ITGA9-AS1

Summary

ITGA9-AS1 (ITGA9 antisense RNA 1, HGNC:49668) is a long non-coding RNA gene on chromosome 3p22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49668
Approved symbol	ITGA9-AS1
Name	ITGA9 antisense RNA 1
Location	3p22.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235257
Ensembl biotype	lncRNA
Entrez	101928153
RNAcentral	URS000075C4ED — lncRNA, 620 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 46 — 45 lncRNA, 1 retained_intron

ENST00000366441, ENST00000420870, ENST00000429532, ENST00000430620, ENST00000438136, ENST00000439246, ENST00000445429, ENST00000449586, ENST00000450990, ENST00000457661, ENST00000594579, ENST00000608505, ENST00000614028, ENST00000626336, ENST00000629314, ENST00000630010, ENST00000630589, ENST00000630762, ENST00000630986, ENST00000653023, ENST00000653285, ENST00000653850, ENST00000655095, ENST00000657484, ENST00000659504, ENST00000660349, ENST00000660689, ENST00000660790, ENST00000660845, ENST00000661580, ENST00000663533, ENST00000663634, ENST00000664002, ENST00000666414, ENST00000667507, ENST00000670835, ENST00000684787, ENST00000685375, ENST00000686387, ENST00000702573, ENST00000720827, ENST00000720828, ENST00000720829, ENST00000720830, ENST00000720831, ENST00000720832

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000366441 — 4 exons

Exon	Start	End
ENSE00001754113	37821014	37821100
ENSE00001756646	37834679	37834767
ENSE00004039991	37861701	37861788
ENSE00004039994	37818256	37818930

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 92.88.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.3259 / max 39.8420, expressed in 1109 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
41693	2.3259	1109

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	92.88	gold quality
calcaneal tendon	UBERON:0003701	87.62	gold quality
adrenal tissue	UBERON:0018303	87.23	gold quality
anterior cingulate cortex	UBERON:0009835	86.27	gold quality
right frontal lobe	UBERON:0002810	84.41	gold quality
amygdala	UBERON:0001876	84.04	gold quality
nucleus accumbens	UBERON:0001882	83.59	gold quality
monocyte	CL:0000576	83.37	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.28	gold quality
right coronary artery	UBERON:0001625	83.24	gold quality
tibial nerve	UBERON:0001323	83.16	gold quality
prefrontal cortex	UBERON:0000451	82.59	gold quality
tibial artery	UBERON:0007610	82.45	gold quality
popliteal artery	UBERON:0002250	82.44	gold quality
leukocyte	CL:0000738	82.39	gold quality
left ovary	UBERON:0002119	82.20	gold quality
caudate nucleus	UBERON:0001873	82.09	gold quality
putamen	UBERON:0001874	82.06	gold quality
endocervix	UBERON:0000458	81.89	gold quality
aorta	UBERON:0000947	81.65	gold quality
bone marrow cell	CL:0002092	81.42	gold quality
right ovary	UBERON:0002118	81.29	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.17	gold quality
ascending aorta	UBERON:0001496	81.04	gold quality
left coronary artery	UBERON:0001626	80.87	gold quality
thoracic aorta	UBERON:0001515	80.85	gold quality
cortical plate	UBERON:0005343	80.84	gold quality
hypothalamus	UBERON:0001898	80.81	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	80.80	gold quality
ectocervix	UBERON:0012249	80.71	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	26.36
E-ANND-3	no	4.93

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting HNRNPU to affect the proliferation and apoptosis of non-small cell lung cancer cells. (PMID:38279497)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.