JMY

Summary

JMY (junction mediating and regulatory protein, p53 cofactor, HGNC:28916) is a protein-coding gene on chromosome 5q14.1, encoding Junction-mediating and -regulatory protein (Q8N9B5). Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions.

Enables microtubule binding activity. Involved in cellular response to starvation. Located in autophagosome membrane; cell leading edge; and cytoplasmic vesicle.

Source: NCBI Gene 133746 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 163 total
• MANE Select transcript: NM_152405

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28916
Approved symbol	JMY
Name	junction mediating and regulatory protein, p53 cofactor
Location	5q14.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ37870, WHAMM2
Ensembl gene	ENSG00000152409
Ensembl biotype	protein_coding
OMIM	604279
Entrez	133746

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000396137, ENST00000412001, ENST00000850851, ENST00000925449, ENST00000925450, ENST00000925451, ENST00000967082, ENST00000967083

RefSeq mRNA: 1 — MANE Select: NM_152405 NM_152405

CCDS: CCDS4047

Canonical transcript exons

ENST00000396137 — 11 exons

Exon	Start	End
ENSE00001005014	79291130	79291299
ENSE00001005016	79300153	79300318
ENSE00001005020	79306375	79306461
ENSE00001005029	79314257	79314851
ENSE00001083544	79290121	79290271
ENSE00001083548	79316000	79316310
ENSE00001083552	79312403	79312498
ENSE00001083553	79300676	79300863
ENSE00001640429	79277910	79278083
ENSE00001837691	79321606	79327211
ENSE00001945884	79236131	79237682

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 98.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.9825 / max 219.2260, expressed in 1712 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57234	11.1575	1704
57235	1.3744	384
57236	0.4505	139

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	98.44	gold quality
sperm	CL:0000019	95.09	gold quality
oocyte	CL:0000023	94.40	gold quality
epithelial cell of pancreas	CL:0000083	93.89	gold quality
Brodmann (1909) area 23	UBERON:0013554	93.89	gold quality
tibialis anterior	UBERON:0001385	93.85	gold quality
cartilage tissue	UBERON:0002418	92.92	gold quality
upper leg skin	UBERON:0004262	92.09	gold quality
secondary oocyte	CL:0000655	91.71	gold quality
visceral pleura	UBERON:0002401	91.08	gold quality
deltoid	UBERON:0001476	91.04	gold quality
skin of hip	UBERON:0001554	90.94	gold quality
mucosa of paranasal sinus	UBERON:0005030	90.94	gold quality
pigmented layer of retina	UBERON:0001782	90.83	gold quality
upper arm skin	UBERON:0004263	90.80	gold quality
epithelium of nasopharynx	UBERON:0001951	90.52	gold quality
parietal pleura	UBERON:0002400	90.46	gold quality
amniotic fluid	UBERON:0000173	90.17	gold quality
gingival epithelium	UBERON:0001949	90.13	gold quality
decidua	UBERON:0002450	89.65	gold quality
tibia	UBERON:0000979	89.37	gold quality
middle temporal gyrus	UBERON:0002771	88.91	gold quality
superficial temporal artery	UBERON:0001614	88.77	gold quality
gingiva	UBERON:0001828	88.52	gold quality
oviduct epithelium	UBERON:0004804	88.22	gold quality
cortical plate	UBERON:0005343	88.09	gold quality
Brodmann (1909) area 46	UBERON:0006483	87.89	gold quality
occipital lobe	UBERON:0002021	87.84	gold quality
primary visual cortex	UBERON:0002436	87.70	gold quality
seminal vesicle	UBERON:0000998	87.59	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.27
E-MTAB-6678	yes	4.81

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

305 targeting JMY, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-33A-5P	99.99	68.62	1055
HSA-MIR-33B-5P	99.99	68.58	1062
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-5696	99.98	72.36	4487

Literature-anchored findings (GeneRIF, showing 12)

• JMY represents a new class of multifunctional actin assembly factor whose activity is regulated, at least in part, by sequestration in the nucleus. (PMID:19287377)
• Data demonstrate a pathway that links the cytoskeleton with the p53 response, and further suggest that the ability of JMY to regulate actin and cadherin is instrumental in coordinating cell motility with the p53 response. (PMID:19897726)
• results establish the interplay between JMY and HIF-1alpha as a new mechanism that controls cell motility under hypoxic stress (PMID:21625218)
• JMY is expressed at high levels in brain tissue, and in various cell lines JMY is predominantly cytoplasmic, with a minor fraction in the nucleus. (PMID:21965285)
• actin assembly regulates nuclear import of JMY in response to DNA damage. (PMID:22262458)
• JMY is related to the severity of AS in Chinese Han patients. (PMID:23758122)
• JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients. (PMID:24069348)
• JMY was expressed in normal tissues and heterogeneously in different tumor types, with close correlation between cytoplasmic and nuclear expression. (PMID:25280461)
• In autophagosomes, the integrity of the WH2 domains allows JMY to promote actin nucleation, which is required for efficient autophagosome formation. (PMID:26223951)
• LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. (PMID:30420355)
• Role of Junction-Mediating and Regulatory Protein in the Pathogenesis of Glucocorticoid-Induced Endothelial Cell Lesions. (PMID:32363797)
• The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis. (PMID:33872315)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	JMY	ENSDARG00000114796
mus_musculus	Jmy	ENSMUSG00000021690
rattus_norvegicus	Jmy	ENSRNOG00000050343

Paralogs (2): PRR11 (ENSG00000068489), WHAMM (ENSG00000156232)

Protein

Protein identifiers

Junction-mediating and -regulatory protein — Q8N9B5 (reviewed: Q8N9B5)

All UniProt accessions (1): Q8N9B5

UniProt curated annotations — full annotation on UniProt →

Function. Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.

Subunit / interactions. Interacts with p300/EP300, the complex activates p53/TP53 transcriptional activity. Interacts with TTC5; the interaction facilitates the association between JMY and p300/EP300. Interacts with MAP1LC3B; the interaction results in the activation of JYM’s nucleation activity in the cytoplasm. Interacts with TTC5/STRAP; the interaction results in the inhibition of JYM’s nucleation activity in the cytoplasm due to competition with MAP1LC3B binding.

Subcellular location. Nucleus. Cytoplasmic vesicle. Cytoplasm. Cytoskeleton. Endomembrane system. Autophagosome membrane.

Post-translational modifications. Ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome. In case of DNA damage, the interaction with MDM2 is altered, preventing degradation and allowing interaction with p300/EP300 and its function in p53/TP53 stress response.

Domain organisation. The N-terminal region is involved in actin binding and actin nucleation activity.

Induction. By E2F.

Similarity. Belongs to the JMY family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N9B5-1	1	yes
Q8N9B5-2	2

RefSeq proteins (1): NP_689618* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003124	WH2_dom	Domain
IPR031738	JMY/WHAMM	Domain
IPR031808	JMY/WHAMM_N	Domain

Pfam: PF15871, PF15920

UniProt features (26 total): compositionally biased region 6, region of interest 6, modified residue 5, coiled-coil region 3, sequence variant 3, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N9B5-F1	66.96	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 115, 121, 713, 888, 974

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-6804760	Regulation of TP53 Activity through Methylation
R-HSA-212436	Generic Transcription Pathway
R-HSA-3700989	Transcriptional Regulation by TP53
R-HSA-5633007	Regulation of TP53 Activity
R-HSA-73857	RNA Polymerase II Transcription
R-HSA-74160	Gene expression (Transcription)

MSigDB gene sets: 215 (showing top): GOCC_VACUOLAR_MEMBRANE, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GOBP_APOPTOTIC_SIGNALING_PATHWAY, GOBP_ACTIN_FILAMENT_ORGANIZATION, GOBP_DNA_DAMAGE_RESPONSE, LIAO_METASTASIS, GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY, GOBP_SIGNAL_TRANSDUCTION_BY_P53_CLASS_MEDIATOR, PID_P53_DOWNSTREAM_PATHWAY, GOBP_CELLULAR_RESPONSE_TO_STARVATION, GOMF_ACTIN_BINDING, SEMBA_FHIT_TARGETS_UP, GOBP_INTRINSIC_APOPTOTIC_SIGNALING_PATHWAY_BY_P53_CLASS_MEDIATOR, GOBP_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION, GOBP_ACTIN_NUCLEATION

GO Biological Process (10): DNA repair (GO:0006281), regulation of transcription by RNA polymerase II (GO:0006357), cellular response to starvation (GO:0009267), Arp2/3 complex-mediated actin nucleation (GO:0034314), positive regulation of apoptotic process (GO:0043065), ‘de novo’ actin filament nucleation (GO:0070060), actin polymerization-dependent cell motility (GO:0070358), intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332), DNA damage response (GO:0006974), positive regulation of DNA-templated transcription (GO:0045893)

GO Molecular Function (5): transcription coactivator activity (GO:0003713), actin binding (GO:0003779), microtubule binding (GO:0008017), Arp2/3 complex binding (GO:0071933), protein binding (GO:0005515)

GO Cellular Component (9): autophagosome membrane (GO:0000421), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), endomembrane system (GO:0012505), cell leading edge (GO:0031252), cytoplasmic vesicle (GO:0031410), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Regulation of TP53 Activity	1
RNA Polymerase II Transcription	1
Generic Transcription Pathway	1
Transcriptional Regulation by TP53	1
Gene expression (Transcription)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
regulation of DNA-templated transcription	2
cellular response to stress	2
actin nucleation	2
DNA metabolic process	1
DNA damage response	1
transcription by RNA polymerase II	1
cellular response to nutrient levels	1
response to starvation	1
apoptotic process	1
regulation of apoptotic process	1
positive regulation of programmed cell death	1
cell motility	1
signal transduction by p53 class mediator	1
intrinsic apoptotic signaling pathway	1
DNA-templated transcription	1
positive regulation of RNA biosynthetic process	1
transcription coregulator activity	1
positive regulation of DNA-templated transcription	1
cytoskeletal protein binding	1
tubulin binding	1
protein-containing complex binding	1
binding	1
vacuolar membrane	1
autophagosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
intracellular anatomical structure	1
intracellular membraneless organelle	1
vacuole	1
plasma membrane	1
cytoplasm	1
intracellular vesicle	1

Protein interactions and networks

STRING

1051 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
JMY	EP300	Q09472	956
JMY	TP53	P04637	844
JMY	WAS	P42768	823
JMY	WASF1	Q92558	799
JMY	GOLGA2	Q08379	594
JMY	COBL	O75128	593
JMY	WASF2	Q9Y6W5	573
JMY	SPIRE2	Q8WWL2	564
JMY	SPIRE1	Q08AE8	548
JMY	TTC5	Q8N0Z6	544
JMY	FMN2	Q9NZ56	538
JMY	LMOD2	Q6P5Q4	525
JMY	LMOD3	Q0VAK6	498
JMY	PFN4	Q8NHR9	470
JMY	LMOD1	P29536	464

IntAct

24 interactions, top by confidence:

A	B	Type	Score
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
AFF4	ELL2	psi-mi:“MI:0914”(association)	0.730
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.640
PTGR3	DBT	psi-mi:“MI:0914”(association)	0.640
VAPA	PITPNM1	psi-mi:“MI:0914”(association)	0.640
PPP1R1A	ACTA1	psi-mi:“MI:0914”(association)	0.530
JMY	MDM2	psi-mi:“MI:0915”(physical association)	0.400
MDM2	JMY	psi-mi:“MI:0915”(physical association)	0.400
JMY	HSPE1	psi-mi:“MI:0915”(physical association)	0.400
JMY	SERPINH1	psi-mi:“MI:0915”(physical association)	0.400
TP53	JMY	psi-mi:“MI:0915”(physical association)	0.400
MAB21L2	PTBP1	psi-mi:“MI:0914”(association)	0.350
BMI1	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
CDKN3	CST8	psi-mi:“MI:0914”(association)	0.350
USP51	GSTA1	psi-mi:“MI:0914”(association)	0.350
MAK16	MAGEB2	psi-mi:“MI:0914”(association)	0.350
ZNF398	DCTN3	psi-mi:“MI:0914”(association)	0.350
GKN1	TMOD1	psi-mi:“MI:0914”(association)	0.350
CPNE4	JMY	psi-mi:“MI:0914”(association)	0.350
CEP63	JMY	psi-mi:“MI:0915”(physical association)	0.000
CDC5L	JMY	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (55): JMY (Two-hybrid), JMY (Affinity Capture-MS), JMY (Affinity Capture-MS), JMY (Two-hybrid), JMY (Affinity Capture-MS), JMY (Affinity Capture-MS), JMY (Affinity Capture-MS), JMY (Affinity Capture-MS), JMY (Affinity Capture-MS), TTC5 (Two-hybrid), JMY (Affinity Capture-Western), JMY (Affinity Capture-Western), JMY (Affinity Capture-RNA), JMY (Affinity Capture-Western), JMY (Reconstituted Complex)

ESM2 similar proteins: A1A4V9, A2A8U2, A4IFI1, A8E4X8, B0BMZ6, F1R7R1, G5E8P0, O75161, P12755, P59017, P59240, P85299, P97432, Q14DQ1, Q2HJA5, Q3B7M3, Q3U0L2, Q3ZBK7, Q3ZK22, Q53GS7, Q569K6, Q58DT5, Q5FVG6, Q5RAS2, Q5SNT2, Q5T7N3, Q5XI52, Q60698, Q6NZQ0, Q80U62, Q812A5, Q8C0R7, Q8C190, Q8CC12, Q8IWY9, Q8IYY4, Q8N9B5, Q8NFW9, Q8R1F1, Q8R322

Diamond homologs: A8E4X8, Q1A5X7, Q571B6, Q6NVC9, Q8N9B5, Q8TF30, Q9QXM1

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
JMY	“up-regulates activity”	ARP2/3	binding
TTC5	“up-regulates activity”	JMY	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

163 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	142
Likely benign	4
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

2342 predictions. Top by Δscore:

Variant	Effect	Δscore
5:79237679:GGAG:G	donor_gain	1.0000
5:79237680:GAG:G	donor_gain	1.0000
5:79237680:GAGG:G	donor_gain	1.0000
5:79237682:GGT:G	donor_loss	1.0000
5:79237683:G:GG	donor_gain	1.0000
5:79237684:T:G	donor_loss	1.0000
5:79277907:C:G	acceptor_gain	1.0000
5:79277908:A:AG	acceptor_gain	1.0000
5:79277908:AGCTC:A	acceptor_loss	1.0000
5:79277909:G:GT	acceptor_gain	1.0000
5:79277909:GC:G	acceptor_gain	1.0000
5:79277909:GCT:G	acceptor_gain	1.0000
5:79277909:GCTC:G	acceptor_gain	1.0000
5:79277909:GCTCT:G	acceptor_gain	1.0000
5:79278080:CAAG:C	donor_loss	1.0000
5:79278082:AGG:A	donor_loss	1.0000
5:79278083:GGT:G	donor_loss	1.0000
5:79278084:G:A	donor_loss	1.0000
5:79278085:T:A	donor_loss	1.0000
5:79290116:T:A	acceptor_gain	1.0000
5:79290116:TGAA:T	acceptor_loss	1.0000
5:79290116:TGAAG:T	acceptor_gain	1.0000
5:79290117:GAAG:G	acceptor_loss	1.0000
5:79290117:GAAGA:G	acceptor_gain	1.0000
5:79290119:A:AG	acceptor_gain	1.0000
5:79290120:G:GA	acceptor_gain	1.0000
5:79290120:GA:G	acceptor_gain	1.0000
5:79290120:GAT:G	acceptor_gain	1.0000
5:79290120:GATT:G	acceptor_gain	1.0000
5:79290120:GATTT:G	acceptor_gain	1.0000

AlphaMissense

6413 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:79236736:T:C	F29S	1.000
5:79236742:T:C	F31S	1.000
5:79236775:T:C	F42S	1.000
5:79236781:T:A	I44K	1.000
5:79236786:T:C	C46R	1.000
5:79236788:C:G	C46W	1.000
5:79236789:C:G	H47D	1.000
5:79237363:T:C	L238P	1.000
5:79237384:T:C	L245P	1.000
5:79237578:T:C	F310L	1.000
5:79237580:C:A	F310L	1.000
5:79237580:C:G	F310L	1.000
5:79237605:T:C	Y319H	1.000
5:79237627:T:C	L326P	1.000
5:79277950:T:C	L358P	1.000
5:79278013:T:C	L379P	1.000
5:79278028:T:C	L384P	1.000
5:79278034:C:A	P386Q	1.000
5:79278040:G:C	R388P	1.000
5:79278049:G:C	R391T	1.000
5:79278049:G:T	R391I	1.000
5:79278050:A:C	R391S	1.000
5:79278050:A:T	R391S	1.000
5:79278055:T:C	L393P	1.000
5:79278057:G:C	A394P	1.000
5:79278058:C:A	A394D	1.000
5:79278064:T:C	L396P	1.000
5:79290146:G:A	G411E	1.000
5:79290167:T:C	L418P	1.000
5:79290187:T:A	W425R	1.000

dbSNP variants (sampled 300 via entrez): RS1000016266 (5:79247138 A>C,G), RS1000142913 (5:79296422 G>A), RS1000154019 (5:79262896 G>T), RS1000203913 (5:79311094 T>C), RS1000251495 (5:79289559 C>G,T), RS1000268997 (5:79263203 A>G), RS1000394236 (5:79238173 G>C), RS1000401047 (5:79309424 T>C), RS1000410922 (5:79309903 C>T), RS1000419987 (5:79256799 G>A), RS1000422544 (5:79279903 G>A), RS1000464863 (5:79262794 C>A), RS1000473801 (5:79268230 G>C), RS1000488076 (5:79279699 AC>A), RS1000494877 (5:79324282 A>G)

Disease associations

OMIM: gene MIM:604279 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST002670_10	Blood and toenail selenium levels	8.000000e-20
GCST002670_2	Blood and toenail selenium levels	6.000000e-11
GCST002670_3	Blood and toenail selenium levels	4.000000e-12
GCST002671_16	Toenail selenium levels	5.000000e-06
GCST002671_6	Toenail selenium levels	2.000000e-11
GCST002671_7	Toenail selenium levels	1.000000e-07
GCST011681_5	Cryptococcosis in HIV infection	7.000000e-06
GCST90002401_167	Platelet distribution width	1.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007984	platelet component distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

78 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	6
Cyclosporine	increases expression	4
Estradiol	increases expression	3
arsenite	increases expression, affects binding, decreases reaction, increases abundance	2
Testosterone	affects cotreatment, increases expression, decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
GSK-J4	increases expression	1
afuresertib	increases expression	1
FR900359	affects phosphorylation	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
sodium arsenate	increases abundance, increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
monomethylarsonic acid	increases expression	1
zinc chromate	increases abundance, increases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
arsenic acid	increases abundance, increases expression	1
didecyldimethylammonium	increases expression	1
2,3-bis(3’-hydroxybenzyl)butyrolactone	affects cotreatment, decreases expression	1
resorcinol	decreases expression	1
avobenzone	increases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	increases abundance, increases expression	1
perfluorooctane sulfonic acid	increases expression	1
pentabromodiphenyl ether	increases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	increases expression	1
monomethylarsonous acid	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_ST80	HAP1 JMY (-) 1	Cancer cell line	Male
CVCL_ST81	HAP1 JMY (-) 2	Cancer cell line	Male
CVCL_ST82	HAP1 JMY (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.