KCNJ15

Summary

KCNJ15 (potassium inwardly rectifying channel subfamily J member 15, HGNC:6261) is a protein-coding gene on chromosome 21q22.13-q22.2, encoding ATP-sensitive inward rectifier potassium channel 15 (Q99712). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene.

Source: NCBI Gene 3772 — RefSeq curated summary.

At a glance

• GWAS associations: 24
• Clinical variants (ClinVar): 63 total
• MANE Select transcript: NM_170736

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6261
Approved symbol	KCNJ15
Name	potassium inwardly rectifying channel subfamily J member 15
Location	21q22.13-q22.2
Locus type	gene with protein product
Status	Approved
Aliases	Kir4.2, Kir1.3, IRKK
Ensembl gene	ENSG00000157551
Ensembl biotype	protein_coding
OMIM	602106
Entrez	3772

Gene structure

Transcript identifiers

Ensembl transcripts: 46 — 45 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000328656, ENST00000398925, ENST00000398927, ENST00000398928, ENST00000398930, ENST00000398932, ENST00000398934, ENST00000398938, ENST00000417042, ENST00000419868, ENST00000438657, ENST00000443341, ENST00000472602, ENST00000547341, ENST00000547595, ENST00000548700, ENST00000549158, ENST00000549805, ENST00000549932, ENST00000551422, ENST00000612702, ENST00000613499, ENST00000866348, ENST00000866349, ENST00000866350, ENST00000866351, ENST00000866352, ENST00000866353, ENST00000866354, ENST00000866355, ENST00000866356, ENST00000866357, ENST00000866358, ENST00000866359, ENST00000866360, ENST00000866361, ENST00000953621, ENST00000953622, ENST00000953623, ENST00000953624, ENST00000953625, ENST00000953626, ENST00000953627, ENST00000953628, ENST00000953629, ENST00000953630

RefSeq mRNA: 8 — MANE Select: NM_170736 NM_001276435, NM_001276436, NM_001276437, NM_001276438, NM_001276439, NM_002243, NM_170736, NM_170737

CCDS: CCDS13656

Canonical transcript exons

ENST00000398938 — 3 exons

Exon	Start	End
ENSE00001033335	38296926	38297023
ENSE00001535646	38256991	38257185
ENSE00003705460	38299244	38307357

Expression profiles

Bgee: expression breadth ubiquitous, 221 present calls, max score 98.98.

FANTOM5 (CAGE): breadth broad, TPM avg 7.7312 / max 2278.4424, expressed in 496 samples.

FANTOM5 promoters (27 alternative TSS)

Promoter ID	TPM avg	Samples expressed
189076	2.5293	68
189092	1.0942	131
189099	0.7271	75
189093	0.4636	105
189116	0.3833	149
189083	0.3590	37
189115	0.2546	115
189113	0.2380	132
189114	0.1916	105
189097	0.1887	33

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
nephron tubule	UBERON:0001231	98.98	gold quality
blood	UBERON:0000178	97.34	gold quality
kidney epithelium	UBERON:0004819	96.78	gold quality
cervix squamous epithelium	UBERON:0006922	96.22	gold quality
parotid gland	UBERON:0001831	96.04	gold quality
gingival epithelium	UBERON:0001949	95.68	gold quality
adult mammalian kidney	UBERON:0000082	94.86	gold quality
kidney	UBERON:0002113	94.65	gold quality
gingiva	UBERON:0001828	94.31	gold quality
renal glomerulus	UBERON:0000074	94.29	gold quality
periodontal ligament	UBERON:0008266	94.19	gold quality
metanephric glomerulus	UBERON:0004736	93.28	gold quality
metanephros cortex	UBERON:0010533	92.24	gold quality
adult organism	UBERON:0007023	91.95	gold quality
metanephros	UBERON:0000081	91.54	gold quality
visceral pleura	UBERON:0002401	91.47	gold quality
cortex of kidney	UBERON:0001225	91.04	gold quality
squamous epithelium	UBERON:0006914	90.98	gold quality
body of pancreas	UBERON:0001150	90.80	gold quality
gall bladder	UBERON:0002110	90.74	gold quality
renal medulla	UBERON:0000362	90.28	gold quality
cervix epithelium	UBERON:0004801	90.14	gold quality
lower lobe of lung	UBERON:0008949	89.45	gold quality
mucosa of urinary bladder	UBERON:0001259	88.92	gold quality
buccal mucosa cell	CL:0002336	88.49	gold quality
right lobe of thyroid gland	UBERON:0001119	88.46	gold quality
tongue squamous epithelium	UBERON:0006919	88.46	gold quality
thyroid gland	UBERON:0002046	88.39	gold quality
esophagus squamous epithelium	UBERON:0006920	87.81	gold quality
epithelial cell of pancreas	CL:0000083	87.55	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-MTAB-10662	yes	485.60
E-CURD-119	yes	56.05
E-HCAD-10	yes	35.89
E-ANND-3	yes	23.43
E-GEOD-130148	yes	10.49
E-HCAD-30	no	58.58

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

81 targeting KCNJ15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-6124	99.87	69.78	3551
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-3681-5P	99.82	66.88	387
HSA-MIR-548AG	99.77	69.25	1492
HSA-MIR-548M	99.70	68.87	1749
HSA-MIR-548AI	99.69	69.24	1494
HSA-MIR-548BA	99.69	69.14	1514
HSA-MIR-570-5P	99.69	69.24	1494
HSA-MIR-6849-5P	99.64	66.00	352
HSA-MIR-6126	99.62	68.09	996
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-4261	99.59	70.30	3415

Literature-anchored findings (GeneRIF, showing 12)

• maintaining electrical integrity of bile-generating hepatocytes. (PMID:11804844)
• The potential synergy and consequences of the overexpression of KIR4.2 and KIR3.2 in Down’s syndrome brain development are discussed. (PMID:15068243)
• Calcium-sensing receptor interacts directly with Kir4.1 and Kir4.2 and can decrease their currents. (PMID:17122384)
• MUPP1 and Kir4.2 may participate in a protein complex in the nephron that could regulate transport of K(+) as well as other ions. (PMID:19420109)
• KCNJ15 is a previously unreported susceptibility gene for T2DM among Asians (PMID:20085713)
• It was shown that downregulation of Kcnj15 leads to increased insulin secretion in vitro and in vivo. The mechanism for regulating insulin secretion inolved a calcium-sensiong receptor. (PMID:22566534)
• We had performed a replication study using an independent larger Japanese population for the association of rs3746876 within KCNJ15, and observed a significant association of rs3746876 with type 2 diabetes, but this study failed to find original finding. (PMID:23595124)
• KCNJ15 has a major role in histamine-stimulated gastric acid secretion. (PMID:26108660)
• KCNJ15 couples with polyamines in sensing weak electric fields. (PMID:26449415)
• RNA-seq evidence of biallelic expression of KCNJ15 and 10 neighboring genes in at least one primary human tissue tested indicates that the expression of KCNJ15 is uncoupled from the control of the maternally inherited 5mCpG imprints at the WRB differentially methylated region (DMR) in disomic controls or trisomy (Down syndrome) individuals. (PMID:27100087)
• KCNJ15 Expression and Malignant Behavior of Esophageal Squamous Cell Carcinoma. (PMID:32052303)
• Hunting for Familial Parkinson’s Disease Mutations in the Post Genome Era. (PMID:33802862)

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
danio_rerio	KCNJ15	ENSDARG00000058988
mus_musculus	Kcnj15	ENSMUSG00000062609
rattus_norvegicus	Kcnj15	ENSRNOG00000062944
drosophila_melanogaster	Irk3	FBGN0032706
drosophila_melanogaster	Irk2	FBGN0039081
drosophila_melanogaster	Irk1	FBGN0265042
caenorhabditis_elegans		WBGENE00002149
caenorhabditis_elegans		WBGENE00002150
caenorhabditis_elegans		WBGENE00002151

Paralogs (15): KCNJ13 (ENSG00000115474), KCNJ5 (ENSG00000120457), KCNJ8 (ENSG00000121361), KCNJ2 (ENSG00000123700), KCNJ1 (ENSG00000151704), KCNJ16 (ENSG00000153822), KCNJ6 (ENSG00000157542), KCNJ9 (ENSG00000162728), KCNJ3 (ENSG00000162989), KCNJ4 (ENSG00000168135), KCNJ10 (ENSG00000177807), KCNJ14 (ENSG00000182324), KCNJ12 (ENSG00000184185), KCNJ11 (ENSG00000187486), KCNJ18 (ENSG00000260458)

Protein

Protein identifiers

ATP-sensitive inward rectifier potassium channel 15 — Q99712 (reviewed: Q99712)

Alternative names: Inward rectifier K(+) channel Kir1.3, Inward rectifier K(+) channel Kir4.2, Potassium channel, inwardly rectifying subfamily J member 15

All UniProt accessions (9): Q99712, A8MTZ5, A8MVK1, C9J0W5, C9JTX1, E7EPG3, E7EWV2, F8VW46, F8VX74

UniProt curated annotations — full annotation on UniProt →

Function. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Subunit / interactions. Can form heteromultimeric channels with Kir5.1/KCNJ16. Interacts with PATJ.

Subcellular location. Membrane. Cell membrane.

Activity regulation. Channel activity is regulated by variations of cytosolic pH; reversibly inhibited by acidic pH values. Inhibited by Ba(2+) and Cs(+) in a voltage-dependent manner.

Similarity. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily.

RefSeq proteins (8): NP_001263364, NP_001263365, NP_001263366, NP_001263367, NP_001263368, NP_002234, NP_733932, NP_733933 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003270	K_chnl_inward-rec_Kir1.3	Family
IPR013518	K_chnl_inward-rec_Kir_cyto	Homologous_superfamily
IPR014756	Ig_E-set	Homologous_superfamily
IPR016449	K_chnl_inward-rec_Kir	Family
IPR040445	Kir_TM	Domain
IPR041647	IRK_C	Domain

Pfam: PF01007, PF17655

Catalyzed reactions (Rhea), 1 shown:

• K(+)(in) = K(+)(out) (RHEA:29463)

UniProt features (15 total): topological domain 4, sequence variant 3, sequence conflict 2, transmembrane region 2, chain 1, intramembrane region 1, short sequence motif 1, site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q99712-F1	85.84	0.57

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 157 (role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium)

Function

Pathways and Gene Ontology

Reactome pathways

11 pathways

ID	Pathway
R-HSA-1296041	Activation of G protein gated Potassium channels
R-HSA-997272	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
R-HSA-112314	Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-112315	Transmission across Chemical Synapses
R-HSA-112316	Neuronal System
R-HSA-1296059	G protein gated Potassium channels
R-HSA-1296065	Inwardly rectifying K+ channels
R-HSA-1296071	Potassium Channels
R-HSA-977443	GABA receptor activation
R-HSA-977444	GABA B receptor activation
R-HSA-991365	Activation of GABAB receptors

MSigDB gene sets: 182 (showing top): GOBP_POTASSIUM_ION_TRANSPORT, GRUETZMANN_PANCREATIC_CANCER_DN, REACTOME_POTASSIUM_CHANNELS, REACTOME_INWARDLY_RECTIFYING_K_CHANNELS, CMYB_01, FOXO4_01, FOXO1_01, PID_INTEGRIN_A9B1_PATHWAY, GOBP_MONOATOMIC_CATION_TRANSPORT, BLALOCK_ALZHEIMERS_DISEASE_UP, GATA6_01, RIGGI_EWING_SARCOMA_PROGENITOR_DN, LYF1_01, FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN, VECCHI_GASTRIC_CANCER_EARLY_DN

GO Biological Process (8): potassium ion transport (GO:0006813), regulation of monoatomic ion transmembrane transport (GO:0034765), potassium ion import across plasma membrane (GO:1990573), monoatomic ion transport (GO:0006811), metal ion transport (GO:0030001), monoatomic ion transmembrane transport (GO:0034220), potassium ion transmembrane transport (GO:0071805), monoatomic cation transmembrane transport (GO:0098655)

GO Molecular Function (3): inward rectifier potassium channel activity (GO:0005242), potassium channel activity (GO:0005267), protein binding (GO:0005515)

GO Cellular Component (3): plasma membrane (GO:0005886), monoatomic ion channel complex (GO:0034702), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-9 pathways:

Category	Pathways
Neuronal System	2
G protein gated Potassium channels	1
Activation of GABAB receptors	1
Transmission across Chemical Synapses	1
Inwardly rectifying K+ channels	1
Potassium Channels	1
Neurotransmitter receptors and postsynaptic signal transmission	1
GABA receptor activation	1
GABA B receptor activation	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
monoatomic ion transmembrane transport	2
monoatomic cation transport	2
metal ion transport	1
regulation of transmembrane transport	1
regulation of monoatomic ion transport	1
potassium ion transmembrane transport	1
inorganic cation import across plasma membrane	1
transport	1
monoatomic ion transport	1
transmembrane transport	1
potassium ion transport	1
monoatomic cation transmembrane transport	1
voltage-gated potassium channel activity	1
ligand-gated monoatomic cation channel activity	1
monoatomic cation channel activity	1
potassium ion transmembrane transporter activity	1
binding	1
membrane	1
cell periphery	1
transmembrane transporter complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

998 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KCNJ15	ABCC8	Q09428	514
KCNJ15	GPD2	P43304	470
KCNJ15	KCNQ1	P51787	461
KCNJ15	WFS1	O76024	440
KCNJ15	PPP1R3A	Q16821	427
KCNJ15	CAPN10	Q9HC96	427
KCNJ15	TFAP2B	Q92481	427
KCNJ15	RETN	Q9HD89	424
KCNJ15	RETNLB	Q9BQ08	424
KCNJ15	ENPP1	P22413	423
KCNJ15	EPHX2	P34913	423
KCNJ15	KCNJ10	P78508	396
KCNJ15	KCNA7	Q96RP8	395
KCNJ15	HAO1	Q9UJM8	392
KCNJ15	NEUROD1	Q13562	389
KCNJ15	LIPC	P11150	389

IntAct

14 interactions, top by confidence:

A	B	Type	Score
KCNJ2	KCNJ15	psi-mi:“MI:0915”(physical association)	0.560
KCNJ5	KCNJ15	psi-mi:“MI:0915”(physical association)	0.560
Il16	KCNJ15	psi-mi:“MI:0915”(physical association)	0.530
KCNJ15	Il16	psi-mi:“MI:0407”(direct interaction)	0.530
KCNJ15	Patj	psi-mi:“MI:0915”(physical association)	0.510
Patj	KCNJ15	psi-mi:“MI:0915”(physical association)	0.510
KCNJ15	OSMR	psi-mi:“MI:0915”(physical association)	0.400
KCNJ5	KCNJ15	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (7): KCNJ15 (Two-hybrid), KCNJ15 (Two-hybrid), OSMR (Affinity Capture-MS), KCNJ15 (Cross-Linking-MS (XL-MS)), KCNJ15 (Cross-Linking-MS (XL-MS)), KCNJ15 (Cross-Linking-MS (XL-MS)), KCNJ15 (Protein-peptide)

ESM2 similar proteins: B7U540, E1BNE9, F1MYR9, F1NHE9, O02670, O18839, O19182, O70339, O88335, O88932, P35560, P35561, P48048, P48050, P48051, P48542, P48543, P48544, P48545, P48548, P48549, P48550, P49655, P49656, P49658, P52185, P52186, P52187, P52188, P52189, P52190, P52191, P63250, P63251, P63252, P63253, P70673, P78508, Q14500, Q4TZY1

Diamond homologs: B7U540, E1BN00, E1BNE9, F1MYR9, F1NHE9, O02670, O02822, O18839, O19182, O60928, O70339, O70596, O70617, O88335, O88932, P35560, P35561, P48048, P48050, P48051, P48542, P48543, P48544, P48545, P48548, P48549, P48550, P49655, P49656, P49658, P52185, P52186, P52187, P52188, P52189, P52190, P52191, P52192, P63250, P63251

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

861 predictions. Top by Δscore:

Variant	Effect	Δscore
21:38156298:TTTCA:T	acceptor_loss	1.0000
21:38156302:A:AG	acceptor_gain	1.0000
21:38156303:G:GA	acceptor_gain	1.0000
21:38156303:GA:G	acceptor_gain	1.0000
21:38156303:GAC:G	acceptor_gain	1.0000
21:38156303:GACA:G	acceptor_gain	1.0000
21:38297012:G:GG	donor_gain	1.0000
21:38299241:A:AG	acceptor_gain	1.0000
21:38299241:AAGT:A	acceptor_gain	1.0000
21:38299242:A:AG	acceptor_gain	1.0000
21:38299243:G:GG	acceptor_gain	1.0000
21:38299243:GT:G	acceptor_gain	1.0000
21:38299243:GTGT:G	acceptor_gain	1.0000
21:38156303:GACAA:G	acceptor_gain	0.9900
21:38296925:GGCA:G	acceptor_gain	0.9900
21:38297007:GCGGA:G	donor_gain	0.9900
21:38297009:GGA:G	donor_gain	0.9900
21:38297010:GA:G	donor_gain	0.9900
21:38297010:GAG:G	donor_gain	0.9900
21:38299242:AGT:A	acceptor_gain	0.9900
21:38299243:GTG:G	acceptor_gain	0.9900
21:38299626:T:TA	acceptor_gain	0.9900
21:38156294:T:TA	acceptor_gain	0.9800
21:38299243:GTGTT:G	acceptor_gain	0.9800
21:38299244:T:TA	acceptor_gain	0.9800
21:38296920:TTTCA:T	acceptor_loss	0.9600
21:38296922:TCAGG:T	acceptor_loss	0.9600
21:38296923:CAG:C	acceptor_loss	0.9600
21:38296924:A:G	acceptor_loss	0.9600
21:38297021:CAG:C	donor_loss	0.9600

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000013062 (21:38253773 T>G), RS1000020096 (21:38234878 C>A,T), RS1000058461 (21:38251499 C>A,T), RS1000080825 (21:38247133 G>C), RS1000118496 (21:38295758 C>A), RS1000128852 (21:38264470 T>G), RS1000135195 (21:38277394 G>A), RS1000186929 (21:38236604 T>C), RS1000244444 (21:38282969 A>G), RS1000261790 (21:38271562 A>G), RS1000348755 (21:38283931 C>T), RS1000359737 (21:38290023 A>G), RS1000419884 (21:38277859 T>C), RS1000475782 (21:38260283 T>A), RS1000480793 (21:38258610 C>T)

Disease associations

OMIM: gene MIM:602106 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

24 associations (top):

Study	Trait	p-value
GCST003812_1	Non-response to antidepressants and depression	3.000000e-07
GCST008839_303	Height	4.000000e-19
GCST009391_1323	Metabolite levels	9.000000e-06
GCST009391_1496	Metabolite levels	5.000000e-06
GCST009391_1512	Metabolite levels	5.000000e-06
GCST009391_285	Metabolite levels	6.000000e-06
GCST012227_1119	Hip circumference adjusted for BMI	8.000000e-09
GCST90000025_699	Appendicular lean mass	1.000000e-43
GCST90002379_170	Basophil count	8.000000e-13
GCST90002380_67	Basophil percentage of white cells	9.000000e-19
GCST90002393_471	Monocyte count	2.000000e-10
GCST90020024_813	A body shape index	6.000000e-09
GCST90020024_814	A body shape index	2.000000e-08
GCST90020024_815	A body shape index	3.000000e-10
GCST90020025_1771	Waist-to-hip ratio adjusted for BMI	7.000000e-10
GCST90020025_1772	Waist-to-hip ratio adjusted for BMI	9.000000e-10
GCST90020025_1773	Waist-to-hip ratio adjusted for BMI	6.000000e-11
GCST90020027_390	Waist-hip index	2.000000e-09
GCST90020027_391	Waist-hip index	3.000000e-09
GCST90020027_392	Waist-hip index	3.000000e-10
GCST90020027_393	Waist-hip index	2.000000e-12
GCST90020028_1540	Hip circumference adjusted for BMI	5.000000e-08
GCST90020028_1542	Hip circumference adjusted for BMI	6.000000e-10
GCST90020028_1582	Hip circumference adjusted for BMI	3.000000e-09

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0010519	pantothenic acid measurement
EFO:0010416	triacylglycerol 52:4 measurement
EFO:0010417	triacylglycerol 52:5 measurement
EFO:0010424	triacylglycerol 54:6 measurement
EFO:0008039	BMI-adjusted hip circumference
EFO:0004980	appendicular lean mass
EFO:0005090	basophil count
EFO:0007992	basophil percentage of leukocytes
EFO:0005091	monocyte count
EFO:0007789	BMI-adjusted waist circumference
EFO:0007788	BMI-adjusted waist-hip ratio

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: vgic — Inwardly rectifying potassium channels (K_IR)

Most potent curated ligand interactions (1 total), top 1:

Ligand	Action	Affinity	Parameter
H+	Antagonist	7.1	pEC50

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects expression, increases abundance, increases expression, decreases expression	3
bisphenol A	affects methylation, increases expression	2
Ozone	increases expression, affects expression, increases abundance	2
Tobacco Smoke Pollution	decreases expression	2
Cadmium Chloride	decreases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
triphenyl phosphate	affects expression	1
arsenite	decreases methylation	1
sodium arsenite	increases expression	1
ochratoxin A	decreases expression	1
cupric chloride	increases expression	1
hydroquinone	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
seocalcitol	decreases expression	1
CGP 52608	affects binding, increases reaction	1
bisphenol S	increases methylation	1
incobotulinumtoxinA	increases expression	1
gardiquimod	decreases expression, decreases reaction	1
(+)-JQ1 compound	decreases expression	1
Rosuvastatin Calcium	decreases expression	1
Decitabine	increases expression	1
Adenosine Triphosphate	increases activity	1
Barium	decreases activity	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Calcitriol	decreases expression	1
Cesium	decreases activity	1
Diazinon	decreases methylation	1
Drugs, Chinese Herbal	increases expression	1
Estradiol	affects cotreatment, increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_YA65	IDG-HEK293T-KCNJ15-V5-OE	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.