JPX

Summary

JPX (JPX transcript, XIST activator, HGNC:37191) is a long non-coding RNA gene on chromosome Xq13.2.

JPX is a nonprotein-coding RNA transcribed from a gene within the X-inactivation center (XIC; MIM 314670) that appears to participate in X chromosome inactivation (Tian et al., 2010 [PubMed 21029862]).

Source: NCBI Gene 554203 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37191
Approved symbol	JPX
Name	JPX transcript, XIST activator
Location	Xq13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	ENOX, LINC00183, DCBALD06
Ensembl gene	ENSG00000225470
Ensembl biotype	lncRNA
OMIM	300832
Entrez	554203
RNAcentral	URS000075CF99 — lncRNA, 1696 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 124 — 124 lncRNA

ENST00000414209, ENST00000415215, ENST00000453317, ENST00000602294, ENST00000602546, ENST00000602737, ENST00000602772, ENST00000602895, ENST00000602920, ENST00000602938, ENST00000602985, ENST00000639185, ENST00000640437, ENST00000653069, ENST00000653479, ENST00000653808, ENST00000653885, ENST00000653929, ENST00000654005, ENST00000654137, ENST00000654196, ENST00000654374, ENST00000654995, ENST00000655090, ENST00000655879, ENST00000655994, ENST00000656263, ENST00000656509, ENST00000656624, ENST00000657096, ENST00000657179, ENST00000657372, ENST00000657638, ENST00000657910, ENST00000658649, ENST00000659023, ENST00000659254, ENST00000659373, ENST00000659622, ENST00000659849, ENST00000659852, ENST00000660087, ENST00000660546, ENST00000660836, ENST00000660840, ENST00000660856, ENST00000661130, ENST00000661546, ENST00000662120, ENST00000662239, ENST00000662543, ENST00000663027, ENST00000663470, ENST00000664295, ENST00000664328, ENST00000664637, ENST00000665032, ENST00000665345, ENST00000666059, ENST00000666318, ENST00000666493, ENST00000667057, ENST00000667294, ENST00000667573, ENST00000667645, ENST00000667886, ENST00000667937, ENST00000668488, ENST00000668590, ENST00000669149, ENST00000669168, ENST00000670192, ENST00000670408, ENST00000670464, ENST00000670503, ENST00000670506, ENST00000670685, ENST00000670805, ENST00000670994, ENST00000671021, ENST00000671207, ENST00000671336, ENST00000671476, ENST00000671518, ENST00000698366, ENST00000805217, ENST00000805218, ENST00000805219, ENST00000805220, ENST00000805221, ENST00000805222, ENST00000805223, ENST00000805224, ENST00000805225, ENST00000805226, ENST00000805227, ENST00000805228, ENST00000805229, ENST00000805230, ENST00000805231, ENST00000805232, ENST00000805233, ENST00000805234, ENST00000805235, ENST00000805236, ENST00000805237, ENST00000805238, ENST00000805239, ENST00000805240, ENST00000805241, ENST00000805242, ENST00000805243, ENST00000805244, ENST00000805245, ENST00000805246, ENST00000805247, ENST00000805248, ENST00000805249, ENST00000805250, ENST00000805251, ENST00000805252, ENST00000805253, ENST00000805254, ENST00000805255

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000414209 — 5 exons

Exon	Start	End
ENSE00001630952	73944584	73944662
ENSE00001719406	73998768	73998844
ENSE00001726933	73998954	74000495
ENSE00003856024	73962731	73962801
ENSE00003887134	73944325	73944465

Expression profiles

Bgee: expression breadth ubiquitous, 246 present calls, max score 95.60.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 38.4294 / max 502.3765, expressed in 1812 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
196751	31.8326	1808
196750	6.5118	1719
196749	0.0851	27

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	95.60	gold quality
calcaneal tendon	UBERON:0003701	94.30	gold quality
right uterine tube	UBERON:0001302	93.32	gold quality
adrenal tissue	UBERON:0018303	93.20	gold quality
bone marrow cell	CL:0002092	92.40	gold quality
adenohypophysis	UBERON:0002196	92.12	gold quality
medial globus pallidus	UBERON:0002477	91.90	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.87	gold quality
pituitary gland	UBERON:0000007	91.38	gold quality
lower esophagus mucosa	UBERON:0035834	91.28	gold quality
left ovary	UBERON:0002119	91.15	gold quality
spinal cord	UBERON:0002240	90.66	gold quality
corpus callosum	UBERON:0002336	90.58	gold quality
right ovary	UBERON:0002118	90.53	gold quality
tendon	UBERON:0000043	90.48	gold quality
body of uterus	UBERON:0009853	90.24	gold quality
buccal mucosa cell	CL:0002336	90.15	gold quality
uterine cervix	UBERON:0000002	90.08	gold quality
globus pallidus	UBERON:0001875	90.07	gold quality
sural nerve	UBERON:0015488	90.02	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	89.82	gold quality
right lobe of liver	UBERON:0001114	89.81	gold quality
endocervix	UBERON:0000458	89.42	gold quality
amygdala	UBERON:0001876	89.29	gold quality
ventricular zone	UBERON:0003053	89.20	gold quality
left lobe of thyroid gland	UBERON:0001120	89.17	gold quality
left uterine tube	UBERON:0001303	89.06	gold quality
thyroid gland	UBERON:0002046	89.05	gold quality
putamen	UBERON:0001874	89.00	gold quality
right lobe of thyroid gland	UBERON:0001119	88.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• JPX and XIST play a suppressive role in HCC[hepatocellular carcinoma]. JPX increases expression levels of XIST in HCC[hepatocellular carcinoma] cells, which suppresses HCC [hepatocellular carcinoma] development by sponging the cancer promoting miR-155-5p. (PMID:30091314)
• Long noncoding RNA JPX promotes ovarian tumor cell proliferation, invasion and migration and inhibits cell apoptosis by activating PI3K/Akt/mTOR signaling pathway. (PMID:30556851)
• Long non-coding RNA JPX correlates with poor prognosis and tumor progression in non-small-cell lung cancer by interacting with miR-145-5p and CCND2. (PMID:31253987)
• We find that human JPX and its mouse homolog, lncRNA Jpx, have deep divergence in their nucleotide sequences and RNA secondary structures. Despite such differences, both lncRNAs demonstrate robust binding to CTCF, a protein that is central to Jpx’s role in X chromosome inactivation (PMID:31518612)
• LncRNA JPX overexpressed in oral squamous cell carcinoma drives malignancy via miR-944/CDH2 axis. (PMID:32881231)
• Long noncoding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR197. (PMID:33215222)
• LncRNA JPX regulates proliferation and apoptosis of nucleus pulposus cells by targeting the miR-18a-5p/HIF-1alpha/Hippo-YAP pathway. (PMID:34111667)
• Long noncoding RNA just proximal to X-inactive specific transcript facilitates aerobic glycolysis and temozolomide chemoresistance by promoting stability of PDK1 mRNA in an m6A-dependent manner in glioblastoma multiforme cells. (PMID:34390075)
• LncRNA JPX contributes to Treg/Th17 imbalance in allergic rhinitis via targeting the miR-378g/CCL5 axis. (PMID:35387544)
• Expression profiling of cancer-related long non-coding RNAs revealed upregulation and biomarker potential of HAR1B and JPX in colorectal cancer. (PMID:35526243)
• Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers. (PMID:37027401)
• The beta-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance. (PMID:37106379)
• lncRNA JPX Promotes Tumor Progression by Interacting with and Destabilizing YTHDF2 in Cutaneous Melanoma. (PMID:38441563)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.