ITCH-AS1

Summary

ITCH-AS1 (ITCH antisense RNA 1, HGNC:40659) is a long non-coding RNA gene on chromosome 20q11.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40659
Approved symbol	ITCH-AS1
Name	ITCH antisense RNA 1
Location	20q11.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236388
Ensembl biotype	lncRNA
Entrez	106480737
RNAcentral	URS000058F37B — lncRNA, 299 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000454205

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000454205 — 2 exons

Exon	Start	End
ENSE00001622365	34441592	34441695
ENSE00001655349	34441831	34442025

Expression profiles

Bgee: expression breadth broad, 98 present calls, max score 84.16.

Top tissues by expression

98 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.16	silver quality
colonic epithelium	UBERON:0000397	77.31	gold quality
bone marrow cell	CL:0002092	73.68	gold quality
bone marrow	UBERON:0002371	68.94	gold quality
lymph node	UBERON:0000029	68.71	gold quality
liver	UBERON:0002107	68.62	gold quality
muscle tissue	UBERON:0002385	67.61	gold quality
tonsil	UBERON:0002372	67.26	silver quality
urinary bladder	UBERON:0001255	67.24	gold quality
skeletal muscle tissue	UBERON:0001134	65.87	gold quality
corpus callosum	UBERON:0002336	65.49	gold quality
monocyte	CL:0000576	64.58	gold quality
uterine cervix	UBERON:0000002	64.47	gold quality
islet of Langerhans	UBERON:0000006	64.15	gold quality
adrenal tissue	UBERON:0018303	63.55	gold quality
prefrontal cortex	UBERON:0000451	62.00	gold quality
blood	UBERON:0000178	60.47	gold quality
placenta	UBERON:0001987	59.60	gold quality
kidney	UBERON:0002113	59.52	gold quality
gastrocnemius	UBERON:0001388	57.96	gold quality
adrenal gland	UBERON:0002369	57.79	gold quality
muscle of leg	UBERON:0001383	57.50	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	56.00	gold quality
stomach	UBERON:0000945	54.37	gold quality
apex of heart	UBERON:0002098	53.65	gold quality
calcaneal tendon	UBERON:0003701	53.21	gold quality
ectocervix	UBERON:0012249	52.99	gold quality
endometrium	UBERON:0001295	52.92	silver quality
body of stomach	UBERON:0001161	52.54	gold quality
lung	UBERON:0002048	52.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.12

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.