ITCH-IT1

Summary

ITCH-IT1 (ITCH intronic transcript 1, HGNC:41397) is a long non-coding RNA gene on chromosome 20q11.22.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41397
Approved symbol	ITCH-IT1
Name	ITCH intronic transcript 1
Location	20q11.22
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231795
Ensembl biotype	lncRNA
Entrez	100874302
RNAcentral	URS00005756BD — lncRNA, 208 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000418598

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418598 — 2 exons

Exon	Start	End
ENSE00001630132	34454415	34454552
ENSE00001793880	34450930	34450999

Expression profiles

Bgee: expression breadth ubiquitous, 111 present calls, max score 97.17.

Top tissues by expression

111 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	97.17	gold quality
corpus callosum	UBERON:0002336	88.61	gold quality
sural nerve	UBERON:0015488	86.00	gold quality
ventricular zone	UBERON:0003053	82.12	gold quality
bone marrow cell	CL:0002092	79.57	gold quality
primary visual cortex	UBERON:0002436	78.66	gold quality
skeletal muscle tissue	UBERON:0001134	76.74	gold quality
tonsil	UBERON:0002372	75.92	gold quality
bone marrow	UBERON:0002371	75.10	gold quality
adrenal tissue	UBERON:0018303	74.07	gold quality
liver	UBERON:0002107	73.14	gold quality
monocyte	CL:0000576	73.13	gold quality
blood	UBERON:0000178	71.16	gold quality
calcaneal tendon	UBERON:0003701	69.65	gold quality
endometrium	UBERON:0001295	69.47	gold quality
urinary bladder	UBERON:0001255	68.90	gold quality
prefrontal cortex	UBERON:0000451	68.35	gold quality
kidney	UBERON:0002113	67.12	gold quality
pancreas	UBERON:0001264	66.32	gold quality
islet of Langerhans	UBERON:0000006	65.73	gold quality
stomach	UBERON:0000945	65.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.82	gold quality
muscle of leg	UBERON:0001383	64.53	gold quality
placenta	UBERON:0001987	63.95	gold quality
uterine cervix	UBERON:0000002	63.79	gold quality
gastrocnemius	UBERON:0001388	63.05	gold quality
adult mammalian kidney	UBERON:0000082	62.75	gold quality
lymph node	UBERON:0000029	62.60	gold quality
body of pancreas	UBERON:0001150	62.42	gold quality
tibial artery	UBERON:0007610	61.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.53

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• cir-ITCH plays a role in CRC by regulating the Wnt/beta-catenin pathway (PMID:26110611)
• circ-ITCH/miR-22-3p/CBL/beta-catenin is involved in papillary thyroid cancer development and progression (PMID:30190130)
• Rs4911154 of circ-ITCH aggravated tumor malignancy of thyroid nodules via the circ-ITCH/miR-22-3p/CBL axis. (PMID:34531437)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.