INO80D

Summary

INO80D (INO80 complex subunit D, HGNC:25997) is a protein-coding gene on chromosome 2q33.3, encoding INO80 complex subunit D (Q53TQ3). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Part of Ino80 complex.

Source: NCBI Gene 54891 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 135 total
• MANE Select transcript: NM_017759

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25997
Approved symbol	INO80D
Name	INO80 complex subunit D
Location	2q33.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20309
Ensembl gene	ENSG00000114933
Ensembl biotype	protein_coding
OMIM	619207
Entrez	54891

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000403263, ENST00000414320, ENST00000424117, ENST00000855655, ENST00000855656, ENST00000855657

RefSeq mRNA: 1 — MANE Select: NM_017759 NM_017759

CCDS: CCDS46500

Canonical transcript exons

ENST00000403263 — 11 exons

Exon	Start	End
ENSE00000784941	206019736	206019845
ENSE00000784942	206028111	206028335
ENSE00000784944	206046504	206046612
ENSE00001129652	206007284	206007441
ENSE00001129658	206009577	206009794
ENSE00001172222	206017680	206017813
ENSE00001234836	206063151	206063244
ENSE00001234843	206085901	206086174
ENSE00001557750	205993721	206005533
ENSE00001621693	206062799	206063045
ENSE00003578946	206056198	206056943

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 85.74.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.4572 / max 60.8505, expressed in 1676 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
33346	4.2189	1366
33343	1.2709	836
33347	1.0434	586
33344	0.5478	313
33345	0.3551	168
33340	0.0120	4
33339	0.0090	2

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	85.74	gold quality
bone marrow	UBERON:0002371	85.25	gold quality
sural nerve	UBERON:0015488	85.04	gold quality
calcaneal tendon	UBERON:0003701	82.53	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.35	gold quality
colonic epithelium	UBERON:0000397	81.15	gold quality
corpus callosum	UBERON:0002336	80.74	gold quality
skeletal muscle tissue	UBERON:0001134	79.82	gold quality
tonsil	UBERON:0002372	79.51	gold quality
endometrium	UBERON:0001295	77.01	gold quality
gastrocnemius	UBERON:0001388	76.75	gold quality
muscle tissue	UBERON:0002385	76.58	gold quality
adrenal tissue	UBERON:0018303	76.56	gold quality
muscle of leg	UBERON:0001383	76.34	gold quality
leukocyte	CL:0000738	76.27	gold quality
monocyte	CL:0000576	76.25	gold quality
skin of abdomen	UBERON:0001416	76.03	gold quality
zone of skin	UBERON:0000014	75.93	gold quality
skin of leg	UBERON:0001511	75.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.41	gold quality
uterine cervix	UBERON:0000002	75.09	gold quality
mucosa of stomach	UBERON:0001199	75.09	gold quality
tibial nerve	UBERON:0001323	74.94	gold quality
cortical plate	UBERON:0005343	74.93	gold quality
ovary	UBERON:0000992	74.76	gold quality
lower esophagus mucosa	UBERON:0035834	74.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	74.64	gold quality
left ovary	UBERON:0002119	74.53	gold quality
thoracic mammary gland	UBERON:0005200	74.49	gold quality
thyroid gland	UBERON:0002046	74.48	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-CURD-10	no	225.32
E-ANND-3	no	2.26

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

742 targeting INO80D, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-4768-5P	100.00	69.49	2861

Literature-anchored findings (GeneRIF, showing 2)

• INO80D is a subunit of the human INO80 chromatin remodeling complex; its Ser818Cys mutation has a role in accelerated arterial aging (PMID:25122053)
• expression levels of CR933609 and INO80D were decreased in CR933609-knockdown NSCLC cells, but only expression levels of INO80D decreased in INO80D knockdown cells. It was shown that there are independent promoters in CR933609 and INO80D (PMID:29750421)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ino80da	ENSDARG00000104727
mus_musculus	Ino80d	ENSMUSG00000040865
rattus_norvegicus	Ino80d	ENSRNOG00000024272
drosophila_melanogaster	l(3)L1231	FBGN0086686
caenorhabditis_elegans		WBGENE00016409

Protein

Protein identifiers

INO80 complex subunit D — Q53TQ3 (reviewed: Q53TQ3)

All UniProt accessions (3): Q53TQ3, C9JLV2, C9JLZ4

UniProt curated annotations — full annotation on UniProt →

Function. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Subunit / interactions. Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.

Subcellular location. Nucleus.

Similarity. Belongs to the INO80D family.

RefSeq proteins (1): NP_060229* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR025927	Znf_KANL2-like	Domain

Pfam: PF13891

UniProt features (19 total): compositionally biased region 6, region of interest 5, sequence conflict 4, chain 1, modified residue 1, cross-link 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q53TQ3-F1	52.25	0.06

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 132, 87

Function

Pathways and Gene Ontology

Reactome pathways

8 pathways

ID	Pathway
R-HSA-5689603	UCH proteinases
R-HSA-5696394	DNA Damage Recognition in GG-NER
R-HSA-392499	Metabolism of proteins
R-HSA-5688426	Deubiquitination
R-HSA-5696398	Nucleotide Excision Repair
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-597592	Post-translational protein modification
R-HSA-73894	DNA Repair

MSigDB gene sets: 416 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_DN, GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN, TGGTGCT_MIR29A_MIR29B_MIR29C, GOBP_CHROMOSOME_ORGANIZATION, RRAGTTGT_UNKNOWN, ATACCTC_MIR202, GOBP_TELOMERE_ORGANIZATION, AP2_Q3, GOBP_POSITIVE_REGULATION_OF_ORGANELLE_ORGANIZATION, CACCAGC_MIR138, GGGTGGRR_PAX4_03, GOBP_REGULATION_OF_DNA_REPAIR, GOBP_REGULATION_OF_TELOMERE_MAINTENANCE, NFKB_C, YY1_02

GO Biological Process (14): telomere maintenance (GO:0000723), regulation of DNA replication (GO:0006275), DNA repair (GO:0006281), regulation of DNA repair (GO:0006282), DNA recombination (GO:0006310), chromatin remodeling (GO:0006338), regulation of chromosome organization (GO:0033044), positive regulation of DNA repair (GO:0045739), positive regulation of DNA-templated transcription (GO:0045893), regulation of embryonic development (GO:0045995), regulation of cell cycle (GO:0051726), regulation of DNA strand elongation (GO:0060382), positive regulation of telomere maintenance in response to DNA damage (GO:1904507), DNA damage response (GO:0006974)

GO Molecular Function (0):

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), Ino80 complex (GO:0031011)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Deubiquitination	1
Global Genome Nucleotide Excision Repair (GG-NER)	1
Post-translational protein modification	1
DNA Repair	1
Nucleotide Excision Repair	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA metabolic process	3
regulation of DNA metabolic process	3
DNA repair	2
positive regulation of response to stimulus	2
telomere organization	1
DNA replication	1
DNA damage response	1
regulation of cellular response to stress	1
chromatin organization	1
regulation of organelle organization	1
chromosome organization	1
regulation of DNA repair	1
positive regulation of DNA metabolic process	1
DNA-templated transcription	1
regulation of DNA-templated transcription	1
positive regulation of RNA biosynthetic process	1
embryo development	1
regulation of multicellular organismal development	1
cell cycle	1
regulation of cellular process	1
DNA strand elongation	1
positive regulation of telomere maintenance	1
telomere maintenance in response to DNA damage	1
regulation of telomere maintenance in response to DNA damage	1
cellular response to stress	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
nuclear chromosome	1
INO80-type complex	1

Protein interactions and networks

STRING

1260 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
INO80D	INO80E	Q8NBZ0	754
INO80D	MRTO4	Q9UKD2	498
INO80D	NOC3L	Q8WTT2	486
INO80D	INO80B	Q9C086	455
INO80D	MPRIP	Q6WCQ1	450
INO80D	GIN1	Q9NXP7	449
INO80D	K7ENP7	K7ENP7	442
INO80D	INO80C	Q6PI98	441
INO80D	LPIN3	Q9BQK8	438
INO80D	FAM110B	Q8TC76	433
INO80D	TMEM216	Q9P0N5	425
INO80D	MAP3K3	Q99759	425
INO80D	BPIFB1	Q8TDL5	417
INO80D	BUD31	P41223	411
INO80D	ATRN	O75882	406

IntAct

29 interactions, top by confidence:

A	B	Type	Score
UCHL5	PSMD11	psi-mi:“MI:0914”(association)	0.840
YY1	ACTL6A	psi-mi:“MI:0914”(association)	0.830
INO80E	TFPT	psi-mi:“MI:0914”(association)	0.790
YY1	TFPT	psi-mi:“MI:0914”(association)	0.740
INO80C	YY1	psi-mi:“MI:0914”(association)	0.740
RUVBL2	POLR3A	psi-mi:“MI:0914”(association)	0.640
RUVBL1	POLR3A	psi-mi:“MI:0914”(association)	0.640
INO80E	ACTL6A	psi-mi:“MI:0914”(association)	0.640
YY1	YY2	psi-mi:“MI:0914”(association)	0.570
Ruvbl1	AAR2	psi-mi:“MI:0914”(association)	0.350
Ruvbl2	TTI2	psi-mi:“MI:0914”(association)	0.350
ACTR5	TBRG1	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
UCHL5	PSMD11	psi-mi:“MI:0914”(association)	0.350
INO80	ACTL6B	psi-mi:“MI:0914”(association)	0.350
TFPT	CCP110	psi-mi:“MI:0914”(association)	0.350
INO80E	CHD1	psi-mi:“MI:0914”(association)	0.350
INO80B	ACTL6A	psi-mi:“MI:0914”(association)	0.350
ACTR8	ACTL6A	psi-mi:“MI:0914”(association)	0.350
ACTL6A	TFPT	psi-mi:“MI:0914”(association)	0.350
MCRS1	ACTL6A	psi-mi:“MI:0914”(association)	0.350
INO80D	ACTL6A	psi-mi:“MI:0914”(association)	0.350

BioGRID (64): INO80D (Affinity Capture-MS), INO80D (Affinity Capture-MS), INO80D (Affinity Capture-MS), INO80D (Affinity Capture-MS), INO80D (Affinity Capture-MS), INO80D (Affinity Capture-MS), INO80D (Affinity Capture-MS), INO80D (Affinity Capture-MS), MED15 (Negative Genetic), INO80D (Positive Genetic), INO80D (Affinity Capture-RNA), INO80D (Affinity Capture-MS), INO80D (Affinity Capture-MS), INO80D (Affinity Capture-MS), INO80D (Positive Genetic)

ESM2 similar proteins: A0A0R4IBL7, A2A891, A3RK74, A4L7N3, B5DE09, E1BPQ1, G3V7R4, O15014, O43524, P11420, P15806, P15881, P15884, P15923, P21677, P30985, P51514, P70365, P98180, Q01978, Q12778, Q14135, Q15596, Q15788, Q4PJW2, Q53TQ3, Q60420, Q60722, Q61026, Q61286, Q62655, Q66IY8, Q66JJ0, Q6DIH5, Q6EUW2, Q6NZT6, Q6PCG7, Q7T2G1, Q7ZXS3, Q80V24

Diamond homologs: A1L1F6, Q2NL14, Q53TQ3, Q54J07, Q566I1, Q5R802, Q66JY2, Q6AY70, Q861R7, Q8BQR4, Q9H9L4

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
INO80D	“form complex”	“INO80 complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 26 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Global Genome Nucleotide Excision Repair (GG-NER)	10	228.4×	3e-21
DNA Damage Recognition in GG-NER	11	157.0×	3e-21
Nucleotide Excision Repair	10	142.8×	6e-19
UCH proteinases	13	80.7×	3e-21
Deubiquitination	10	62.1×	4e-15
DNA Repair	10	49.2×	3e-14
Chromatin organization	5	20.4×	6e-05
Chromatin modifying enzymes	5	18.1×	9e-05

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of telomere maintenance in response to DNA damage	13	608.5×	3e-35
regulation of DNA strand elongation	13	570.5×	7e-35
regulation of chromosome organization	13	507.1×	7e-34
regulation of DNA replication	13	198.4×	6e-27
positive regulation of DNA repair	13	194.2×	7e-27
regulation of embryonic development	13	179.0×	2e-26
DNA recombination	11	154.5×	2e-21
regulation of DNA repair	13	149.6×	2e-25

Disease & clinical

Clinical variants and AI predictions

ClinVar

135 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	118
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2731 predictions. Top by Δscore:

Variant	Effect	Δscore
2:206007278:CTATA:C	donor_loss	1.0000
2:206007279:TATA:T	donor_loss	1.0000
2:206007280:ATACC:A	donor_loss	1.0000
2:206007281:TAC:T	donor_loss	1.0000
2:206007283:C:CA	donor_loss	1.0000
2:206007346:T:TA	donor_gain	1.0000
2:206007439:CTC:C	acceptor_gain	1.0000
2:206007441:CCTGG:C	acceptor_loss	1.0000
2:206007442:C:CC	acceptor_gain	1.0000
2:206019698:A:AC	donor_gain	1.0000
2:206019699:C:CC	donor_gain	1.0000
2:206019715:T:A	donor_gain	1.0000
2:206019841:TTATG:T	acceptor_gain	1.0000
2:206019842:TATG:T	acceptor_gain	1.0000
2:206019843:ATG:A	acceptor_gain	1.0000
2:206019844:TG:T	acceptor_gain	1.0000
2:206019844:TGC:T	acceptor_loss	1.0000
2:206019846:C:CC	acceptor_gain	1.0000
2:206019846:CTAAG:C	acceptor_loss	1.0000
2:206019847:T:C	acceptor_loss	1.0000
2:206028105:TCTAA:T	donor_loss	1.0000
2:206028106:CTAAC:C	donor_loss	1.0000
2:206028107:TAA:T	donor_loss	1.0000
2:206028108:AAC:A	donor_loss	1.0000
2:206028110:C:CG	donor_loss	1.0000
2:206028331:CTGAC:C	acceptor_gain	1.0000
2:206028343:G:C	acceptor_gain	1.0000
2:206028343:G:GC	acceptor_gain	1.0000
2:206046497:GACTT:G	donor_loss	1.0000
2:206046499:CTTAC:C	donor_loss	1.0000

AlphaMissense

6735 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:206005488:A:G	L655P	1.000
2:206017692:A:C	H510Q	1.000
2:206017692:A:T	H510Q	1.000
2:206017701:A:C	C507W	1.000
2:206017702:C:A	C507F	1.000
2:206017702:C:G	C507S	1.000
2:206017702:C:T	C507Y	1.000
2:206017703:A:G	C507R	1.000
2:206017703:A:T	C507S	1.000
2:206017743:G:C	C493W	1.000
2:206017744:C:G	C493S	1.000
2:206017744:C:T	C493Y	1.000
2:206017745:A:G	C493R	1.000
2:206017745:A:T	C493S	1.000
2:206017761:A:C	F487L	1.000
2:206017761:A:T	F487L	1.000
2:206017762:A:C	F487C	1.000
2:206017762:A:G	F487S	1.000
2:206017763:A:G	F487L	1.000
2:206017768:G:T	A485D	1.000
2:206017773:G:C	C483W	1.000
2:206017774:C:G	C483S	1.000
2:206017774:C:T	C483Y	1.000
2:206017775:A:G	C483R	1.000
2:206017775:A:T	C483S	1.000
2:206056928:G:C	H78Q	1.000
2:206056928:G:T	H78Q	1.000
2:206056929:T:C	H78R	1.000
2:206056930:G:A	H78Y	1.000
2:206056930:G:C	H78D	1.000

dbSNP variants (sampled 300 via entrez): RS1000023869 (2:206000500 G>T), RS1000060084 (2:206005846 T>C), RS1000118195 (2:206000302 T>C,G), RS1000146949 (2:206085560 G>A), RS1000148194 (2:206045400 A>G), RS1000213995 (2:206043608 C>A,T), RS1000287065 (2:206021426 C>G), RS1000313870 (2:206046886 T>C), RS1000345622 (2:206076981 C>A,G), RS1000386590 (2:206081137 T>C), RS1000398387 (2:206070206 A>T), RS1000401492 (2:206025371 T>C), RS1000434964 (2:206045675 A>G), RS1000439000 (2:206027975 G>A,T), RS1000458790 (2:206076710 C>T)

Disease associations

OMIM: gene MIM:619207 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): megacolon (MONDO:0001273)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST000426_9	Obesity (extreme)	8.000000e-06
GCST004619_200	Reticulocyte fraction of red cells	8.000000e-09
GCST005951_45	Body mass index	1.000000e-09
GCST007565_91	Morning person	1.000000e-13
GCST007576_291	Chronotype	1.000000e-13
GCST011494_17	Daytime nap	4.000000e-12
GCST90020024_1166	A body shape index	4.000000e-09
GCST90020029_853	Waist circumference adjusted for body mass index	2.000000e-08

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0007986	reticulocyte count
EFO:0004340	body mass index
EFO:0008328	chronotype measurement
EFO:0007828	daytime rest measurement
EFO:0007789	BMI-adjusted waist circumference

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D008531	Megacolon	C06.405.469.158.701

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	5
mercuric bromide	decreases expression, affects cotreatment	2
Cisplatin	affects cotreatment, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
aristolochic acid I	decreases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
trichostatin A	affects expression	1
sodium arsenite	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
entinostat	decreases expression	1
scriptaid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
torcetrapib	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
suberoyl bis-hydroxamic acid	decreases expression	1
jinfukang	affects cotreatment, decreases expression	1
Vorinostat	decreases expression	1
Acetaminophen	decreases expression	1
Cadmium	decreases expression, increases abundance	1
Caffeine	decreases phosphorylation	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Rifampin	decreases expression	1
Dronabinol	increases expression	1
Thimerosal	increases expression	1

Clinical trials (associated diseases)

2 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT04340856	Not specified	COMPLETED	Retrospective, Uncontrolled Cohort Study on the Therapy of Chronic Megalon
NCT07470892	Not specified	NOT_YET_RECRUITING	Preoperative Fish Oil PN and Prognosis After Constipation Surgery