ITGA2-AS1

Summary

ITGA2-AS1 (ITGA2 antisense RNA 1, HGNC:40306) is a long non-coding RNA gene on chromosome 5q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40306
Approved symbol	ITGA2-AS1
Name	ITGA2 antisense RNA 1
Location	5q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	I2ALR
Ensembl gene	ENSG00000249899
Ensembl biotype	lncRNA
Entrez	121232372
RNAcentral	URS00026A1DCC — lncRNA, 2284 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000503559, ENST00000505701, ENST00000662246, ENST00000765995

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503559 — 5 exons

Exon	Start	End
ENSE00002021633	52988204	52988276
ENSE00002030473	52932476	52932536
ENSE00002042045	52978252	52978399
ENSE00002062351	52948825	52948907
ENSE00002065628	52990090	52990278

Expression profiles

Bgee: expression breadth ubiquitous, 129 present calls, max score 88.09.

Top tissues by expression

129 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.09	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.03	gold quality
calcaneal tendon	UBERON:0003701	82.24	gold quality
colonic epithelium	UBERON:0000397	79.97	gold quality
bone marrow cell	CL:0002092	79.06	gold quality
mucosa of stomach	UBERON:0001199	78.91	gold quality
popliteal artery	UBERON:0002250	74.73	gold quality
tibial artery	UBERON:0007610	74.73	gold quality
sural nerve	UBERON:0015488	72.29	gold quality
right lung	UBERON:0002167	71.13	gold quality
right coronary artery	UBERON:0001625	70.94	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.73	gold quality
lower esophagus	UBERON:0013473	70.66	gold quality
adrenal tissue	UBERON:0018303	70.62	gold quality
skeletal muscle tissue	UBERON:0001134	70.36	gold quality
left coronary artery	UBERON:0001626	69.70	gold quality
corpus callosum	UBERON:0002336	69.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.87	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.40	gold quality
descending thoracic aorta	UBERON:0002345	67.51	gold quality
ascending aorta	UBERON:0001496	67.28	gold quality
thoracic aorta	UBERON:0001515	67.20	gold quality
urinary bladder	UBERON:0001255	67.01	gold quality
ventricular zone	UBERON:0003053	66.69	gold quality
lung	UBERON:0002048	65.29	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.78	gold quality
upper lobe of left lung	UBERON:0008952	64.41	gold quality
body of uterus	UBERON:0009853	62.85	gold quality
esophagus	UBERON:0001043	62.75	gold quality
stromal cell of endometrium	CL:0002255	62.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• A novel long non-coding RNA regulates the integrin, ITGA2 in breast cancer. (PMID:35098437)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.