KBTBD11-OT1

Summary

KBTBD11-OT1 (KBTBD11 overlapping transcript 1, HGNC:49147) is a long non-coding RNA gene on chromosome 8p23.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49147
Approved symbol	KBTBD11-OT1
Name	KBTBD11 overlapping transcript 1
Location	8p23.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000253696
Ensembl biotype	lncRNA
Entrez	104266957
RNAcentral	URS00007E35B5 — lncRNA, 781 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000518539, ENST00000832958, ENST00000832959, ENST00000832960, ENST00000832961, ENST00000832962, ENST00000832963, ENST00000832964, ENST00000832965, ENST00000832966, ENST00000832967, ENST00000832968, ENST00000832969, ENST00000832970

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000518539 — 3 exons

Exon	Start	End
ENSE00002132875	1971925	1972037
ENSE00002138175	1975899	1976478
ENSE00004249004	1971329	1971518

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 93.13.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0660 / max 23.5303, expressed in 22 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
87193	0.0579	21
87194	0.0081	1

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.13	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.08	gold quality
mucosa of transverse colon	UBERON:0004991	78.20	gold quality
duodenum	UBERON:0002114	71.98	gold quality
cortical plate	UBERON:0005343	69.01	gold quality
ganglionic eminence	UBERON:0004023	68.94	gold quality
small intestine	UBERON:0002108	65.85	gold quality
ventricular zone	UBERON:0003053	65.12	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.06	gold quality
transverse colon	UBERON:0001157	62.55	gold quality
skeletal muscle tissue	UBERON:0001134	62.36	gold quality
cerebellar hemisphere	UBERON:0002245	62.19	gold quality
cerebellum	UBERON:0002037	62.05	gold quality
cerebellar cortex	UBERON:0002129	62.02	gold quality
adult mammalian kidney	UBERON:0000082	61.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.49	gold quality
right lobe of liver	UBERON:0001114	61.40	gold quality
rectum	UBERON:0001052	61.30	gold quality
liver	UBERON:0002107	60.72	gold quality
adrenal tissue	UBERON:0018303	60.54	gold quality
kidney	UBERON:0002113	59.68	gold quality
metanephros cortex	UBERON:0010533	59.54	gold quality
intestine	UBERON:0000160	59.41	gold quality
left adrenal gland cortex	UBERON:0035825	59.24	gold quality
hindlimb stylopod muscle	UBERON:0004252	59.15	gold quality
right adrenal gland cortex	UBERON:0035827	59.12	gold quality
anterior cingulate cortex	UBERON:0009835	58.87	gold quality
prefrontal cortex	UBERON:0000451	58.30	gold quality
superior frontal gyrus	UBERON:0002661	57.95	gold quality
adrenal gland	UBERON:0002369	57.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.38

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.