KBTBD4

Summary

KBTBD4 (kelch repeat and BTB domain containing 4, HGNC:23761) is a protein-coding gene on chromosome 11p11.2, encoding Kelch repeat and BTB domain-containing protein 4 (Q9NVX7). Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex which targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation.

At a glance

• GWAS associations: 17
• Clinical variants (ClinVar): 78 total
• MANE Select transcript: NM_018095

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23761
Approved symbol	KBTBD4
Name	kelch repeat and BTB domain containing 4
Location	11p11.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10450, HSPC252
Ensembl gene	ENSG00000123444
Ensembl biotype	protein_coding
OMIM	617645
Entrez	55709

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 11 protein_coding, 1 nonsense_mediated_decay

ENST00000395288, ENST00000430070, ENST00000525720, ENST00000526005, ENST00000529499, ENST00000529946, ENST00000530668, ENST00000531067, ENST00000533290, ENST00000534239, ENST00000915129, ENST00000962990

RefSeq mRNA: 12 — MANE Select: NM_018095 NM_001318716, NM_001318717, NM_001318718, NM_001318719, NM_001318720, NM_001318721, NM_001318722, NM_001318723, NM_001318724, NM_001318725, NM_016506, NM_018095

CCDS: CCDS44594, CCDS7940, CCDS81566

Canonical transcript exons

ENST00000430070 — 4 exons

Exon	Start	End
ENSE00000989210	47575593	47575699
ENSE00001521224	47572197	47573790
ENSE00002250647	47578933	47578970
ENSE00003539158	47577411	47578028

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 91.04.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.4133 / max 33.9493, expressed in 1633 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119640	4.4133	1633

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	91.04	gold quality
cortical plate	UBERON:0005343	89.54	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.59	gold quality
muscle of leg	UBERON:0001383	86.53	gold quality
gastrocnemius	UBERON:0001388	86.42	gold quality
ganglionic eminence	UBERON:0004023	85.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.86	gold quality
skeletal muscle tissue	UBERON:0001134	84.75	gold quality
ventricular zone	UBERON:0003053	84.59	gold quality
prefrontal cortex	UBERON:0000451	84.07	gold quality
smooth muscle tissue	UBERON:0001135	83.89	gold quality
stromal cell of endometrium	CL:0002255	83.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.32	gold quality
fallopian tube	UBERON:0003889	82.94	gold quality
bone marrow	UBERON:0002371	82.76	gold quality
cerebellum	UBERON:0002037	82.43	gold quality
cerebellar cortex	UBERON:0002129	82.31	gold quality
superior frontal gyrus	UBERON:0002661	82.31	gold quality
cerebellar hemisphere	UBERON:0002245	82.30	gold quality
right adrenal gland	UBERON:0001233	82.26	gold quality
frontal cortex	UBERON:0001870	82.26	gold quality
blood	UBERON:0000178	82.24	gold quality
right adrenal gland cortex	UBERON:0035827	82.21	gold quality
calcaneal tendon	UBERON:0003701	82.14	gold quality
right hemisphere of cerebellum	UBERON:0014890	82.07	gold quality
lymph node	UBERON:0000029	81.94	gold quality
muscle tissue	UBERON:0002385	81.78	gold quality
left adrenal gland	UBERON:0001234	81.74	gold quality
bone marrow cell	CL:0002092	81.68	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-CURD-10	no	62.27
E-ANND-3	no	2.22

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

57 targeting KBTBD4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-3134	100.00	66.43	777
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6505-5P	99.73	69.25	1595
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-3660	99.68	67.33	1149
HSA-MIR-4526	99.68	67.07	1136

Literature-anchored findings (GeneRIF, showing 3)

• Our findings suggest that KBTBD4 mutations are uncommon in Brazilian MBGRP3 and MBGRP4 medulloblastomas subgroups. (PMID:31403685)
• Role of proliferative marker index and KBTBD4 mutation in the pathological diagnosis of pineal parenchymal tumors. (PMID:35000018)
• Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation. (PMID:35379950)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	kbtbd4	ENSDARG00000069271
mus_musculus	Kbtbd4	ENSMUSG00000005505
rattus_norvegicus	Kbtbd4	ENSRNOG00000009397
drosophila_melanogaster	BTBD9	FBGN0030228
drosophila_melanogaster	CG17068	FBGN0031098
drosophila_melanogaster	lute	FBGN0262871
caenorhabditis_elegans		WBGENE00015463

Paralogs (11): BTBD1 (ENSG00000064726), ABTB1 (ENSG00000114626), SPOP (ENSG00000121067), BTBD3 (ENSG00000132640), BTBD2 (ENSG00000133243), SPOPL (ENSG00000144228), ABTB3 (ENSG00000151136), ABTB2 (ENSG00000166016), KLHL11 (ENSG00000178502), BTBD9 (ENSG00000183826), BTBD6 (ENSG00000184887)

Protein

Protein identifiers

Kelch repeat and BTB domain-containing protein 4 — Q9NVX7 (reviewed: Q9NVX7)

Alternative names: BTB and kelch domain-containing protein 4

All UniProt accessions (7): E9PJ66, E9PJY1, E9PL18, E9PM58, Q9NVX7, E9PQ38, E9PSA4

UniProt curated annotations — full annotation on UniProt →

Function. Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex which targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation. RCOR1 is likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1. Also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1. Degradation is dependent on the presence of an ELM2 domain in the target proteins.

Subunit / interactions. Component of the BCR(KBTBD4) E3 ubiquitin ligase complex, at least composed of CUL3, KBTBD4 and RBX1.

Miscellaneous. As part of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, mediates the effects of the small molecule UM171 in enhancing hematopoietic stem and progenitor cell expansion ex vivo by specifically targeting the CoREST repressor complex for proteasomal degradation.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NVX7-2	1	yes
Q9NVX7-1	2
Q9NVX7-3	3

RefSeq proteins (12): NP_001305645, NP_001305646, NP_001305647, NP_001305648, NP_001305649, NP_001305650, NP_001305651, NP_001305652, NP_001305653, NP_001305654, NP_057590, NP_060565* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000210	BTB/POZ_dom	Domain
IPR011333	SKP1/BTB/POZ_sf	Homologous_superfamily
IPR011498	Kelch_2	Repeat
IPR011705	BACK	Domain
IPR015915	Kelch-typ_b-propeller	Homologous_superfamily
IPR017096	BTB-kelch_protein	Family
IPR042884	KBTBD4	Family
IPR042949	KBTBD4_BTB_POZ	Domain
IPR042950	KBTBD4_BACK	Domain

Pfam: PF00651, PF07646, PF07707

UniProt features (83 total): strand 36, helix 18, turn 11, sequence conflict 6, repeat 5, domain 2, splice variant 2, chain 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

10 structures.

PDB	Method	Resolution (Å)
9GGM	ELECTRON MICROSCOPY	2.71
9DTQ	ELECTRON MICROSCOPY	2.87
9GGN	ELECTRON MICROSCOPY	2.9
9GGL	ELECTRON MICROSCOPY	3.13
8VPQ	ELECTRON MICROSCOPY	3.3
9I2C	ELECTRON MICROSCOPY	3.3
8VRT	ELECTRON MICROSCOPY	3.42
8VOJ	ELECTRON MICROSCOPY	3.77
9DTG	ELECTRON MICROSCOPY	3.83
2EQX	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NVX7-F1	78.20	0.42

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 137 (showing top): TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, CACCAGC_MIR138, WANG_LMO4_TARGETS_DN, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, GTCAGGA_MIR378, GOBP_PROTEIN_CATABOLIC_PROCESS, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, GOCC_TRANSFERASE_COMPLEX, GAL_LEUKEMIC_STEM_CELL_UP, LIU_SOX4_TARGETS_UP, GOBP_PROTEOLYSIS, GOCC_CULLIN_RING_UBIQUITIN_LIGASE_COMPLEX, GOCC_CUL3_RING_UBIQUITIN_LIGASE_COMPLEX, MGGAAGTG_GABP_B

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

568 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KBTBD4	PRDM6	Q9NQX0	622
KBTBD4	ZMYM3	Q14202	513
KBTBD4	SNCAIP	Q9Y6H5	464
KBTBD4	PTPMT1	Q8WUK0	461
KBTBD4	MBLAC1	A4D2B0	456
KBTBD4	RBM26	Q5T8P6	449
KBTBD4	MTCH2	Q9Y6C9	440
KBTBD4	ZC3H6	P61129	425
KBTBD4	GFI1B	Q5VTD9	418
KBTBD4	ATOSA	Q32MH5	415
KBTBD4	NDUFS3	O75489	388
KBTBD4	GFI1	Q99684	367
KBTBD4	ISG20L2	Q9H9L3	363
KBTBD4	KDM6A	O15550	349
KBTBD4	NDUFAF3	Q9BU61	342

IntAct

20 interactions, top by confidence:

A	B	Type	Score
CUL3	RHOBTB1	psi-mi:“MI:0914”(association)	0.530
KBTBD4	KPNA5	psi-mi:“MI:0914”(association)	0.530
CUL3	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
BCL6	CUL1	psi-mi:“MI:0914”(association)	0.530
HSP90AB1	KBTBD4	psi-mi:“MI:0915”(physical association)	0.400
COPS5	FBLL1	psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
MPG	ELP1	psi-mi:“MI:0914”(association)	0.350
	FUCA1	psi-mi:“MI:0914”(association)	0.350
CUL3	ZBTB24	psi-mi:“MI:0914”(association)	0.350
FBXL17	ENC1	psi-mi:“MI:0914”(association)	0.350
KLHL14	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
MPP3	KBTBD4	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (353): KBTBD4 (Affinity Capture-MS), KBTBD4 (Reconstituted Complex), CACUL1 (Affinity Capture-MS), KBTBD4 (Affinity Capture-MS), DDX11 (Affinity Capture-MS), CUL3 (Affinity Capture-MS), PEX6 (Affinity Capture-MS), NUDCD3 (Affinity Capture-MS), CCT2 (Affinity Capture-MS), PI4K2B (Affinity Capture-MS), KPNA6 (Affinity Capture-MS), KPNA5 (Affinity Capture-MS), LZTR1 (Affinity Capture-MS), HSPA8 (Affinity Capture-MS), TCP1 (Affinity Capture-MS)

ESM2 similar proteins: A0A1B8YAB1, B1H285, B3DIV9, E9QIN8, E9QJ30, F1QEG2, O88879, Q08CL3, Q08CY1, Q0D2A9, Q13939, Q28068, Q3UQV5, Q3ZCT8, Q503R4, Q5F3N5, Q5R4S6, Q5R663, Q5RG82, Q5XHZ6, Q5XI58, Q5ZI33, Q69ZK5, Q6DFF7, Q6DFU2, Q6Q7X9, Q6V595, Q7ZVQ8, Q86V97, Q8BHI4, Q8BUL5, Q8BWA5, Q8CA72, Q8CDE2, Q8CE33, Q8IXQ5, Q8NAB2, Q8NFY9, Q8R179, Q8WVZ9

Diamond homologs: A0A072VIM5, A0A0K0PU92, A2CIR7, E7BQV0, G3LSH3, G8GTN7, Q05823, Q0JJ01, Q2HW56, Q2QXZ2, Q2RAQ5, Q5D0W8, Q5ICL9, Q5R4S6, Q75HA6, Q8L746, Q8R179, Q9FDY4, Q9M1I7, Q9N010, Q9NVX7, Q9ZVC2, S4VGD0, A0JN76, A1L4W5, A2AAX3, B1WBS3, B2RXF5, B7U179, D3YUB6, D3ZA50, O14867, O15062, O43167, P0DMR5, P0DMR6, P41182, P41183, P97303, Q0IJ29

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 19 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
protein ubiquitination	5	12.2×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

78 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

583 predictions. Top by Δscore:

Variant	Effect	Δscore
11:47573787:TTTC:T	acceptor_gain	1.0000
11:47573787:TTTCC:T	acceptor_loss	1.0000
11:47573788:TTCC:T	acceptor_loss	1.0000
11:47575587:CCTTA:C	donor_loss	1.0000
11:47575588:CTTA:C	donor_loss	1.0000
11:47575589:TTAC:T	donor_loss	1.0000
11:47575590:TA:T	donor_loss	1.0000
11:47575591:A:AC	donor_gain	1.0000
11:47575592:C:CC	donor_gain	1.0000
11:47575592:CCTT:C	donor_gain	1.0000
11:47575696:CCAT:C	acceptor_gain	1.0000
11:47575697:CAT:C	acceptor_gain	1.0000
11:47575697:CATC:C	acceptor_gain	1.0000
11:47575698:ATCTG:A	acceptor_loss	1.0000
11:47575699:TCTGT:T	acceptor_loss	1.0000
11:47575700:C:CC	acceptor_gain	1.0000
11:47575700:C:CG	acceptor_loss	1.0000
11:47575710:C:CT	acceptor_gain	1.0000
11:47575710:C:T	acceptor_gain	1.0000
11:47575711:A:T	acceptor_gain	1.0000
11:47577406:CTTA:C	donor_loss	1.0000
11:47577408:TA:T	donor_loss	1.0000
11:47577409:A:AC	donor_gain	1.0000
11:47577409:AC:A	donor_gain	1.0000
11:47577409:ACCCG:A	donor_loss	1.0000
11:47577410:C:CC	donor_gain	1.0000
11:47577410:CC:C	donor_gain	1.0000
11:47573788:TTC:T	acceptor_gain	0.9900
11:47573791:C:CC	acceptor_gain	0.9900
11:47573792:T:G	acceptor_loss	0.9900

AlphaMissense

3491 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:47573415:A:G	W358R	1.000
11:47573415:A:T	W358R	1.000
11:47573413:C:A	W358C	0.999
11:47573413:C:G	W358C	0.999
11:47573414:C:G	W358S	0.999
11:47573436:A:C	Y351D	0.999
11:47573490:A:C	Y333D	0.999
11:47573534:C:G	R318P	0.999
11:47573563:C:A	W308C	0.999
11:47573563:C:G	W308C	0.999
11:47573565:A:G	W308R	0.999
11:47573565:A:T	W308R	0.999
11:47573615:C:A	G291V	0.999
11:47573615:C:T	G291E	0.999
11:47573625:A:C	Y288D	0.999
11:47575655:A:G	W212R	0.999
11:47575655:A:T	W212R	0.999
11:47577539:G:T	A154E	0.999
11:47577540:C:G	A154P	0.999
11:47577620:A:G	L127P	0.999
11:47577779:A:G	F74S	0.999
11:47577791:A:G	F70S	0.999
11:47577799:G:C	S67R	0.999
11:47577799:G:T	S67R	0.999
11:47577801:T:G	S67R	0.999
11:47577812:A:G	L63P	0.999
11:47577812:A:T	L63H	0.999
11:47577821:C:G	R60P	0.999
11:47573336:C:T	G384E	0.998
11:47573337:C:A	G384W	0.998

dbSNP variants (sampled 300 via entrez): RS1000147083 (11:47575986 G>A), RS1000243573 (11:47578514 C>G), RS1000332324 (11:47574850 ATCTC>A,ATC,ATCTCTC), RS1000458989 (11:47578743 G>A), RS1000771608 (11:47574021 C>T), RS1001335529 (11:47575467 A>C), RS1001981342 (11:47573244 A>C,G), RS1002290501 (11:47571968 T>G), RS1002317878 (11:47578999 AGAT>A), RS1002539493 (11:47579856 C>T), RS1002590039 (11:47576589 G>A), RS1002608455 (11:47578738 C>A,G,T), RS1002643822 (11:47576475 C>T), RS1003655609 (11:47574803 G>A), RS1004214589 (11:47579178 T>A,C)

Disease associations

OMIM: gene MIM:617645 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

17 associations (top):

Study	Trait	p-value
GCST005232_56	Neuroticism	1.000000e-16
GCST006923_11	Loneliness	1.000000e-07
GCST006924_13	Loneliness (MTAG)	1.000000e-08
GCST007293_118	Body fat distribution (arm fat ratio)	3.000000e-08
GCST007293_19	Body fat distribution (arm fat ratio)	2.000000e-10
GCST007293_45	Body fat distribution (arm fat ratio)	5.000000e-14
GCST007294_28	Body fat distribution (trunk fat ratio)	6.000000e-09
GCST007294_9	Body fat distribution (trunk fat ratio)	4.000000e-06
GCST007295_159	Body fat distribution (leg fat ratio)	1.000000e-18
GCST007295_24	Body fat distribution (leg fat ratio)	7.000000e-08
GCST007295_50	Body fat distribution (leg fat ratio)	2.000000e-12
GCST007559_27	Sleep duration (short sleep)	4.000000e-08
GCST007825_4	Alzheimer’s disease or fasting glucose levels (pleiotropy)	3.000000e-16
GCST008103_60	Bipolar disorder	5.000000e-07
GCST008357_37	Mood instability	9.000000e-14
GCST010136_2	Fruit consumption	5.000000e-09
GCST010703_36	Brain morphology (MOSTest)	8.000000e-09

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0007660	neuroticism measurement
EFO:0007865	loneliness measurement
EFO:0004341	body fat distribution
EFO:0008475	mood instability measurement
EFO:0008111	diet measurement
EFO:0004346	neuroimaging measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, decreases methylation	7
trichostatin A	decreases expression	2
sodium arsenite	increases abundance, increases expression, decreases expression	2
Cyclosporine	decreases expression	2
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cupric oxide	increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Leflunomide	decreases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Phenylmercuric Acetate	decreases expression	1
Quercetin	decreases expression	1
Aflatoxin B1	increases methylation	1
Particulate Matter	increases abundance, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.