ITGAX

Summary

ITGAX (integrin subunit alpha X, HGNC:6152) is a protein-coding gene on chromosome 16p11.2, encoding Integrin alpha-X (P20702). Integrin alpha-X/beta-2 is a receptor for fibrinogen.

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 3687 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 222 total
• MANE Select transcript: NM_000887

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6152
Approved symbol	ITGAX
Name	integrin subunit alpha X
Location	16p11.2
Locus type	gene with protein product
Status	Approved
Aliases	CD11c
Ensembl gene	ENSG00000140678
Ensembl biotype	protein_coding
OMIM	151510
Entrez	3687

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 4 retained_intron

ENST00000268296, ENST00000562138, ENST00000562522, ENST00000562918, ENST00000564308, ENST00000567409, ENST00000571644, ENST00000958326, ENST00000958327

RefSeq mRNA: 2 — MANE Select: NM_000887 NM_000887, NM_001286375

CCDS: CCDS10711, CCDS67014

Canonical transcript exons

ENST00000268296 — 30 exons

Exon	Start	End
ENSE00000944391	31373249	31373390
ENSE00001389530	31381803	31382999
ENSE00001681517	31359700	31359830
ENSE00001738489	31357253	31357364
ENSE00001772645	31361063	31361213
ENSE00001787655	31359920	31360065
ENSE00001794926	31360310	31360463
ENSE00003458695	31355176	31355291
ENSE00003478039	31377182	31377265
ENSE00003490342	31379757	31379864
ENSE00003520292	31355893	31355998
ENSE00003533837	31371084	31371214
ENSE00003544630	31371630	31371784
ENSE00003551271	31362075	31362204
ENSE00003552879	31376799	31376915
ENSE00003560864	31377000	31377079
ENSE00003576899	31380523	31380624
ENSE00003582283	31356625	31356728
ENSE00003587662	31379568	31379646
ENSE00003610587	31379982	31380065
ENSE00003631983	31362935	31363075
ENSE00003641567	31380266	31380379
ENSE00003642303	31363165	31363374
ENSE00003642343	31372378	31372509
ENSE00003667826	31362611	31362753
ENSE00003670441	31361836	31361909
ENSE00003671968	31372597	31372670
ENSE00003678007	31371334	31371497
ENSE00003679227	31380897	31381007
ENSE00003728338	31357031	31357101

Expression profiles

Bgee: expression breadth ubiquitous, 174 present calls, max score 99.12.

FANTOM5 (CAGE): breadth broad, TPM avg 61.6862 / max 4104.2043, expressed in 677 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
153809	55.2300	674
153810	6.4562	274

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	99.12	gold quality
monocyte	CL:0000576	97.43	gold quality
mononuclear cell	CL:0000842	97.02	gold quality
leukocyte	CL:0000738	96.98	gold quality
blood	UBERON:0000178	96.15	gold quality
upper lobe of left lung	UBERON:0008952	95.33	gold quality
spleen	UBERON:0002106	95.22	gold quality
right lung	UBERON:0002167	94.74	gold quality
upper lobe of lung	UBERON:0008948	93.56	gold quality
vermiform appendix	UBERON:0001154	92.45	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.08	gold quality
spinal cord	UBERON:0002240	88.62	gold quality
gall bladder	UBERON:0002110	88.23	gold quality
bone marrow cell	CL:0002092	87.56	gold quality
lymph node	UBERON:0000029	86.62	gold quality
caecum	UBERON:0001153	86.29	gold quality
lung	UBERON:0002048	82.85	gold quality
omental fat pad	UBERON:0010414	82.54	gold quality
left uterine tube	UBERON:0001303	82.50	gold quality
peritoneum	UBERON:0002358	82.47	gold quality
right coronary artery	UBERON:0001625	81.95	gold quality
adipose tissue of abdominal region	UBERON:0007808	81.68	gold quality
bone marrow	UBERON:0002371	81.45	gold quality
right lobe of liver	UBERON:0001114	79.03	gold quality
colonic epithelium	UBERON:0000397	78.75	gold quality
substantia nigra	UBERON:0002038	78.37	gold quality
ascending aorta	UBERON:0001496	78.30	gold quality
subcutaneous adipose tissue	UBERON:0002190	78.20	gold quality
descending thoracic aorta	UBERON:0002345	78.15	gold quality
minor salivary gland	UBERON:0001830	78.14	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-MTAB-8498	yes	516.35
E-GEOD-106540	yes	346.35
E-GEOD-84465	yes	43.55
E-MTAB-6678	yes	29.86
E-MTAB-9221	yes	25.73
E-MTAB-9067	yes	12.74
E-MTAB-9801	yes	7.84
E-ANND-3	no	0.00

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

7 targets.

Target	Regulation
AKT1	Activation
CXCR4	Activation
IGF1	Activation
KDR	Activation
MYC	Activation
PIK3R1	Activation
VEGFA	Activation

Upstream regulators (CollecTRI, top): AP1, CCL2, CEBPA, CEBPB, CEBPG, CSF1, FOS, FOSL2, GATA1, GLI3, HAND1, HAND2, IFNG, IL34, IRF4, JUN, JUND, LHX2, MYB, NFKB1, NFKB, PAX3, POU2F1, POU2F2, RELA, RUNX1, SP1, SP3, SPI1, SSRP1, TFAP2A, WT1

miRNA regulators (miRDB)

41 targeting ITGAX, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-1296-3P	99.72	64.04	636
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-2113	99.58	71.22	1521
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-544B	99.18	67.41	1632
HSA-MIR-892C-5P	99.16	70.56	2116
HSA-MIR-491-5P	99.13	65.98	1468
HSA-MIR-4434	99.10	67.01	1984
HSA-MIR-5703	99.10	67.09	2053
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-3117-5P	99.04	67.93	618
HSA-MIR-4650-3P	99.01	68.39	1062
HSA-MIR-6877-3P	98.98	65.83	560
HSA-MIR-6819-3P	98.95	65.57	572
HSA-MIR-4742-3P	98.73	69.82	1803
HSA-MIR-6804-5P	98.39	65.77	1084
HSA-MIR-653-3P	98.31	67.71	1542
HSA-MIR-6831-5P	98.26	67.20	990
HSA-MIR-6867-3P	98.12	66.07	1305
HSA-MIR-340-3P	98.11	68.25	679

Literature-anchored findings (GeneRIF, showing 40)

• Activation of the CD11c gene promoter is mediated by Puralpha during phorbol myristate acetate-induced differentiation of monocytic U937 cells. (PMID:11937543)
• The presence of CR1 (CD35) and CR4 (CD1c/CD18) on HUVEC indicates that endothelial cells (EC) have the potential to bind C3b and iC3b, respectively, which both mediate biological effects in the course of complement activation. (PMID:12083416)
• serum amyloid P component does not circulate in complex with C4-binding protein (CD11c antigen), fibronectin or any other major protein ligand (PMID:12100475)
• myeloid dendritic cells containing this antigen are able to stimulate T lymphocytes (PMID:12351396)
• abnormal expression of the CD11c gene characteristic of hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD (PMID:12576324)
• adhesion of human neutrophil granulocytes to fibrinogen is greatly increased by plasmin digestion in a mode where alphaXbeta2 dominates the integrin-dependent binding (PMID:15665082)
• The maturation of dendritic cells induced by CD11c- T cells through TNF-alpha production appears to result in the efficient expansion and activation of killer cells. (PMID:15900581)
• In DVT subjects, at baseline, the phenotypical expression of CD11b was decreased and that of CD11c was increased, and upon PMN activation in DVT subjects CD11b, CD11c and CD18 increased, while CD11a expression did not show any change (PMID:16037628)
• expression of the CD11c gene is regulated by PLD1 and is enhanced by Se-MSC during PMA-induced U937 differentiation. (PMID:16716806)
• Negative stain electron microscopy was used to examine the conformational changes in the ectodomains required for activation of the leukocyte integrins alpha(X)beta(2) and alpha(L)beta(2). (PMID:17045822)
• The results from this study present TANGO as a novel ligand for CD11c, regulating migratory processes of hematopoietic cells. (PMID:17726152)
• These data indicate that AP-2 and Ets-1 regulated expression of integrin alpha10 plays a role in migration of malignant melanoma cells. (PMID:17726260)
• Expression of alpha10 increases during aggregate culture of mesenchymal stem cells in a chondrogenic medium. (PMID:18047418)
• CD11c transgene identifies a discrete network of dendritic cells in mouse embryonic central nervous system and in postnatal brain cells. (PMID:18386786)
• The differential involvement of CD11c and CD11b in adhesion and subsequent cytoskeletal changes in monocytes exposed to different conditions. (PMID:18541300)
• The CD11c antibody was both sensitive and specific for hairy cell leukemia, even in cases with minimal infiltration. (PMID:18580071)
• CD11c levels decreased in response to anti-TB treatment. CD11c/Arg47Trp polymorphism is not associated with pulmonary tuberculosis. (PMID:19237023)
• Data show high expression of CD86 and CD11C, moderate expression of CD1a and CD123, low levels of CD83 on dendritic cells after induction by GM-CSF and IL-4. (PMID:19257981)
• The combination of high environmental stress and low CNS serotonin lead to increased expression of the beta(2)-integrins CD11b and CD11c on monocyte cell surfaces. (PMID:19800635)
• Diet-induced obesity increased CD11c in both adipose tissue and blood. (PMID:19910635)
• There was increased expression of CD11c in monocytes of responders to adalimumab monotherapy. (PMID:20032971)
• Structure of an integrin with an alphaI domain, complement receptor type 4. (PMID:20033057)
• Depletion of CD11c-positive dendritic cells (DCs) increases the susceptibility of CD11c-diphtheria toxin receptor transgenic mice to infection with cell-free virus in both CD4 cell and non-CD4 fractions. (PMID:20382884)
• CD141+ dendritic cells are the only cells in human blood that express the chemokine receptor XCR1 and respond to the specific ligand XCL1 by Ca2+ mobilization and potent chemotaxis. (PMID:20479115)
• Case Report: Possible acceleration of regression by antibiotic treatment in benign cephalic histiocytosis with infiltration of CD11a/CD11c+ macrophages. (PMID:20574620)
• CD11c-positive dendritic cells play an important role in CD8 T cell responses following replication-defective adenovirus serotype 5 immunization, but striking redundancy for innate cytokines and signaling is revealed. (PMID:20610651)
• CD11c expression is rare in MCL and may aid in differentiation of CD5+ B-cell neoplasms (PMID:20660331)
• Data revealed that alpha(X)beta(2) in the extended-open headpiece conformation had high affinity for ligand, whereas both the bent conformation and the extended-closed headpiece conformation represented the low affinity state. (PMID:20679211)
• Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood. (PMID:20888334)
• During hypertriglyceridemia, monocytes internalize lipids, upregulate CD11c/CD18, and increase adhesion to VCAM-1. (PMID:21030716)
• CD56(bright)CD11c(positive) cells play a key role in the interleukin (IL)-18-mediated proliferation of gammadelta T cells. (PMID:21239711)
• CD11c(HI)-expressing first-trimester decidual macrophages are associated with lipid metabolism and inflammation; CD11c(LO)-expressing macrophages are involved in extracellular matrix formation, muscle regulation and tissue growth. (PMID:21257965)
• Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells (PMID:21273385)
• Two large cohorts of systemic sclerosis (SSc) patients of European Caucasian ancestry do not support the implication of ITGAM, ITGAX, and CD58 genes in the genetic susceptibility of SSc, although they were identified as autoimmune disease risk genes. (PMID:21362770)
• CD11c-positive dendritic cells of transgenic mice express natural killer (NK) cell marker NK1.1 in the thyroid, indicating their NK cell origin. (PMID:21666055)
• The data obtained suggest that spontaneous cell adhesion to fibrinogen is mediated to a greater extent by CD11b/CD18 integrins, while chemokine-stimulated adhesion and migration is mostly dependent on CD11c/CD18 molecules. (PMID:21874872)
• CD11c+HLADR+ dendritic cells are present in human ovarian follicular fluid, and their maturity correlates with serum estradiol levels in response to gonadotropins. (PMID:22244783)
• analysis of complement recognition by integrin alphaXbeta2 (PMID:22393018)
• Mice lacking protein tyrosine phosphatase Shp1 specifically in dendritic cells (DCs) develop splenomegaly associated with more CD11c+ DCs. (PMID:22539788)
• Upon expression on surface of human embryonic kidney (HEK)293 cells, alphaXbeta2 supports adhesive, migratory and phagocytic activities of human cells toward Candida albicans. (PMID:22844116)

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
danio_rerio	itgam.1	ENSDARG00000002956
danio_rerio	itgam.2	ENSDARG00000096587
mus_musculus	Itgax	ENSMUSG00000030789
rattus_norvegicus	Itgax	ENSRNOG00000036703
drosophila_melanogaster	if	FBGN0001250
drosophila_melanogaster	ItgaPS4	FBGN0034005
drosophila_melanogaster	ItgaPS5	FBGN0034880
drosophila_melanogaster	scb	FBGN0286785
caenorhabditis_elegans		WBGENE00003929

Paralogs (17): ITGAL (ENSG00000005844), ITGA3 (ENSG00000005884), ITGA2B (ENSG00000005961), ITGA8 (ENSG00000077943), ITGAE (ENSG00000083457), ITGA6 (ENSG00000091409), ITGA4 (ENSG00000115232), ITGA7 (ENSG00000135424), ITGA11 (ENSG00000137809), ITGAV (ENSG00000138448), ITGA10 (ENSG00000143127), ITGA9 (ENSG00000144668), ITGAD (ENSG00000156886), ITGA5 (ENSG00000161638), ITGA2 (ENSG00000164171), ITGAM (ENSG00000169896), ITGA1 (ENSG00000213949)

Protein

Protein identifiers

Integrin alpha-X — P20702 (reviewed: P20702)

Alternative names: CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95

All UniProt accessions (3): A0A087X131, P20702, H3BN02

UniProt curated annotations — full annotation on UniProt →

Function. Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis.

Subunit / interactions. Heterodimer of an alpha and a beta subunit. Alpha-X associates with beta-2.

Subcellular location. Cell membrane.

Tissue specificity. Predominantly expressed in monocytes and granulocytes.

Domain organisation. The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Similarity. Belongs to the integrin alpha chain family.

RefSeq proteins (2): NP_000878, NP_001273304 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000413	Integrin_alpha	Family
IPR002035	VWF_A	Domain
IPR013517	FG-GAP	Repeat
IPR013519	Int_alpha_beta-p	Repeat
IPR013649	Integrin_alpha_Ig-like_1	Domain
IPR018184	Integrin_alpha_C_CS	Conserved_site
IPR028994	Integrin_alpha_N	Homologous_superfamily
IPR032695	Integrin_dom_sf	Homologous_superfamily
IPR036465	vWFA_dom_sf	Homologous_superfamily
IPR048285	Integrin_alpha_Ig-like_2	Domain
IPR048633	ITGAX-like_Ig_3	Domain

Pfam: PF00092, PF00357, PF01839, PF08441, PF20805, PF21520

UniProt features (189 total): strand 81, helix 21, turn 18, binding site 15, sequence conflict 14, disulfide bond 10, glycosylation site 8, sequence variant 8, repeat 7, topological domain 2, signal peptide 1, chain 1, short sequence motif 1, transmembrane region 1, domain 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
1N3Y	X-RAY DIFFRACTION	1.65
4NEH	X-RAY DIFFRACTION	2.75
4NEN	X-RAY DIFFRACTION	2.9
5ES4	X-RAY DIFFRACTION	3.3
3K6S	X-RAY DIFFRACTION	3.5
3K72	X-RAY DIFFRACTION	3.7
3K71	X-RAY DIFFRACTION	3.95
2LUV	SOLUTION NMR
9ECM	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P20702-F1	88.02	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (15): 157; 159; 161; 259; 466; 468; 470; 474; 530; 532; 534; 538 …

Disulfide bonds (10): 69–76, 108–126, 116–145, 495–506, 639–722, 655–712, 771–777, 848–863, 998–1022, 1027–1032

Glycosylation sites (8): 61, 89, 392, 697, 735, 899, 939, 1050

Function

Pathways and Gene Ontology

Reactome pathways

11 pathways

ID	Pathway
R-HSA-202733	Cell surface interactions at the vascular wall
R-HSA-216083	Integrin cell surface interactions
R-HSA-3000178	ECM proteoglycans
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling
R-HSA-6798695	Neutrophil degranulation
R-HSA-109582	Hemostasis
R-HSA-1280215	Cytokine Signaling in Immune system
R-HSA-1474244	Extracellular matrix organization
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-449147	Signaling by Interleukins

MSigDB gene sets: 356 (showing top): GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, AP1_01, GOBP_EPITHELIUM_DEVELOPMENT, MULLIGHAN_NPM1_SIGNATURE_3_UP, REACTOME_INNATE_IMMUNE_SYSTEM, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, RORA1_01, GOCC_SECRETORY_GRANULE, STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN, MODULE_64, GOBP_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT, GOCC_CELL_SURFACE, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_REGULATION_OF_MYELINATION, GOBP_REGULATION_OF_NERVOUS_SYSTEM_DEVELOPMENT

GO Biological Process (14): cell adhesion (GO:0007155), cell-matrix adhesion (GO:0007160), integrin-mediated signaling pathway (GO:0007229), positive regulation of cell population proliferation (GO:0008284), animal organ morphogenesis (GO:0009887), positive regulation of gene expression (GO:0010628), positive regulation of cell migration (GO:0030335), positive regulation of myelination (GO:0031643), heterotypic cell-cell adhesion (GO:0034113), positive regulation of angiogenesis (GO:0045766), defense response to virus (GO:0051607), cell-cell adhesion (GO:0098609), positive regulation of endothelial tube morphogenesis (GO:1905956), positive regulation of metabolic process (GO:0009893)

GO Molecular Function (5): integrin binding (GO:0005178), receptor tyrosine kinase binding (GO:0030971), signaling receptor activity (GO:0038023), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (9): plasma membrane (GO:0005886), integrin complex (GO:0008305), external side of plasma membrane (GO:0009897), cell surface (GO:0009986), membrane (GO:0016020), secretory granule membrane (GO:0030667), integrin alphaX-beta2 complex (GO:0034689), tertiary granule membrane (GO:0070821), ficolin-1-rich granule membrane (GO:0101003)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Extracellular matrix organization	2
Immune System	2
Hemostasis	1
Signaling by Interleukins	1
Innate Immune System	1
Cytokine Signaling in Immune system	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
positive regulation of cellular process	3
signaling receptor binding	2
cellular anatomical structure	2
secretory granule membrane	2
tertiary granule	2
cellular process	1
cell-substrate adhesion	1
cell surface receptor signaling pathway	1
cell population proliferation	1
regulation of cell population proliferation	1
anatomical structure morphogenesis	1
animal organ development	1
gene expression	1
regulation of gene expression	1
positive regulation of macromolecule biosynthetic process	1
cell migration	1
regulation of cell migration	1
positive regulation of cell motility	1
regulation of myelination	1
positive regulation of nervous system process	1
myelination	1
cell-cell adhesion	1
angiogenesis	1
regulation of angiogenesis	1
positive regulation of vasculature development	1
defense response	1
response to virus	1
cell adhesion	1
positive regulation of multicellular organismal process	1
endothelial tube morphogenesis	1
regulation of endothelial tube morphogenesis	1
positive regulation of morphogenesis of an epithelium	1
metabolic process	1
regulation of metabolic process	1
protein-containing complex binding	1
cell adhesion molecule binding	1
protein tyrosine kinase binding	1
molecular transducer activity	1
cation binding	1
binding	1

Protein interactions and networks

STRING

3320 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ITGAX	ITGB2	P05107	998
ITGAX	ICAM1	P05362	980
ITGAX	CD4	P01730	941
ITGAX	CD8A	P01732	932
ITGAX	IFNG	P01579	926
ITGAX	PTPRC	P08575	911
ITGAX	CD19	P15391	903
ITGAX	VCAM1	P19320	894
ITGAX	CD86	P42081	890
ITGAX	CD80	P33681	883
ITGAX	FCGR3A	P08637	881
ITGAX	FCGR3B	O75015	881
ITGAX	CD1C	P29017	879
ITGAX	FOXP3	Q9BZS1	874
ITGAX	CD40	P25942	872

IntAct

5 interactions, top by confidence:

A	B	Type	Score
ITGAX	ITGB2	psi-mi:“MI:0407”(direct interaction)	0.660
ITGAX	pepT	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): ITGAX (Affinity Capture-MS), ITGAX (Reconstituted Complex), ITGAX (Proximity Label-MS), ITGAX (Reconstituted Complex), NDUFB10 (Cross-Linking-MS (XL-MS)), ITGAX (Cross-Linking-MS (XL-MS)), PGM2 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A2ARA8, B0S5N4, B8JK39, F1MMS9, O75578, O94985, P05555, P08514, P08648, P11215, P11688, P13612, P17301, P17852, P18614, P20701, P20702, P24063, P26006, P26009, P38570, P43406, P53708, P53710, P53711, P61622, P61625, P70206, P70275, P80747, Q00651, Q06274, Q13219, Q13349, Q13683, Q13797, Q3V0T4, Q3V3R4, Q5STE3, Q60677

Diamond homologs: A2AX52, A6H584, A6NMZ7, A6QLN9, A8TX70, E7FF10, O00339, O08746, O42401, O75578, O89029, P05099, P05555, P11215, P12111, P15989, P20701, P20702, P34576, P51942, P61625, Q02388, Q13349, Q21281, Q21540, Q28902, Q3V0T4, Q63870, Q642A6, Q6PCB0, Q6UXI7, Q8C6K9, Q8NFW1, Q8R2Z5, Q90615, Q91145, Q923P0, Q95LI2, Q96P44, Q9P218

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
FGA	up-regulates	ITGAX	binding
ICAM1	up-regulates	ITGAX	binding
ITGAX	“form complex”	“AX/b2 integrin”	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

222 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	156
Likely benign	22
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

4932 predictions. Top by Δscore:

Variant	Effect	Δscore
16:31355289:CAGG:C	donor_loss	1.0000
16:31355292:G:T	donor_loss	1.0000
16:31355984:G:GG	donor_gain	1.0000
16:31356620:C:CA	acceptor_gain	1.0000
16:31356620:CGCAG:C	acceptor_loss	1.0000
16:31356621:GCAGG:G	acceptor_loss	1.0000
16:31356622:CA:C	acceptor_loss	1.0000
16:31356623:A:AG	acceptor_gain	1.0000
16:31356623:A:T	acceptor_loss	1.0000
16:31356623:AG:A	acceptor_gain	1.0000
16:31356623:AGG:A	acceptor_gain	1.0000
16:31356623:AGGGT:A	acceptor_gain	1.0000
16:31356624:G:A	acceptor_gain	1.0000
16:31356624:G:GA	acceptor_gain	1.0000
16:31356624:GGG:G	acceptor_gain	1.0000
16:31356624:GGGT:G	acceptor_gain	1.0000
16:31356624:GGGTG:G	acceptor_gain	1.0000
16:31356724:GCAGG:G	donor_gain	1.0000
16:31356727:GG:G	donor_gain	1.0000
16:31356727:GGGT:G	donor_loss	1.0000
16:31356728:GG:G	donor_gain	1.0000
16:31356728:GGTG:G	donor_loss	1.0000
16:31356729:G:GC	donor_loss	1.0000
16:31356729:G:GG	donor_gain	1.0000
16:31356730:T:A	donor_loss	1.0000
16:31357029:A:AG	acceptor_gain	1.0000
16:31357029:AGT:A	acceptor_gain	1.0000
16:31357030:G:GC	acceptor_gain	1.0000
16:31357030:GT:G	acceptor_gain	1.0000
16:31357030:GTG:G	acceptor_gain	1.0000

AlphaMissense

7631 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:31359935:T:C	F193L	0.993
16:31359937:C:A	F193L	0.993
16:31359937:C:G	F193L	0.993
16:31371699:T:G	F692C	0.988
16:31380550:A:C	S1068R	0.988
16:31380552:T:A	S1068R	0.988
16:31380552:T:G	S1068R	0.988
16:31372604:T:G	F767C	0.986
16:31363225:T:C	F521L	0.985
16:31363227:T:A	F521L	0.985
16:31363227:T:G	F521L	0.985
16:31355964:T:C	F37L	0.983
16:31355966:T:A	F37L	0.983
16:31355966:T:G	F37L	0.983
16:31380954:A:C	S1112R	0.982
16:31380956:C:A	S1112R	0.982
16:31380956:C:G	S1112R	0.982
16:31359786:T:C	F173L	0.981
16:31359788:C:A	F173L	0.981
16:31359788:C:G	F173L	0.981
16:31361156:T:C	F319L	0.981
16:31361158:T:A	F319L	0.981
16:31361158:T:G	F319L	0.981
16:31359740:T:A	D157E	0.979
16:31359740:T:G	D157E	0.979
16:31356686:T:A	C69S	0.978
16:31356687:G:C	C69S	0.978
16:31357312:C:G	C126W	0.978
16:31360363:T:C	L254P	0.978
16:31359768:T:C	F167L	0.977

dbSNP variants (sampled 300 via entrez): RS1000145527 (16:31376223 A>G), RS1000200595 (16:31373783 G>A), RS1000211681 (16:31368603 A>G,T), RS1000391622 (16:31370154 C>T), RS1000404770 (16:31379529 A>G), RS1000635249 (16:31371454 C>A,T), RS1000724957 (16:31371270 G>A,C), RS1000762295 (16:31375779 C>G), RS1000827863 (16:31374355 C>T), RS1000979372 (16:31365013 C>G), RS1001159391 (16:31363452 C>G,T), RS1001196016 (16:31376260 T>C), RS1001362567 (16:31381270 G>A,T), RS1001507316 (16:31363642 G>A,T), RS1001560645 (16:31360252 C>A)

Disease associations

OMIM: gene MIM:151510 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST000144_6	Systemic lupus erythematosus	3.000000e-11
GCST002655_1	IgA nephropathy	1.000000e-08
GCST002655_10	IgA nephropathy	8.000000e-13
GCST002655_9	IgA nephropathy	1.000000e-11
GCST003262_328	Post bronchodilator FEV1	1.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004314	forced expiratory volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: catalytic receptor — Integrins

CTD chemical–gene interactions

60 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tretinoin	decreases reaction, increases expression	6
Benzo(a)pyrene	affects methylation, increases expression, increases methylation	3
sodium arsenite	increases expression	2
tesmilifene	decreases expression	2
Arsenic Trioxide	decreases expression, increases expression, decreases reaction	2
Cisplatin	affects expression, affects cotreatment, increases expression	2
Zinc	affects cotreatment, affects expression, increases expression	2
GSK-J4	increases expression	1
sotorasib	affects cotreatment, decreases expression	1
lasiocarpine	increases expression	1
methyleugenol	increases expression	1
triphenyl phosphate	affects expression	1
propionaldehyde	increases expression	1
bisphenol A	decreases expression, decreases reaction	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium bichromate	decreases expression	1
sulforaphane	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	increases expression	1
aflatoxin B2	increases methylation	1
endotoxin, Escherichia coli	decreases expression, decreases reaction	1
pentanal	increases expression	1
bryostatin 1	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
bisphenol S	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
gardiquimod	decreases expression, decreases reaction	1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B8IV	Abcam HCT 116 ITGAX KO	Cancer cell line	Male
CVCL_B8XQ	Abcam MCF-7 ITGAX KO	Cancer cell line	Female
CVCL_B9L5	Abcam A-549 ITGAX KO	Cancer cell line	Male
CVCL_E4AJ	K-562 P/5	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.