INSIG1-DT

Summary

INSIG1-DT (INSIG1 divergent transcript, HGNC:55155) is a long non-coding RNA gene on chromosome 7q36.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55155
Approved symbol	INSIG1-DT
Name	INSIG1 divergent transcript
Location	7q36.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000273117
Ensembl biotype	lncRNA
Entrez	105375591
RNAcentral	URS00026A27D6 — lncRNA, 1624 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000609974, ENST00000743985, ENST00000743986, ENST00000743987, ENST00000743988, ENST00000743989, ENST00000743990, ENST00000743991, ENST00000743992, ENST00000743993, ENST00000743994, ENST00000743995, ENST00000743996, ENST00000743997, ENST00000743998, ENST00000743999, ENST00000744000, ENST00000744001, ENST00000744002, ENST00000744003, ENST00000744004, ENST00000744005, ENST00000744006

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000609974 — 1 exons

Exon	Start	End
ENSE00004082952	155295906	155297541

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 83.49.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9991 / max 22.8407, expressed in 519 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
87022	0.8073	456
87021	0.1917	84

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.49	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.85	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	79.92	gold quality
cortical plate	UBERON:0005343	78.44	gold quality
spinal cord	UBERON:0002240	78.16	gold quality
endothelial cell	CL:0000115	75.71	silver quality
granulocyte	CL:0000094	75.47	gold quality
monocyte	CL:0000576	74.66	gold quality
leukocyte	CL:0000738	74.50	gold quality
ganglionic eminence	UBERON:0004023	74.20	gold quality
hypothalamus	UBERON:0001898	73.57	gold quality
prefrontal cortex	UBERON:0000451	73.47	gold quality
sperm	CL:0000019	72.27	gold quality
ventricular zone	UBERON:0003053	72.11	gold quality
neocortex	UBERON:0001950	71.39	gold quality
frontal cortex	UBERON:0001870	71.34	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	71.34	gold quality
anterior cingulate cortex	UBERON:0009835	71.33	gold quality
Ammon’s horn	UBERON:0001954	71.29	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.13	gold quality
right frontal lobe	UBERON:0002810	71.11	gold quality
amniotic fluid	UBERON:0000173	71.03	silver quality
upper leg skin	UBERON:0004262	70.99	silver quality
amygdala	UBERON:0001876	70.98	gold quality
cerebral cortex	UBERON:0000956	70.77	gold quality
substantia nigra	UBERON:0002038	70.47	gold quality
cartilage tissue	UBERON:0002418	70.39	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	70.17	gold quality
primary visual cortex	UBERON:0002436	69.98	gold quality
right lobe of liver	UBERON:0001114	69.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.51

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.