ITGB2-AS1

Summary

ITGB2-AS1 (ITGB2 antisense RNA 1, HGNC:44304) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44304
Approved symbol	ITGB2-AS1
Name	ITGB2 antisense RNA 1
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000227039
Ensembl biotype	lncRNA
Entrez	100505746
RNAcentral	URS000075A18C — lncRNA, 2425 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000429132, ENST00000441379, ENST00000608043, ENST00000609592, ENST00000609694, ENST00000610063, ENST00000688945, ENST00000692198, ENST00000798960, ENST00000798961, ENST00000832784

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000429132 — 3 exons

Exon	Start	End
ENSE00001598901	44927854	44928028
ENSE00001617442	44926868	44927004
ENSE00001640376	44921326	44921351

Expression profiles

Bgee: expression breadth ubiquitous, 206 present calls, max score 98.07.

FANTOM5 (CAGE): breadth broad, TPM avg 5.2287 / max 193.3725, expressed in 618 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189509	1.6670	405
189506	1.1053	224
189511	0.9820	168
189512	0.9373	227
189510	0.3976	198
189508	0.0802	23
189507	0.0592	28

Top tissues by expression

233 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	98.07	gold quality
blood	UBERON:0000178	95.15	gold quality
thymus	UBERON:0002370	94.65	gold quality
monocyte	CL:0000576	92.94	gold quality
leukocyte	CL:0000738	92.47	gold quality
spleen	UBERON:0002106	92.29	gold quality
lymph node	UBERON:0000029	92.04	gold quality
trabecular bone tissue	UBERON:0002483	90.07	gold quality
bone marrow	UBERON:0002371	89.12	gold quality
epithelium of nasopharynx	UBERON:0001951	89.02	gold quality
vermiform appendix	UBERON:0001154	88.56	gold quality
pancreatic ductal cell	CL:0002079	87.35	silver quality
ileal mucosa	UBERON:0000331	86.41	gold quality
epithelial cell of pancreas	CL:0000083	85.83	silver quality
tonsil	UBERON:0002372	84.59	gold quality
caecum	UBERON:0001153	84.45	gold quality
bone marrow cell	CL:0002092	83.41	gold quality
superficial temporal artery	UBERON:0001614	83.31	gold quality
nasal cavity epithelium	UBERON:0005384	81.52	silver quality
palpebral conjunctiva	UBERON:0001812	79.73	gold quality
tibia	UBERON:0000979	79.33	gold quality
buccal mucosa cell	CL:0002336	77.61	gold quality
mucosa of transverse colon	UBERON:0004991	77.20	gold quality
upper arm skin	UBERON:0004263	77.09	gold quality
kidney epithelium	UBERON:0004819	76.58	gold quality
gall bladder	UBERON:0002110	76.27	gold quality
parietal pleura	UBERON:0002400	75.56	gold quality
upper lobe of left lung	UBERON:0008952	75.30	gold quality
upper lobe of lung	UBERON:0008948	74.52	gold quality
superior surface of tongue	UBERON:0007371	74.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.14

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells by up-regulating ITGB2. (PMID:29941860)
• study suggested that ITGB2-AS1 played critical roles in the development and progression of osteosarcoma via Wnt/beta-catenin signalling, indicating that ITGB2-AS1 might be a valuable diagnostic biomarker and potential anticancer therapeutic target for osteosarcoma. (PMID:30260245)
• Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancer. (PMID:32165090)
• LncRNA ITGB2-AS1 promotes the progression of clear cell renal cell carcinoma by modulating miR-328-5p/HMGA1 axis. (PMID:34170494)
• [Overexpression of LncRNA ITGB2-AS1 Predicts Adverse Prognosis in Acute Myeloid Leukemia]. (PMID:34627422)
• The expression and significance of long non-coding RNA ITGB2-AS1 in renal clear cell carcinoma. (PMID:36634939)
• LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis. (PMID:37370246)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.