ITM2C

Summary

ITM2C (integral membrane protein 2C, HGNC:6175) is a protein-coding gene on chromosome 2q37.1, encoding Integral membrane protein 2C (Q9NQX7). Negative regulator of amyloid-beta peptide production.

Enables amyloid-beta binding activity. Involved in negative regulation of neuron projection development and neuron differentiation. Located in several cellular components, including Golgi apparatus; lysosome; and perinuclear region of cytoplasm.

Source: NCBI Gene 81618 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 62 total
• MANE Select transcript: NM_030926

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6175
Approved symbol	ITM2C
Name	integral membrane protein 2C
Location	2q37.1
Locus type	gene with protein product
Status	Approved
Aliases	BRI3, E25, hRPC.1050_D_4, ITM3, BRICD2C
Ensembl gene	ENSG00000135916
Ensembl biotype	protein_coding
OMIM	609554
Entrez	81618

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 9 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000326407, ENST00000326427, ENST00000335005, ENST00000409704, ENST00000418408, ENST00000457215, ENST00000492029, ENST00000541852, ENST00000543957, ENST00000620962

RefSeq mRNA: 5 — MANE Select: NM_030926 NM_001012514, NM_001012516, NM_001287240, NM_001287241, NM_030926

CCDS: CCDS2479, CCDS33395, CCDS33396, CCDS74665

Canonical transcript exons

ENST00000326427 — 6 exons

Exon	Start	End
ENSE00000922497	230877400	230877550
ENSE00001868342	230878008	230879248
ENSE00001899015	230864942	230865145
ENSE00003548237	230873417	230873557
ENSE00003611891	230875620	230875808
ENSE00003784419	230876857	230876967

Expression profiles

Bgee: expression breadth ubiquitous, 275 present calls, max score 99.66.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 164.2906 / max 1966.1830, expressed in 1811 samples.

FANTOM5 promoters (13 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25828	151.3967	1793
25827	5.2933	1563
25829	2.4477	817
25831	1.3348	580
25830	0.7148	338
25832	0.5243	288
25834	0.4790	277
25838	0.4667	232
25837	0.4142	208
25833	0.4096	223

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nucleus accumbens	UBERON:0001882	99.66	gold quality
mucosa of transverse colon	UBERON:0004991	99.66	gold quality
anterior cingulate cortex	UBERON:0009835	99.60	gold quality
cingulate cortex	UBERON:0003027	99.59	gold quality
caudate nucleus	UBERON:0001873	99.56	gold quality
amygdala	UBERON:0001876	99.53	gold quality
lateral globus pallidus	UBERON:0002476	99.53	gold quality
prefrontal cortex	UBERON:0000451	99.47	gold quality
rectum	UBERON:0001052	99.47	gold quality
hypothalamus	UBERON:0001898	99.46	gold quality
putamen	UBERON:0001874	99.42	gold quality
right frontal lobe	UBERON:0002810	99.38	gold quality
Brodmann (1909) area 9	UBERON:0013540	99.34	gold quality
transverse colon	UBERON:0001157	99.28	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	99.17	gold quality
colonic mucosa	UBERON:0000317	99.12	gold quality
pituitary gland	UBERON:0000007	99.11	gold quality
frontal cortex	UBERON:0001870	99.09	gold quality
adenohypophysis	UBERON:0002196	99.09	gold quality
mucosa of sigmoid colon	UBERON:0004993	99.09	gold quality
neocortex	UBERON:0001950	99.01	gold quality
forebrain	UBERON:0001890	98.97	gold quality
Ammon’s horn	UBERON:0001954	98.97	gold quality
telencephalon	UBERON:0001893	98.96	gold quality
substantia nigra	UBERON:0002038	98.93	gold quality
spinal cord	UBERON:0002240	98.90	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.88	gold quality
midbrain	UBERON:0001891	98.85	gold quality
temporal lobe	UBERON:0001871	98.83	gold quality
substantia nigra pars reticulata	UBERON:0001966	98.83	gold quality

Single-cell (SCXA)

Detected in 46 experiment(s), a significant marker in 38.

Experiment	Marker?	Max mean expression
E-GEOD-125970	yes	2451.42
E-CURD-120	yes	1734.99
E-MTAB-9467	yes	1551.01
E-HCAD-10	yes	1520.22
E-GEOD-150728	yes	1467.01
E-GEOD-149689	yes	1438.55
E-MTAB-8410	yes	1325.94
E-MTAB-9154	yes	1319.79
E-HCAD-32	yes	1300.46
E-CURD-77	yes	1223.15
E-MTAB-7407	yes	1138.29
E-HCAD-4	yes	1017.62
E-MTAB-10553	yes	899.47
E-CURD-55	yes	852.80
E-MTAB-9221	yes	826.07

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

74 targeting ITM2C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-4648	99.91	67.00	710
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-659-3P	99.85	70.69	1620
HSA-MIR-636	99.80	69.58	1500
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-1976	99.74	65.48	1127
HSA-MIR-4306	99.72	70.50	3630

Literature-anchored findings (GeneRIF, showing 1)

• Unlocking the Potential of the CA2, CA7, and ITM2C Gene Signatures for the Early Detection of Colorectal Cancer: A Comprehensive Analysis of RNA-Seq Data by Utilizing Machine Learning Algorithms. (PMID:37895185)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	itm2cb	ENSDARG00000039650
danio_rerio	itm2ca	ENSDARG00000043448
mus_musculus	Itm2c	ENSMUSG00000026223
rattus_norvegicus	Itm2c	ENSRNOG00000017359
drosophila_melanogaster	CG3662	FBGN0031285
caenorhabditis_elegans		WBGENE00016106

Paralogs (2): ITM2A (ENSG00000078596), ITM2B (ENSG00000136156)

Protein

Protein identifiers

Integral membrane protein 2C — Q9NQX7 (reviewed: Q9NQX7)

Alternative names: Cerebral protein 14, Transmembrane protein BRI3

All UniProt accessions (6): B8ZZM6, C9JG41, E7EUS6, F5H4I5, Q96JS4, Q9NQX7

UniProt curated annotations — full annotation on UniProt →

Function. Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.

Subunit / interactions. Interacts with BACE1. Interacts with APP. Interacts with STMN2.

Subcellular location. Lysosome membrane. Cell membrane.

Tissue specificity. High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs.

Post-translational modifications. Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B.

Similarity. Belongs to the ITM2 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NQX7-1	1	yes
Q9NQX7-2	2
Q9NQX7-3	3

RefSeq proteins (5): NP_001012532, NP_001012534, NP_001274169, NP_001274170, NP_112188* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007084	BRICHOS_dom	Domain
IPR040145	ITM2	Family

Pfam: PF04089

UniProt features (15 total): sequence conflict 3, splice variant 2, chain 1, peptide 1, sequence variant 1, mutagenesis site 1, transmembrane region 1, domain 1, site 1, modified residue 1, glycosylation site 1, disulfide bond 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NQX7-F1	77.12	0.42

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 242–243 (cleavage; by furin)

Post-translational modifications (1): 37

Disulfide bonds (1): 163–222

Glycosylation sites (1): 169

Mutagenesis-validated functional residues (1):

Position	Phenotype
241–242	completely abrogates proteolytic processing.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 488 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_UP, VERHAAK_AML_WITH_NPM1_MUTATED_DN, REACTOME_INNATE_IMMUNE_SYSTEM, MODULE_255, GOCC_VACUOLAR_MEMBRANE, GOCC_SECRETORY_GRANULE, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, MODULE_317, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, GOBP_EXTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, GOBP_NEUROGENESIS, HANN_RESISTANCE_TO_BCL2_INHIBITOR_UP, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION

GO Biological Process (4): negative regulation of neuron projection development (GO:0010977), neuron differentiation (GO:0030182), negative regulation of amyloid precursor protein biosynthetic process (GO:0042985), positive regulation of extrinsic apoptotic signaling pathway (GO:2001238)

GO Molecular Function (3): amyloid-beta binding (GO:0001540), ATP binding (GO:0005524), protein binding (GO:0005515)

GO Cellular Component (7): lysosome (GO:0005764), lysosomal membrane (GO:0005765), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), perinuclear region of cytoplasm (GO:0048471), extracellular exosome (GO:0070062), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
cellular anatomical structure	2
regulation of neuron projection development	1
neuron projection development	1
negative regulation of cell projection organization	1
cell differentiation	1
generation of neurons	1
negative regulation of glycoprotein biosynthetic process	1
amyloid precursor protein biosynthetic process	1
regulation of amyloid precursor protein biosynthetic process	1
extrinsic apoptotic signaling pathway	1
positive regulation of apoptotic signaling pathway	1
regulation of extrinsic apoptotic signaling pathway	1
peptide binding	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
binding	1
lytic vacuole	1
lysosome	1
lytic vacuole membrane	1
endomembrane system	1
intracellular membrane-bounded organelle	1
membrane	1
cell periphery	1
extracellular vesicle	1

Protein interactions and networks

STRING

1026 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ITM2C	BACE1	P56817	752
ITM2C	PCSK7	Q16549	748
ITM2C	CLPTM1	O96005	611
ITM2C	FURIN	P09958	589
ITM2C	SLC35A5	Q9BS91	525
ITM2C	KNDC1	Q76NI1	513
ITM2C	KIAA1755	Q5JYT7	454
ITM2C	PDZD11	Q5EBL8	431
ITM2C	INSYN1	Q2T9L4	410
ITM2C	ERBB2	P04626	399
ITM2C	SYT11	Q9BT88	391
ITM2C	EPB41L4A	Q9HCS5	388
ITM2C	MED31	Q9Y3C7	371
ITM2C	EML6	Q6ZMW3	363
ITM2C	GAS2L3	Q86XJ1	359

IntAct

75 interactions, top by confidence:

A	B	Type	Score
TSPAN15	ADAM10	psi-mi:“MI:0914”(association)	0.840
TSPAN5	ADAM10	psi-mi:“MI:0914”(association)	0.800
APP	APBB1	psi-mi:“MI:0914”(association)	0.740
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
SLC39A5	FAM171A2	psi-mi:“MI:0914”(association)	0.640
MTNR1B	IRS4	psi-mi:“MI:0914”(association)	0.530
TNFSF8	LGALS8	psi-mi:“MI:0914”(association)	0.530
TIMP3	ZZEF1	psi-mi:“MI:0914”(association)	0.530
ANKH	FAM234B	psi-mi:“MI:0914”(association)	0.530
CFTR	ITM2C	psi-mi:“MI:0915”(physical association)	0.520
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
ITM2C	Dlg4	psi-mi:“MI:0407”(direct interaction)	0.440
RNF7	ITM2C	psi-mi:“MI:0915”(physical association)	0.370
		psi-mi:“MI:0914”(association)	0.350
	ESYT2	psi-mi:“MI:0914”(association)	0.350
	PGRMC1	psi-mi:“MI:0914”(association)	0.350
	SNAP23	psi-mi:“MI:0914”(association)	0.350
	HAX1	psi-mi:“MI:0914”(association)	0.350
APP	RTL1	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
NS3	C15orf61	psi-mi:“MI:0914”(association)	0.350
	SHTN1	psi-mi:“MI:0914”(association)	0.350
	TMEM223	psi-mi:“MI:0914”(association)	0.350
	TNFRSF10A	psi-mi:“MI:0914”(association)	0.350
POMK	ESYT2	psi-mi:“MI:0914”(association)	0.350
SCN2A	IGLL5	psi-mi:“MI:0914”(association)	0.350

BioGRID (134): ITM2C (Affinity Capture-MS), MVB12B (Affinity Capture-MS), ITM2C (Two-hybrid), ITM2C (Proximity Label-MS), ITM2C (Proximity Label-MS), MVB12B (Affinity Capture-MS), ITM2C (Reconstituted Complex), ITM2C (Proximity Label-MS), ITM2C (Proximity Label-MS), ITM2C (Proximity Label-MS), ITM2C (Affinity Capture-MS), ITM2C (Two-hybrid), ITM2C (Two-hybrid), CXCL9 (Two-hybrid), FNDC9 (Two-hybrid)

ESM2 similar proteins: A2VDN0, A5A6H8, B5DFM7, E9Q9F6, O18638, O42204, O43736, O88393, O89051, P0DP43, P21841, P26342, P58239, Q03167, Q06890, Q06AV4, Q14CH0, Q29TV8, Q3T0P7, Q4R540, Q52N47, Q5NVC3, Q5PQL7, Q5R876, Q5SC59, Q5SC60, Q5SY80, Q5XIE8, Q60HC1, Q61500, Q6AYE5, Q6GPK2, Q6P7C7, Q6P995, Q6W3E5, Q71SY6, Q802A9, Q86XM0, Q86XP6, Q8BGN6

Diamond homologs: A2VDN0, A5A6H8, O42204, O43736, O89051, Q06AV4, Q3T0P7, Q4R540, Q52N47, Q5NVC3, Q5PQL7, Q5R876, Q5XIE8, Q60HC1, Q61500, Q91VK4, Q9NQX7, Q9Y287

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

62 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	2
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

885 predictions. Top by Δscore:

Variant	Effect	Δscore
2:230865144:GG:G	donor_gain	1.0000
2:230865145:GG:G	donor_gain	1.0000
2:230865146:G:GG	donor_gain	1.0000
2:230875608:C:CA	acceptor_gain	1.0000
2:230875613:T:TA	acceptor_gain	1.0000
2:230875617:CAG:C	acceptor_loss	1.0000
2:230875618:A:AG	acceptor_gain	1.0000
2:230875618:AGC:A	acceptor_loss	1.0000
2:230875618:AGCT:A	acceptor_gain	1.0000
2:230875618:AGCTG:A	acceptor_gain	1.0000
2:230875619:G:GA	acceptor_gain	1.0000
2:230875619:GC:G	acceptor_gain	1.0000
2:230875619:GCT:G	acceptor_gain	1.0000
2:230875619:GCTG:G	acceptor_gain	1.0000
2:230875619:GCTGG:G	acceptor_gain	1.0000
2:230875805:GCGG:G	donor_gain	1.0000
2:230875807:GG:G	donor_gain	1.0000
2:230875808:GG:G	donor_gain	1.0000
2:230875809:G:GG	donor_gain	1.0000
2:230875809:GTG:G	donor_loss	1.0000
2:230875810:T:A	donor_loss	1.0000
2:230876852:GCCA:G	acceptor_loss	1.0000
2:230876853:CCAG:C	acceptor_loss	1.0000
2:230876854:CA:C	acceptor_loss	1.0000
2:230876855:A:AC	acceptor_loss	1.0000
2:230876855:A:AG	acceptor_gain	1.0000
2:230876855:AG:A	acceptor_gain	1.0000
2:230876855:AGG:A	acceptor_gain	1.0000
2:230876856:G:GT	acceptor_gain	1.0000
2:230876856:GG:G	acceptor_gain	1.0000

AlphaMissense

1738 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:230875800:T:C	F148L	1.000
2:230875801:T:G	F148C	1.000
2:230875802:C:A	F148L	1.000
2:230875802:C:G	F148L	1.000
2:230875794:C:G	H146D	0.999
2:230875801:T:C	F148S	0.999
2:230876861:T:C	L152P	0.999
2:230876866:G:C	A154P	0.999
2:230876869:T:G	Y155D	0.999
2:230876893:T:A	C163S	0.999
2:230876893:T:C	C163R	0.999
2:230876894:G:A	C163Y	0.999
2:230876894:G:C	C163S	0.999
2:230876894:G:T	C163F	0.999
2:230876895:C:G	C163W	0.999
2:230876900:T:A	V165D	0.999
2:230876909:T:A	L168H	0.999
2:230877502:T:A	C222S	0.999
2:230877502:T:C	C222R	0.999
2:230877503:G:A	C222Y	0.999
2:230877503:G:C	C222S	0.999
2:230877503:G:T	C222F	0.999
2:230877504:C:G	C222W	0.999
2:230875789:T:A	I144N	0.998
2:230875789:T:C	I144T	0.998
2:230875789:T:G	I144S	0.998
2:230875795:A:C	H146P	0.998
2:230875796:T:A	H146Q	0.998
2:230875796:T:G	H146Q	0.998
2:230875798:A:C	D147A	0.998

dbSNP variants (sampled 300 via entrez): RS1000416614 (2:230868292 G>A), RS1000548826 (2:230864035 G>A,T), RS1000571796 (2:230870165 G>A), RS1000972729 (2:230875151 C>A), RS1000996914 (2:230864399 G>A,T), RS1001151902 (2:230869399 C>T), RS1001178782 (2:230871137 G>T), RS1001228166 (2:230865844 C>T), RS1001229758 (2:230873684 C>T), RS1001233646 (2:230865482 TGGGG>T,TGGG,TGGGGG), RS1001279224 (2:230866017 G>A,C,T), RS1001297753 (2:230877750 T>C), RS1001682952 (2:230868961 C>A), RS1001702041 (2:230873863 G>A), RS1001736680 (2:230868745 C>T)

Disease associations

OMIM: gene MIM:609554 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST90002390_468	Mean corpuscular hemoglobin	2.000000e-12
GCST90002392_176	Mean corpuscular volume	7.000000e-13
GCST90002396_183	Mean reticulocyte volume	1.000000e-09
GCST90002397_464	Mean spheric corpuscular volume	7.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin
EFO:0010701	mean reticulocyte volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases methylation, decreases expression, affects expression, affects cotreatment	4
Arsenic	affects methylation, decreases ubiquitination, increases methylation, decreases expression, increases abundance	4
Valproic Acid	affects expression, increases expression, increases methylation	4
sodium arsenite	decreases expression, increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Cyclosporine	decreases expression	2
TAK-243	increases sumoylation	1
lead acetate	increases expression	1
beta-lapachone	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
beta-methylcholine	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
MT19c compound	decreases expression	1
Fulvestrant	increases methylation, affects cotreatment	1
Acetaminophen	increases expression	1
Atrazine	increases expression	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Cytarabine	decreases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Doxorubicin	increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Gallic Acid	decreases expression	1
Ivermectin	decreases expression	1
Lead	affects expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E0FM	Ubigene HeLa ITM2C KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.