IRAG1-AS1

Summary

IRAG1-AS1 (IRAG1 antisense RNA 1, HGNC:43434) is a long non-coding RNA gene on chromosome 11p15.4.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43434
Approved symbol	IRAG1-AS1
Name	IRAG1 antisense RNA 1
Location	11p15.4
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000177112
Ensembl biotype	lncRNA
Entrez	100129827
RNAcentral	URS000075B4AF — lncRNA, 671 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 lncRNA

ENST00000525578, ENST00000529829, ENST00000529979, ENST00000663840, ENST00000671658, ENST00000803642, ENST00000803643, ENST00000803644, ENST00000803645, ENST00000803646, ENST00000803647, ENST00000803648, ENST00000803649, ENST00000803650, ENST00000803651, ENST00000803652, ENST00000803653, ENST00000803654, ENST00000803655, ENST00000803656, ENST00000803657, ENST00000803658, ENST00000803659, ENST00000803660

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000525578 — 5 exons

Exon	Start	End
ENSE00001286538	10594117	10594228
ENSE00002161620	10599729	10599906
ENSE00002181845	10593820	10593980
ENSE00002199089	10595721	10595795
ENSE00002201074	10593197	10593499

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 97.91.

FANTOM5 (CAGE): breadth broad, TPM avg 1.4699 / max 396.9548, expressed in 366 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
113062	0.7834	202
113064	0.4360	147
113063	0.2456	90
113065	0.0050	3

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	97.91	gold quality
right testis	UBERON:0004534	97.72	gold quality
testis	UBERON:0000473	94.93	gold quality
sperm	CL:0000019	93.44	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.69	gold quality
adult organism	UBERON:0007023	86.48	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	84.46	gold quality
ileal mucosa	UBERON:0000331	83.62	silver quality
left ventricle myocardium	UBERON:0006566	81.74	gold quality
cardiac muscle of right atrium	UBERON:0003379	81.69	gold quality
kidney epithelium	UBERON:0004819	81.31	gold quality
pancreatic ductal cell	CL:0002079	78.11	silver quality
upper arm skin	UBERON:0004263	77.45	gold quality
epithelial cell of pancreas	CL:0000083	77.18	gold quality
tibialis anterior	UBERON:0001385	76.26	silver quality
secondary oocyte	CL:0000655	75.20	silver quality
colonic epithelium	UBERON:0000397	74.12	gold quality
blood	UBERON:0000178	74.07	gold quality
myocardium	UBERON:0002349	73.43	gold quality
descending thoracic aorta	UBERON:0002345	72.63	gold quality
ascending aorta	UBERON:0001496	72.49	gold quality
thoracic aorta	UBERON:0001515	72.42	gold quality
sural nerve	UBERON:0015488	71.72	gold quality
aorta	UBERON:0000947	71.58	gold quality
nasal cavity epithelium	UBERON:0005384	71.50	gold quality
bone marrow cell	CL:0002092	71.31	silver quality
popliteal artery	UBERON:0002250	71.14	gold quality
tibial artery	UBERON:0007610	71.09	gold quality
right adrenal gland	UBERON:0001233	71.00	gold quality
endothelial cell	CL:0000115	70.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Hypoxia-induced lncRNA MRVI1-AS1 accelerates hepatocellular carcinoma progression by recruiting RNA-binding protein CELF2 to stabilize SKA1 mRNA. (PMID:36973749)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.