IRX2-DT

Summary

IRX2-DT (IRX2 divergent transcript, HGNC:24226) is a long non-coding RNA gene on chromosome 5p15.33.

Predicted to be located in extracellular region.

Source: NCBI Gene 153571 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24226
Approved symbol	IRX2-DT
Name	IRX2 divergent transcript
Location	5p15.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	CEI, IRX2NB
Ensembl gene	ENSG00000186493
Ensembl biotype	lncRNA
OMIM	610522
Entrez	153571
RNAcentral	URS00021EDA86 — lncRNA, 4283 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 lncRNA, 1 retained_intron

ENST00000397835, ENST00000503940, ENST00000505106, ENST00000515640, ENST00000647681, ENST00000649739, ENST00000650439

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000397835 — 3 exons

Exon	Start	End
ENSE00003364076	2755029	2755376
ENSE00003832721	2752622	2752754
ENSE00003839830	2752265	2752464

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 90.32.

FANTOM5 (CAGE): breadth broad, TPM avg 7.6119 / max 145.3909, expressed in 767 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
55589	4.2711	706
55590	1.2093	451
55593	1.0340	429
55594	0.5321	232
55595	0.3268	162
55588	0.1689	94
55592	0.0388	11
55591	0.0309	8

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	90.32	gold quality
saliva-secreting gland	UBERON:0001044	89.55	gold quality
minor salivary gland	UBERON:0001830	89.47	gold quality
skin of leg	UBERON:0001511	86.83	gold quality
skin of abdomen	UBERON:0001416	86.71	gold quality
zone of skin	UBERON:0000014	86.48	gold quality
thoracic mammary gland	UBERON:0005200	85.43	gold quality
upper lobe of left lung	UBERON:0008952	85.07	gold quality
subcutaneous adipose tissue	UBERON:0002190	84.64	gold quality
substantia nigra	UBERON:0002038	84.51	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	83.96	gold quality
hypothalamus	UBERON:0001898	83.40	gold quality
lower esophagus mucosa	UBERON:0035834	82.59	gold quality
metanephros cortex	UBERON:0010533	82.26	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.94	gold quality
lung	UBERON:0002048	81.39	gold quality
body of stomach	UBERON:0001161	81.00	gold quality
prostate gland	UBERON:0002367	80.13	gold quality
esophagus mucosa	UBERON:0002469	77.17	gold quality
adult mammalian kidney	UBERON:0000082	77.04	gold quality
stomach	UBERON:0000945	76.98	gold quality
left lobe of thyroid gland	UBERON:0001120	76.10	gold quality
right lobe of thyroid gland	UBERON:0001119	75.81	gold quality
thyroid gland	UBERON:0002046	75.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.17	gold quality
fundus of stomach	UBERON:0001160	75.13	gold quality
adipose tissue	UBERON:0001013	74.38	gold quality
cerebellum	UBERON:0002037	74.20	gold quality
placenta	UBERON:0001987	74.15	gold quality
cerebellar hemisphere	UBERON:0002245	74.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• CEI may play an important role in the evolution of higher primates in coordination with the IRX genes (PMID:16515847)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.