JCAD

Summary

JCAD (junctional cadherin 5 associated, HGNC:29283) is a protein-coding gene on chromosome 10p11.23, encoding Junctional cadherin 5-associated protein (Q9P266).

This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution.

Source: NCBI Gene 57608 — RefSeq curated summary.

At a glance

• GWAS associations: 30
• Clinical variants (ClinVar): 294 total
• MANE Select transcript: NM_020848

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29283
Approved symbol	JCAD
Name	junctional cadherin 5 associated
Location	10p11.23
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000165757
Ensembl biotype	protein_coding
OMIM	614398
Entrez	57608

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding_CDS_not_defined, 1 protein_coding

ENST00000375377, ENST00000464386, ENST00000465712

RefSeq mRNA: 4 — MANE Select: NM_020848 NM_001350001, NM_001350021, NM_001350022, NM_020848

CCDS: CCDS41500

Canonical transcript exons

ENST00000375377 — 4 exons

Exon	Start	End
ENSE00001096241	30026103	30029866
ENSE00001466892	30012803	30017917
ENSE00001466904	30059482	30059586
ENSE00003496588	30047532	30047871

Expression profiles

Bgee: expression breadth ubiquitous, 266 present calls, max score 93.34.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.6061 / max 153.8346, expressed in 1172 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108899	9.0042	1167
108900	0.5501	133
108898	0.0518	30

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
saphenous vein	UBERON:0007318	93.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	93.16	gold quality
trigeminal ganglion	UBERON:0001675	92.28	gold quality
right lung	UBERON:0002167	92.22	gold quality
vena cava	UBERON:0004087	92.10	gold quality
putamen	UBERON:0001874	91.81	gold quality
apex of heart	UBERON:0002098	90.95	gold quality
calcaneal tendon	UBERON:0003701	90.73	gold quality
caudate nucleus	UBERON:0001873	90.72	gold quality
tendon	UBERON:0000043	90.27	gold quality
tendon of biceps brachii	UBERON:0008188	90.23	gold quality
descending thoracic aorta	UBERON:0002345	89.75	gold quality
thoracic aorta	UBERON:0001515	88.64	gold quality
ascending aorta	UBERON:0001496	88.45	gold quality
pericardium	UBERON:0002407	88.41	gold quality
upper lobe of left lung	UBERON:0008952	88.26	gold quality
upper lobe of lung	UBERON:0008948	88.12	gold quality
lung	UBERON:0002048	88.07	gold quality
colonic epithelium	UBERON:0000397	87.95	gold quality
myometrium	UBERON:0001296	87.95	gold quality
primary visual cortex	UBERON:0002436	87.71	gold quality
prefrontal cortex	UBERON:0000451	87.62	gold quality
body of uterus	UBERON:0009853	87.38	gold quality
nucleus accumbens	UBERON:0001882	86.89	gold quality
lower lobe of lung	UBERON:0008949	86.82	gold quality
occipital lobe	UBERON:0002021	86.64	gold quality
right frontal lobe	UBERON:0002810	86.55	gold quality
left uterine tube	UBERON:0001303	86.51	gold quality
right atrium auricular region	UBERON:0006631	86.18	gold quality
endothelial cell	CL:0000115	86.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.60

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

223 targeting JCAD, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548C-3P	99.99	74.01	7587

Literature-anchored findings (GeneRIF, showing 9)

• KIAA1462 gene encodes a yet uncharacterized protein, on chromosome 10p11.23 with genome-wide significant association for CAD/MI (PMID:21088011)
• Results in this study identify the KIAA1462 locus as a candidate locus for late onset Alzheimer disease in APOE4 carriers. (PMID:24349219)
• JCAD has a redundant functional role in physiological angiogenesis but serves a pivotal role in pathological angiogenic process after birth. (PMID:28705794)
• High JCAD expression is associated with Liver Cancer. (PMID:28775168)
• JCAD negatively regulates Hippo signaling in endothelial cells and contributes to atherosclerosis by regulating YAP activity and endothelial dysfunction. (PMID:29794114)
• The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis. (PMID:31539914)
• A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. (PMID:31584065)
• JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. (PMID:36469488)
• JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis. (PMID:38190829)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Jcad	ENSMUSG00000033960
rattus_norvegicus	Jcad	ENSRNOG00000027938

Protein

Protein identifiers

Junctional cadherin 5-associated protein — Q9P266 (reviewed: Q9P266)

Alternative names: Junctional protein associated with coronary artery disease

All UniProt accessions (1): Q9P266

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cell junction. Adherens junction.

RefSeq proteins (4): NP_001336930, NP_001336950, NP_001336951, NP_065899* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR028221	JCAD	Family

Pfam: PF15351

UniProt features (39 total): compositionally biased region 15, region of interest 9, sequence variant 6, modified residue 4, sequence conflict 4, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P266-F1	43.18	0.01

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 1044, 1050, 1194, 1281

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 183 (showing top): GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, WALLACE_PROSTATE_CANCER_RACE_UP, GOBP_VASCULAR_ENDOTHELIAL_GROWTH_FACTOR_SIGNALING_PATHWAY, GOBP_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT, GOBP_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS, GOBP_POSITIVE_REGULATION_OF_MAPK_CASCADE, GOCC_RUFFLE, GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION, BROWNE_HCMV_INFECTION_48HR_DN, GOBP_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION, MODULE_205, GOBP_SPROUTING_ANGIOGENESIS, GOBP_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION, GOBP_REGULATION_OF_CELL_MIGRATION_INVOLVED_IN_SPROUTING_ANGIOGENESIS, BROWNE_HCMV_INFECTION_14HR_DN

GO Biological Process (6): cell adhesion (GO:0007155), positive regulation of MAPK cascade (GO:0043410), positive regulation of cell migration involved in sprouting angiogenesis (GO:0090050), positive regulation of vascular endothelial growth factor signaling pathway (GO:1900748), positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis (GO:1903589), positive regulation of sprouting angiogenesis (GO:1903672)

GO Molecular Function (0):

GO Cellular Component (6): adherens junction (GO:0005912), ruffle membrane (GO:0032587), perinuclear region of cytoplasm (GO:0048471), cell-cell junction (GO:0005911), cell junction (GO:0030054), anchoring junction (GO:0070161)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cellular process	1
MAPK cascade	1
regulation of MAPK cascade	1
positive regulation of intracellular signal transduction	1
cell migration involved in sprouting angiogenesis	1
positive regulation of blood vessel endothelial cell migration	1
regulation of cell migration involved in sprouting angiogenesis	1
positive regulation of signal transduction	1
vascular endothelial growth factor signaling pathway	1
regulation of vascular endothelial growth factor signaling pathway	1
positive regulation of endothelial cell proliferation	1
blood vessel endothelial cell proliferation involved in sprouting angiogenesis	1
regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	1
sprouting angiogenesis	1
positive regulation of angiogenesis	1
regulation of sprouting angiogenesis	1
cell-cell junction	1
ruffle	1
cell projection membrane	1
leading edge membrane	1
cytoplasm	1
anchoring junction	1
cell junction	1

Protein interactions and networks

STRING

542 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
JCAD	LATS2	Q9NRM7	623
JCAD	ADISSP	Q9GZN8	552
JCAD	ADAMTS7	Q9UKP4	507
JCAD	TOR4A	Q9NXH8	490
JCAD	HIP1R	O75146	475
JCAD	MTPAP	Q9NVV4	472
JCAD	SWAP70	Q9UH65	460
JCAD	PDZK1	Q5T2W1	458
JCAD	UGCG	Q16739	457
JCAD	RNF212	Q495C1	453
JCAD	CPNE1	Q99829	442
JCAD	ZNF799	Q96GE5	439
JCAD	PCYT2	Q99447	437
JCAD	BRK1	Q8WUW1	433
JCAD	SEC24C	P53992	432

IntAct

24 interactions, top by confidence:

A	B	Type	Score
CAMKV	AP3B1	psi-mi:“MI:0914”(association)	0.640
YWHAG	BLTP3B	psi-mi:“MI:0914”(association)	0.640
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
DYNLL2	BLTP3B	psi-mi:“MI:0914”(association)	0.640
YWHAH	BLTP3B	psi-mi:“MI:0914”(association)	0.570
YWHAH	BLTP3B	psi-mi:“MI:2364”(proximity)	0.570
YAP1	JCAD	psi-mi:“MI:0407”(direct interaction)	0.440
NCKIPSD	GEMIN4	psi-mi:“MI:2364”(proximity)	0.420
BVLF1	VWA8	psi-mi:“MI:0914”(association)	0.350
EGLN3	FAM168B	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
CREB3L2	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
FIBP	AGRN	psi-mi:“MI:0914”(association)	0.350
MCM7		psi-mi:“MI:0914”(association)	0.350
CDH1	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
CDC14A	CEP290	psi-mi:“MI:2364”(proximity)	0.270
SFN	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
YWHAE	PLEKHG3	psi-mi:“MI:2364”(proximity)	0.270
YWHAQ	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270
Lats2	CCDC85C	psi-mi:“MI:2364”(proximity)	0.270
DYRK1A	JCAD	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (44): KIAA1462 (Affinity Capture-MS), KIAA1462 (Proximity Label-MS), KIAA1462 (Proximity Label-MS), KIAA1462 (Affinity Capture-Western), KIAA1462 (Affinity Capture-MS), KIAA1462 (Affinity Capture-RNA), KIAA1462 (Proximity Label-MS), KIAA1462 (Affinity Capture-MS), KIAA1462 (Proximity Label-MS), KIAA1462 (Proximity Label-MS), KIAA1462 (Proximity Label-MS), KIAA1462 (Proximity Label-MS), KIAA1462 (Proximity Label-MS), KIAA1462 (Proximity Label-MS), KIAA1462 (Proximity Label-MS)

ESM2 similar proteins: A0A096MK47, A0JNH1, A6H5Y1, A6NCI8, A6NFA0, A6NGG8, B2RQL2, D3Z1D3, D3ZMK9, E9Q286, E9Q309, M0RD54, O14513, P51816, Q01613, Q03172, Q05860, Q2M2Z5, Q32LN6, Q3MHH3, Q3UXL4, Q3V0A6, Q569L8, Q571I4, Q5DTX6, Q5FW52, Q5HYW2, Q5R9I1, Q5VT06, Q5VWP3, Q60988, Q66HG9, Q68DA7, Q6P1W5, Q6P9P0, Q6PAC4, Q6PG16, Q711Q0, Q7TP36, Q7TSA6

Diamond homologs: A2VE02, Q5DTX6, Q9P266

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 29 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	5	181.3×	4e-09
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	5	159.9×	4e-09
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	5	159.9×	4e-09
Activation of BH3-only proteins	5	118.2×	2e-08
RHO GTPases activate PKNs	5	75.5×	1e-07
Intrinsic Pathway for Apoptosis	5	69.7×	2e-07
Apoptosis	6	48.0×	7e-08
Programmed Cell Death	6	41.8×	1e-07

GO biological processes:

GO term	Partners	Fold	FDR
intracellular protein localization	5	21.8×	7e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

294 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	247
Likely benign	26
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

1144 predictions. Top by Δscore:

Variant	Effect	Δscore
10:30047867:CAGCA:C	acceptor_gain	0.9900
10:30047872:C:CC	acceptor_gain	0.9900
10:30059475:GACTT:G	donor_loss	0.9900
10:30059476:ACTT:A	donor_loss	0.9900
10:30059477:CTTA:C	donor_loss	0.9900
10:30059478:TTA:T	donor_loss	0.9900
10:30059479:TACCG:T	donor_loss	0.9900
10:30059480:A:AC	donor_gain	0.9900
10:30059480:A:AT	donor_loss	0.9900
10:30059481:C:CC	donor_gain	0.9900
10:30059481:CCGAG:C	donor_gain	0.9900
10:30017847:A:AC	donor_gain	0.9800
10:30017848:A:C	donor_gain	0.9800
10:30029865:ACC:A	acceptor_loss	0.9800
10:30029868:T:C	acceptor_loss	0.9800
10:30047525:AACTT:A	donor_loss	0.9800
10:30047526:ACTTA:A	donor_loss	0.9800
10:30047527:CTT:C	donor_loss	0.9800
10:30047528:TTA:T	donor_loss	0.9800
10:30047529:T:TG	donor_loss	0.9800
10:30047530:A:AC	donor_gain	0.9800
10:30047530:AC:A	donor_gain	0.9800
10:30047531:C:CC	donor_gain	0.9800
10:30047531:C:CG	donor_loss	0.9800
10:30047531:CC:C	donor_gain	0.9800
10:30047531:CCCCG:C	donor_gain	0.9800
10:30047870:CA:C	acceptor_gain	0.9800
10:30035898:G:A	donor_gain	0.9700
10:30047530:ACC:A	donor_gain	0.9700
10:30047530:ACCC:A	donor_gain	0.9700

AlphaMissense

8924 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:30027644:A:G	L835S	0.998
10:30027691:A:C	F819L	0.997
10:30027691:A:T	F819L	0.997
10:30027693:A:G	F819L	0.997
10:30047793:A:G	L7P	0.997
10:30027692:A:G	F819S	0.996
10:30027659:T:G	D830A	0.995
10:30027659:T:A	D830V	0.994
10:30027660:C:G	D830H	0.994
10:30027669:G:T	R827S	0.994
10:30027686:A:G	L821P	0.994
10:30027659:T:C	D830G	0.993
10:30027663:A:G	W829R	0.993
10:30027663:A:T	W829R	0.993
10:30028407:A:G	C581R	0.993
10:30028400:A:T	V583D	0.992
10:30028403:A:G	L582S	0.992
10:30028408:A:C	F580L	0.992
10:30028408:A:T	F580L	0.992
10:30028410:A:G	F580L	0.992
10:30047778:C:T	G12E	0.992
10:30027672:G:T	R826S	0.990
10:30027682:T:A	K822N	0.990
10:30027682:T:G	K822N	0.990
10:30028405:G:C	C581W	0.990
10:30028409:A:G	F580S	0.990
10:30047782:G:C	H11D	0.990
10:30047790:A:G	L8P	0.990
10:30026882:A:G	I1089T	0.989
10:30026891:G:T	A1086D	0.989

dbSNP variants (sampled 300 via entrez): RS1000018922 (10:30036174 T>C), RS1000058756 (10:30066046 A>C), RS1000076251 (10:30034253 A>G), RS1000160907 (10:30084313 T>A,C), RS1000164959 (10:30065573 C>G), RS1000169225 (10:30056655 A>C,G), RS1000192921 (10:30036368 G>T), RS1000215571 (10:30030665 G>A), RS1000236411 (10:30090489 C>T), RS1000274206 (10:30020961 T>C), RS1000317119 (10:30030041 C>G), RS1000327477 (10:30097436 A>G), RS1000381419 (10:30014482 T>C), RS1000382222 (10:30061679 G>A,C,T), RS1000402571 (10:30097167 A>G,T)

Disease associations

OMIM: gene MIM:614398 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

30 associations (top):

Study	Trait	p-value
GCST000875_1	Coronary heart disease	1.000000e-11
GCST000999_3	Coronary heart disease	4.000000e-08
GCST003116_25	Coronary artery disease	4.000000e-11
GCST003117_18	Myocardial infarction	7.000000e-09
GCST003761_8	Emphysema distribution in smoking	4.000000e-08
GCST004185_16	Lung function (FEV1/FVC)	8.000000e-11
GCST004278_4	Pulse pressure	3.000000e-15
GCST004787_45	Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease)	4.000000e-12
GCST005194_38	Coronary artery disease	1.000000e-17
GCST005195_127	Coronary artery disease	2.000000e-17
GCST005196_28	Coronary artery disease	2.000000e-17
GCST005352_20	Paclitaxel disposition in epithelial ovarian cancer	6.000000e-06
GCST005580_193	Intraocular pressure	4.000000e-08
GCST006168_56	Pulse pressure x alcohol consumption interaction (2df test)	1.000000e-12
GCST006168_58	Pulse pressure x alcohol consumption interaction (2df test)	2.000000e-15
GCST006427_46	Depression in smokers	1.000000e-07
GCST006716_12	Alcohol use disorder (total score)	1.000000e-08
GCST007096_72	Pulse pressure	1.000000e-19
GCST007097_112	Pulse pressure	3.000000e-08
GCST007097_113	Pulse pressure	9.000000e-10
GCST007268_39	Diastolic blood pressure	3.000000e-12
GCST007269_185	Pulse pressure	3.000000e-28
GCST007430_115	Peak expiratory flow	1.000000e-10
GCST007431_156	Lung function (FEV1/FVC)	3.000000e-08
GCST010479_13	Coronary artery disease	2.000000e-08
GCST010796_5204	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-09
GCST010796_5205	Electrocardiogram morphology (amplitude at temporal datapoints)	7.000000e-09
GCST010796_5206	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-08
GCST010866_141	Coronary artery disease	6.000000e-15
GCST011365_74	Myocardial infarction	7.000000e-10

EFO canonical traits (9, from GWAS)

EFO ID	Trait name
EFO:0005850	emphysema pattern measurement
EFO:0004713	FEV/FVC ratio
EFO:0005763	pulse pressure measurement
EFO:0004695	intraocular pressure measurement
EFO:0004329	alcohol drinking
EFO:0009458	alcohol use disorder measurement
EFO:0006336	diastolic blood pressure
EFO:0009718	peak expiratory flow
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, increases methylation	7
trichostatin A	increases expression, affects cotreatment	3
Aflatoxin B1	affects expression, increases expression, increases methylation	3
entinostat	increases expression, affects cotreatment	2
Vorinostat	affects cotreatment, increases expression	2
Panobinostat	affects cotreatment, increases expression	2
Benzo(a)pyrene	increases expression, affects methylation, decreases methylation	2
Estradiol	affects cotreatment, increases expression	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
sodium arsenite	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
3-nitrobenzanthrone	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, increases expression	1
NSC 689534	affects binding, decreases expression	1
Sunitinib	increases expression	1
Arsenic	affects methylation	1
Cisplatin	affects cotreatment, increases expression	1
Copper	affects binding, decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Doxorubicin	decreases expression	1
Drugs, Chinese Herbal	decreases expression	1
Nickel	decreases expression	1
Tetrachlorodibenzodioxin	decreases expression, increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.