ITGB8-AS1

Summary

ITGB8-AS1 (ITGB8 antisense RNA 1, HGNC:55257) is a long non-coding RNA gene on chromosome 7p21.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55257
Approved symbol	ITGB8-AS1
Name	ITGB8 antisense RNA 1
Location	7p21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000271133
Ensembl biotype	lncRNA
Entrez	101927811
RNAcentral	URS000075BC59 — lncRNA, 924 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 31 lncRNA

ENST00000603156, ENST00000605357, ENST00000688475, ENST00000789454, ENST00000789455, ENST00000789456, ENST00000789457, ENST00000789458, ENST00000789459, ENST00000789460, ENST00000789461, ENST00000789462, ENST00000789463, ENST00000789464, ENST00000789465, ENST00000789466, ENST00000789467, ENST00000789468, ENST00000789469, ENST00000789470, ENST00000789471, ENST00000789472, ENST00000789473, ENST00000789474, ENST00000789475, ENST00000789476, ENST00000789477, ENST00000789478, ENST00000789479, ENST00000789480, ENST00000789481

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000603156 — 4 exons

Exon	Start	End
ENSE00003565065	20329367	20329513
ENSE00003596748	20329690	20329782
ENSE00004168738	20328284	20328856
ENSE00004168747	20331650	20331803

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 94.97.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0231 / max 23.4332, expressed in 660 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82993	0.8923	578
82994	0.1308	50

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	94.97	gold quality
buccal mucosa cell	CL:0002336	88.59	gold quality
parotid gland	UBERON:0001831	86.79	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.91	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.27	gold quality
nasal cavity epithelium	UBERON:0005384	82.71	silver quality
saliva-secreting gland	UBERON:0001044	80.93	gold quality
minor salivary gland	UBERON:0001830	80.06	gold quality
pancreatic ductal cell	CL:0002079	79.57	silver quality
bronchial epithelial cell	CL:0002328	78.18	gold quality
right uterine tube	UBERON:0001302	78.16	gold quality
mouth mucosa	UBERON:0003729	78.15	gold quality
bronchus	UBERON:0002185	77.29	gold quality
sural nerve	UBERON:0015488	77.26	gold quality
corpus epididymis	UBERON:0004359	76.38	gold quality
nasal cavity mucosa	UBERON:0001826	75.42	gold quality
kidney epithelium	UBERON:0004819	74.93	gold quality
secondary oocyte	CL:0000655	74.48	gold quality
mucosa of transverse colon	UBERON:0004991	74.31	gold quality
metanephros cortex	UBERON:0010533	73.73	gold quality
rectum	UBERON:0001052	73.62	gold quality
upper arm skin	UBERON:0004263	73.62	gold quality
caput epididymis	UBERON:0004358	73.37	gold quality
left ovary	UBERON:0002119	73.25	gold quality
oral cavity	UBERON:0000167	72.84	silver quality
colonic epithelium	UBERON:0000397	72.76	gold quality
cauda epididymis	UBERON:0004360	72.23	silver quality
body of pancreas	UBERON:0001150	71.97	gold quality
ventricular zone	UBERON:0003053	71.74	gold quality
body of uterus	UBERON:0009853	71.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.09

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.