IRAIN

Summary

IRAIN (IGF1R antisense imprinted non-protein coding RNA, HGNC:50365) is a long non-coding RNA gene on chromosome 15q26.3.

This gene expresses a long non-coding RNA in antisense to the insulin-like growth factor type I receptor (IGF1R) gene. This transcript is imprinted and expressed from the paternal allele. It interacts with chromatin and may promote long-range DNA interactions that influence the regulation of gene expression.

Source: NCBI Gene 104472848 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50365
Approved symbol	IRAIN
Name	IGF1R antisense imprinted non-protein coding RNA
Location	15q26.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	IGF1R-AS, IGF1R-AS1
Ensembl gene	ENSG00000259424
Ensembl biotype	lncRNA
OMIM	619212
Entrez	104472848
RNAcentral	URS00021EDA19 — lncRNA, 4925 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000560221, ENST00000687383, ENST00000692203, ENST00000747123, ENST00000747124, ENST00000747125, ENST00000747126, ENST00000747127, ENST00000747128, ENST00000747129

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000560221 — 2 exons

Exon	Start	End
ENSE00002566407	98646951	98647193
ENSE00002572861	98647281	98647371

Expression profiles

Bgee: expression breadth ubiquitous, 123 present calls, max score 82.65.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1486 / max 8.3871, expressed in 72 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
151735	0.1486	72

Top tissues by expression

123 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	82.65	gold quality
cortical plate	UBERON:0005343	72.90	gold quality
ventricular zone	UBERON:0003053	71.89	gold quality
ganglionic eminence	UBERON:0004023	70.74	gold quality
stromal cell of endometrium	CL:0002255	69.66	gold quality
sural nerve	UBERON:0015488	69.13	gold quality
adrenal tissue	UBERON:0018303	68.97	gold quality
adenohypophysis	UBERON:0002196	67.83	gold quality
endocervix	UBERON:0000458	67.53	gold quality
pituitary gland	UBERON:0000007	67.27	gold quality
popliteal artery	UBERON:0002250	66.84	gold quality
tibial artery	UBERON:0007610	66.75	gold quality
descending thoracic aorta	UBERON:0002345	66.71	gold quality
lymph node	UBERON:0000029	66.62	gold quality
fallopian tube	UBERON:0003889	65.94	gold quality
gall bladder	UBERON:0002110	65.46	gold quality
prostate gland	UBERON:0002367	65.26	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	64.83	gold quality
left adrenal gland cortex	UBERON:0035825	64.81	gold quality
right ovary	UBERON:0002118	64.73	gold quality
left ovary	UBERON:0002119	64.60	gold quality
ovary	UBERON:0000992	64.57	gold quality
thoracic aorta	UBERON:0001515	64.01	gold quality
endometrium	UBERON:0001295	63.92	gold quality
ascending aorta	UBERON:0001496	63.86	gold quality
adrenal gland	UBERON:0002369	63.63	gold quality
smooth muscle tissue	UBERON:0001135	63.60	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.54	gold quality
left adrenal gland	UBERON:0001234	63.48	gold quality
primary visual cortex	UBERON:0002436	63.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Data indicate that IRAIN intragenic long non-coding RNA (lncRNA) as a novel imprinted gene that is aberrantly regulated in breast cancer. (PMID:25465188)
• upregulation of Long non-coding RNA IRAIN was significantly correlated with tumor size, TNM stage, and lymph node metastasis in a cohort of 37 PC patients. In vitro experiments showed that knockdown of IRAIN by small interfering RNA significantly induced cell apoptosis and inhibited cell proliferation in both BxPC-3 and PANC-1 cells. (PMID:27644252)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.