KCNK17

Summary

KCNK17 (potassium two pore domain channel subfamily K member 17, HGNC:14465) is a protein-coding gene on chromosome 6p21.2, encoding Potassium channel subfamily K member 17 (Q96T54). K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization.

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 89822 — RefSeq curated summary.

At a glance

• Gene–disease (curated): heart conduction disease (Limited, GenCC)
• GWAS associations: 2
• Clinical variants (ClinVar): 66 total — 1 likely-pathogenic
• Druggable target: yes
• MANE Select transcript: NM_031460

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14465
Approved symbol	KCNK17
Name	potassium two pore domain channel subfamily K member 17
Location	6p21.2
Locus type	gene with protein product
Status	Approved
Aliases	K2p17.1, TALK-2, TALK2, TASK4, TASK-4
Ensembl gene	ENSG00000124780
Ensembl biotype	protein_coding
OMIM	607370
Entrez	89822

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 retained_intron

ENST00000373231, ENST00000453413, ENST00000503878, ENST00000884805, ENST00000884806, ENST00000884807, ENST00000969858

RefSeq mRNA: 2 — MANE Select: NM_031460 NM_001135111, NM_031460

CCDS: CCDS47419, CCDS4842

Canonical transcript exons

ENST00000373231 — 5 exons

Exon	Start	End
ENSE00000849838	39303957	39304131
ENSE00000849839	39304495	39304655
ENSE00001814406	39299001	39299737
ENSE00002021329	39314084	39314419
ENSE00003522284	39310893	39311007

Expression profiles

Bgee: expression breadth ubiquitous, 140 present calls, max score 87.05.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5000 / max 115.2183, expressed in 146 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73475	0.4229	134
73476	0.0720	26
73477	0.0050	2

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ascending aorta	UBERON:0001496	87.05	gold quality
thoracic aorta	UBERON:0001515	86.90	gold quality
descending thoracic aorta	UBERON:0002345	86.40	gold quality
tibialis anterior	UBERON:0001385	80.80	silver quality
right coronary artery	UBERON:0001625	80.43	gold quality
islet of Langerhans	UBERON:0000006	79.62	gold quality
left coronary artery	UBERON:0001626	79.20	gold quality
right lung	UBERON:0002167	79.01	gold quality
coronary artery	UBERON:0001621	78.44	gold quality
upper lobe of lung	UBERON:0008948	75.42	gold quality
upper lobe of left lung	UBERON:0008952	75.42	gold quality
lower lobe of lung	UBERON:0008949	74.57	gold quality
cardiac muscle of right atrium	UBERON:0003379	74.50	gold quality
ileal mucosa	UBERON:0000331	74.47	silver quality
tibia	UBERON:0000979	73.58	gold quality
right atrium auricular region	UBERON:0006631	73.15	gold quality
right lobe of thyroid gland	UBERON:0001119	72.90	gold quality
left lobe of thyroid gland	UBERON:0001120	72.75	gold quality
cardiac atrium	UBERON:0002081	72.72	gold quality
left ventricle myocardium	UBERON:0006566	71.99	gold quality
thyroid gland	UBERON:0002046	71.54	gold quality
parotid gland	UBERON:0001831	71.39	silver quality
pancreas	UBERON:0001264	71.02	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.98	gold quality
right lobe of liver	UBERON:0001114	70.83	gold quality
aorta	UBERON:0000947	70.77	gold quality
granulocyte	CL:0000094	70.60	gold quality
lung	UBERON:0002048	69.06	gold quality
body of pancreas	UBERON:0001150	68.59	gold quality
secondary oocyte	CL:0000655	67.61	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9067	yes	12.01
E-ANND-3	no	2.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

30 targeting KCNK17, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-1193	100.00	65.93	529
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-4679	99.76	69.19	1229
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-1275	99.47	67.90	2749
HSA-MIR-363-5P	99.46	64.51	1015
HSA-MIR-2392	99.43	67.50	708
HSA-MIR-593-3P	99.22	67.28	1327
HSA-MIR-760	98.81	66.65	1392
HSA-MIR-12125	98.59	67.54	1044
HSA-MIR-1262	98.17	66.52	757
HSA-MIR-4701-3P	98.17	66.25	788
HSA-MIR-6736-5P	98.17	66.43	760
HSA-MIR-8071	95.69	64.93	484
HSA-MIR-1468-5P	94.18	69.04	176
HSA-MIR-6879-3P	93.93	64.00	759
HSA-MIR-6741-5P	93.86	63.06	437
HSA-MIR-6743-3P	80.87	61.31	50

Literature-anchored findings (GeneRIF, showing 7)

• The A allele of the rs10947803 variant of KCNK17 was associated with increased risk of IS and increased levels of KCNK17 gene expression. (PMID:19647252)
• The rs10947803 SNP (A allele) in KCNK17 increases the risk of cerebral hemorrhage but not ischemic stroke in the Chinese population. (PMID:23391755)
• This study demonstrates that Gly88 is a crucial residue for normal TASK-4 gating behavior and that the channel is strongly expressed in the cardiac conduction system. (PMID:24972929)
• The T carrier of an single-nucleotide polymorphism is associated with reduced risk of cerebral hemorrhage in the Chinese population. (PMID:25179130)
• The results suggested that heterodimerization of TASK1 and TALK2 provides cells with the ability to make multiple responses to a variety of physiological and pharmacological stimuli. (PMID:29016681)
• 2 novel gene variants in REM2 and KCNK17 that provide a physiologically plausible explanation for variable expressivity in a large subset of patients in a multigenerational long QT syndrome type 2 family (PMID:29431731)
• Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2. (PMID:39215031)

Cross-species orthologs

18 orthologs

Organism	Symbol	Gene ID
danio_rerio	kcnk12l	ENSDARG00000057037
danio_rerio	si:ch211-261a10.5	ENSDARG00000097085
drosophila_melanogaster	Ork1	FBGN0017561
drosophila_melanogaster	sand	FBGN0033257
drosophila_melanogaster	Task7	FBGN0037690
drosophila_melanogaster	Task6	FBGN0038165
drosophila_melanogaster	CG10864	FBGN0038621
drosophila_melanogaster	CG34396	FBGN0085425
drosophila_melanogaster	CG42340	FBGN0259242
drosophila_melanogaster	CG42594	FBGN0260971
caenorhabditis_elegans		WBGENE00006661
caenorhabditis_elegans		WBGENE00006674
caenorhabditis_elegans		WBGENE00006675
caenorhabditis_elegans		WBGENE00006679
caenorhabditis_elegans		WBGENE00006685
caenorhabditis_elegans		WBGENE00006686
caenorhabditis_elegans		WBGENE00006695
caenorhabditis_elegans		WBGENE00006696

Paralogs (14): KCNK2 (ENSG00000082482), KCNK16 (ENSG00000095981), KCNK6 (ENSG00000099337), KCNK10 (ENSG00000100433), KCNK15 (ENSG00000124249), KCNK1 (ENSG00000135750), KCNK13 (ENSG00000152315), KCNK5 (ENSG00000164626), KCNK9 (ENSG00000169427), KCNK3 (ENSG00000171303), KCNK7 (ENSG00000173338), KCNK4 (ENSG00000182450), KCNK12 (ENSG00000184261), KCNK18 (ENSG00000186795)

Protein

Protein identifiers

Potassium channel subfamily K member 17 — Q96T54 (reviewed: Q96T54)

Alternative names: 2P domain potassium channel Talk-2, Acid-sensitive potassium channel protein TASK-4, TWIK-related acid-sensitive K(+) channel 4, TWIK-related alkaline pH-activated K(+) channel 2

All UniProt accessions (1): Q96T54

UniProt curated annotations — full annotation on UniProt →

Function. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an ‘ion flux gating’ mode where outward but not inward ion flow opens the gate. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. Present in the cardiac conduction system where it may regulate action potential duration and beating frequency of cardiac myocytes. Permeable to other monovalent cations such as Rb(+) and Cs(+).

Subunit / interactions. Homodimer; disulfide-linked. Heterodimer with KCNK5 and KCNK16.

Subcellular location. Cell membrane.

Tissue specificity. Widely expressed. Highly expressed in aorta and coronary artery. Expressed in pancreas, in both endocrine (alpha, beta, gamma, delta, and epsilon) and exocrine (acinar and ductal) cells.

Activity regulation. Inhibited by Ba(2+), quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.

Domain organisation. The pore-forming domains 1 and 2 assemble to form a single pore in which M2 and M4 transmembrane helices line the central cavity and M1 and M3 face the lipid bilayer. The transmembrane helices are bridged by the selectivity filters 1 and 2 carrying a signature sequence TxTTxGYGD that coordinate the permeant ions. Up to four ions can simultaneously occupy the selectivity filter and at least two elementary charges must translocate across the filter to convert it into the open conformation.

Similarity. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96T54-3	1	yes
Q96T54-4	2

RefSeq proteins (2): NP_001128583, NP_113648* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003092	2pore_dom_K_chnl_TASK	Family
IPR003280	2pore_dom_K_chnl	Family
IPR013099	K_chnl_dom	Domain

Pfam: PF07885

Catalyzed reactions (Rhea), 3 shown:

• K(+)(in) = K(+)(out) (RHEA:29463)
• Rb(+)(in) = Rb(+)(out) (RHEA:78547)
• Cs(+)(in) = Cs(+)(out) (RHEA:78555)

UniProt features (38 total): binding site 14, transmembrane region 4, sequence variant 4, topological domain 3, region of interest 3, mutagenesis site 3, glycosylation site 2, intramembrane region 2, chain 1, disulfide bond 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96T54-F1	77.25	0.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (14): 116; 116; 117; 117; 118; 118; 119; 221; 221; 222; 222; 223 …

Disulfide bonds (1): 68

Glycosylation sites (2): 65, 94

Mutagenesis-validated functional residues (3):

Position	Phenotype
88	slightly increased current conductance when compared to wild-type.
88	3.6-fold increased current conductance when compared to wild-type.
88	7.3-fold increased current conductance when compared to wild-type.

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-1299361	TWIK-related alkaline pH activated K+ channel (TALK)
R-HSA-5576886	Phase 4 - resting membrane potential
R-HSA-112316	Neuronal System
R-HSA-1296071	Potassium Channels
R-HSA-1296346	Tandem pore domain potassium channels
R-HSA-397014	Muscle contraction
R-HSA-5576891	Cardiac conduction

MSigDB gene sets: 65 (showing top): GOBP_POTASSIUM_ION_TRANSPORT, BENPORATH_ES_WITH_H3K27ME3, REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS, REACTOME_POTASSIUM_CHANNELS, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_TRANSMEMBRANE_TRANSPORT, GOCC_TRANSPORTER_COMPLEX, GOCC_MEMBRANE_PROTEIN_COMPLEX, GOMF_NARROW_PORE_CHANNEL_ACTIVITY, GOMF_PROTEIN_HETERODIMERIZATION_ACTIVITY, GOMF_VOLTAGE_GATED_MONOATOMIC_CATION_CHANNEL_ACTIVITY, GOMF_PROTEIN_DIMERIZATION_ACTIVITY, GOMF_METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY, GOMF_GATED_CHANNEL_ACTIVITY, GOMF_PASSIVE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY

GO Biological Process (4): potassium ion transport (GO:0006813), potassium ion transmembrane transport (GO:0071805), monoatomic ion transport (GO:0006811), monoatomic ion transmembrane transport (GO:0034220)

GO Molecular Function (6): potassium channel activity (GO:0005267), outward rectifier potassium channel activity (GO:0015271), potassium ion leak channel activity (GO:0022841), metal ion binding (GO:0046872), protein heterodimerization activity (GO:0046982), protein binding (GO:0005515)

GO Cellular Component (3): plasma membrane (GO:0005886), monoatomic ion channel complex (GO:0034702), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Tandem pore domain potassium channels	1
Cardiac conduction	1
Neuronal System	1
Potassium Channels	1
Muscle contraction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
metal ion transport	1
potassium ion transport	1
monoatomic cation transmembrane transport	1
transport	1
monoatomic ion transport	1
transmembrane transport	1
monoatomic cation channel activity	1
potassium ion transmembrane transporter activity	1
voltage-gated potassium channel activity	1
potassium channel activity	1
leak channel activity	1
cation binding	1
protein dimerization activity	1
binding	1
membrane	1
cell periphery	1
transmembrane transporter complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

520 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KCNK17	KRT76	Q01546	720
KCNK17	KCNK18	Q7Z418	697
KCNK17	PRKACB	P22694	506
KCNK17	KCNH8	Q96L42	496
KCNK17	DPY19L4	Q7Z388	493
KCNK17	KCNC2	Q96PR1	493
KCNK17	PRKACA	P17612	490
KCNK17	PRKACG	P22612	485
KCNK17	TMEM9B	Q9NQ34	473
KCNK17	CCNQ	Q8N1B3	462
KCNK17	NOC4L	Q9BVI4	460
KCNK17	KCNJ1	P48048	459
KCNK17	VWA7	Q9Y334	458
KCNK17	GK5	Q6ZS86	449
KCNK17	SAYSD1	Q9NPB0	447

IntAct

0 interactions, top by confidence:

BioGRID (1): KCNK17 (Two-hybrid)

ESM2 similar proteins: A1L1C2, A2RRU4, A6QM06, A6QP75, E1BE10, E2RD63, G5E872, O75888, P29376, P70295, P97260, Q12770, Q1LZ97, Q28DT3, Q2M2I3, Q3TAA7, Q3U5Q7, Q3ZCA1, Q4FZD7, Q5EBM0, Q5MNU5, Q5SWZ9, Q60I26, Q60I27, Q69Z89, Q6AZ51, Q6GQT6, Q6IN84, Q6NUI2, Q6P9U1, Q7Z6J9, Q8BH06, Q8BTM9, Q8C0R7, Q8IYL2, Q8N1F8, Q8N2A8, Q8NAC3, Q8NFR9, Q8TDF6

Diamond homologs: G3V8R8, G3V8V5, G5E845, O00180, O08581, O14649, O17185, O35111, O54912, O88454, O95069, O95279, P57789, P97438, Q0P5A0, Q23435, Q3LS21, Q3TBV4, Q5RD07, Q5UE96, Q5VSE6, Q63ZI0, Q6Q1P3, Q6VV64, Q7Z418, Q8BUW1, Q8R454, Q8R5I0, Q920B6, Q96T54, Q96T55, Q9ERS1, Q9ES08, Q9H427, Q9HB14, Q9HB15, Q9JIS4, Q9JL58, Q9NPC2, Q9NYG8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	55
Likely benign	6
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
132903	NM_031460.4(KCNK17):c.262G>A (p.Gly88Arg)	Likely pathogenic

SpliceAI

1144 predictions. Top by Δscore:

Variant	Effect	Δscore
6:39304532:ACTC:A	donor_gain	1.0000
6:39304533:CTCC:C	donor_gain	1.0000
6:39304535:C:CA	donor_gain	1.0000
6:39299735:TTC:T	acceptor_gain	0.9900
6:39299735:TTCC:T	acceptor_loss	0.9900
6:39299736:TCCTG:T	acceptor_loss	0.9900
6:39299738:C:CG	acceptor_loss	0.9900
6:39299739:T:A	acceptor_loss	0.9900
6:39303146:A:AC	donor_gain	0.9900
6:39303147:C:CC	donor_gain	0.9900
6:39303951:TCTCA:T	donor_loss	0.9900
6:39303952:CTCAC:C	donor_loss	0.9900
6:39303953:TCA:T	donor_loss	0.9900
6:39303954:CA:C	donor_loss	0.9900
6:39303955:A:C	donor_loss	0.9900
6:39303956:CCAA:C	donor_gain	0.9900
6:39303956:CCAAT:C	donor_gain	0.9900
6:39303966:AGTCG:A	donor_gain	0.9900
6:39310886:CCCTT:C	donor_loss	0.9900
6:39310887:CCTTA:C	donor_loss	0.9900
6:39310888:CTTAC:C	donor_loss	0.9900
6:39310889:TTACC:T	donor_loss	0.9900
6:39310890:T:TG	donor_loss	0.9900
6:39310891:A:AT	donor_loss	0.9900
6:39310892:C:CA	donor_loss	0.9900
6:39314077:C:A	donor_gain	0.9900
6:39314140:C:CA	donor_gain	0.9900
6:39314143:A:AC	donor_gain	0.9900
6:39314144:C:CC	donor_gain	0.9900
6:39299738:C:CC	acceptor_gain	0.9800

AlphaMissense

2154 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:39303985:G:C	S220R	0.995
6:39303985:G:T	S220R	0.995
6:39303987:T:G	S220R	0.995
6:39310942:C:A	W101C	0.995
6:39310942:C:G	W101C	0.995
6:39304003:G:C	F214L	0.991
6:39304003:G:T	F214L	0.991
6:39304005:A:G	F214L	0.991
6:39299684:A:G	W248R	0.990
6:39299684:A:T	W248R	0.990
6:39303973:G:C	F224L	0.990
6:39303973:G:T	F224L	0.990
6:39303975:A:G	F224L	0.990
6:39303971:C:A	G225V	0.989
6:39304029:A:G	W206R	0.983
6:39304029:A:T	W206R	0.983
6:39304027:C:A	W206C	0.982
6:39304027:C:G	W206C	0.982
6:39310918:A:C	F109L	0.982
6:39310918:A:T	F109L	0.982
6:39310920:A:G	F109L	0.982
6:39310944:A:G	W101R	0.982
6:39310944:A:T	W101R	0.982
6:39303974:A:C	F224C	0.981
6:39303997:G:C	F216L	0.980
6:39303997:G:T	F216L	0.980
6:39303999:A:G	F216L	0.980
6:39304590:C:G	G140R	0.979
6:39304590:C:T	G140R	0.979
6:39299663:A:G	W255R	0.978

dbSNP variants (sampled 300 via entrez): RS1000052218 (6:39311803 T>C,G), RS1000142649 (6:39308443 A>G), RS1000479957 (6:39315723 T>C), RS1000654575 (6:39310746 C>T), RS1000815762 (6:39304858 C>T), RS1001410275 (6:39303547 G>C), RS1001410921 (6:39303418 C>T), RS1001800165 (6:39300218 G>A,T), RS1001961869 (6:39315631 A>G), RS1001990057 (6:39309282 C>A,T), RS1002167590 (6:39310456 C>G,T), RS1002224382 (6:39304084 C>A,T), RS1002255359 (6:39304296 T>C), RS1002941876 (6:39314037 C>A,G,T), RS1002973113 (6:39314206 C>G,T)

Disease associations

OMIM: gene MIM:607370 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
heart conduction disease	Limited	Unknown

Mondo (1): heart conduction disease (MONDO:0000992)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002221_61	Cholesterol, total	3.000000e-08
GCST010243_107	Apolipoprotein B levels	2.000000e-12

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004574	total cholesterol measurement
EFO:0004615	apolipoprotein B measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523433 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: vgic — Two-pore domain potassium channels (K_2P)

ChEMBL bioactivities

1 potent at pChembl≥5 of 1 total, top 1 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.09	IC50	8100	nM	CHEMBL148342

PubChem BioAssay actives

1 with measured affinity, of 3 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
N-[(2,4-difluorophenyl)methyl]-2-[2-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]phenyl]benzamide	1525549: Inhibition of human TASK4 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay	ic50	8.1000	uM

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
ethyl-p-hydroxybenzoate	decreases expression	1
CGP 52608	affects binding, increases reaction	1
Arsenic	affects expression	1
Benzo(a)pyrene	increases methylation, affects methylation	1
Folic Acid	decreases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4322152	Binding	Inhibition of human TASK4 expressed in CHO cells by Inside-out macro-patches based electrophysiology assay	TASK Channels Pharmacology: New Challenges in Drug Design. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.