-MIR-6515-5P	97.08	65.48	1219
HSA-MIR-584-5P	95.82	68.05	848

Literature-anchored findings (GeneRIF, showing 2)

• C18orf37, similar in sequence to yeast Ies6p. A subunit of the Ino80 chromatin remodeling complex, which has roles in transcription and DNA repair. (PMID:16230350)
• Data indicate metabolic enzymes NAD kinase and ketohexokinase as candidate metabolic gene targets, and the chromatin remodeling protein INO80C as a tumor suppressor in KRAS(MUT) colorectal tumor xenograft. (PMID:28954733)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	ino80c	ENSDARG00000055719
mus_musculus	Ino80c	ENSMUSG00000047989
rattus_norvegicus	Ino80c	ENSRNOG00000016532
drosophila_melanogaster	CG12659	FBGN0040929

Protein

Protein identifiers

INO80 complex subunit C — Q6PI98 (reviewed: Q6PI98)

Alternative names: IES6 homolog

All UniProt accessions (7): Q6PI98, K7EIY8, K7EKI6, K7ELX9, K7ENM4, K7EQ79, M0R3E2

UniProt curated annotations — full annotation on UniProt →

Function. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Subunit / interactions. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.

Subcellular location. Nucleus.

Isoforms (3)

UniProt ID	Names	Canonical?
Q6PI98-1	1	yes
Q6PI98-3	2
Q6PI98-4	3

RefSeq proteins (3): NP_001092287, NP_001294993, NP_919257* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013272	Vps72/YL1_C	Domain
IPR029525	INO80C/Ies6	Family

Pfam: PF08265

UniProt features (5 total): splice variant 2, chain 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
7ZI4	ELECTRON MICROSCOPY	3.2
9GE5	ELECTRON MICROSCOPY	3.35
9GCG	ELECTRON MICROSCOPY	3.43
9GEV	ELECTRON MICROSCOPY	3.47
9GFB	ELECTRON MICROSCOPY	3.55

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6PI98-F1	71.46	0.32

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-5689603	UCH proteinases
R-HSA-5696394	DNA Damage Recognition in GG-NER
R-HSA-392499	Metabolism of proteins
R-HSA-5688426	Deubiquitination
R-HSA-5696398	Nucleotide Excision Repair
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-597592	Post-translational protein modification
R-HSA-73894	DNA Repair

MSigDB gene sets: 160 (showing top): GOBP_CHROMOSOME_ORGANIZATION, GOBP_TELOMERE_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, BILD_SRC_ONCOGENIC_SIGNATURE, GOBP_REGULATION_OF_DNA_REPAIR, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_REGULATION_OF_TELOMERE_MAINTENANCE, chr18q12, BILD_E2F3_ONCOGENIC_SIGNATURE, GOBP_REGULATION_OF_CELL_CYCLE, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_DNA_STRAND_ELONGATION, GOBP_DNA_DAMAGE_RESPONSE, GOBP_POSITIVE_REGULATION_OF_DNA_REPAIR, GOBP_POSITIVE_REGULATION_OF_TELOMERE_MAINTENANCE

GO Biological Process (14): telomere maintenance (GO:0000723), regulation of DNA replication (GO:0006275), DNA repair (GO:0006281), regulation of DNA repair (GO:0006282), DNA recombination (GO:0006310), chromatin remodeling (GO:0006338), regulation of chromosome organization (GO:0033044), positive regulation of DNA repair (GO:0045739), positive regulation of DNA-templated transcription (GO:0045893), regulation of embryonic development (GO:0045995), regulation of cell cycle (GO:0051726), regulation of DNA strand elongation (GO:0060382), positive regulation of telomere maintenance in response to DNA damage (GO:1904507), DNA damage response (GO:0006974)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): fibrillar center (GO:0001650), nucleoplasm (GO:0005654), cytosol (GO:0005829), Ino80 complex (GO:0031011), MLL1 complex (GO:0071339), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Deubiquitination	1
Global Genome Nucleotide Excision Repair (GG-NER)	1
Post-translational protein modification	1
DNA Repair	1
Nucleotide Excision Repair	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA metabolic process	3
regulation of DNA metabolic process	3
cellular anatomical structure	3
DNA repair	2
positive regulation of response to stimulus	2
telomere organization	1
DNA replication	1
DNA damage response	1
regulation of cellular response to stress	1
chromatin organization	1
regulation of organelle organization	1
chromosome organization	1
regulation of DNA repair	1
positive regulation of DNA metabolic process	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
positive regulation of RNA biosynthetic process	1
embryo development	1
regulation of multicellular organismal development	1
cell cycle	1
regulation of cellular process	1
DNA strand elongation	1
positive regulation of telomere maintenance	1
telomere maintenance in response to DNA damage	1
regulation of telomere maintenance in response to DNA damage	1
cellular response to stress	1
binding	1
nucleolus	1
nuclear lumen	1
cytoplasm	1
nuclear chromosome	1
INO80-type complex	1
MLL1/2 complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

950 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
INO80C	RUVBL1	P82276	971
INO80C	RUVBL2	Q9Y230	967
INO80C	INO80B	Q9C086	915
INO80C	ACTR5	Q9H9F9	833
INO80C	ACTR8	Q9H981	744
INO80C	SMARCA2	P51531	704
INO80C	INO80	Q9ULG1	666
INO80C	SMARCA4	P51532	651
INO80C	H2AZ1	P0C0S5	631
INO80C	VPS72	Q15906	614
INO80C	ACTL6A	O96019	603
INO80C	INO80E	Q8NBZ0	545
INO80C	SRCAP	Q6ZRS2	527
INO80C	CHD1	O14646	518
INO80C	KAT5	Q92993	491

IntAct

55 interactions, top by confidence:

A	B	Type	Score
INO80E	YY1	psi-mi:“MI:0914”(association)	0.900
RUVBL1	ZNHIT1	psi-mi:“MI:0914”(association)	0.860
UCHL5	PSMD11	psi-mi:“MI:0914”(association)	0.840
UCHL5	PSMD12	psi-mi:“MI:0914”(association)	0.840
YY1	ACTL6A	psi-mi:“MI:0914”(association)	0.830
INO80E	TFPT	psi-mi:“MI:0914”(association)	0.790
INO80C	YY1	psi-mi:“MI:0914”(association)	0.740
ACTR5	INO80C	psi-mi:“MI:0915”(physical association)	0.670
RUVBL2	POLR3A	psi-mi:“MI:0914”(association)	0.640
RUVBL1	POLR3A	psi-mi:“MI:0914”(association)	0.640
INO80E	ACTL6A	psi-mi:“MI:0914”(association)	0.640
BCL7C	ARID1A	psi-mi:“MI:0914”(association)	0.640
YY1AP1	YY1	psi-mi:“MI:0914”(association)	0.630
YY1	YY2	psi-mi:“MI:0914”(association)	0.570
INO80C	SERPINH1	psi-mi:“MI:0915”(physical association)	0.560
INO80C	TGFBR2	psi-mi:“MI:0915”(physical association)	0.560
WBP2NL	OTUD4	psi-mi:“MI:0914”(association)	0.530

BioGRID (86): INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INO80C (Affinity Capture-MS), INTS9 (Negative Genetic), INO80C (Positive Genetic)

ESM2 similar proteins: A0JPP1, B2GV05, B2RXH8, B7ZW38, G3V9R8, O60812, O77768, P07910, P0DMR1, P19600, P23588, P37285, P52756, P59326, P97379, P97855, Q08BA6, Q08BJ2, Q08DJ0, Q0IIC4, Q0VCZ3, Q0VFL7, Q13283, Q14919, Q1RMU5, Q2YDP3, Q32LC7, Q4R5D9, Q5BJY3, Q5R9L3, Q5RA82, Q5RB87, Q5VWX1, Q64012, Q6PI98, Q86SE5, Q8BGD9, Q8BHA0, Q8BTF8, Q91YE7

Diamond homologs: P32617, Q5BJY3, Q6PI98, Q8BHA0, Q8RWS0, Q9UTE8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
INO80C	“form complex”	“INO80 complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 44 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Global Genome Nucleotide Excision Repair (GG-NER)	10	157.5×	7e-19
Formation of the canonical BAF (cBAF) complex	6	131.3×	1e-10
DNA Damage Recognition in GG-NER	11	108.3×	7e-19
Formation of the embryonic stem cell BAF (esBAF) complex	5	103.6×	3e-08
Nucleotide Excision Repair	10	98.5×	1e-16
Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	6	94.5×	1e-09
UCH proteinases	15	64.2×	2e-22
Regulation of endogenous retroelements	5	63.5×	3e-07

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of telomere maintenance in response to DNA damage	12	337.0×	6e-28
regulation of DNA strand elongation	12	316.0×	1e-27
regulation of chromosome organization	12	280.9×	8e-27
positive regulation of DNA repair	13	116.5×	6e-23
regulation of DNA replication	12	109.9×	6e-21
regulation of embryonic development	13	107.4×	2e-22
regulation of G0 to G1 transition	6	101.1×	4e-10
DNA recombination	11	92.7×	2e-18

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1228 predictions. Top by Δscore:

Variant	Effect	Δscore
18:35468634:T:TA	donor_gain	1.0000
18:35478280:A:AC	donor_gain	1.0000
18:35478281:C:CC	donor_gain	1.0000
18:35478350:C:CC	acceptor_gain	1.0000
18:35479431:T:TC	acceptor_gain	1.0000
18:35480563:CCT:C	acceptor_gain	1.0000
18:35497715:GTAC:G	donor_loss	1.0000
18:35497716:TACCT:T	donor_loss	1.0000
18:35497717:A:C	donor_loss	1.0000
18:35497755:A:AC	donor_gain	1.0000
18:35497756:C:CC	donor_gain	1.0000
18:35468586:T:A	donor_gain	0.9900
18:35468598:C:CA	donor_gain	0.9900
18:35468740:GGCC:G	acceptor_loss	0.9900
18:35468741:GCCT:G	acceptor_loss	0.9900
18:35468743:C:CA	acceptor_loss	0.9900
18:35468743:C:CC	acceptor_gain	0.9900
18:35468744:T:C	acceptor_loss	0.9900
18:35478274:ATAC:A	donor_loss	0.9900
18:35478274:ATACT:A	donor_loss	0.9900
18:35478275:TACT:T	donor_loss	0.9900
18:35478276:AC:A	donor_loss	0.9900
18:35478277:C:CA	donor_loss	0.9900
18:35478278:T:TC	donor_loss	0.9900
18:35478278:T:TG	donor_loss	0.9900
18:35478279:CAC:C	donor_loss	0.9900
18:35478279:CACA:C	donor_loss	0.9900
18:35478280:A:T	donor_loss	0.9900
18:35478280:AC:A	donor_loss	0.9900
18:35478281:C:CA	donor_loss	0.9900

AlphaMissense

1265 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:35468635:C:A	R185S	1.000
18:35468635:C:G	R185S	1.000
18:35468636:C:A	R185M	1.000
18:35468636:C:G	R185T	1.000
18:35468639:A:G	L184P	1.000
18:35468645:A:G	L182P	1.000
18:35468672:A:G	L173P	1.000
18:35468689:A:C	F167L	1.000
18:35468689:A:T	F167L	1.000
18:35468691:A:G	F167L	1.000
18:35468707:G:C	F161L	1.000
18:35468707:G:T	F161L	1.000
18:35468708:A:G	F161S	1.000
18:35468709:A:G	F161L	1.000
18:35468711:C:G	R160P	1.000
18:35468714:A:G	L159P	1.000
18:35468729:T:C	D154G	1.000
18:35478289:C:A	G147V	1.000
18:35478289:C:T	G147D	1.000
18:35478290:C:G	G147R	1.000
18:35478298:T:A	D144V	1.000
18:35478298:T:C	D144G	1.000
18:35478298:T:G	D144A	1.000
18:35478299:C:A	D144Y	1.000
18:35478299:C:G	D144H	1.000
18:35478301:G:A	S143F	1.000
18:35478301:G:T	S143Y	1.000
18:35478302:A:G	S143P	1.000
18:35478305:A:C	Y142D	1.000
18:35479356:A:G	L108P	1.000

dbSNP variants (sampled 300 via entrez): RS1000004294 (18:35474139 T>C), RS1000016143 (18:35473654 T>A), RS1000028025 (18:35498787 A>G), RS1000098530 (18:35473710 C>G), RS1000257090 (18:35498513 C>G), RS1000288200 (18:35498180 G>A), RS1000507686 (18:35482921 T>C), RS1000534959 (18:35494250 C>G,T), RS1000578351 (18:35474983 G>A), RS1000594590 (18:35499790 G>A), RS1000600309 (18:35492714 C>T), RS1000626943 (18:35499503 A>G), RS1000664830 (18:35488692 C>T), RS1000716633 (18:35488456 T>C), RS1000870332 (18:35468317 AT>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST003059_21	Parkinson’s disease	1.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5724656 (SINGLE PROTEIN)

Molecules with ChEMBL bioactivity

1 molecules (phase ≥1), by development phase (incl. off-target/promiscuous compounds). Patent mentions across the top 20 by phase: 1,538 (via chembl_molecule»patent_compound — counts attach to the compound, not the gene–compound relationship, so off-target/promiscuous molecules can dominate).

Molecule	Name	Phase	Patents
CHEMBL1232461	MOLIBRESIB	2	1,538

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

1 potent at pChembl≥5 of 1 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.00	IC50	100	nM	MOLIBRESIB

PubChem BioAssay actives

1 with measured affinity, of 6 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide	2178829: Inhibition of INO80C (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	ic50	0.1000	uM

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	3
bisphenol A	affects cotreatment, increases methylation, increases expression	2
Benzo(a)pyrene	increases expression, increases methylation	2
Cyclosporine	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
FR900359	decreases phosphorylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
quercitrin	decreases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	affects expression	1
isobutyl alcohol	decreases expression, increases abundance, affects cotreatment	1
K 7174	increases expression	1
abrine	increases expression	1
Fulvestrant	increases methylation, affects cotreatment	1
Cisplatin	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Indomethacin	affects cotreatment, increases expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
Urethane	decreases expression	1
1-Methyl-3-isobutylxanthine	increases expression, affects cotreatment	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Aflatoxin B1	decreases methylation	1
Lactic Acid	decreases expression	1
Particulate Matter	affects cotreatment, decreases expression, increases abundance	1

ChEMBL screening assays

6 unique, capped per target: 6 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5697559	Binding	Inhibition of INO80C (unknown origin) assessed as fold change at 10 uM incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis	Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. — Nature

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.