KCNK6

Summary

KCNK6 (potassium two pore domain channel subfamily K member 6, HGNC:6281) is a protein-coding gene on chromosome 19q13.2, encoding Potassium channel subfamily K member 6 (Q9Y257). K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system.

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.

Source: NCBI Gene 9424 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 80 total
• MANE Select transcript: NM_004823

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:6281
Approved symbol	KCNK6
Name	potassium two pore domain channel subfamily K member 6
Location	19q13.2
Locus type	gene with protein product
Status	Approved
Aliases	K2p6.1, TWIK-2
Ensembl gene	ENSG00000099337
Ensembl biotype	protein_coding
OMIM	603939
Entrez	9424

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000263372, ENST00000588137, ENST00000884216, ENST00000963801

RefSeq mRNA: 1 — MANE Select: NM_004823 NM_004823

CCDS: CCDS12513

Canonical transcript exons

ENST00000263372 — 3 exons

Exon	Start	End
ENSE00000648390	38326593	38326988
ENSE00000892785	38327180	38332076
ENSE00000892786	38319845	38320272

Expression profiles

Bgee: expression breadth ubiquitous, 205 present calls, max score 92.18.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.0220 / max 95.6933, expressed in 1420 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
175613	7.0220	1420

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	92.18	gold quality
decidua	UBERON:0002450	90.24	gold quality
ectocervix	UBERON:0012249	89.23	gold quality
esophagus mucosa	UBERON:0002469	88.91	gold quality
monocyte	CL:0000576	87.61	gold quality
right coronary artery	UBERON:0001625	87.28	gold quality
leukocyte	CL:0000738	87.24	gold quality
ascending aorta	UBERON:0001496	86.59	gold quality
thoracic aorta	UBERON:0001515	86.37	gold quality
uterine cervix	UBERON:0000002	85.05	gold quality
myometrium	UBERON:0001296	85.00	gold quality
mucosa of transverse colon	UBERON:0004991	84.84	gold quality
vagina	UBERON:0000996	84.77	gold quality
smooth muscle tissue	UBERON:0001135	84.74	gold quality
parotid gland	UBERON:0001831	84.42	silver quality
buccal mucosa cell	CL:0002336	84.40	gold quality
skin of leg	UBERON:0001511	84.32	gold quality
left coronary artery	UBERON:0001626	84.28	gold quality
body of uterus	UBERON:0009853	84.16	gold quality
skin of abdomen	UBERON:0001416	84.15	gold quality
oral cavity	UBERON:0000167	84.01	gold quality
endocervix	UBERON:0000458	83.88	gold quality
gingival epithelium	UBERON:0001949	83.67	gold quality
coronary artery	UBERON:0001621	83.61	gold quality
gingiva	UBERON:0001828	83.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	83.31	gold quality
mouth mucosa	UBERON:0003729	83.28	gold quality
zone of skin	UBERON:0000014	83.21	gold quality
minor salivary gland	UBERON:0001830	83.07	gold quality
saliva-secreting gland	UBERON:0001044	82.86	gold quality

Single-cell (SCXA)

Detected in 6 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-MTAB-8060	yes	98.75
E-HCAD-9	yes	15.17
E-ANND-3	yes	11.73
E-MTAB-6678	yes	7.48
E-ENAD-27	no	3.79
E-MTAB-5061	no	2.14

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

52 targeting KCNK6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-6772-5P	99.94	67.01	577
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-4753-3P	99.90	71.03	3786
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-130B-5P	99.83	68.50	1888
HSA-MIR-4760-5P	99.80	69.88	1619
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-8061	99.63	69.44	1411
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-4688	99.48	64.68	828
HSA-MIR-766-3P	99.47	65.24	1811
HSA-MIR-147B-5P	99.45	70.62	2432
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-4685-5P	99.25	65.99	1563
HSA-MIR-6837-5P	99.25	65.47	1632

Literature-anchored findings (GeneRIF, showing 2)

• Identification and characterization of Kcnk6 expression within the mammalian cochlea established the gene as a functional candidate for DFNA4. (PMID:14689445)
• Potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells (PMID:21964404)

Cross-species orthologs

15 orthologs

Organism	Symbol	Gene ID
danio_rerio	kcnk6	ENSDARG00000007383
mus_musculus	Kcnk6	ENSMUSG00000046410
drosophila_melanogaster	Ork1	FBGN0017561
drosophila_melanogaster	Task7	FBGN0037690
drosophila_melanogaster	Task6	FBGN0038165
drosophila_melanogaster	CG10864	FBGN0038621
drosophila_melanogaster	CG42340	FBGN0259242
caenorhabditis_elegans		WBGENE00006661
caenorhabditis_elegans		WBGENE00006674
caenorhabditis_elegans		WBGENE00006675
caenorhabditis_elegans		WBGENE00006679
caenorhabditis_elegans		WBGENE00006685
caenorhabditis_elegans		WBGENE00006686
caenorhabditis_elegans		WBGENE00006695
caenorhabditis_elegans		WBGENE00006696

Paralogs (14): KCNK2 (ENSG00000082482), KCNK16 (ENSG00000095981), KCNK10 (ENSG00000100433), KCNK15 (ENSG00000124249), KCNK17 (ENSG00000124780), KCNK1 (ENSG00000135750), KCNK13 (ENSG00000152315), KCNK5 (ENSG00000164626), KCNK9 (ENSG00000169427), KCNK3 (ENSG00000171303), KCNK7 (ENSG00000173338), KCNK4 (ENSG00000182450), KCNK12 (ENSG00000184261), KCNK18 (ENSG00000186795)

Protein

Protein identifiers

Potassium channel subfamily K member 6 — Q9Y257 (reviewed: Q9Y257)

Alternative names: Inward rectifying potassium channel protein TWIK-2, TWIK-originated similarity sequence

All UniProt accessions (2): Q9Y257, B2RDS2

UniProt curated annotations — full annotation on UniProt →

Function. K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system. Active in lysosomes where it regulates lysosome numbers and size. In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 channels to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux. Does not display channel activity.

Subunit / interactions. Homodimer; disulfide-linked.

Subcellular location. Late endosome membrane. Lysosome membrane.

Tissue specificity. Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.

Post-translational modifications. N-glycosylation is necessary for targeting to lysosomes.

Domain organisation. Each subunit contributes two pore-forming domains 1 and 2 which assemble to form a single pore with M2 and M4 transmembrane helices lining the central cavity and M1 and M3 facing the lipid bilayer. The transmembrane helices are bridged by the selectivity filters 1 and 2 that coordinate the permeant ions. Up to four ions can simultaneously occupy the selectivity filter and at least two elementary charges must translocate across the filter to convert it into the open conformation.

Similarity. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y257-1	1	yes
Q9Y257-2	2

RefSeq proteins (1): NP_004814* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003092	2pore_dom_K_chnl_TASK	Family
IPR003280	2pore_dom_K_chnl	Family
IPR005408	2pore_dom_K_chnl_TWIK	Family
IPR005409	2pore_dom_K_chnl_TWIK2	Family
IPR013099	K_chnl_dom	Domain

Pfam: PF07885

Catalyzed reactions (Rhea), 1 shown:

• K(+)(in) = K(+)(out) (RHEA:29463)

UniProt features (40 total): binding site 13, transmembrane region 4, mutagenesis site 4, topological domain 3, region of interest 3, sequence variant 3, short sequence motif 2, glycosylation site 2, intramembrane region 2, chain 1, compositionally biased region 1, disulfide bond 1, splice variant 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
9MEK	ELECTRON MICROSCOPY	2.85
9MEL	ELECTRON MICROSCOPY	3.17
9OTA	ELECTRON MICROSCOPY	3.2
9E94	ELECTRON MICROSCOPY	3.67
9OTK	ELECTRON MICROSCOPY	3.7
9OV0	ELECTRON MICROSCOPY	3.9
9OV9	ELECTRON MICROSCOPY	3.9
9OVD	ELECTRON MICROSCOPY	3.9
9OVE	ELECTRON MICROSCOPY	4.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y257-F1	82.88	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (13): 106; 106; 107; 107; 108; 108; 109; 214; 214; 215; 215; 216 …

Disulfide bonds (1): 53

Glycosylation sites (2): 79, 85

Mutagenesis-validated functional residues (4):

Position	Phenotype
53	no channel activity.
289	disrupts lysosomal targeting signal. increases localization and k(+) current at the plasma membrane; when associated wit
290	disrupts lysosomal targeting signal. increases localization and k(+) current at the plasma membrane; when associated wit
308	disrupts lysosomal targeting signal. increases localization and k(+) current at the plasma membrane. displays additive e

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-1299308	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
R-HSA-5576886	Phase 4 - resting membrane potential
R-HSA-112316	Neuronal System
R-HSA-1296071	Potassium Channels
R-HSA-1296346	Tandem pore domain potassium channels
R-HSA-397014	Muscle contraction
R-HSA-5576891	Cardiac conduction

MSigDB gene sets: 241 (showing top): GOBP_POTASSIUM_ION_TRANSPORT, GOBP_REGULATION_OF_BLOOD_PRESSURE, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_INFLAMMATORY_RESPONSE, GOCC_VACUOLAR_MEMBRANE, REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS, REACTOME_POTASSIUM_CHANNELS, GOZGIT_ESR1_TARGETS_DN, GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_MONOATOMIC_CATION_TRANSPORT, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_POSITIVE_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS

GO Biological Process (9): negative regulation of systemic arterial blood pressure (GO:0003085), potassium ion transport (GO:0006813), regulation of resting membrane potential (GO:0060075), regulation of lysosome size (GO:0062196), potassium ion transmembrane transport (GO:0071805), positive regulation of NLRP3 inflammasome complex assembly (GO:1900227), regulation of systemic arterial blood pressure (GO:0003073), monoatomic ion transport (GO:0006811), monoatomic ion transmembrane transport (GO:0034220)

GO Molecular Function (5): inward rectifier potassium channel activity (GO:0005242), potassium channel activity (GO:0005267), outward rectifier potassium channel activity (GO:0015271), potassium ion leak channel activity (GO:0022841), metal ion binding (GO:0046872)

GO Cellular Component (8): lysosomal membrane (GO:0005765), plasma membrane (GO:0005886), voltage-gated potassium channel complex (GO:0008076), late endosome membrane (GO:0031902), lysosome (GO:0005764), endosome (GO:0005768), membrane (GO:0016020), monoatomic ion channel complex (GO:0034702)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Tandem pore domain potassium channels	1
Cardiac conduction	1
Neuronal System	1
Potassium Channels	1
Muscle contraction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
voltage-gated potassium channel activity	2
regulation of systemic arterial blood pressure	1
negative regulation of blood pressure	1
metal ion transport	1
regulation of membrane potential	1
regulation of cellular component size	1
potassium ion transport	1
monoatomic cation transmembrane transport	1
positive regulation of protein-containing complex assembly	1
NLRP3 inflammasome complex assembly	1
positive regulation of inflammasome-mediated signaling pathway	1
regulation of NLRP3 inflammasome complex assembly	1
regulation of blood pressure	1
transport	1
monoatomic ion transport	1
transmembrane transport	1
ligand-gated monoatomic cation channel activity	1
monoatomic cation channel activity	1
potassium ion transmembrane transporter activity	1
potassium channel activity	1
leak channel activity	1
cation binding	1
lysosome	1
lytic vacuole membrane	1
membrane	1
cell periphery	1
potassium channel complex	1
plasma membrane protein complex	1
late endosome	1
endosome membrane	1
lytic vacuole	1
endomembrane system	1
cytoplasmic vesicle	1
cellular anatomical structure	1
transmembrane transporter complex	1

Protein interactions and networks

STRING

512 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
KCNK6	KRT76	Q01546	980
KCNK6	KCNAB3	O43448	536
KCNK6	KCNK13	Q9HB14	536
KCNK6	KCNJ13	O60928	523
KCNK6	KCNG1	Q9UIX4	508
KCNK6	KCNJ14	Q9UNX9	485
KCNK6	CLCN3	P51790	468
KCNK6	SLC9A2	Q9UBY0	447
KCNK6	KCNH7	Q9NS40	440
KCNK6	WNK4	Q96J92	435
KCNK6	KCNN4	O15554	422
KCNK6	KCNA3	P22001	416
KCNK6	CREBL2	O60519	409
KCNK6	NEK7	Q8TDX7	392
KCNK6	ANO10	Q9NW15	387

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A2Z2U4G9, A4K2M4, A4K2N8, A4K2P6, A4K2Q6, A4K2R3, A4K2S2, A4K2T1, A4K2V2, A4K2W6, A4K2X4, A4K2Y2, G3V8R8, G5E845, L5KLU7, O00180, O08581, O14649, O17185, O19179, O35111, O35173, O54912, O88758, P26770, P51840, P55203, Q02846, Q0P5A0, Q17ST2, Q1KZG0, Q3LS21, Q3TBV4, Q5RD07, Q5UE96, Q7TNJ2, Q8BH02, Q8IZY2, Q8R454, Q8R5I0

Diamond homologs: A8X8I4, Q19907, Q9Y257, G3V8R8, G3V8V5, G5E845, O00180, O08581, O14649, O17185, O35111, O54912, O88454, O95069, O95279, P57789, P97438, Q0P5A0, Q23435, Q3LS21, Q3TBV4, Q5RD07, Q5UE96, Q5VSE6, Q63ZI0, Q6Q1P3, Q6VV64, Q7Z418, Q8BUW1, Q8R454, Q8R5I0, Q920B6, Q96T54, Q96T55, Q9ERS1, Q9ES08, Q9H427, Q9HB14, Q9HB15, Q9JIS4

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

80 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	67
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

573 predictions. Top by Δscore:

Variant	Effect	Δscore
19:38320269:GTGG:G	donor_gain	1.0000
19:38326986:CAGG:C	donor_loss	1.0000
19:38326987:AG:A	donor_loss	1.0000
19:38326989:GTGA:G	donor_loss	1.0000
19:38327178:A:AG	acceptor_gain	1.0000
19:38327179:G:GG	acceptor_gain	1.0000
19:38327179:GTCT:G	acceptor_gain	1.0000
19:38327179:GTCTA:G	acceptor_gain	1.0000
19:38320271:GG:G	donor_gain	0.9900
19:38320272:GG:G	donor_gain	0.9900
19:38320273:GTA:G	donor_loss	0.9900
19:38320273:GTAC:G	donor_gain	0.9900
19:38320277:G:GG	donor_gain	0.9900
19:38324605:G:GT	donor_gain	0.9900
19:38326587:CCCTA:C	acceptor_loss	0.9900
19:38326588:CCTAG:C	acceptor_loss	0.9900
19:38326589:CTAGG:C	acceptor_loss	0.9900
19:38326590:TAG:T	acceptor_loss	0.9900
19:38326591:A:AC	acceptor_loss	0.9900
19:38326591:A:AG	acceptor_gain	0.9900
19:38326591:AG:A	acceptor_gain	0.9900
19:38326592:G:GA	acceptor_gain	0.9900
19:38326592:GG:G	acceptor_gain	0.9900
19:38326592:GGCT:G	acceptor_gain	0.9900
19:38326592:GGCTA:G	acceptor_gain	0.9900
19:38327177:CA:C	acceptor_loss	0.9900
19:38327178:A:AC	acceptor_loss	0.9900
19:38327179:GT:G	acceptor_gain	0.9900
19:38327179:GTC:G	acceptor_gain	0.9900
19:38326592:GGC:G	acceptor_gain	0.9800

AlphaMissense

1958 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:38326630:G:C	K120N	0.995
19:38326630:G:T	K120N	0.995
19:38320251:A:C	S101R	0.994
19:38320253:C:A	S101R	0.994
19:38320253:C:G	S101R	0.994
19:38326889:T:C	F207L	0.990
19:38326891:C:A	F207L	0.990
19:38326891:C:G	F207L	0.990
19:38320223:G:C	W91C	0.989
19:38320223:G:T	W91C	0.989
19:38326599:G:A	G110E	0.985
19:38326658:G:C	G130R	0.985
19:38320245:T:C	F99L	0.984
19:38320247:C:A	F99L	0.984
19:38320247:C:G	F99L	0.984
19:38326598:G:T	G110W	0.983
19:38326893:G:A	C208Y	0.983
19:38326617:C:T	T116I	0.982
19:38326894:C:G	C208W	0.982
19:38326650:C:A	A127E	0.981
19:38326593:G:A	G108D	0.980
19:38320011:G:C	G21R	0.979
19:38320272:G:C	G108R	0.977
19:38326659:G:A	G130D	0.977
19:38326914:T:A	I215N	0.976
19:38326917:G:A	G216D	0.976
19:38320267:C:T	T106I	0.975
19:38326892:T:C	C208R	0.975
19:38326902:C:A	S211Y	0.975
19:38320012:G:A	G21D	0.974

dbSNP variants (sampled 300 via entrez): RS1000308085 (19:38322165 G>T), RS1000311762 (19:38330093 G>A,C), RS1000372110 (19:38323995 A>G), RS1000387631 (19:38317897 A>C), RS1000488188 (19:38324309 G>A,C), RS1000662488 (19:38330474 C>T), RS1000835862 (19:38319235 A>T), RS1001268720 (19:38331776 T>C), RS1001314777 (19:38327206 A>C,G), RS1001383353 (19:38325419 G>A,T), RS1001721465 (19:38331498 A>C,T), RS1001764678 (19:38321396 C>A), RS1001786620 (19:38320869 G>A,T), RS1002122175 (19:38331649 T>C,G), RS1002449716 (19:38331641 G>A)

Disease associations

OMIM: gene MIM:603939 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: vgic — Two-pore domain potassium channels (K_2P)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	7
Estradiol	affects binding, increases expression, affects cotreatment	3
entinostat	increases expression, affects cotreatment	2
Benzo(a)pyrene	decreases methylation, increases expression	2
Nickel	increases expression	2
Smoke	decreases expression, increases abundance	2
aristolochic acid I	increases expression	1
propionaldehyde	increases expression	1
bisphenol A	increases expression	1
trichostatin A	increases expression	1
perfluorooctanoic acid	affects cotreatment, decreases expression	1
picene	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
nutlin 3	affects cotreatment, increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol Z	increases expression	1
Arsenic Trioxide	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Camptothecin	increases expression	1
Cosmetics	affects cotreatment, decreases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Diethylhexyl Phthalate	increases expression	1
Doxorubicin	decreases expression	1
Flame Retardants	affects cotreatment, decreases expression	1
Plasticizers	affects cotreatment, decreases expression	1
Progesterone	increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2A6	HAP1 KCNK6 (-) 1	Cancer cell line	Male
CVCL_E2A7	HAP1 KCNK6 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.