ISL2

Summary

ISL2 (ISL LIM homeobox 2, HGNC:18524) is a protein-coding gene on chromosome 15q24.3, encoding Insulin gene enhancer protein ISL-2 (Q96A47). Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in axonogenesis; neuron fate specification; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of neuron differentiation and neuron differentiation. Predicted to be located in chromatin. Predicted to be active in nucleus.

Source: NCBI Gene 64843 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 43 total
• MANE Select transcript: NM_145805

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18524
Approved symbol	ISL2
Name	ISL LIM homeobox 2
Location	15q24.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10160
Ensembl gene	ENSG00000159556
Ensembl biotype	protein_coding
OMIM	609481
Entrez	64843

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 1 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000290759, ENST00000558437, ENST00000558656

RefSeq mRNA: 1 — MANE Select: NM_145805 NM_145805

CCDS: CCDS10290

Canonical transcript exons

ENST00000290759 — 6 exons

Exon	Start	End
ENSE00001110855	76337778	76337967
ENSE00001207935	76341719	76342475
ENSE00001299340	76336773	76336941
ENSE00003497426	76341134	76341301
ENSE00003540383	76338252	76338514
ENSE00003618559	76340276	76340559

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 86.23.

FANTOM5 (CAGE): breadth broad, TPM avg 3.3937 / max 146.6949, expressed in 617 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147842	2.1222	431
147841	0.9013	396
147840	0.2099	87
147839	0.1603	42

Top tissues by expression

219 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.23	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.77	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.44	gold quality
lower esophagus	UBERON:0013473	69.37	gold quality
granulocyte	CL:0000094	69.34	gold quality
mucosa of stomach	UBERON:0001199	68.16	gold quality
mucosa of transverse colon	UBERON:0004991	67.87	gold quality
vagina	UBERON:0000996	67.25	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.04	gold quality
pituitary gland	UBERON:0000007	65.52	gold quality
urethra	UBERON:0000057	64.96	silver quality
penis	UBERON:0000989	64.25	gold quality
blood	UBERON:0000178	63.88	gold quality
body of stomach	UBERON:0001161	63.18	gold quality
adenohypophysis	UBERON:0002196	63.05	gold quality
transverse colon	UBERON:0001157	62.63	gold quality
bone marrow cell	CL:0002092	62.47	silver quality
stomach	UBERON:0000945	61.67	gold quality
leukocyte	CL:0000738	61.22	gold quality
esophagus	UBERON:0001043	60.80	gold quality
colon	UBERON:0001155	60.60	gold quality
monocyte	CL:0000576	60.45	gold quality
prostate gland	UBERON:0002367	60.24	gold quality
small intestine Peyer’s patch	UBERON:0003454	59.81	gold quality
epithelium of nasopharynx	UBERON:0001951	59.80	gold quality
large intestine	UBERON:0000059	59.73	gold quality
intestine	UBERON:0000160	59.43	gold quality
small intestine	UBERON:0002108	58.94	gold quality
minor salivary gland	UBERON:0001830	57.59	gold quality
trigeminal ganglion	UBERON:0001675	57.16	silver quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.23
E-GEOD-99795	no	12.75

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
EPHB1	Repression
INS	Activation

JASPAR motifs

Motif	Name	Family
MA0914.1	ISL2	HD-LIM
MA0914.2	ISL2	HD-LIM

JASPAR matrix evidence (PMIDs): PMID:7999775

Upstream regulators (CollecTRI, top): ATOH7

miRNA regulators (miRDB)

34 targeting ISL2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-3156-3P	99.76	66.72	939
HSA-MIR-10394-5P	99.65	66.83	1852
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-17-3P	99.55	66.77	1311
HSA-MIR-1207-5P	99.49	69.11	2983
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-6722-3P	99.45	67.62	1919
HSA-MIR-4763-3P	99.10	67.83	2649
HSA-MIR-1909-3P	99.03	66.56	1662
HSA-MIR-4270	99.02	66.26	1987
HSA-MIR-4326	98.97	67.63	962
HSA-MIR-29B-1-5P	98.86	68.35	1364
HSA-MIR-4477A	98.83	69.75	2952
HSA-MIR-887-5P	98.82	65.90	1347
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-6754-5P	98.60	65.54	1627
HSA-MIR-6780A-3P	98.42	67.49	1518
HSA-MIR-6810-5P	98.29	66.21	975
HSA-MIR-4299	98.28	66.96	850
HSA-MIR-6732-3P	98.17	67.52	802
HSA-MIR-375-3P	97.91	65.12	483

Literature-anchored findings (GeneRIF, showing 3)

• The broad expression of Isl-2 gene in tissues during embryogenesis and adult development suggests that it may be involved in both differentiation and maintenance of these tissues and might play an important role. (PMID:17091338)
• Experiments in Isl2/EphA3 knock-in mice test the interactions between effects of molecular labels and correlated activity during the development of neural connectivity. (PMID:21190559)
• ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer. (PMID:35508175)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	isl2a	ENSDARG00000003971
danio_rerio	isl2b	ENSDARG00000053499
mus_musculus	Isl2	ENSMUSG00000032318
rattus_norvegicus	Isl2	ENSRNOG00000015336
drosophila_melanogaster	tup	FBGN0003896
caenorhabditis_elegans	lim-7	WBGENE00002989

Paralogs (1): ISL1 (ENSG00000016082)

Protein

Protein identifiers

Insulin gene enhancer protein ISL-2 — Q96A47 (reviewed: Q96A47)

All UniProt accessions (2): Q96A47, H0YN25

UniProt curated annotations — full annotation on UniProt →

Function. Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.

Subunit / interactions. Interacts with LHX4.

Subcellular location. Nucleus.

RefSeq proteins (1): NP_665804* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR001781	Znf_LIM	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR047169	ISL1/2-like	Family
IPR047244	ISL1/2-like_LIM1	Domain

Pfam: PF00046, PF00412

UniProt features (12 total): modified residue 3, region of interest 3, domain 2, compositionally biased region 2, chain 1, DNA-binding region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96A47-F1	69.66	0.25

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 157, 279, 154

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 99 (showing top): GOBP_SPINAL_CORD_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_NEURON_DIFFERENTIATION, BENPORATH_ES_WITH_H3K27ME3, GOBP_RETINAL_GANGLION_CELL_AXON_GUIDANCE, GOBP_NEUROGENESIS, GOBP_CELL_DIFFERENTIATION_IN_SPINAL_CORD, GOBP_SPINAL_CORD_MOTOR_NEURON_DIFFERENTIATION, PATIL_LIVER_CANCER, GOBP_VENTRAL_SPINAL_CORD_DEVELOPMENT, GOBP_SPINAL_CORD_MOTOR_NEURON_CELL_FATE_SPECIFICATION, GOBP_REGULATION_OF_NEURON_DIFFERENTIATION, GOBP_PERIPHERAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION, GOBP_NEURON_FATE_SPECIFICATION, GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION, ZHAN_MULTIPLE_MYELOMA_HP_UP

GO Biological Process (13): axonogenesis (GO:0007409), spinal cord motor neuron cell fate specification (GO:0021520), visceral motor neuron differentiation (GO:0021524), retinal ganglion cell axon guidance (GO:0031290), negative regulation of neuron differentiation (GO:0045665), positive regulation of transcription by RNA polymerase II (GO:0045944), neuron fate specification (GO:0048665), neuron development (GO:0048666), peripheral nervous system neuron development (GO:0048935), regulation of DNA-templated transcription (GO:0006355), cell differentiation (GO:0030154), neuron differentiation (GO:0030182), neuron fate commitment (GO:0048663)

GO Molecular Function (7): DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), cis-regulatory region sequence-specific DNA binding (GO:0000987), DNA binding (GO:0003677), metal ion binding (GO:0046872), sequence-specific double-stranded DNA binding (GO:1990837), protein binding (GO:0005515), sequence-specific DNA binding (GO:0043565)

GO Cellular Component (2): chromatin (GO:0000785), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
neuron differentiation	3
spinal cord motor neuron differentiation	2
regulation of transcription by RNA polymerase II	2
cell morphogenesis involved in neuron differentiation	1
neuron projection morphogenesis	1
axon development	1
neuron fate specification	1
axon guidance	1
negative regulation of cell differentiation	1
regulation of neuron differentiation	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
cell fate specification	1
neuron fate commitment	1
cell development	1
neuron development	1
peripheral nervous system neuron differentiation	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cellular developmental process	1
cell differentiation	1
generation of neurons	1
cell fate commitment	1
chromatin	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
DNA-binding transcription factor activity	1
transcription cis-regulatory region binding	1
nucleic acid binding	1
cation binding	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
binding	1
DNA binding	1
chromosome	1
cellular anatomical structure	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

1182 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ISL2	MNX1	P50219	808
ISL2	NEUROG2	Q9H2A3	794
ISL2	GDPD5	Q8WTR4	762
ISL2	ZIC2	O95409	742
ISL2	EPHB1	P54762	733
ISL2	OLIG2	Q13516	708
ISL2	LHX3	Q9UBR4	704
ISL2	LHX4	Q969G2	683
ISL2	LDB1	Q86U70	640
ISL2	EVX1	P49640	626
ISL2	GDPD2	Q9HCC8	597
ISL2	VSX2	P58304	546
ISL2	POU4F1	Q01851	543
ISL2	POU4F2	Q12837	537
ISL2	NKX6-2	Q9C056	518

IntAct

55 interactions, top by confidence:

A	B	Type	Score
LHX4	ISL2	psi-mi:“MI:0915”(physical association)	0.760
PYGO1	BCL9	psi-mi:“MI:0914”(association)	0.700
SSBP3	LHX1	psi-mi:“MI:0914”(association)	0.570
LDB1	ISL2	psi-mi:“MI:0915”(physical association)	0.560
LMO3	ZBTB43	psi-mi:“MI:0914”(association)	0.550
SSBP4	LDB2	psi-mi:“MI:0914”(association)	0.550
SSBP2	CLEC18A	psi-mi:“MI:0914”(association)	0.530
LHX4	THAP12	psi-mi:“MI:0914”(association)	0.530
ARIH1	SPOP	psi-mi:“MI:0914”(association)	0.530
SSBP4	GM2A	psi-mi:“MI:0914”(association)	0.530
SYNGAP1	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
SYNGAP1	SEC16A	psi-mi:“MI:0914”(association)	0.530
PICK1	ILVBL	psi-mi:“MI:0914”(association)	0.530
IFNA10	ISL2	psi-mi:“MI:0915”(physical association)	0.370
IFNA21	ISL2	psi-mi:“MI:0915”(physical association)	0.370
IFNA4	ISL2	psi-mi:“MI:0915”(physical association)	0.370
IFNA7	ISL2	psi-mi:“MI:0915”(physical association)	0.370
SSBP3	LHX2	psi-mi:“MI:0914”(association)	0.350
COPS5	FBLL1	psi-mi:“MI:0914”(association)	0.350
LMO2	APBB1	psi-mi:“MI:0914”(association)	0.350
IDI2	LMX1B	psi-mi:“MI:0914”(association)	0.350
SSBP3	LHX1	psi-mi:“MI:0914”(association)	0.350
LHX1	AIFM1	psi-mi:“MI:0914”(association)	0.350
LHX3	HAL	psi-mi:“MI:0914”(association)	0.350
LHX4	FLOT1	psi-mi:“MI:0914”(association)	0.350
DYRK1A	TEX13D	psi-mi:“MI:0914”(association)	0.350

BioGRID (73): ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), ISL2 (Affinity Capture-MS), LDB1 (Two-hybrid), LHX3 (Reconstituted Complex)

ESM2 similar proteins: A0JNI8, A2I8Z7, A2PZF9, G5EC36, G5EE86, G5EEA1, P20154, P29673, P29674, P34764, P34765, P36198, P36200, P37137, P48742, P50211, P50212, P50458, P50481, P52889, P53405, P53406, P53407, P53408, P53409, P53411, P53412, P61371, P61372, P61373, P61374, P61375, P61376, P63006, P63007, P63008, Q1LWV4, Q5IS44, Q5IS89, Q68EY3

Diamond homologs: A0JNI8, A2I8Z7, A2PZF9, G5EC36, G5EE86, O14639, O35652, O60663, O88609, O94929, O97581, P20154, P25791, P25800, P25801, P29673, P29674, P34764, P34765, P36198, P36200, P37137, P48742, P50211, P50212, P50458, P50480, P50481, P52889, P53405, P53406, P53407, P53408, P53409, P53410, P53411, P53412, P53413, P53667, P53668

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
LHX3	“up-regulates activity”	ISL2	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 55 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SARS-CoV-2 activates/modulates innate and adaptive immune responses	5	12.8×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
neuron differentiation	9	17.7×	4e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

898 predictions. Top by Δscore:

Variant	Effect	Δscore
15:76337777:GAGAA:G	acceptor_gain	1.0000
15:76337968:GTGA:G	donor_loss	1.0000
15:76337969:T:G	donor_loss	1.0000
15:76340135:G:GT	donor_gain	1.0000
15:76340555:AGACG:A	donor_gain	1.0000
15:76340556:GACG:G	donor_gain	1.0000
15:76340556:GACGG:G	donor_gain	1.0000
15:76340559:GGTG:G	donor_loss	1.0000
15:76340560:G:A	donor_loss	1.0000
15:76340560:G:GG	donor_gain	1.0000
15:76340561:T:G	donor_loss	1.0000
15:76341132:A:AG	acceptor_gain	1.0000
15:76341133:G:GG	acceptor_gain	1.0000
15:76341133:GA:G	acceptor_gain	1.0000
15:76341298:GCTG:G	donor_gain	1.0000
15:76341300:TGGTG:T	donor_loss	1.0000
15:76341301:GGT:G	donor_loss	1.0000
15:76341302:G:GG	donor_gain	1.0000
15:76341302:GTGAG:G	donor_loss	1.0000
15:76341303:T:A	donor_loss	1.0000
15:76336939:AGA:A	donor_gain	0.9900
15:76336940:GA:G	donor_gain	0.9900
15:76336940:GAG:G	donor_gain	0.9900
15:76336942:G:GG	donor_gain	0.9900
15:76337772:C:CA	acceptor_gain	0.9900
15:76337774:GCA:G	acceptor_loss	0.9900
15:76337775:CA:C	acceptor_loss	0.9900
15:76337776:A:AC	acceptor_loss	0.9900
15:76337776:A:AG	acceptor_gain	0.9900
15:76337777:G:GA	acceptor_gain	0.9900

AlphaMissense

2360 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:76337798:T:A	C27S	1.000
15:76337798:T:C	C27R	1.000
15:76337799:G:A	C27Y	1.000
15:76337799:G:C	C27S	1.000
15:76337800:C:G	C27W	1.000
15:76337807:T:A	C30S	1.000
15:76337807:T:C	C30R	1.000
15:76337808:G:A	C30Y	1.000
15:76337808:G:C	C30S	1.000
15:76337808:G:T	C30F	1.000
15:76337809:C:G	C30W	1.000
15:76337838:T:C	L40P	1.000
15:76337861:T:A	W48R	1.000
15:76337861:T:C	W48R	1.000
15:76337862:G:C	W48S	1.000
15:76337863:G:C	W48C	1.000
15:76337863:G:T	W48C	1.000
15:76337864:C:G	H49D	1.000
15:76337866:C:A	H49Q	1.000
15:76337866:C:G	H49Q	1.000
15:76337873:T:A	C52S	1.000
15:76337873:T:C	C52R	1.000
15:76337874:G:A	C52Y	1.000
15:76337874:G:C	C52S	1.000
15:76337874:G:T	C52F	1.000
15:76337875:C:G	C52W	1.000
15:76337877:T:A	L53H	1.000
15:76337877:T:C	L53P	1.000
15:76337882:T:A	C55S	1.000
15:76337882:T:C	C55R	1.000

dbSNP variants (sampled 300 via entrez): RS1000191675 (15:76338559 C>A), RS1001063008 (15:76340660 A>G), RS1001369842 (15:76340434 C>G), RS1001414775 (15:76339486 C>T), RS1002049240 (15:76336611 ACCCAACCCACC>A), RS1002372018 (15:76339871 T>C), RS1002802662 (15:76338610 G>C), RS1002878541 (15:76340141 G>A,C), RS1003250502 (15:76342232 G>T), RS1003470214 (15:76342017 A>T), RS1003724703 (15:76335852 G>C), RS1004100584 (15:76340774 C>A), RS1004722496 (15:76341000 A>C,G), RS1004864055 (15:76340962 C>G,T), RS1004938593 (15:76334819 A>G)

Disease associations

OMIM: gene MIM:609481 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST006479_152	Diverticular disease	1.000000e-07
GCST006479_153	Diverticular disease	7.000000e-06
GCST007876_30	Estimated glomerular filtration rate	3.000000e-25

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009959	diverticular disease

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, increases methylation	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Silver	increases expression	2
FR900359	decreases phosphorylation	1
dicrotophos	increases expression	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
tetrabromobisphenol A	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
ochratoxin A	decreases expression	1
potassium chromate(VI)	affects cotreatment, increases expression	1
S-(1,2-dichlorovinyl)cysteine	increases expression	1
mercuric bromide	affects cotreatment, increases expression	1
epigallocatechin gallate	affects cotreatment, increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
abrine	increases expression	1
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	increases expression, affects cotreatment	1
dorsomorphin	affects cotreatment, increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Arsenic Trioxide	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	increases abundance, increases expression, affects cotreatment	1
Hexachlorocyclohexane	increases expression	1
Cisplatin	increases expression	1
Cyclophosphamide	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A3I6	SEES3-1V human ISL2, clone1	Embryonic stem cell	Male
CVCL_A3I7	SEES3-1V human ISL2, clone2	Embryonic stem cell	Male
CVCL_A3I8	SEES3-1V human ISL2, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.