INTS12

Summary

INTS12 (integrator complex subunit 12, HGNC:25067) is a protein-coding gene on chromosome 4q24, encoding Integrator complex subunit 12 (Q96CB8). Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. It is a selective cancer dependency (DepMap: 43.4% of cell lines).

INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).

Source: NCBI Gene 57117 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 53 total
• Cancer dependency (DepMap): dependent in 43.4% of screened cell lines
• MANE Select transcript: NM_020395

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25067
Approved symbol	INTS12
Name	integrator complex subunit 12
Location	4q24
Locus type	gene with protein product
Status	Approved
Aliases	SBBI22, INT12
Ensembl gene	ENSG00000138785
Ensembl biotype	protein_coding
OMIM	611355
Entrez	57117

Gene structure

Transcript identifiers

Ensembl transcripts: 41 — 40 protein_coding, 1 retained_intron

ENST00000340139, ENST00000394735, ENST00000416543, ENST00000420368, ENST00000433009, ENST00000451321, ENST00000493425, ENST00000503746, ENST00000510876, ENST00000515819, ENST00000891042, ENST00000891043, ENST00000891044, ENST00000891045, ENST00000891046, ENST00000891047, ENST00000891048, ENST00000891049, ENST00000891050, ENST00000891051, ENST00000891052, ENST00000891053, ENST00000891054, ENST00000891055, ENST00000891056, ENST00000891057, ENST00000891058, ENST00000891059, ENST00000891060, ENST00000891061, ENST00000891062, ENST00000925833, ENST00000925834, ENST00000925835, ENST00000925836, ENST00000925837, ENST00000925838, ENST00000925839, ENST00000947226, ENST00000947227, ENST00000947228

RefSeq mRNA: 2 — MANE Select: NM_020395 NM_001142471, NM_020395

CCDS: CCDS3671

Canonical transcript exons

ENST00000340139 — 8 exons

Exon	Start	End
ENSE00000735874	105695516	105695668
ENSE00000735877	105693299	105693486
ENSE00000735885	105691976	105692135
ENSE00000735915	105686692	105686838
ENSE00001387082	105699850	105700014
ENSE00001519403	105682627	105683317
ENSE00001519414	105703648	105703809
ENSE00002075774	105708638	105708689

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 91.98.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.1477 / max 88.6392, expressed in 1771 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
53474	7.9921	1771
53476	0.1556	93

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.98	gold quality
oocyte	CL:0000023	91.35	gold quality
cortical plate	UBERON:0005343	91.14	gold quality
secondary oocyte	CL:0000655	91.12	gold quality
heart right ventricle	UBERON:0002080	90.15	gold quality
islet of Langerhans	UBERON:0000006	89.80	gold quality
gastrocnemius	UBERON:0001388	89.07	gold quality
jejunal mucosa	UBERON:0000399	88.96	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.88	gold quality
muscle of leg	UBERON:0001383	88.79	gold quality
triceps brachii	UBERON:0001509	88.79	gold quality
ganglionic eminence	UBERON:0004023	88.77	gold quality
hindlimb stylopod muscle	UBERON:0004252	88.73	gold quality
biceps brachii	UBERON:0001507	88.62	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	88.58	gold quality
muscle organ	UBERON:0001630	88.10	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	88.02	gold quality
calcaneal tendon	UBERON:0003701	87.68	gold quality
rectum	UBERON:0001052	87.48	gold quality
heart left ventricle	UBERON:0002084	87.40	gold quality
jejunum	UBERON:0002115	87.40	gold quality
cardiac ventricle	UBERON:0002082	87.36	gold quality
myocardium	UBERON:0002349	87.36	gold quality
thoracic aorta	UBERON:0001515	87.32	gold quality
left lobe of thyroid gland	UBERON:0001120	87.30	gold quality
ascending aorta	UBERON:0001496	87.23	gold quality
right lobe of thyroid gland	UBERON:0001119	87.15	gold quality
aorta	UBERON:0000947	87.08	gold quality
pancreas	UBERON:0001264	87.07	gold quality
descending thoracic aorta	UBERON:0002345	87.07	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	26.89
E-ANND-3	yes	8.91

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

16 targeting INTS12, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8087	99.90	69.55	1351
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-4517	99.76	69.19	1867
HSA-MIR-154-3P	99.50	70.05	831
HSA-MIR-487A-3P	99.50	69.95	840
HSA-MIR-6083	99.47	68.73	2393
HSA-MIR-5683	99.36	68.59	2083
HSA-MIR-223-5P	99.24	68.82	1206
HSA-MIR-10399-5P	99.17	69.87	2610
HSA-MIR-6504-3P	99.17	69.31	2891
HSA-MIR-4477A	98.83	69.75	2952
HSA-MIR-12116	97.94	68.91	595

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 43.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• In fixed sections of human lung tissue, GSTCD protein expression was ubiquitous, whereas INTS12 expression was predominantly in epithelial cells and pneumocytes. (PMID:24058608)
• INTS12 activities on a genome-wide scale (PMID:28335732)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	ints12	ENSDARG00000091678
mus_musculus	Ints12	ENSMUSG00000028016
rattus_norvegicus	Ints12	ENSRNOG00000011844
drosophila_melanogaster	IntS12	FBGN0039459
caenorhabditis_elegans		WBGENE00018778
caenorhabditis_elegans		WBGENE00020716

Protein

Protein identifiers

Integrator complex subunit 12 — Q96CB8 (reviewed: Q96CB8)

Alternative names: PHD finger protein 22

All UniProt accessions (7): Q96CB8, A0A1B0GX90, C9J0M6, C9JDP3, D6R9W3, D6R9Y5, E9PGI3

UniProt curated annotations — full annotation on UniProt →

Function. Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex.

Subunit / interactions. Component of the Integrator complex, composed of core subunits INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L, INTS12, INTS13, INTS14 and INTS15. The core complex associates with protein phosphatase 2A subunits PPP2CA and PPP2R1A, to form the Integrator-PP2A (INTAC) complex.

Subcellular location. Nucleus.

Post-translational modifications. Dephosphorylated at Ser-128 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release.

Similarity. Belongs to the Integrator subunit 12 family.

RefSeq proteins (2): NP_001135943, NP_065128* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001965	Znf_PHD	Domain
IPR011011	Znf_FYVE_PHD	Homologous_superfamily
IPR013083	Znf_RING/FYVE/PHD	Homologous_superfamily
IPR019786	Zinc_finger_PHD-type_CS	Conserved_site
IPR019787	Znf_PHD-finger	Domain
IPR039054	Int12_PHD	Domain
IPR051776	Integrator_subunit_12	Family

Pfam: PF00628

UniProt features (14 total): compositionally biased region 6, cross-link 2, region of interest 2, chain 1, zinc finger region 1, modified residue 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96CB8-F1	58.95	0.14

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 128, 68, 254

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-6807505	RNA polymerase II transcribes snRNA genes
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)

MSigDB gene sets: 199 (showing top): chr4q24, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP, MARTINEZ_RB1_TARGETS_UP, GOBP_RNA_SURVEILLANCE, BRN2_01, E4F1_Q6, GOBP_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, GOBP_TRANSCRIPTION_INITIATION_AT_RNA_POLYMERASE_II_PROMOTER, DODD_NASOPHARYNGEAL_CARCINOMA_UP, GOBP_SNRNA_PROCESSING, MARTINEZ_RB1_AND_TP53_TARGETS_UP, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, TAANNYSGCG_UNKNOWN, GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION

GO Biological Process (4): snRNA processing (GO:0016180), regulation of transcription elongation by RNA polymerase II (GO:0034243), snRNA 3’-end processing (GO:0034472), RNA polymerase II transcription initiation surveillance (GO:0160240)

GO Molecular Function (3): zinc ion binding (GO:0008270), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), integrator complex (GO:0032039), INTAC complex (GO:0160232)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
RNA Polymerase II Transcription	1
Gene expression (Transcription)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nuclear protein-containing complex	2
RNA processing	1
snRNA metabolic process	1
transcription elongation by RNA polymerase II	1
regulation of DNA-templated transcription elongation	1
snRNA processing	1
RNA 3’-end processing	1
transcription initiation at RNA polymerase II promoter	1
nuclear RNA surveillance	1
transition metal ion binding	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
integrator complex	1

Protein interactions and networks

STRING

1244 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
INTS12	INTS11	Q5TA45	976
INTS12	INTS1	Q8N201	884
INTS12	INTS7	Q9NVH2	879
INTS12	INTS9	Q9NV88	852
INTS12	INTS5	Q6P9B9	811
INTS12	INTS10	Q9NVR2	811
INTS12	INTS4	Q96HW7	810
INTS12	GSTCD	Q8NEC7	766
INTS12	INTS8	Q75QN2	755
INTS12	POLR2A	P24928	713
INTS12	INTS6	Q9UL03	694
INTS12	INTS3	Q68E01	667
INTS12	INTS14	Q96SY0	667
INTS12	INTS2	Q9H0H0	665
INTS12	INTS13	Q9NVM9	616

IntAct

173 interactions, top by confidence:

A	B	Type	Score
PPP2R1A	STRN	psi-mi:“MI:0914”(association)	0.880
GATAD2A	CDK2AP1	psi-mi:“MI:0914”(association)	0.730
INTS12	INTS1	psi-mi:“MI:0915”(physical association)	0.690
POLR2C	SUPT5H	psi-mi:“MI:0914”(association)	0.640
ILVBL	COG7	psi-mi:“MI:0914”(association)	0.640
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
HAPSTR1	INTS12	psi-mi:“MI:0915”(physical association)	0.560
FAM9A	INTS12	psi-mi:“MI:0915”(physical association)	0.560
MAS1	POTEF	psi-mi:“MI:0914”(association)	0.530
ST8SIA1	POTEF	psi-mi:“MI:0914”(association)	0.530
APLNR	METTL15	psi-mi:“MI:0914”(association)	0.530
IL13RA2	METTL15	psi-mi:“MI:0914”(association)	0.530
FZD10	NRP1	psi-mi:“MI:0914”(association)	0.530
POLR2I	SUPT5H	psi-mi:“MI:0914”(association)	0.530
POLR2J	SUPT5H	psi-mi:“MI:0914”(association)	0.530
SUPT5H	POLR2D	psi-mi:“MI:0914”(association)	0.530
CXCR4	TMEM120B	psi-mi:“MI:0914”(association)	0.530
ILVBL	SLC33A1	psi-mi:“MI:0914”(association)	0.530
INTS12	GTF2IRD1	psi-mi:“MI:0915”(physical association)	0.510
GTF2IRD1	INTS12	psi-mi:“MI:0915”(physical association)	0.510
TAS2R7	ATP2B4	psi-mi:“MI:0914”(association)	0.500
PPP2CA	SMCO3	psi-mi:“MI:0914”(association)	0.420
INTS12	CALU	psi-mi:“MI:0915”(physical association)	0.400
ECE1	INTS12	psi-mi:“MI:0915”(physical association)	0.370
Ppp2r1a	CCHCR1	psi-mi:“MI:0914”(association)	0.350

BioGRID (156): INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS1 (Co-fractionation), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS), INTS12 (Affinity Capture-MS)

ESM2 similar proteins: A1Z9E2, B0R0I6, B5DE69, G5ED89, O94842, P25425, P32519, P34333, P34447, Q02086, Q08CM4, Q09XV5, Q0IHV2, Q0P5K4, Q0V9U1, Q15723, Q28BL7, Q3TUF7, Q571G4, Q5E9U0, Q5F3U0, Q5R6A9, Q5RBN8, Q5RCV7, Q60775, Q641Z1, Q6DJM6, Q6IQU7, Q6MZP7, Q7Z589, Q7ZUV7, Q7ZX03, Q86NP2, Q8AYC1, Q8BIH0, Q8BMB0, Q8BU11, Q8CHI8, Q8IRW8, Q8WNV2

Diamond homologs: O43189, Q02395, Q0V9U1, Q24459, Q32LL5, Q5R7T9, Q5RCV7, Q5T6S3, Q68FR3, Q6DJM6, Q6IQU7, Q8WNV2, Q96CB8, Q9CXG9, Q9D168, Q9VBB3, Q9Y483, Q9Z1B8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
INTS12	“form complex”	“Integrator complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 212 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
FGFR2 mutant receptor activation	8	41.1×	3e-10
Abortive elongation of HIV-1 transcript in the absence of Tat	10	33.5×	3e-11
Signaling by FGFR2 IIIa TM	8	32.5×	2e-09
MicroRNA (miRNA) biogenesis	9	27.8×	6e-10
Signaling by FGFR2	10	27.6×	1e-10
Pausing and recovery of Tat-mediated HIV elongation	11	27.4×	3e-11
Tat-mediated HIV elongation arrest and recovery	11	27.4×	3e-11
Activation of HOX genes during differentiation	9	26.7×	9e-10

GO biological processes:

GO term	Partners	Fold	FDR
RNA polymerase II transcription initiation surveillance	5	22.6×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3464 predictions. Top by Δscore:

Variant	Effect	Δscore
4:105686687:TATAC:T	donor_loss	1.0000
4:105686688:ATACC:A	donor_loss	1.0000
4:105686689:TACC:T	donor_loss	1.0000
4:105686690:ACCTT:A	donor_loss	1.0000
4:105686837:GCCT:G	acceptor_loss	1.0000
4:105686850:A:T	acceptor_gain	1.0000
4:105691975:CCATT:C	donor_gain	1.0000
4:105693294:CTTA:C	donor_loss	1.0000
4:105693295:TTA:T	donor_loss	1.0000
4:105693297:A:AC	donor_gain	1.0000
4:105693297:A:C	donor_loss	1.0000
4:105693297:AC:A	donor_gain	1.0000
4:105693298:C:CC	donor_gain	1.0000
4:105693298:CC:C	donor_gain	1.0000
4:105693298:CCT:C	donor_gain	1.0000
4:105693298:CCTA:C	donor_gain	1.0000
4:105693482:TTCAT:T	acceptor_gain	1.0000
4:105693483:TCAT:T	acceptor_gain	1.0000
4:105693484:CAT:C	acceptor_gain	1.0000
4:105693484:CATC:C	acceptor_gain	1.0000
4:105693485:AT:A	acceptor_gain	1.0000
4:105693487:C:CC	acceptor_gain	1.0000
4:105693488:T:G	acceptor_loss	1.0000
4:105693489:A:C	acceptor_gain	1.0000
4:105693504:C:CT	acceptor_gain	1.0000
4:105693505:A:T	acceptor_gain	1.0000
4:105695510:TCTTA:T	donor_loss	1.0000
4:105695512:TTA:T	donor_loss	1.0000
4:105695514:A:AC	donor_gain	1.0000
4:105695515:C:CG	donor_gain	1.0000

AlphaMissense

2996 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:105682779:A:G	L448S	0.998
4:105691998:C:G	C212S	0.998
4:105691999:A:G	C212R	0.998
4:105691999:A:T	C212S	0.998
4:105692007:C:T	C209Y	0.998
4:105692008:A:G	C209R	0.998
4:105699905:A:G	L34P	0.998
4:105699914:A:G	L31P	0.998
4:105699968:A:G	F13S	0.998
4:105692006:A:C	C209W	0.997
4:105692007:C:G	C209S	0.997
4:105692008:A:T	C209S	0.997
4:105692014:A:G	W207R	0.997
4:105692014:A:T	W207R	0.997
4:105692089:A:G	C182R	0.997
4:105692098:A:G	C179R	0.997
4:105693312:A:G	C162R	0.997
4:105699956:A:G	L17P	0.997
4:105691997:A:C	C212W	0.996
4:105692074:G:C	H187D	0.996
4:105692088:C:G	C182S	0.996
4:105692089:A:T	C182S	0.996
4:105692097:C:G	C179S	0.996
4:105692098:A:T	C179S	0.996
4:105693303:A:G	C165R	0.996
4:105693310:G:C	C162W	0.996
4:105693311:C:T	C162Y	0.996
4:105699959:G:T	A16E	0.996
4:105682766:C:A	K452N	0.995
4:105682766:C:G	K452N	0.995

dbSNP variants (sampled 300 via entrez): RS1000025192 (4:105701632 A>G), RS1000169514 (4:105694973 G>A), RS1000263456 (4:105709236 T>C), RS1000296049 (4:105708970 C>G), RS1000304162 (4:105708087 T>G), RS1000340908 (4:105687537 T>C), RS1000494007 (4:105703180 C>A,T), RS1000509394 (4:105683598 A>C), RS1000539314 (4:105703488 T>C), RS1000692093 (4:105691366 A>C), RS10008158 (4:105683066 G>A), RS1000820461 (4:105697902 T>C), RS1000844087 (4:105682353 A>G), RS1000873081 (4:105698118 A>G), RS1001506339 (4:105688050 C>G)

Disease associations

OMIM: gene MIM:611355 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST000542_6	Pulmonary function	5.000000e-17
GCST001784_49	Pulmonary function (smoking interaction)	1.000000e-16
GCST002165_9	Lung function (FEV1)	1.000000e-07
GCST003262_462	Post bronchodilator FEV1	5.000000e-06
GCST003262_463	Post bronchodilator FEV1	4.000000e-06
GCST003262_888	Post bronchodilator FEV1	5.000000e-06
GCST003542_180	Night sleep phenotypes	4.000000e-06
GCST004554_1	Weight	3.000000e-08
GCST007692_16	Chronic obstructive pulmonary disease	5.000000e-15
GCST009798_66	Asthma	4.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0003892	pulmonary function measurement
EFO:0004314	forced expiratory volume
EFO:0004338	body weight

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
FR900359	affects phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
coumarin	increases phosphorylation	1
CGP 52608	increases reaction, affects binding	1
abrine	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Caffeine	increases phosphorylation	1
Phenobarbital	affects expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tretinoin	decreases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases expression	1
Particulate Matter	increases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.