ITGA10

Summary

ITGA10 (integrin subunit alpha 10, HGNC:6135) is a protein-coding gene on chromosome 1q21.1, encoding Integrin alpha-10 (O75578). Integrin alpha-10/beta-1 is a receptor for collagen.

Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 8515 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 169 total
• Druggable target: yes
• MANE Select transcript: NM_003637

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6135
Approved symbol	ITGA10
Name	integrin subunit alpha 10
Location	1q21.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000143127
Ensembl biotype	protein_coding
OMIM	604042
Entrez	8515

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000369304, ENST00000468261, ENST00000481236, ENST00000539363, ENST00000889439, ENST00000889440, ENST00000889441, ENST00000965598

RefSeq mRNA: 3 — MANE Select: NM_003637 NM_001303040, NM_001303041, NM_003637

CCDS: CCDS72869, CCDS76204

Canonical transcript exons

ENST00000369304 — 30 exons

Exon	Start	End
ENSE00000958255	145904052	145904200
ENSE00000958256	145902811	145902961
ENSE00001002937	145904684	145904811
ENSE00001002939	145896268	145896352
ENSE00001002940	145897011	145897087
ENSE00001002941	145897247	145897339
ENSE00001002942	145901135	145901278
ENSE00001002943	145902246	145902319
ENSE00001002945	145896769	145896858
ENSE00001002946	145899175	145899341
ENSE00001002947	145906733	145906824
ENSE00001002948	145906394	145906508
ENSE00001002949	145897815	145897900
ENSE00001002953	145898936	145899078
ENSE00001002955	145902454	145902619
ENSE00001002956	145898110	145898223
ENSE00001002958	145900057	145900187
ENSE00001002959	145901516	145901664
ENSE00001002960	145897512	145897653
ENSE00001068793	145895983	145896096
ENSE00001068796	145893540	145893635
ENSE00001068798	145895631	145895711
ENSE00001068799	145901877	145902021
ENSE00001068800	145893161	145893274
ENSE00001068801	145900790	145900993
ENSE00001068802	145895280	145895393
ENSE00001449447	145891208	145892863
ENSE00001920904	145909963	145910050
ENSE00003492057	145907354	145907465
ENSE00003642348	145907041	145907150

Expression profiles

Bgee: expression breadth ubiquitous, 201 present calls, max score 99.12.

FANTOM5 (CAGE): breadth broad, TPM avg 3.2645 / max 245.0869, expressed in 608 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14151	2.9672	588
14152	0.2973	134

Top tissues by expression

285 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	99.12	gold quality
descending thoracic aorta	UBERON:0002345	98.25	gold quality
thoracic aorta	UBERON:0001515	97.57	gold quality
cartilage tissue	UBERON:0002418	97.54	gold quality
ascending aorta	UBERON:0001496	97.50	gold quality
right coronary artery	UBERON:0001625	95.05	gold quality
calcaneal tendon	UBERON:0003701	94.63	gold quality
mucosa of stomach	UBERON:0001199	94.55	gold quality
aorta	UBERON:0000947	94.13	gold quality
periodontal ligament	UBERON:0008266	92.99	gold quality
left coronary artery	UBERON:0001626	92.49	gold quality
right lung	UBERON:0002167	92.23	gold quality
popliteal artery	UBERON:0002250	91.73	gold quality
tibial artery	UBERON:0007610	91.73	gold quality
coronary artery	UBERON:0001621	91.36	gold quality
tendon	UBERON:0000043	88.86	gold quality
upper lobe of left lung	UBERON:0008952	86.35	gold quality
upper lobe of lung	UBERON:0008948	85.64	gold quality
tendon of biceps brachii	UBERON:0008188	84.61	gold quality
blood vessel layer	UBERON:0004797	84.34	gold quality
tibial nerve	UBERON:0001323	84.22	gold quality
sural nerve	UBERON:0015488	83.36	gold quality
right atrium auricular region	UBERON:0006631	82.09	gold quality
tibialis anterior	UBERON:0001385	81.10	gold quality
secondary oocyte	CL:0000655	80.94	gold quality
gastrocnemius	UBERON:0001388	80.64	gold quality
cardiac atrium	UBERON:0002081	80.35	gold quality
endocervix	UBERON:0000458	80.03	gold quality
oocyte	CL:0000023	79.43	gold quality
muscle of leg	UBERON:0001383	79.02	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-CURD-7	yes	322.00
E-ENAD-21	yes	322.00
E-GEOD-135922	yes	229.99
E-CURD-112	yes	16.45
E-ANND-3	yes	6.15

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): E2F1, E2F3, ETS1, LRP3, RB1, SOX9, TFAP2A, TFAP2E

miRNA regulators (miRDB)

83 targeting ITGA10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-4779	99.86	66.50	1583
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767
HSA-MIR-548AU-3P	99.70	68.22	1373
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-4756-3P	99.62	66.30	1319
HSA-MIR-4663	99.62	65.33	957
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-4269	99.55	69.89	1373

Literature-anchored findings (GeneRIF, showing 6)

• Mouse and human articular chondrocytes express extracellular splice variants of the alpha10 subunit (PMID:11731273)
• Analyses of the functional regulatory domains of the integrin alpha 10 promoter suggest that AP-2epsilon and Ets-1 are involved in the transcriptional regulation of this gene in chondrocytes. (PMID:16684505)
• Unique charge-dependent constraints on collagen recognition by integrin alpha10beta1 have been described. (PMID:27569273)
• CNS disease was associated with enhanced expression of cytoplasmic and membranous ITGA10 and nuclear PTEN (P < 0.0005, P = 0.002, P = 0.024, respectively). sCNSL presented decreased membranous CD44 and nuclear and cytoplasmic cadherin-11 expressions (P = 0.001, P = 0.006, P = 0.048, respectively). In PCNSL lactoferrin expression was upregulated (P < 0.0005). (PMID:28854563)
• Systematic screening identifies a 2-gene signature as a high-potential prognostic marker of undifferentiated pleomorphic sarcoma/myxofibrosarcoma. (PMID:31742892)
• ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway. (PMID:34706747)

Cross-species orthologs

10 orthologs

Organism	Symbol	Gene ID
danio_rerio	itga10	ENSDARG00000002507
mus_musculus	Itga10	ENSMUSG00000090210
rattus_norvegicus	Itga10	ENSRNOG00000021217
drosophila_melanogaster	if	FBGN0001250
drosophila_melanogaster	mew	FBGN0004456
drosophila_melanogaster	ItgaPS4	FBGN0034005
drosophila_melanogaster	ItgaPS5	FBGN0034880
drosophila_melanogaster	scb	FBGN0286785
caenorhabditis_elegans		WBGENE00002081
caenorhabditis_elegans		WBGENE00003929

Paralogs (17): ITGAL (ENSG00000005844), ITGA3 (ENSG00000005884), ITGA2B (ENSG00000005961), ITGA8 (ENSG00000077943), ITGAE (ENSG00000083457), ITGA6 (ENSG00000091409), ITGA4 (ENSG00000115232), ITGA7 (ENSG00000135424), ITGA11 (ENSG00000137809), ITGAV (ENSG00000138448), ITGAX (ENSG00000140678), ITGA9 (ENSG00000144668), ITGAD (ENSG00000156886), ITGA5 (ENSG00000161638), ITGA2 (ENSG00000164171), ITGAM (ENSG00000169896), ITGA1 (ENSG00000213949)

Protein

Protein identifiers

Integrin alpha-10 — O75578 (reviewed: O75578)

All UniProt accessions (1): O75578

UniProt curated annotations — full annotation on UniProt →

Function. Integrin alpha-10/beta-1 is a receptor for collagen.

Subunit / interactions. Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1.

Subcellular location. Membrane.

Tissue specificity. Widely expressed with highest expression in muscle and heart. Found in articular cartilage.

Domain organisation. The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Similarity. Belongs to the integrin alpha chain family.

Isoforms (3)

UniProt ID	Names	Canonical?
O75578-1	1	yes
O75578-2	2
O75578-3	3

RefSeq proteins (3): NP_001289969, NP_001289970, NP_003628* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000413	Integrin_alpha	Family
IPR002035	VWF_A	Domain
IPR013517	FG-GAP	Repeat
IPR013519	Int_alpha_beta-p	Repeat
IPR013649	Integrin_alpha_Ig-like_1	Domain
IPR028994	Integrin_alpha_N	Homologous_superfamily
IPR032695	Integrin_dom_sf	Homologous_superfamily
IPR036465	vWFA_dom_sf	Homologous_superfamily
IPR048285	Integrin_alpha_Ig-like_2	Domain

Pfam: PF00092, PF01839, PF08441, PF20805

UniProt features (51 total): binding site 12, glycosylation site 11, repeat 7, sequence variant 5, disulfide bond 4, splice variant 3, sequence conflict 3, topological domain 2, signal peptide 1, chain 1, transmembrane region 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75578-F1	85.10	0.48

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (12): 494; 496; 498; 502; 558; 560; 562; 566; 620; 622; 624; 628

Disulfide bonds (4): 76–86, 666–675, 681–736, 789–795

Glycosylation sites (11): 98, 234, 336, 364, 733, 763, 839, 921, 1011, 1018, 1039

Function

Pathways and Gene Ontology

Reactome pathways

9 pathways

ID	Pathway
R-HSA-216083	Integrin cell surface interactions
R-HSA-447041	CHL1 interactions
R-HSA-75892	Platelet Adhesion to exposed collagen
R-HSA-109582	Hemostasis
R-HSA-1266738	Developmental Biology
R-HSA-1474244	Extracellular matrix organization
R-HSA-373760	L1CAM interactions
R-HSA-422475	Axon guidance
R-HSA-9675108	Nervous system development

MSigDB gene sets: 152 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_DN, MODULE_45, MODULE_64, GOCC_CELL_SURFACE, MODULE_16, GGGTGGRR_PAX4_03, AAAYRNCTG_UNKNOWN, GOBP_CELL_CELL_ADHESION, PID_CXCR4_PATHWAY, AML_Q6, BLALOCK_ALZHEIMERS_DISEASE_UP, ONDER_CDH1_TARGETS_2_UP, MODULE_88, GFI1_01, AML1_01

GO Biological Process (4): cell-matrix adhesion (GO:0007160), integrin-mediated signaling pathway (GO:0007229), cell-cell adhesion (GO:0098609), cell adhesion (GO:0007155)

GO Molecular Function (4): collagen binding (GO:0005518), signaling receptor activity (GO:0038023), metal ion binding (GO:0046872), collagen binding involved in cell-matrix adhesion (GO:0098639)

GO Cellular Component (5): plasma membrane (GO:0005886), integrin complex (GO:0008305), cell surface (GO:0009986), integrin alpha10-beta1 complex (GO:0034680), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Extracellular matrix organization	1
L1CAM interactions	1
Hemostasis	1
Axon guidance	1
Nervous system development	1
Developmental Biology	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cell-substrate adhesion	1
cell surface receptor signaling pathway	1
cell adhesion	1
cellular process	1
protein-containing complex binding	1
molecular transducer activity	1
cation binding	1
collagen binding	1
cell-matrix adhesion	1
cell-matrix adhesion mediator activity	1
membrane	1
cell periphery	1
protein complex involved in cell adhesion	1
plasma membrane signaling receptor complex	1
integrin complex	1

Protein interactions and networks

STRING

624 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ITGA10	ITGB8	P26012	678
ITGA10	ITGB5	P18084	677
ITGA10	ITGB3	P05106	647
ITGA10	ITGB1	P05556	629
ITGA10	ITGB2	P05107	607
ITGA10	ITGB7	P26010	600
ITGA10	ITGA1	P56199	581
ITGA10	FN1	P02751	548
ITGA10	COL1A1	P02452	532
ITGA10	COL6A1	P12109	530
ITGA10	LAMC3	Q9Y6N6	529
ITGA10	RICTOR	Q6R327	522
ITGA10	ITGA2B	P08514	509
ITGA10	ITGB6	P18564	505
ITGA10	COL3A1	P02461	504

IntAct

2 interactions, top by confidence:

A	B	Type	Score
Fabp3	ITGA10	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (4): ITGA10 (Affinity Capture-MS), ITGA10 (Affinity Capture-MS), ITGB1 (Affinity Capture-Western), SLMAP (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A0JND9, E1BPW0, O14773, O18956, O35795, O55026, O75173, O75355, O75356, O75578, O89023, O93295, P08514, P08648, P11688, P17405, P49961, P55772, P56201, P79784, P97687, Q04519, Q0VD19, Q12794, Q32M88, Q49HH9, Q49KI5, Q5DRK1, Q5IS74, Q5MY95, Q5RFL1, Q5RFQ8, Q60HH1, Q6P3E7, Q6P6S9, Q717C1, Q717C2, Q7RTX0, Q8BFW6, Q8BNJ2

Diamond homologs: A2AX52, A6H584, A6NMZ7, A6QLN9, A8TX70, E7FF10, O00339, O08746, O42401, O75578, O89029, P05099, P05555, P11215, P12111, P15989, P20701, P20702, P34576, P51942, P61625, Q02388, Q13349, Q21281, Q21540, Q28902, Q3V0T4, Q63870, Q642A6, Q6PCB0, Q6UXI7, Q8C6K9, Q8NFW1, Q8R2Z5, Q90615, Q91145, Q923P0, Q95LI2, Q96P44, Q9P218

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
RB1	“up-regulates quantity by expression”	ITGA10	“transcriptional regulation”
ITGA10	“form complex”	“A10/b1 integrin”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

169 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	163
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4298 predictions. Top by Δscore:

Variant	Effect	Δscore
1:145893634:G:GC	acceptor_loss	1.0000
1:145893634:G:GG	acceptor_gain	1.0000
1:145893635:A:AC	acceptor_loss	1.0000
1:145893635:A:AG	acceptor_gain	1.0000
1:145893636:TA:T	acceptor_loss	1.0000
1:145893638:CATA:C	acceptor_loss	1.0000
1:145895277:G:GG	donor_gain	1.0000
1:145900053:T:A	donor_loss	1.0000
1:145900054:G:A	donor_loss	1.0000
1:145900055:GG:G	donor_loss	1.0000
1:145900186:GA:G	acceptor_gain	1.0000
1:145900186:GAGG:G	acceptor_gain	1.0000
1:145900186:GAGGA:G	acceptor_gain	1.0000
1:145900187:AGAG:A	acceptor_gain	1.0000
1:145900786:T:G	donor_loss	1.0000
1:145900787:GTCAG:G	donor_loss	1.0000
1:145900788:GGTCA:G	donor_loss	1.0000
1:145900789:AG:A	donor_loss	1.0000
1:145900791:CCAGG:C	donor_loss	1.0000
1:145900844:G:GT	donor_gain	1.0000
1:145900992:GC:G	acceptor_gain	1.0000
1:145900992:GCA:G	acceptor_gain	1.0000
1:145900992:GCAGT:G	acceptor_gain	1.0000
1:145901512:T:G	donor_loss	1.0000
1:145901513:G:GA	donor_loss	1.0000
1:145901514:GG:G	donor_loss	1.0000
1:145901515:AGGTA:A	donor_loss	1.0000
1:145901516:CAGGT:C	donor_loss	1.0000
1:145901518:AGCAG:A	donor_loss	1.0000
1:145901635:G:A	acceptor_gain	1.0000

AlphaMissense

7529 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:145902501:A:G	L343P	0.999
1:145902893:T:A	D276V	0.999
1:145904750:C:A	W181C	0.999
1:145904750:C:G	W181C	0.999
1:145904775:T:A	D173V	0.999
1:145904781:A:T	V171D	0.999
1:145902501:A:T	L343Q	0.998
1:145902896:G:A	T275I	0.998
1:145902899:A:T	V274D	0.998
1:145904732:G:C	F187L	0.998
1:145904732:G:T	F187L	0.998
1:145904734:A:G	F187L	0.998
1:145904752:A:G	W181R	0.998
1:145904752:A:T	W181R	0.998
1:145904769:G:A	S175F	0.998
1:145904774:A:C	D173E	0.998
1:145904774:A:T	D173E	0.998
1:145901983:C:A	W396C	0.997
1:145901983:C:G	W396C	0.997
1:145902815:A:T	I302N	0.997
1:145902892:A:C	D276E	0.997
1:145902892:A:T	D276E	0.997
1:145902902:A:T	V273D	0.997
1:145902908:A:G	L271P	0.997
1:145904762:G:C	S177R	0.997
1:145904762:G:T	S177R	0.997
1:145904764:T:G	S177R	0.997
1:145904769:G:T	S175Y	0.997
1:145904770:A:G	S175P	0.997
1:145904775:T:G	D173A	0.997

dbSNP variants (sampled 300 via entrez): RS1000870831 (1:145908491 A>C), RS1001052461 (1:145895198 G>A,T), RS1001081990 (1:145894909 A>G), RS1002380307 (1:145908049 C>T), RS1002663329 (1:145906182 G>T), RS1002682830 (1:145907079 C>A,G), RS1002730456 (1:145900221 C>T), RS1002734233 (1:145907839 G>A,C), RS1002783212 (1:145899804 C>G), RS1003991073 (1:145909300 A>C), RS1004043912 (1:145893413 G>A,T), RS1004126917 (1:145909628 T>C), RS1005268205 (1:145903112 T>C), RS1005285608 (1:145894293 A>G), RS1005662913 (1:145907760 T>A,C)

Disease associations

OMIM: gene MIM:604042 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST010241_375	Apolipoprotein A1 levels	5.000000e-10
GCST010242_374	HDL cholesterol levels	3.000000e-10

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004614	apolipoprotein A 1 measurement
EFO:0004612	high density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (2): CHEMBL3430895 (PROTEIN COMPLEX), CHEMBL5882 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: catalytic receptor — Integrins

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tetrachlorodibenzodioxin	decreases expression, increases expression	3
sodium arsenite	decreases expression	2
methacrylaldehyde	increases abundance, affects cotreatment, increases expression	2
Acrolein	affects cotreatment, increases expression, increases abundance	2
Doxorubicin	decreases expression, increases expression	2
Ozone	affects cotreatment, increases expression, increases abundance	2
Progesterone	increases expression	2
aristolochic acid I	increases expression	1
GSK-J4	decreases expression	1
OTX015	decreases expression	1
mivebresib	decreases expression	1
peracetylated N-azidoacetylmannosamine	decreases expression	1
sotorasib	decreases expression, affects cotreatment	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
deoxynivalenol	decreases expression	1
mono-(2-ethylhexyl)phthalate	decreases expression	1
butyraldehyde	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
trametinib	affects cotreatment, decreases expression	1
(+)-JQ1 compound	decreases expression	1
NVP-BKM120	affects cotreatment, decreases expression	1
Air Pollutants	affects cotreatment, increases abundance, increases expression	1
Atrazine	increases expression	1
Calcitriol	decreases expression	1
Chelating Agents	affects binding, decreases expression	1
Copper	affects binding, decreases expression	1
Hydrocortisone	increases expression	1
Quercetin	increases expression	1
Rotenone	decreases expression	1
T-2 Toxin	decreases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL3368787	Binding	Antagonist activity at alpha10beta1 integrin receptor (unknown origin) by cell-free ELISA	Strategies to inhibit tumor associated integrin receptors: rationale for dual and multi-antagonists. — J Med Chem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D8NF	Ubigene HCT 116 ITGA10 KO	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.