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ITIH3

gene
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Also known as H3P

Summary

ITIH3 (inter-alpha-trypsin inhibitor heavy chain 3, HGNC:6168) is a protein-coding gene on chromosome 3p21.1, encoding Inter-alpha-trypsin inhibitor heavy chain H3 (Q06033). May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological p….

This gene encodes the heavy chain subunit of the pre-alpha-trypsin inhibitor complex. This complex may stabilize the extracellular matrix through its ability to bind hyaluronic acid. Polymorphisms of this gene may be associated with increased risk for schizophrenia and major depressive disorder. This gene is present in an inter-alpha-trypsin inhibitor family gene cluster on chromosome 3.

Source: NCBI Gene 3699 — RefSeq curated summary.

At a glance

  • GWAS associations: 36
  • Clinical variants (ClinVar): 149 total
  • MANE Select transcript: NM_002217

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:6168
Approved symbolITIH3
Nameinter-alpha-trypsin inhibitor heavy chain 3
Location3p21.1
Locus typegene with protein product
StatusApproved
AliasesH3P
Ensembl geneENSG00000162267
Ensembl biotypeprotein_coding
OMIM146650
Entrez3699

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 6 protein_coding, 6 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000416872, ENST00000449956, ENST00000463893, ENST00000464804, ENST00000465243, ENST00000465314, ENST00000467268, ENST00000475931, ENST00000493136, ENST00000495622, ENST00000703834, ENST00000889655, ENST00000889656, ENST00000956185

RefSeq mRNA: 10 — MANE Select: NM_002217 NM_001392019, NM_001392020, NM_001392021, NM_001392022, NM_001392023, NM_001392024, NM_001392025, NM_001392026, NM_001392027, NM_002217

CCDS: CCDS46845, CCDS93287, CCDS93288

Canonical transcript exons

ENST00000449956 — 22 exons

ExonStartEnd
ENSE000004213605279710552797267
ENSE000008609835279648152796647
ENSE000008609845279673952796843
ENSE000008609945280233452802519
ENSE000009670085280385552804009
ENSE000010638655279560352795623
ENSE000018878565279479652794896
ENSE000023351015280472652804734
ENSE000023727485280580852805840
ENSE000023940195279781752797930
ENSE000024199245280855252808797
ENSE000034705215280610352806138
ENSE000034770265280053852800663
ENSE000035264615279937252799488
ENSE000035332275280811052808221
ENSE000035994545280774752807916
ENSE000036106935280266752802806
ENSE000036136645280096552801146
ENSE000036491405279896652799091
ENSE000036717015280629352806406
ENSE000036787875279975352799921
ENSE000036879995280690152807105

Expression profiles

Bgee: expression breadth ubiquitous, 178 present calls, max score 99.67.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 5.6938 / max 2609.3115, expressed in 82 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
369065.642481
369080.02895
369090.02254

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
right lobe of liverUBERON:000111499.67gold quality
liverUBERON:000210799.52gold quality
right coronary arteryUBERON:000162597.87gold quality
popliteal arteryUBERON:000225097.78gold quality
tibial arteryUBERON:000761097.78gold quality
left coronary arteryUBERON:000162694.87gold quality
coronary arteryUBERON:000162194.37gold quality
saphenous veinUBERON:000731893.36gold quality
aortaUBERON:000094788.31gold quality
tibial nerveUBERON:000132386.08gold quality
sural nerveUBERON:001548885.73gold quality
spleenUBERON:000210684.58gold quality
blood vessel layerUBERON:000479784.00gold quality
spermCL:000001980.19silver quality
right lungUBERON:000216780.11gold quality
hindlimb stylopod muscleUBERON:000425278.86gold quality
endocervixUBERON:000045878.30gold quality
gastrocnemiusUBERON:000138878.30gold quality
male germ cellCL:000001577.69silver quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099177.64gold quality
left testisUBERON:000453377.44gold quality
muscle of legUBERON:000138377.26gold quality
right testisUBERON:000453476.92gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047376.89gold quality
upper lobe of left lungUBERON:000895276.53gold quality
thoracic aortaUBERON:000151576.32gold quality
body of uterusUBERON:000985376.25gold quality
ascending aortaUBERON:000149676.13gold quality
descending thoracic aortaUBERON:000234575.68gold quality
testisUBERON:000047375.49gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ATF4, GLI1, KLF4, SP1

miRNA regulators (miRDB)

14 targeting ITIH3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-605-3P99.8869.221833
HSA-MIR-3679-3P99.6469.881599
HSA-MIR-612699.6268.09996
HSA-MIR-6895-3P98.7965.69996
HSA-MIR-429798.7766.952013
HSA-MIR-806098.6166.931187
HSA-MIR-5008-5P98.4265.871019
HSA-MIR-427798.3467.171323
HSA-MIR-430897.5667.131385
HSA-MIR-55897.5067.16977
HSA-MIR-2467-5P97.3667.71991
HSA-MIR-4749-3P96.4066.24798
HSA-MIR-5009-5P94.8263.89775
HSA-MIR-805894.7663.41632

Literature-anchored findings (GeneRIF, showing 14)

  • Transfection into H460M Human large cell lung carcinoma line decreased tumor metastasis in nude mice (PMID:11807786)
  • ITIH3 single-nucleotide polymorphism is a novel genetic risk factor of myocardial infarction. (PMID:17211523)
  • Widespread heavy chain 3 was only present in urinary stone formers (PMID:17898697)
  • ITIH3 protein was found to be more highly expressed in plasma of tumor bearing mice compared to control. (PMID:20515073)
  • This study demonistrated that Genome-wide significant associations in schizophrenia to ITIH3/4 and extensive replication of associations reported by the Schizophrenia. (PMID:22614287)
  • Study showed the association of a polymorphism (rs2535629) of ITIH3 with psychiatric disorders in an Asian population and that rs2535629 influences the susceptibility to psychiatric disorders by affecting the expression level of GLT8D1 (PMID:24373612)
  • A novel association between suicide attempt and the ITIH3/4-region in a combined group of patients with bipolar disorder, schizophrenia and related psychosis spectrum disorders. (PMID:24461634)
  • confirmed the association of schizophrenia with ITIH3/4 in a Han Chinese population (PMID:26206863)
  • ITIH3 rs2535629 SNP was genotyped in N=256 patients receiving various antipsychotics for up to 26weeks. Study found no association of genotype with overall changes in Brief Psychiatric Rating Scale scores, but greater improvement of negative symptoms in minor allele carriers indicates that rs2535629 may help to identify a subset of schizophrenia patients with better treatment response to clozapine. (PMID:27396837)
  • ITIH3 SNPs rs2535629 and rs736408 were studied in pregnant depressed Japanese women. Neither was related to depressive symptoms during pregnancy.The GCCT haplotype of rs2535629, rs736408, rs3821831, and rs2239547 was significantly positively associated with depressive symptoms during pregnancy. (PMID:29992445)
  • Integrative analyses indicate an association between ITIH3 polymorphisms with autism spectrum disorder. (PMID:32251353)
  • A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population. (PMID:32712163)
  • Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression. (PMID:34978167)
  • A psychiatric disorder risk polymorphism of ITIH3 is associated with multiple neuroimaging phenotypes in young healthy adults. (PMID:35261121)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
danio_rerioitih3a.1ENSDARG00000055036
danio_rerioitih3a.2ENSDARG00000055053
mus_musculusItih3ENSMUSG00000006522
rattus_norvegicusItih3ENSRNOG00000017689

Paralogs (11): ITIH4 (ENSG00000055955), ITIH1 (ENSG00000055957), ITIH6 (ENSG00000102313), PARP4 (ENSG00000102699), VWA5A (ENSG00000110002), ITIH5 (ENSG00000123243), VWA5B2 (ENSG00000145198), ITIH2 (ENSG00000151655), VWA5B1 (ENSG00000158816), VWA3B (ENSG00000168658), VWA3A (ENSG00000175267)

Protein

Protein identifiers

Inter-alpha-trypsin inhibitor heavy chain H3 — Q06033 (reviewed: Q06033)

Alternative names: Serum-derived hyaluronan-associated protein

All UniProt accessions (3): A0A994J439, E7ET33, Q06033

UniProt curated annotations — full annotation on UniProt →

Function. May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

Subunit / interactions. I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Pre-alpha-inhibitor (P-alpha-I) is composed of ITIH3/HC3 and bikunin.

Subcellular location. Secreted.

Post-translational modifications. Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.

Similarity. Belongs to the ITIH family.

Isoforms (2)

UniProt IDNamesCanonical?
Q06033-11yes
Q06033-22

RefSeq proteins (10): NP_001378948, NP_001378949, NP_001378950, NP_001378951, NP_001378952, NP_001378953, NP_001378954, NP_001378955, NP_001378956, NP_002208* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR002035VWF_ADomain
IPR010600ITI_HC_CDomain
IPR013694VITDomain
IPR036465vWFA_dom_sfHomologous_superfamily
IPR050934ITIHFamily

Pfam: PF00092, PF06668, PF08487

UniProt features (23 total): sequence conflict 7, sequence variant 6, propeptide 2, domain 2, glycosylation site 2, signal peptide 1, chain 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q06033-F183.130.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 651

Glycosylation sites (2): 91, 580

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

IDPathway
R-HSA-114608Platelet degranulation
R-HSA-109582Hemostasis
R-HSA-76002Platelet activation, signaling and aggregation
R-HSA-76005Response to elevated platelet cytosolic Ca2+

MSigDB gene sets: 162 (showing top): MORF_MSH3, GNF2_GSTM1, GOCC_SECRETORY_GRANULE, REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION, GNF2_HPN, MORF_BRCA1, MODULE_453, GGGTGGRR_PAX4_03, MORF_RAD51L3, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GHO_ATF5_TARGETS_UP, GOBP_HYALURONAN_METABOLIC_PROCESS, WANG_RESPONSE_TO_BEXAROTENE_DN, HOSHIDA_LIVER_CANCER_SUBCLASS_S3, ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_DN

GO Biological Process (1): hyaluronan metabolic process (GO:0030212)

GO Molecular Function (4): endopeptidase inhibitor activity (GO:0004866), serine-type endopeptidase inhibitor activity (GO:0004867), protein binding (GO:0005515), peptidase inhibitor activity (GO:0030414)

GO Cellular Component (3): extracellular region (GO:0005576), platelet dense granule lumen (GO:0031089), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-3 pathways:

CategoryPathways
Response to elevated platelet cytosolic Ca2+1
Hemostasis1
Platelet activation, signaling and aggregation1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
glycosaminoglycan metabolic process1
endopeptidase activity1
peptidase inhibitor activity1
endopeptidase regulator activity1
serine-type endopeptidase activity1
endopeptidase inhibitor activity1
binding1
enzyme inhibitor activity1
peptidase activity1
peptidase regulator activity1
cellular anatomical structure1
secretory granule lumen1
platelet dense granule1
extracellular vesicle1

Protein interactions and networks

STRING

1898 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ITIH3AMBPP00977881
ITIH3APOA1P02647734
ITIH3APOEP02649679
ITIH3TENM4Q6N022646
ITIH3APOL1O14791627
ITIH3NEK4P51957612
ITIH3ITIH2P19823609
ITIH3ITIH1P19827593
ITIH3SERPINA10Q9UK55563
ITIH3NT5C2P49902534
ITIH3GLT8D1Q68CQ7517
ITIH3SYNE1Q8NF91509
ITIH3TRANK1O15050509
ITIH3GCP02774509
ITIH3TRIM26Q12899493

IntAct

11 interactions, top by confidence:

ABTypeScore
CST7CTSLpsi-mi:“MI:0914”(association)0.530
ITIH3psi-mi:“MI:0915”(physical association)0.370
EP300ITIH3psi-mi:“MI:0915”(physical association)0.370
TNFRSF10Bpsi-mi:“MI:0914”(association)0.350
MAPTLANCL1psi-mi:“MI:0914”(association)0.350
ITM2BILVBLpsi-mi:“MI:0914”(association)0.350
TNFAIP6ZMYM6psi-mi:“MI:0914”(association)0.350
ITIH3HSP90B1psi-mi:“MI:0914”(association)0.350
TNFAIP6ITIH2psi-mi:“MI:0914”(association)0.350
MFSD6EIF3CLpsi-mi:“MI:0914”(association)0.350

BioGRID (33): ITIH3 (Affinity Capture-MS), ITIH3 (Affinity Capture-MS), ITIH3 (Affinity Capture-MS), ITIH3 (Affinity Capture-MS), ITIH3 (Two-hybrid), ITIH3 (Affinity Capture-MS), ITIH3 (Affinity Capture-MS), ITIH3 (Affinity Capture-MS), ITIH3 (Affinity Capture-MS), ITIH3 (Affinity Capture-MS), ITIH3 (Affinity Capture-MS), IKBIP (Affinity Capture-MS), METAP1 (Affinity Capture-MS), TUBB8 (Affinity Capture-MS), HSP90B1 (Affinity Capture-MS)

ESM2 similar proteins: A0AAQ4VMX2, A0RZC6, A8K7I4, C9XI63, C9XI66, I2C090, J3S836, P01023, P01024, P01025, P01026, P01027, P01029, P01030, P01031, P06684, P06756, P08649, P08650, P0C0L4, P0C0L5, P12247, P12387, P19069, P20740, P26007, P26008, P56652, P80746, P97280, P98093, Q01833, Q06033, Q0ZZJ6, Q2UVX4, Q3UU35, Q5RB37, Q61704, Q61739, Q63041

Diamond homologs: A2VE29, A6X935, O02668, P19823, P19827, P56652, P79263, P97278, P97279, P97280, Q06033, Q0VCM5, Q14624, Q29052, Q3T052, Q5RB37, Q5RER0, Q61702, Q61703, Q61704, Q63416, Q6UXX5, Q86UX2, Q8BJD1, Q9GLY5, P56651, A1A5Q7, Q5RJF7, A6NCI4, Q8CFG5, Q8IZS8, Q9Z1L5, Q3UVV9, A8XP97, P34374, Q9ZQ46

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

149 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance135
Likely benign3
Benign6

Top pathogenic / likely-pathogenic (0)

SpliceAI

3590 predictions. Top by Δscore:

VariantEffectΔscore
3:52795621:GGG:Gdonor_gain1.0000
3:52795622:GGG:Gdonor_gain1.0000
3:52796592:G:GTdonor_gain1.0000
3:52796644:CCTT:Cdonor_gain1.0000
3:52796646:TT:Tdonor_gain1.0000
3:52796648:G:GGdonor_gain1.0000
3:52796734:TGCAG:Tacceptor_loss1.0000
3:52796735:GCAGG:Gacceptor_loss1.0000
3:52796737:A:AGacceptor_gain1.0000
3:52796737:AG:Aacceptor_gain1.0000
3:52796737:AGGAC:Aacceptor_loss1.0000
3:52796738:G:GCacceptor_gain1.0000
3:52796738:GG:Gacceptor_gain1.0000
3:52796738:GGA:Gacceptor_gain1.0000
3:52796738:GGAC:Gacceptor_gain1.0000
3:52796738:GGACC:Gacceptor_gain1.0000
3:52796839:GTCAA:Gdonor_gain1.0000
3:52796840:TC:Tdonor_gain1.0000
3:52796840:TCAA:Tdonor_gain1.0000
3:52796841:CAA:Cdonor_gain1.0000
3:52796841:CAAG:Cdonor_loss1.0000
3:52796842:AA:Adonor_gain1.0000
3:52796844:G:GGdonor_gain1.0000
3:52796844:GT:Gdonor_loss1.0000
3:52796848:G:GGdonor_gain1.0000
3:52797098:T:TAacceptor_gain1.0000
3:52797805:T:TAacceptor_gain1.0000
3:52797810:A:AGacceptor_gain1.0000
3:52797813:TCAG:Tacceptor_loss1.0000
3:52797815:A:AGacceptor_gain1.0000

AlphaMissense

5930 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
3:52800646:A:TD395V0.998
3:52799451:A:CD290A0.997
3:52799451:A:TD290V0.997
3:52799452:C:AD290E0.997
3:52799452:C:GD290E0.997
3:52799456:A:CS292R0.997
3:52799458:C:AS292R0.997
3:52799458:C:GS292R0.997
3:52799819:T:CF325L0.997
3:52799821:C:AF325L0.997
3:52799821:C:GF325L0.997
3:52800643:C:TT394I0.997
3:52799450:G:CD290H0.996
3:52799457:G:TS292I0.996
3:52800541:C:TT360I0.996
3:52800555:G:TG365W0.996
3:52800647:T:AD395E0.996
3:52800647:T:GD395E0.996
3:52797179:T:CL154P0.995
3:52799457:G:AS292N0.995
3:52803943:T:CS600P0.995
3:52797130:T:CF138L0.994
3:52797132:C:AF138L0.994
3:52797132:C:GF138L0.994
3:52799766:T:CL307P0.994
3:52799840:T:AW332R0.994
3:52799840:T:CW332R0.994
3:52799842:G:CW332C0.994
3:52799842:G:TW332C0.994
3:52800640:T:CL393P0.994

dbSNP variants (sampled 300 via entrez): RS1000008868 (3:52803885 C>A,T), RS1000036222 (3:52802120 T>C), RS1000226377 (3:52803710 T>C), RS1000601227 (3:52797596 T>A), RS1000921728 (3:52794196 G>A), RS1001013190 (3:52805404 T>C), RS1001388848 (3:52797026 G>T), RS1001408044 (3:52808928 T>C), RS1001419602 (3:52803517 C>T), RS1001487574 (3:52799541 G>A,C,T), RS1001662652 (3:52802178 G>A), RS1001941526 (3:52792914 C>A), RS1001974899 (3:52793242 G>A,C), RS1002306343 (3:52798886 C>T), RS1002448276 (3:52804795 G>C)

Disease associations

OMIM: gene MIM:146650 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

36 associations (top):

StudyTraitp-value
GCST001241_15Bipolar disorder2.000000e-06
GCST001242_6Schizophrenia6.000000e-08
GCST001535_1Immune reponse to smallpox (secreted IL-2)2.000000e-09
GCST001877_7Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)3.000000e-12
GCST002149_14Schizophrenia1.000000e-08
GCST002539_48Schizophrenia4.000000e-11
GCST002647_89Height5.000000e-17
GCST004521_123Autism spectrum disorder or schizophrenia3.000000e-12
GCST004521_201Autism spectrum disorder or schizophrenia4.000000e-08
GCST004521_259Autism spectrum disorder or schizophrenia6.000000e-09
GCST004601_41Red blood cell count2.000000e-09
GCST004902_20Parkinson’s disease3.000000e-08
GCST004904_157Body mass index2.000000e-12
GCST006803_55Schizophrenia1.000000e-11
GCST007201_166Schizophrenia1.000000e-10
GCST007255_2Broad depression or bipolar disorder1.000000e-09
GCST007257_5Broad depression or schizophrenia2.000000e-11
GCST007483_25Waist-to-hip ratio adjusted for BMI (additive genetic model)2.000000e-12
GCST007487_51Waist-to-hip ratio adjusted for BMI (additive genetic model)5.000000e-14
GCST007492_12Waist-to-hip ratio adjusted for BMI (additive genetic model)3.000000e-06
GCST007494_1Waist-to-hip ratio adjusted for BMI (additive genetic model)7.000000e-08
GCST007500_42Waist-to-hip ratio adjusted for BMI (additive genetic model)2.000000e-08
GCST007502_39Waist-to-hip ratio adjusted for BMI (additive genetic model)1.000000e-08
GCST008103_3Bipolar disorder7.000000e-11
GCST009600_27Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy)5.000000e-17
GCST010083_295Hemoglobin levels3.000000e-11
GCST010698_14Subcortical volume (min-P)8.000000e-09
GCST010699_73Brain morphology (min-P)1.000000e-18
GCST010701_137Cortical surface area (MOSTest)8.000000e-10
GCST010702_70Subcortical volume (MOSTest)2.000000e-11

EFO canonical traits (9, from GWAS)

EFO IDTrait name
EFO:0004645response to vaccine
EFO:0004873cytokine measurement
EFO:0004305erythrocyte count
EFO:0004340body mass index
EFO:0007788BMI-adjusted waist-hip ratio
EFO:0004509hemoglobin measurement
EFO:0004346neuroimaging measurement
EFO:0005670smoking initiation
EFO:0007789BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

VariantTypeLevelDrugsPhenotypes
rs2535629Efficacy3clozapineSchizophrenia

PharmGKB variants

1 variants.

VariantGenesLevelScore#Clin annotsDrugs
rs2535629ITIH331.501clozapine

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Cyclosporineincreases expression, decreases expression3
bisphenol Aaffects cotreatment, decreases methylation1
trimellitic anhydridedecreases expression1
sodium arseniteincreases expression1
tetrabromobisphenol Adecreases expression1
perfluorooctanoic acidincreases expression1
periodate-oxidized adenosineaffects expression1
triadimefondecreases expression1
ciglitazoneaffects binding, increases expression1
2,3-dimethoxy-1,4-naphthoquinonedecreases expression1
CGP 52608affects binding, increases reaction1
2,2’,4,4’-tetrabromodiphenyl etherdecreases expression1
pentabrominated diphenyl ether 100decreases expression1
hexabrominated diphenyl ether 153decreases expression1
Resveratrolaffects cotreatment, decreases expression1
Zoledronic Acidincreases expression1
Fulvestrantaffects cotreatment, decreases methylation1
Antimonydecreases expression1
Antimony Potassium Tartratedecreases expression1
Benzo(a)pyreneaffects methylation1
Bleomycinincreases expression1
Chenodeoxycholic Acidaffects cotreatment, increases expression1
Chromiumdecreases expression1
Deoxycholic Acidincreases expression, affects cotreatment1
Glycochenodeoxycholic Acidaffects cotreatment, increases expression1
Glycocholic Acidaffects cotreatment, increases expression1
Glycodeoxycholic Acidaffects cotreatment, increases expression1
Mercurydecreases expression1
Nickelaffects binding1
Plant Extractsaffects cotreatment, decreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

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Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot