IRS4-AS1

Summary

IRS4-AS1 (IRS4 antisense RNA 1, HGNC:55650) is a long non-coding RNA gene on chromosome Xq22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55650
Approved symbol	IRS4-AS1
Name	IRS4 antisense RNA 1
Location	Xq22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237863
Ensembl biotype	lncRNA
Entrez	101928358
RNAcentral	URS00001C3317 — lncRNA, 1142 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000436013, ENST00000608811, ENST00000656850, ENST00000664433, ENST00000668534, ENST00000746037, ENST00000746038, ENST00000746039, ENST00000746040, ENST00000746041, ENST00000746042

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000436013 — 3 exons

Exon	Start	End
ENSE00001665419	108737265	108737879
ENSE00001735872	108736513	108736591
ENSE00001740925	108738429	108739223

Expression profiles

Bgee: expression breadth ubiquitous, 112 present calls, max score 79.25.

Top tissues by expression

112 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ovary	UBERON:0002119	79.25	gold quality
pituitary gland	UBERON:0000007	78.85	gold quality
ovary	UBERON:0000992	78.47	gold quality
adenohypophysis	UBERON:0002196	78.28	gold quality
right ovary	UBERON:0002118	74.93	gold quality
thyroid gland	UBERON:0002046	70.72	gold quality
left lobe of thyroid gland	UBERON:0001120	70.38	gold quality
endocervix	UBERON:0000458	69.76	gold quality
hypothalamus	UBERON:0001898	68.52	gold quality
right lobe of thyroid gland	UBERON:0001119	68.46	gold quality
body of uterus	UBERON:0009853	67.86	gold quality
mucosa of stomach	UBERON:0001199	67.67	gold quality
cortical plate	UBERON:0005343	66.76	gold quality
smooth muscle tissue	UBERON:0001135	65.94	gold quality
ectocervix	UBERON:0012249	64.76	gold quality
left uterine tube	UBERON:0001303	64.51	gold quality
myometrium	UBERON:0001296	63.29	gold quality
ganglionic eminence	UBERON:0004023	63.22	gold quality
calcaneal tendon	UBERON:0003701	62.79	gold quality
prefrontal cortex	UBERON:0000451	62.58	gold quality
ventricular zone	UBERON:0003053	61.97	gold quality
substantia nigra	UBERON:0002038	61.73	gold quality
primary visual cortex	UBERON:0002436	61.02	gold quality
brain	UBERON:0000955	60.62	gold quality
monocyte	CL:0000576	59.96	gold quality
temporal lobe	UBERON:0001871	59.75	gold quality
amygdala	UBERON:0001876	59.73	gold quality
nucleus accumbens	UBERON:0001882	59.52	gold quality
frontal cortex	UBERON:0001870	59.14	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.04	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.