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KCNH4

gene
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Also known as Kv12.3elk1

Summary

KCNH4 (potassium voltage-gated channel subfamily H member 4, HGNC:6253) is a protein-coding gene on chromosome 17q21.2, encoding Voltage-gated delayed rectifier potassium channel KCNH4 (Q9UQ05). Pore-forming (alpha) subunit of a voltage-gated delayed rectifier.

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. The gene is brain-specific, and located in the neocortex and the striatum. It may be involved in cellular excitability of restricted neurons in the central nervous system.

Source: NCBI Gene 23415 — RefSeq curated summary.

At a glance

  • GWAS associations: 4
  • Clinical variants (ClinVar): 214 total
  • Druggable target: yes
  • Dosage sensitivity (ClinGen): haploinsufficiency no evidence, triplosensitivity no evidence
  • MANE Select transcript: NM_012285

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:6253
Approved symbolKCNH4
Namepotassium voltage-gated channel subfamily H member 4
Location17q21.2
Locus typegene with protein product
StatusApproved
AliasesKv12.3, elk1
Ensembl geneENSG00000089558
Ensembl biotypeprotein_coding
OMIM604528
Entrez23415

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000264661, ENST00000607371

RefSeq mRNA: 1 — MANE Select: NM_012285 NM_012285

CCDS: CCDS11420

Canonical transcript exons

ENST00000264661 — 17 exons

ExonStartEnd
ENSE000010590584217557942175736
ENSE000010590594217178842171995
ENSE000010590604217010742170301
ENSE000010590634217810042178227
ENSE000010590654217833142178477
ENSE000010590664217605442176297
ENSE000010590674217879342179026
ENSE000011369324218087042181142
ENSE000011794454216224842162321
ENSE000011794524216322842163334
ENSE000011794834216413042164168
ENSE000011794984216629742166546
ENSE000011795054216947742169676
ENSE000012312234216360642163958
ENSE000012312374216544942165693
ENSE000012313004215973142160435
ENSE000036969824215689142157118

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 82.80.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1764 / max 36.3058, expressed in 77 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
1661110.107253
1661100.069236

Top tissues by expression

215 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
buccal mucosa cellCL:000233682.80gold quality
putamenUBERON:000187477.67gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047375.97silver quality
caudate nucleusUBERON:000187375.46gold quality
nucleus accumbensUBERON:000188273.02gold quality
myocardiumUBERON:000234969.28gold quality
prefrontal cortexUBERON:000045168.32gold quality
right frontal lobeUBERON:000281066.37gold quality
Brodmann (1909) area 9UBERON:001354064.36gold quality
frontal cortexUBERON:000187063.52gold quality
dorsolateral prefrontal cortexUBERON:000983463.10gold quality
primary visual cortexUBERON:000243663.05gold quality
nasal cavity epitheliumUBERON:000538462.97gold quality
skeletal muscle tissue of biceps brachiiUBERON:000450262.13gold quality
neocortexUBERON:000195061.54gold quality
skeletal muscle tissue of rectus abdominisUBERON:000451160.36gold quality
biceps brachiiUBERON:000150760.16gold quality
forebrainUBERON:000189058.81gold quality
cerebral cortexUBERON:000095657.81gold quality
secondary oocyteCL:000065557.39gold quality
superficial temporal arteryUBERON:000161457.29gold quality
occipital lobeUBERON:000202157.24gold quality
anterior cingulate cortexUBERON:000983557.08gold quality
heart right ventricleUBERON:000208057.01gold quality
gingivaUBERON:000182856.91gold quality
vastus lateralisUBERON:000137956.61gold quality
quadriceps femorisUBERON:000137756.25gold quality
oral cavityUBERON:000016756.10gold quality
medial globus pallidusUBERON:000247755.95gold quality
vermiform appendixUBERON:000115455.41gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes3.08

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

46 targeting KCNH4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-4425100.0067.591049
HSA-MIR-6870-5P99.9968.552115
HSA-MIR-1213699.9872.815713
HSA-MIR-4723-5P99.9768.702034
HSA-MIR-569899.9768.492029
HSA-MIR-7111-5P99.9768.482062
HSA-MIR-6825-5P99.9669.813431
HSA-MIR-990299.8969.152250
HSA-MIR-548AZ-5P99.8369.943230
HSA-MIR-548T-5P99.8369.913220
HSA-MIR-431999.7669.832586
HSA-MIR-6794-5P99.7666.381048
HSA-MIR-6887-3P99.6667.831778
HSA-MIR-317599.6566.302031
HSA-MIR-314799.5266.34388
HSA-MIR-671-5P99.5267.111277
HSA-MIR-127599.4767.902749
HSA-MIR-125A-5P99.3670.591640
HSA-MIR-125B-5P99.3670.361662
HSA-MIR-6507-3P99.3567.321059
HSA-MIR-6852-5P99.1766.692073
HSA-MIR-939-3P98.9765.072347
HSA-MIR-445198.8268.171455
HSA-MIR-4716-5P98.8268.571168
HSA-MIR-4763-5P98.7563.89854
HSA-MIR-19898.7067.32920
HSA-MIR-7155-5P98.6566.141290
HSA-MIR-4700-5P98.6367.431915
HSA-MIR-6878-5P98.4967.912142
HSA-MIR-5089-5P98.4566.061388

Functional genomics

ClinGen dosage: haploinsufficiency 0 (no evidence), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Cross-species orthologs

15 orthologs

OrganismSymbolGene ID
danio_reriokcnh4bENSDARG00000061990
danio_reriokcnh4aENSDARG00000062565
mus_musculusKcnh4ENSMUSG00000035355
rattus_norvegicusKcnh4ENSRNOG00000018790
drosophila_melanogasterseiFBGN0003353
drosophila_melanogasterElkFBGN0011589
drosophila_melanogasterCG6026FBGN0038676
drosophila_melanogasterCngAFBGN0261612
drosophila_melanogasterCnglFBGN0263257
drosophila_melanogasterCngBFBGN0266346
caenorhabditis_elegansWBGENE00000487
caenorhabditis_eleganstax-2WBGENE00006525
caenorhabditis_elegansWBGENE00006526
caenorhabditis_elegansWBGENE00006830
caenorhabditis_elegansWBGENE00022295

Paralogs (17): KCNH2 (ENSG00000055118), CNGB1 (ENSG00000070729), HCN2 (ENSG00000099822), CNGA4 (ENSG00000132259), KCNH3 (ENSG00000135519), HCN4 (ENSG00000138622), KCNH5 (ENSG00000140015), KCNH1 (ENSG00000143473), HCN3 (ENSG00000143630), CNGA3 (ENSG00000144191), HCN1 (ENSG00000164588), CNGB3 (ENSG00000170289), KCNH6 (ENSG00000173826), CNGA2 (ENSG00000183862), KCNH8 (ENSG00000183960), KCNH7 (ENSG00000184611), CNGA1 (ENSG00000198515)

Protein

Protein identifiers

Voltage-gated delayed rectifier potassium channel KCNH4 — Q9UQ05 (reviewed: Q9UQ05)

Alternative names: Brain-specific eag-like channel 2, Ether-a-go-go-like potassium channel 1, Potassium voltage-gated channel subfamily H member 4, Voltage-gated potassium channel subunit Kv12.3

All UniProt accessions (1): Q9UQ05

UniProt curated annotations — full annotation on UniProt →

Function. Pore-forming (alpha) subunit of a voltage-gated delayed rectifier. Activates at more negative voltages, exhibits fast prepulse-independent activation kinetics and deactivates much more slowly, but shows no inactivation.

Subunit / interactions. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

Subcellular location. Membrane.

Tissue specificity. Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus.

Similarity. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.3/KCNH4 sub-subfamily.

RefSeq proteins (1): NP_036417* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000014PASDomain
IPR000595cNMP-bd_domDomain
IPR000700PAS-assoc_CDomain
IPR001610PACRepeat
IPR003938K_chnl_volt-dep_EAG/ELK/ERGFamily
IPR003950K_chnl_volt-dep_ELKFamily
IPR005821Ion_trans_domDomain
IPR014710RmlC-like_jellyrollHomologous_superfamily
IPR018490cNMP-bd_dom_sfHomologous_superfamily
IPR035965PAS-like_dom_sfHomologous_superfamily
IPR050818KCNH_animal-typeFamily

Pfam: PF00520, PF13426

Catalyzed reactions (Rhea), 1 shown:

  • K(+)(in) = K(+)(out) (RHEA:29463)

UniProt features (34 total): topological domain 8, transmembrane region 6, region of interest 6, compositionally biased region 5, glycosylation site 3, domain 2, chain 1, intramembrane region 1, short sequence motif 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9UQ05-F167.690.26

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (3): 326, 414, 473

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

IDPathway
R-HSA-1296072Voltage gated Potassium channels
R-HSA-112316Neuronal System
R-HSA-1296071Potassium Channels

MSigDB gene sets: 388 (showing top): PID_BCR_5PATHWAY, GOBP_POTASSIUM_ION_TRANSPORT, RNGTGGGC_UNKNOWN, GOBP_RESPONSE_TO_ETHANOL, GOBP_HEPATICOBILIARY_SYSTEM_DEVELOPMENT, GOBP_RESPONSE_TO_IONIZING_RADIATION, BIOCARTA_FMLP_PATHWAY, REACTOME_INNATE_IMMUNE_SYSTEM, REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS, REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM, GOBP_CELLULAR_RESPONSE_TO_LIPID, REACTOME_POTASSIUM_CHANNELS, KEGG_MAPK_SIGNALING_PATHWAY, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, AAGCCAT_MIR135A_MIR135B

GO Biological Process (6): potassium ion transport (GO:0006813), regulation of membrane potential (GO:0042391), potassium ion transmembrane transport (GO:0071805), monoatomic ion transport (GO:0006811), monoatomic ion transmembrane transport (GO:0034220), transmembrane transport (GO:0055085)

GO Molecular Function (3): voltage-gated potassium channel activity (GO:0005249), monoatomic ion channel activity (GO:0005216), potassium channel activity (GO:0005267)

GO Cellular Component (4): plasma membrane (GO:0005886), voltage-gated potassium channel complex (GO:0008076), membrane (GO:0016020), monoatomic ion channel complex (GO:0034702)

Reactome top-level categories

Rollup of top-2 pathways:

CategoryPathways
Potassium Channels1
Neuronal System1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
transport2
metal ion transport1
monoatomic ion transmembrane transport1
regulation of biological quality1
potassium ion transport1
monoatomic cation transmembrane transport1
monoatomic ion transport1
transmembrane transport1
cellular process1
potassium channel activity1
voltage-gated monoatomic cation channel activity1
monoatomic ion transmembrane transporter activity1
channel activity1
monoatomic cation channel activity1
potassium ion transmembrane transporter activity1
membrane1
cell periphery1
potassium channel complex1
plasma membrane protein complex1
cellular anatomical structure1
transmembrane transporter complex1

Protein interactions and networks

STRING

820 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
KCNH4DHX58Q96C10695
KCNH4GHDCQ8N2G8549
KCNH4HCRTO43612506
KCNH4KCNS2Q9ULS6500
KCNH4KCNG1Q9UIX4491
KCNH4KAT2AQ92830478
KCNH4KCNF1Q9H3M0476
KCNH4NRSN1Q8IZ57436
KCNH4KCNV1Q6PIU1435
KCNH4STAT5BP51692420
KCNH4ARHGAP9Q9BRR9418
KCNH4CAMK2N1Q7Z7J9405
KCNH4RNF214Q8ND24404
KCNH4KCNG3Q8TAE7403
KCNH4NGEFQ8N5V2398

IntAct

3 interactions, top by confidence:

ABTypeScore
Mpsi-mi:“MI:0914”(association)0.350
KCNH4ARFGEF2psi-mi:“MI:0914”(association)0.350

BioGRID (11): KCNH4 (Affinity Capture-RNA), KCNH4 (Affinity Capture-RNA), ARFGEF2 (Affinity Capture-MS), TUBB7P (Affinity Capture-MS), ARFGEF1 (Affinity Capture-MS), KCNH4 (Negative Genetic), KCNH4 (Negative Genetic), KCNH4 (Negative Genetic), KCNH5 (Negative Genetic), KCNH6 (Negative Genetic), KCNH8 (Negative Genetic)

ESM2 similar proteins: G5EFJ9, O08703, O08962, O35219, O54852, O54853, O60307, O70344, O88427, O88943, O89047, O95622, P0C550, P40144, P51787, P58126, P59111, P84309, P97414, Q02280, Q02343, Q04400, Q0JKV1, Q12809, Q15878, Q5RDS0, Q61290, Q6ZV29, Q810W7, Q8H569, Q8IY17, Q8WNY2, Q96L42, Q9EQ60, Q9ER47, Q9H252, Q9MYS6, Q9NR82, Q9NS40, Q9PT84

Diamond homologs: A0A364LYQ6, A2XKR7, A6X554, B0G188, B8AX51, O34627, O48963, O49741, O49743, O64511, O65515, O82632, O89047, P58724, P69781, P93025, Q00858, Q01371, Q02280, Q10F25, Q1M667, Q2NB77, Q2NB98, Q2NCA3, Q2QYY8, Q2R2W1, Q2RBR1, Q48IV1, Q4ZSY3, Q54HA4, Q54KX0, Q54NM5, Q54TE3, Q54TM6, Q550D5, Q55C49, Q55GK0, Q59LY1, Q5HZ36, Q5Z8K3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

214 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance160
Likely benign10
Benign7

Top pathogenic / likely-pathogenic (0)

SpliceAI

3093 predictions. Top by Δscore:

VariantEffectΔscore
17:42165448:CA:Cdonor_gain1.0000
17:42166291:CCTTA:Cdonor_loss1.0000
17:42166292:CTTA:Cdonor_loss1.0000
17:42166293:TTA:Tdonor_loss1.0000
17:42166294:TA:Tdonor_loss1.0000
17:42166295:A:ATdonor_loss1.0000
17:42166295:AC:Adonor_gain1.0000
17:42166296:CC:Cdonor_gain1.0000
17:42166547:C:CCacceptor_gain1.0000
17:42169473:CTA:Cdonor_loss1.0000
17:42169474:TACCT:Tdonor_loss1.0000
17:42169475:A:ACdonor_gain1.0000
17:42169475:A:ATdonor_loss1.0000
17:42169476:C:CCdonor_gain1.0000
17:42169476:CC:Cdonor_loss1.0000
17:42169476:CCT:Cdonor_gain1.0000
17:42169478:T:TAdonor_gain1.0000
17:42171993:GGT:Gacceptor_gain1.0000
17:42171994:GT:Gacceptor_gain1.0000
17:42171995:TCT:Tacceptor_loss1.0000
17:42171996:C:CCacceptor_gain1.0000
17:42171997:T:Cacceptor_loss1.0000
17:42175572:CACT:Cdonor_loss1.0000
17:42175573:ACTC:Adonor_loss1.0000
17:42175574:CTCA:Cdonor_loss1.0000
17:42175575:TCA:Tdonor_loss1.0000
17:42175576:C:CGdonor_loss1.0000
17:42175577:A:ACdonor_gain1.0000
17:42175577:A:ATdonor_loss1.0000
17:42175578:C:CCdonor_gain1.0000

AlphaMissense

6543 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
17:42170171:A:CF442L1.000
17:42170171:A:TF442L1.000
17:42170173:A:GF442L1.000
17:42170180:A:CS439R1.000
17:42170180:A:TS439R1.000
17:42170182:T:GS439R1.000
17:42170189:G:CS436R1.000
17:42170189:G:TS436R1.000
17:42170191:T:GS436R1.000
17:42169654:G:CF471L0.999
17:42169654:G:TF471L0.999
17:42169656:A:GF471L0.999
17:42170109:C:TG463D0.999
17:42170165:G:CN444K0.999
17:42170165:G:TN444K0.999
17:42170169:C:AG443V0.999
17:42170169:C:TG443D0.999
17:42170172:A:CF442C0.999
17:42170175:C:TG441D0.999
17:42170176:C:GG441R0.999
17:42170192:G:CS435R0.999
17:42170192:G:TS435R0.999
17:42170194:T:GS435R0.999
17:42170297:C:AW400C0.999
17:42170297:C:GW400C0.999
17:42170299:A:GW400R0.999
17:42170299:A:TW400R0.999
17:42178957:A:GF49S0.999
17:42166350:A:TV596D0.998
17:42169583:A:GL495P0.998

dbSNP variants (sampled 300 via entrez): RS1000010324 (17:42178144 C>G,T), RS1000293921 (17:42173033 C>T), RS1000385284 (17:42161174 C>T), RS1000386312 (17:42167081 C>T), RS1000457651 (17:42165367 G>A,T), RS1000664315 (17:42159472 G>A), RS1000665374 (17:42159771 C>A), RS1000686714 (17:42172665 G>A), RS1000734032 (17:42160995 C>A,G,T), RS1000960099 (17:42159638 T>C), RS1001074741 (17:42165820 G>A,C,T), RS1001077720 (17:42177943 C>G), RS1001104185 (17:42166166 C>A,T), RS1001129438 (17:42168221 G>A), RS1001543495 (17:42178154 G>A)

Disease associations

OMIM: gene MIM:604528 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

StudyTraitp-value
GCST004278_32Pulse pressure3.000000e-09
GCST004278_41Pulse pressure6.000000e-08
GCST004278_63Pulse pressure3.000000e-09
GCST004278_71Pulse pressure4.000000e-07

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0005763pulse pressure measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2362996 (PROTEIN FAMILY)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: vgic — Voltage-gated potassium channels (Kv)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChemblTypeValueUnitMolecule
9.82Ki0.15nMCHEMBL5722941
9.74IC500.18nMCHEMBL5722941

PubChem BioAssay actives

2 with measured affinity, of 34 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

CompoundAssayTypeValueUnit
3-[(1R,2aS,4S,5aS,8aS,10S,11aR,14aS,16S,17aS,19S,20aS,22S,23aS,25S,26aS,28S,29aS,31R,32aS,35aS,36R,38aS,39S,41aS,42S,44aS,45S,48R,50aS,51S,53aS,54S,56aS,57S,59aS,60S,63S,66S,69S,72S,75S,78S,87R,93S,96S,99S)-17a,20a,23a,53a,63-pentakis(4-aminobutyl)-31-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-5-carbamimidamido-2-[[(2S)-5-carbamimidamido-2-[[(2S)-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]pentanoyl]amino]pentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-16,29a,72,78-tetrakis(2-amino-2-oxoethyl)-14a,26a-bis(3-amino-3-oxopropyl)-2a,38a,66-tribenzyl-28,50a,57-tris[(2S)-butan-2-yl]-4,5a,19,42,45,69-hexakis(3-carbamimidamidopropyl)-51,54-bis(2-carboxyethyl)-56a,99-bis(carboxymethyl)-36-[[(2S,3S)-1-(carboxymethylamino)-3-methyl-1-oxopentan-2-yl]carbamoyl]-39,60-bis[(1R)-1-hydroxyethyl]-75,93-bis(hydroxymethyl)-32a,35a,59a-tris[(4-hydroxyphenyl)methyl]-22-(1H-imidazol-4-ylmethyl)-96-(1H-indol-3-ylmethyl)-41a-methyl-25-(2-methylpropyl)-1a,3,4a,6,7a,9,10a,13a,15,16a,18,19a,21,22a,24,25a,27,28a,30,31a,34a,37a,38,40a,41,43a,44,47,49a,50,52a,53,55a,56,58a,59,61a,62,65,68,71,74,77,80,83,86,89,92,95,98-pentacontaoxo-33,34,63a,64a,67a,68a-hexathia-a,2,3a,5,6a,8,9a,12a,14,15a,17,18a,20,21a,23,24a,26,27a,29,30a,33a,36a,37,39a,40,42a,43,46,48a,49,51a,52,54a,55,57a,58,60a,61,64,67,70,73,76,79,82,85,88,91,94,97-pentacontazapentacyclo[85.74.4.448,111.010,14.0144,148]nonahexacontahectan-8a-yl]propanoic acid2198828: Binding affinity to KV channel (unknown origin) assessed as inhibition constantki0.0001uM

CTD chemical–gene interactions

12 total (human), top 12 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arseniteincreases expression2
benzo(e)pyreneincreases methylation1
CGP 52608affects binding, increases reaction1
Resveratrolaffects cotreatment, decreases expression1
Benzo(a)pyreneincreases methylation, affects methylation1
Ivermectinincreases expression1
Methapyrileneincreases methylation1
Plant Extractsaffects cotreatment, decreases expression1
Tretinoinincreases expression1
Valproic Acidincreases methylation1
Sodium Selenitedecreases expression1
Coal Ashincreases expression1

ChEMBL screening assays

21 unique, capped per target: 20 binding, 1 toxicity

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL1787442BindingInhibition of human recombinant Kv channel at 10 uM by radioligand binding assayStructure-activity relationships of pyrrole based S-nitrosoglutathione reductase inhibitors: pyrrole regioisomers and propionic acid replacement. — Bioorg Med Chem Lett
CHEMBL5522525ToxicityInhibition of human K+ channel by automated electrophysiologyDiscovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 79

This page pulls from 79 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_assaychembl_documentchembl_moleculechembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgtopdb_interactiongwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot