ISL1-DT

Summary

ISL1-DT (ISL1 divergent transcript, HGNC:55414) is a long non-coding RNA gene on chromosome 5q11.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55414
Approved symbol	ISL1-DT
Name	ISL1 divergent transcript
Location	5q11.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259663
Ensembl biotype	lncRNA
Entrez	642366
RNAcentral	URS000075C44E — lncRNA, 6699 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000558403, ENST00000559112, ENST00000601500, ENST00000820577

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558403 — 2 exons

Exon	Start	End
ENSE00002544432	51379645	51379675
ENSE00002546301	51378575	51379075

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 95.74.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2905 / max 174.4691, expressed in 375 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
61619	1.2905	375

Top tissues by expression

105 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	95.74	silver quality
thymus	UBERON:0002370	95.10	silver quality
bone marrow	UBERON:0002371	95.04	silver quality
skeletal muscle tissue	UBERON:0001134	93.73	silver quality
quadriceps femoris	UBERON:0001377	85.67	gold quality
islet of Langerhans	UBERON:0000006	79.23	gold quality
vagina	UBERON:0000996	75.00	gold quality
mucosa of stomach	UBERON:0001199	73.63	gold quality
prostate gland	UBERON:0002367	73.00	gold quality
fundus of stomach	UBERON:0001160	72.07	gold quality
colonic epithelium	UBERON:0000397	68.79	silver quality
frontal cortex	UBERON:0001870	68.20	gold quality
cerebellar vermis	UBERON:0004720	67.75	gold quality
ectocervix	UBERON:0012249	67.53	gold quality
stomach	UBERON:0000945	67.49	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.33	gold quality
placenta	UBERON:0001987	67.04	gold quality
body of stomach	UBERON:0001161	66.37	gold quality
omental fat pad	UBERON:0010414	63.06	gold quality
pancreas	UBERON:0001264	62.98	gold quality
uterine cervix	UBERON:0000002	62.72	gold quality
adipose tissue	UBERON:0001013	61.28	gold quality
adrenal tissue	UBERON:0018303	59.93	gold quality
gall bladder	UBERON:0002110	59.49	gold quality
rectum	UBERON:0001052	58.88	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	58.68	gold quality
calcaneal tendon	UBERON:0003701	57.46	gold quality
ventricular zone	UBERON:0003053	57.34	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.13	gold quality
endocervix	UBERON:0000458	56.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.72

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.