ITPR1-DT

Summary

ITPR1-DT (ITPR1 divergent transcript, HGNC:44470) is a long non-coding RNA gene on chromosome 3p26.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44470
Approved symbol	ITPR1-DT
Name	ITPR1 divergent transcript
Location	3p26.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231249
Ensembl biotype	lncRNA
Entrez	100996539
RNAcentral	URS000075B0B9 — lncRNA, 1432 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000412804, ENST00000688861, ENST00000690136, ENST00000770437, ENST00000770438, ENST00000770439, ENST00000770440, ENST00000770441, ENST00000770442, ENST00000770443, ENST00000770444, ENST00000770445, ENST00000770446, ENST00000770447

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412804 — 2 exons

Exon	Start	End
ENSE00003984328	4490312	4491368
ENSE00004132482	4492784	4493205

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 83.58.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1816 / max 57.1017, expressed in 613 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
40831	1.1816	613

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.58	gold quality
buccal mucosa cell	CL:0002336	80.12	gold quality
popliteal artery	UBERON:0002250	79.11	gold quality
tibial artery	UBERON:0007610	79.06	gold quality
aorta	UBERON:0000947	76.66	gold quality
right coronary artery	UBERON:0001625	76.46	gold quality
descending thoracic aorta	UBERON:0002345	75.83	gold quality
left coronary artery	UBERON:0001626	74.72	gold quality
ascending aorta	UBERON:0001496	73.89	gold quality
thoracic aorta	UBERON:0001515	73.83	gold quality
coronary artery	UBERON:0001621	72.99	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.64	gold quality
cerebellar hemisphere	UBERON:0002245	72.17	gold quality
cerebellar cortex	UBERON:0002129	71.95	gold quality
right lobe of thyroid gland	UBERON:0001119	71.58	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.32	gold quality
lower esophagus	UBERON:0013473	71.24	gold quality
left lobe of thyroid gland	UBERON:0001120	71.19	gold quality
cerebellum	UBERON:0002037	70.74	gold quality
thyroid gland	UBERON:0002046	70.61	gold quality
caudate nucleus	UBERON:0001873	69.96	gold quality
nucleus accumbens	UBERON:0001882	69.66	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.37	gold quality
primary visual cortex	UBERON:0002436	69.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.84	gold quality
metanephros cortex	UBERON:0010533	68.54	gold quality
body of uterus	UBERON:0009853	68.28	gold quality
apex of heart	UBERON:0002098	67.97	gold quality
putamen	UBERON:0001874	67.78	gold quality
Brodmann (1909) area 23	UBERON:0013554	67.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• ITPR1-AS1 promotes small cell lung cancer metastasis by facilitating P21[HRAS] splicing and stabilizing DDX3X to activate the cRaf-MEK-ERK cascade. (PMID:37820992)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.