KCNK15-AS1

Summary

KCNK15-AS1 (KCNK15 and WISP2 antisense RNA 1, HGNC:49901) is a long non-coding RNA gene on chromosome 20q13.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49901
Approved symbol	KCNK15-AS1
Name	KCNK15 and WISP2 antisense RNA 1
Location	20q13.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	RP11-445H22.4
Ensembl gene	ENSG00000244558
Ensembl biotype	lncRNA
Entrez	106144538
RNAcentral	URS00008E399E — lncRNA, 734 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 17 lncRNA

ENST00000255183, ENST00000415889, ENST00000419931, ENST00000427303, ENST00000427598, ENST00000445420, ENST00000715845, ENST00000798950, ENST00000798951, ENST00000798952, ENST00000798953, ENST00000798954, ENST00000798955, ENST00000798956, ENST00000798957, ENST00000798958, ENST00000798959

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000255183 — 5 exons

Exon	Start	End
ENSE00003792784	44659711	44659778
ENSE00003793428	44656451	44657051
ENSE00003796649	44658995	44659181
ENSE00004187074	44671639	44671707
ENSE00004187078	44663354	44663553

Expression profiles

Bgee: expression breadth ubiquitous, 152 present calls, max score 90.29.

FANTOM5 (CAGE): breadth broad, TPM avg 1.3860 / max 108.5483, expressed in 478 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
187362	0.9208	376
187361	0.4045	209
187358	0.0607	20

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.29	gold quality
prefrontal cortex	UBERON:0000451	76.48	gold quality
descending thoracic aorta	UBERON:0002345	75.89	gold quality
ascending aorta	UBERON:0001496	74.84	gold quality
thoracic aorta	UBERON:0001515	74.83	gold quality
right frontal lobe	UBERON:0002810	74.43	gold quality
anterior cingulate cortex	UBERON:0009835	73.77	gold quality
aorta	UBERON:0000947	73.36	gold quality
calcaneal tendon	UBERON:0003701	72.94	gold quality
nucleus accumbens	UBERON:0001882	72.79	gold quality
right coronary artery	UBERON:0001625	72.62	gold quality
popliteal artery	UBERON:0002250	72.60	gold quality
tibial artery	UBERON:0007610	72.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.28	gold quality
left coronary artery	UBERON:0001626	71.69	gold quality
hypothalamus	UBERON:0001898	71.63	gold quality
putamen	UBERON:0001874	71.57	gold quality
cortical plate	UBERON:0005343	70.69	gold quality
amygdala	UBERON:0001876	70.26	gold quality
caudate nucleus	UBERON:0001873	70.09	gold quality
coronary artery	UBERON:0001621	70.06	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.80	gold quality
neocortex	UBERON:0001950	69.74	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.68	gold quality
frontal cortex	UBERON:0001870	69.53	gold quality
substantia nigra	UBERON:0002038	68.56	gold quality
ventricular zone	UBERON:0003053	68.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.73	gold quality
lower esophagus	UBERON:0013473	67.68	gold quality
ganglionic eminence	UBERON:0004023	67.44	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• RP11-445H22.4 inhibition significantly rescued the expressions and concentrations of IL-1beta, IL-6, IL-8 and TNF-alpha after induced by LPS in ATDC5 cells. (PMID:29414810)
• KCNK15-AS1 was demethylated by ALKBH5 and was negatively correlated with m6A modification and KCNK15-AS1 inhibits Epithelial-mesenchymal transition. (PMID:30032148)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.