ITIH2

Summary

ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2, HGNC:6167) is a protein-coding gene on chromosome 10p14, encoding Inter-alpha-trypsin inhibitor heavy chain H2 (P19823). May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological p….

The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).

Source: NCBI Gene 3698 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 156 total
• Druggable target: yes
• MANE Select transcript: NM_002216

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6167
Approved symbol	ITIH2
Name	inter-alpha-trypsin inhibitor heavy chain 2
Location	10p14
Locus type	gene with protein product
Status	Approved
Aliases	H2P
Ensembl gene	ENSG00000151655
Ensembl biotype	protein_coding
OMIM	146640
Entrez	3698

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 21 protein_coding, 2 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000358415, ENST00000379587, ENST00000429820, ENST00000473227, ENST00000477751, ENST00000480387, ENST00000899752, ENST00000899753, ENST00000899754, ENST00000899755, ENST00000899756, ENST00000899757, ENST00000899758, ENST00000899759, ENST00000899760, ENST00000899761, ENST00000899762, ENST00000899763, ENST00000899764, ENST00000899765, ENST00000899766, ENST00000899767, ENST00000899768, ENST00000899769

RefSeq mRNA: 1 — MANE Select: NM_002216 NM_002216

CCDS: CCDS31141

Canonical transcript exons

ENST00000358415 — 21 exons

Exon	Start	End
ENSE00001000896	7720856	7720963
ENSE00001604757	7738621	7738758
ENSE00001612470	7744791	7744963
ENSE00001621529	7727703	7727828
ENSE00001637435	7746593	7746704
ENSE00001649888	7744082	7744280
ENSE00001666876	7743146	7743259
ENSE00001709507	7732338	7732477
ENSE00001719911	7726950	7727118
ENSE00001752012	7749187	7749520
ENSE00001753218	7729952	7730133
ENSE00001773649	7723451	7723567
ENSE00001778763	7734922	7735091
ENSE00001811236	7703316	7703518
ENSE00002160656	7721649	7721777
ENSE00003548900	7731811	7731996
ENSE00003565647	7707201	7707233
ENSE00003640166	7713181	7713285
ENSE00003646292	7709022	7709191
ENSE00003655024	7717626	7717788
ENSE00003673472	7705108	7705182

Expression profiles

Bgee: expression breadth ubiquitous, 166 present calls, max score 99.35.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 7.5258 / max 2078.6055, expressed in 142 samples.

FANTOM5 promoters (9 alternative TSS)

Promoter ID	TPM avg	Samples expressed
103752	4.0351	81
103753	3.0547	111
103754	0.2158	21
103751	0.0707	12
103749	0.0563	10
103750	0.0507	13
103757	0.0292	10
103748	0.0068	5
103756	0.0065	5

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	99.35	gold quality
right lobe of liver	UBERON:0001114	98.92	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.54	gold quality
olfactory bulb	UBERON:0002264	79.66	gold quality
choroid plexus epithelium	UBERON:0003911	79.03	gold quality
type B pancreatic cell	CL:0000169	76.76	gold quality
adrenal tissue	UBERON:0018303	74.28	gold quality
diaphragm	UBERON:0001103	70.27	gold quality
tibialis anterior	UBERON:0001385	69.82	silver quality
cerebellar hemisphere	UBERON:0002245	66.32	gold quality
putamen	UBERON:0001874	66.24	gold quality
cerebellar cortex	UBERON:0002129	66.20	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.54	gold quality
cerebellum	UBERON:0002037	64.10	gold quality
prefrontal cortex	UBERON:0000451	63.87	gold quality
pancreatic ductal cell	CL:0002079	63.74	silver quality
caudate nucleus	UBERON:0001873	63.20	gold quality
colonic epithelium	UBERON:0000397	62.97	silver quality
C1 segment of cervical spinal cord	UBERON:0006469	62.56	gold quality
hypothalamus	UBERON:0001898	62.52	gold quality
spinal cord	UBERON:0002240	61.99	gold quality
islet of Langerhans	UBERON:0000006	61.65	gold quality
substantia nigra	UBERON:0002038	61.63	gold quality
gastrocnemius	UBERON:0001388	60.89	gold quality
muscle of leg	UBERON:0001383	60.60	gold quality
midbrain	UBERON:0001891	60.24	gold quality
adenohypophysis	UBERON:0002196	60.00	gold quality
corpus callosum	UBERON:0002336	59.51	gold quality
nucleus accumbens	UBERON:0001882	59.39	gold quality
muscle organ	UBERON:0001630	59.23	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-130473	yes	2553.95
E-MTAB-7407	yes	1023.71
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

22 targeting ITIH2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-497-3P	99.61	69.71	1990
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-3171	99.49	69.06	776
HSA-MIR-6853-3P	99.36	70.79	1558
HSA-MIR-7151-3P	99.04	69.72	2370
HSA-MIR-29B-1-5P	98.86	68.35	1364
HSA-MIR-6715B-3P	98.80	68.07	1204
HSA-MIR-6776-3P	98.38	66.34	655
HSA-MIR-4438	97.96	63.70	947
HSA-MIR-3620-3P	97.78	64.88	772
HSA-MIR-6783-5P	97.67	67.21	1528
HSA-MIR-4671-5P	97.10	65.70	93

Literature-anchored findings (GeneRIF, showing 8)

• TSG-6 acts as cofactor and catalyst in the production of IalphaI heavy chain x hyaluronan complexes (PMID:15840581)
• Leukocytes infiltrated to the synovium were strongly positive for hyaluronic acid, SHAP, and CD44 on their surfaces, suggesting a role for the adhesion-enhancing effect of SHAP in inflammation. (PMID:16702221)
• Increased levels of SHAP-HA complex in sera are possible predictive markers for cervical ripening in premature labor. (PMID:18382897)
• serum-derived hyaluronan-associated protein-hyaluronan complex has a role in progression of ovarian cancer (PMID:18425383)
• It forms complex with hyaluronan and the comlex is a functional molecule involved in inflammation. (PMID:20297716)
• Human inter-alpha-inhibitor is a substrate for factor XIIIa and tissue transglutaminase. (PMID:21939789)
• Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains. (PMID:26728454)
• Both IalphaI and the HC-hyaluronan complex are substrates for the extracellular matrix proteases ADAMTS-5 and matrix metalloprotease (MMP) -3, -7, and -13. (PMID:31484722)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	itih2	ENSDARG00000045516
mus_musculus	Itih2	ENSMUSG00000037254
rattus_norvegicus	Itih2	ENSRNOG00000001066

Paralogs (11): ITIH4 (ENSG00000055955), ITIH1 (ENSG00000055957), ITIH6 (ENSG00000102313), PARP4 (ENSG00000102699), VWA5A (ENSG00000110002), ITIH5 (ENSG00000123243), VWA5B2 (ENSG00000145198), VWA5B1 (ENSG00000158816), ITIH3 (ENSG00000162267), VWA3B (ENSG00000168658), VWA3A (ENSG00000175267)

Protein

Protein identifiers

Inter-alpha-trypsin inhibitor heavy chain H2 — P19823 (reviewed: P19823)

Alternative names: Inter-alpha-trypsin inhibitor complex component II, Serum-derived hyaluronan-associated protein

All UniProt accessions (3): P19823, Q5T985, Q5T987

UniProt curated annotations — full annotation on UniProt →

Function. May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

Subunit / interactions. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin.

Subcellular location. Secreted.

Tissue specificity. Plasma.

Post-translational modifications. Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Phosphorylated by FAM20C in the extracellular medium.

Similarity. Belongs to the ITIH family.

RefSeq proteins (1): NP_002207* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002035	VWF_A	Domain
IPR010600	ITI_HC_C	Domain
IPR013694	VIT	Domain
IPR036465	vWFA_dom_sf	Homologous_superfamily
IPR050934	ITIH	Family

Pfam: PF00092, PF06668, PF08487

UniProt features (28 total): modified residue 6, glycosylation site 6, sequence conflict 4, sequence variant 3, propeptide 2, disulfide bond 2, domain 2, signal peptide 1, chain 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P19823-F1	82.85	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (6): 466, 702, 886, 60, 282, 283

Disulfide bonds (2): 261–264, 650–651

Glycosylation sites (6): 118, 445, 666, 673, 675, 691

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-381426	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275	Post-translational protein phosphorylation
R-HSA-392499	Metabolism of proteins
R-HSA-597592	Post-translational protein modification

MSigDB gene sets: 96 (showing top): RIZKI_TUMOR_INVASIVENESS_3D_DN, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_HYALURONAN_METABOLIC_PROCESS, HSIAO_LIVER_SPECIFIC_GENES, GOBP_AMINOGLYCAN_METABOLIC_PROCESS, GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN, TSENG_IRS1_TARGETS_DN, GOMF_GLYCOSAMINOGLYCAN_BINDING, MODULE_88, AACTTT_UNKNOWN, MODULE_112, ZHONG_SECRETOME_OF_LUNG_CANCER_AND_MACROPHAGE, ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST, GOCC_BLOOD_MICROPARTICLE, GOCC_ENDOPLASMIC_RETICULUM_LUMEN

GO Biological Process (1): hyaluronan metabolic process (GO:0030212)

GO Molecular Function (5): endopeptidase inhibitor activity (GO:0004866), serine-type endopeptidase inhibitor activity (GO:0004867), hyaluronic acid binding (GO:0005540), protein binding (GO:0005515), peptidase inhibitor activity (GO:0030414)

GO Cellular Component (5): extracellular region (GO:0005576), endoplasmic reticulum lumen (GO:0005788), extracellular matrix (GO:0031012), extracellular exosome (GO:0070062), blood microparticle (GO:0072562)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Metabolism of proteins	2
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
glycosaminoglycan metabolic process	1
endopeptidase activity	1
peptidase inhibitor activity	1
endopeptidase regulator activity	1
serine-type endopeptidase activity	1
endopeptidase inhibitor activity	1
carboxylic acid binding	1
binding	1
enzyme inhibitor activity	1
peptidase activity	1
peptidase regulator activity	1
endoplasmic reticulum	1
intracellular organelle lumen	1
external encapsulating structure	1
extracellular vesicle	1
extracellular region	1

Protein interactions and networks

STRING

1886 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ITIH2	AMBP	P00977	932
ITIH2	ITIH1	P19827	763
ITIH2	AHSG	P02765	637
ITIH2	TF	P02787	615
ITIH2	CP	P00450	612
ITIH2	ITIH3	Q06033	609
ITIH2	A2M	P01023	590
ITIH2	FGA	P02671	590
ITIH2	C3	P01024	585
ITIH2	APOA1	P02647	583
ITIH2	SERPINA1	P01009	580
ITIH2	APOA4	P06727	568
ITIH2	C4A	P01028	566
ITIH2	APOB	P04114	561
ITIH2	MARCHF2	Q9P0N8	558

IntAct

103 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
CFTR	HAX1	psi-mi:“MI:0914”(association)	0.610
LIPG	NRP1	psi-mi:“MI:0914”(association)	0.530
ANGPTL4	NMT2	psi-mi:“MI:0914”(association)	0.530
FGF10	ITIH2	psi-mi:“MI:0914”(association)	0.530
ZG16B	ITIH2	psi-mi:“MI:0914”(association)	0.530
EGFR	NDUFA4	psi-mi:“MI:0914”(association)	0.530
KLRG2	GXYLT2	psi-mi:“MI:0914”(association)	0.530
ERP44	MEX3A	psi-mi:“MI:0914”(association)	0.530
CMA1	MANBA	psi-mi:“MI:0914”(association)	0.530
LRRC4C	DVL2	psi-mi:“MI:0914”(association)	0.530
PDGFRL	ANKRD28	psi-mi:“MI:0914”(association)	0.530
TNF	B4GALT5	psi-mi:“MI:0914”(association)	0.530
MMP10	TIMP1	psi-mi:“MI:0914”(association)	0.530
B4GALT4	HSPA5	psi-mi:“MI:0914”(association)	0.530
ELANE	ITIH2	psi-mi:“MI:0914”(association)	0.530
SPSB2	ARHGEF10	psi-mi:“MI:0914”(association)	0.530
ITIH2	FAM20C	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
H3C1	SMCHD1	psi-mi:“MI:2364”(proximity)	0.410
	CD5L	psi-mi:“MI:0915”(physical association)	0.400
	LECT2	psi-mi:“MI:0915”(physical association)	0.400
MAPT	LANCL1	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
DKKL1	VWA8	psi-mi:“MI:0914”(association)	0.350

BioGRID (106): ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS), ITIH2 (Affinity Capture-MS)

ESM2 similar proteins: A0A481NSZ4, A0JPN3, A2BGH0, A6QP57, D4A5U3, G3HIK4, O02668, O76879, P11597, P17213, P17453, P17454, P18428, P19823, P19827, P22687, P47896, P55058, P55065, P59826, P59827, P97278, Q05701, Q05704, Q08188, Q08189, Q0VCM5, Q10011, Q24764, Q28739, Q29052, Q2TBI0, Q61114, Q61702, Q61703, Q61805, Q63313, Q67E05, Q6AXU0, Q80ZU7

Diamond homologs: A2VE29, A6X935, O02668, P19823, P19827, P56652, P79263, P97278, P97279, P97280, Q06033, Q0VCM5, Q14624, Q29052, Q3T052, Q5RB37, Q5RER0, Q61702, Q61703, Q61704, Q63416, Q6UXX5, Q86UX2, Q8BJD1, Q9GLY5, P56651, A1A5Q7, Q5RJF7, A6NCI4, Q8CFG5, Q8IZS8, Q9Z1L5, Q3UVV9, A8XP97, P34374, Q9ZQ46

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 128 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Glycosaminoglycan metabolism	5	13.1×	5e-03
Post-translational protein phosphorylation	8	9.5×	9e-04
Metabolism of carbohydrates and carbohydrate derivatives	6	8.6×	6e-03
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	8	8.2×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

156 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	143
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3555 predictions. Top by Δscore:

Variant	Effect	Δscore
10:7703516:GAA:G	donor_gain	1.0000
10:7704890:G:GT	donor_gain	1.0000
10:7709192:G:GG	donor_gain	1.0000
10:7717786:GAG:G	donor_gain	1.0000
10:7717789:GT:G	donor_loss	1.0000
10:7717790:T:A	donor_loss	1.0000
10:7721774:GGAG:G	donor_gain	1.0000
10:7721775:GAG:G	donor_gain	1.0000
10:7721775:GAGG:G	donor_gain	1.0000
10:7721775:GAGGT:G	donor_loss	1.0000
10:7721776:AGGTG:A	donor_loss	1.0000
10:7721777:GGTG:G	donor_loss	1.0000
10:7721778:G:A	donor_loss	1.0000
10:7721779:T:A	donor_loss	1.0000
10:7723445:TTTCA:T	acceptor_loss	1.0000
10:7723446:TTCA:T	acceptor_loss	1.0000
10:7723447:TCA:T	acceptor_loss	1.0000
10:7723448:CA:C	acceptor_loss	1.0000
10:7723449:A:AG	acceptor_gain	1.0000
10:7723449:A:G	acceptor_loss	1.0000
10:7723450:G:GG	acceptor_gain	1.0000
10:7723450:GGT:G	acceptor_gain	1.0000
10:7723564:ACAA:A	donor_gain	1.0000
10:7723565:CAA:C	donor_gain	1.0000
10:7723566:AAG:A	donor_loss	1.0000
10:7723568:G:GG	donor_gain	1.0000
10:7726940:A:AG	acceptor_gain	1.0000
10:7726940:ATT:A	acceptor_gain	1.0000
10:7726941:T:G	acceptor_gain	1.0000
10:7726942:T:A	acceptor_gain	1.0000

AlphaMissense

6261 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:7723535:A:C	S318R	0.999
10:7723536:G:T	S318I	0.999
10:7723537:T:A	S318R	0.999
10:7723537:T:G	S318R	0.999
10:7727016:T:C	F351L	0.999
10:7727018:C:A	F351L	0.999
10:7727018:C:G	F351L	0.999
10:7723524:T:A	V314D	0.998
10:7723536:G:A	S318N	0.998
10:7726959:G:C	A332P	0.998
10:7727082:G:C	A373P	0.998
10:7727811:A:T	D421V	0.998
10:7727814:G:A	G422E	0.998
10:7723521:T:C	F313S	0.997
10:7723529:G:C	D316H	0.997
10:7723530:A:C	D316A	0.997
10:7723530:A:T	D316V	0.997
10:7723531:T:A	D316E	0.997
10:7723531:T:G	D316E	0.997
10:7723541:T:C	S320P	0.997
10:7726984:T:C	L340P	0.997
10:7727706:C:T	T386I	0.997
10:7727724:T:C	L392P	0.997
10:7727807:T:C	S420P	0.997
10:7727808:C:T	S420F	0.997
10:7727812:T:A	D421E	0.997
10:7727812:T:G	D421E	0.997
10:7727814:G:T	G422V	0.997
10:7730020:A:C	S450R	0.997
10:7730022:T:A	S450R	0.997

dbSNP variants (sampled 300 via entrez): RS1000061762 (10:7702401 T>A), RS1000098543 (10:7741635 C>G,T), RS1000176705 (10:7719455 T>C), RS1000206468 (10:7719738 A>G,T), RS1000230112 (10:7723449 A>C,G,T), RS1000284414 (10:7734902 C>T), RS1000442019 (10:7709411 G>C), RS1000583749 (10:7723809 C>G), RS1000617907 (10:7731301 C>A), RS1000625357 (10:7718853 C>T), RS1000656354 (10:7703862 G>C), RS1000714415 (10:7714394 G>A,C), RS1000788423 (10:7724718 A>G), RS1000846752 (10:7709437 C>T), RS1000921982 (10:7730614 G>A)

Disease associations

OMIM: gene MIM:146640 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001330_7	Ovarian reserve	2.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004770	ovarian reserve

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4295727 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cyclosporine	decreases expression	3
bisphenol A	affects expression, affects cotreatment, increases abundance	2
sodium arsenite	affects methylation, decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
Valproic Acid	affects expression, decreases expression	2
Aflatoxin B1	affects methylation, decreases methylation	2
aristolochic acid I	increases expression	1
ginger extract	affects cotreatment, affects expression, increases abundance	1
propionaldehyde	decreases expression	1
deoxynivalenol	decreases expression	1
cobaltous chloride	decreases expression	1
butyraldehyde	decreases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	affects binding, increases reaction	1
nivalenol	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
abrine	decreases expression	1
(+)-JQ1 compound	decreases expression	1
Olanzapine	affects phosphorylation	1
Acetaminophen	decreases expression	1
Amiodarone	increases expression	1
Benzo(a)pyrene	increases methylation	1
Cadmium	affects binding	1
Caffeine	increases phosphorylation	1
Calcium	affects binding, increases reaction	1
Calcium Chloride	increases reaction, affects binding	1
Citrulline	increases expression	1
Copper	affects binding	1
Diethylnitrosamine	decreases expression	1
Magnesium	affects binding, increases reaction	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4118706	Binding	Binding affinity to ITIH2 in human NCI-H23 cells at 1 uM by mass spectrometry based pull down assay	Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. — Bioorg Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.