ISLR2-AS1

Summary

ISLR2-AS1 (ISLR2 antisense RNA 1, HGNC:27530) is a long non-coding RNA gene on chromosome 15q24.1.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27530
Approved symbol	ISLR2-AS1
Name	ISLR2 antisense RNA 1
Location	15q24.1
Locus type	RNA, long non-coding
Status	Approved
Entrez	283731

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• we successfully identified promoter hypermethylation of LOC283731 as a novel, independent prognostic biomarker in GBM patients associated with a better patient survival. (PMID:26934681)

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000394964 (15:74128440 G>A,T), RS1000762644 (15:74129411 C>A,T), RS1001760570 (15:74126827 G>A), RS1001954305 (15:74131265 T>C), RS1002252721 (15:74128816 C>A,T), RS1003269682 (15:74127773 G>A,C,T), RS1003632178 (15:74129870 C>A,T), RS1003708360 (15:74127549 A>C), RS1003749673 (15:74130139 G>A), RS1004147760 (15:74125996 C>A), RS1004202079 (15:74128756 C>T), RS1004421935 (15:74129099 C>T), RS1004538366 (15:74130125 G>A), RS1004617797 (15:74129790 C>T), RS1005175192 (15:74127743 C>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.