KCNMA1-AS1

Summary

KCNMA1-AS1 (KCNMA1 antisense RNA 1, HGNC:51213) is a long non-coding RNA gene on chromosome 10q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51213
Approved symbol	KCNMA1-AS1
Name	KCNMA1 antisense RNA 1
Location	10q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236467
Ensembl biotype	lncRNA
Entrez	101929328
RNAcentral	URS0000759FA9 — lncRNA, 808 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000426234, ENST00000429850, ENST00000458661, ENST00000595702, ENST00000598613, ENST00000600782, ENST00000608791, ENST00000609102, ENST00000611475, ENST00000617241

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000426234 — 5 exons

Exon	Start	End
ENSE00001654274	76939678	76939783
ENSE00001659040	76949144	76949463
ENSE00001673726	76904727	76904875
ENSE00003010515	76901804	76902022
ENSE00003775004	76888213	76888281

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 82.58.

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	82.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.27	gold quality
sural nerve	UBERON:0015488	78.81	gold quality
adrenal tissue	UBERON:0018303	73.45	gold quality
colonic epithelium	UBERON:0000397	71.81	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.31	gold quality
bone marrow cell	CL:0002092	70.23	gold quality
body of uterus	UBERON:0009853	69.94	gold quality
mucosa of stomach	UBERON:0001199	69.79	gold quality
ventricular zone	UBERON:0003053	68.25	gold quality
tendon	UBERON:0000043	66.64	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.15	gold quality
cortical plate	UBERON:0005343	64.46	gold quality
popliteal artery	UBERON:0002250	64.20	gold quality
tibial artery	UBERON:0007610	64.17	gold quality
ectocervix	UBERON:0012249	63.99	gold quality
corpus callosum	UBERON:0002336	63.60	gold quality
aorta	UBERON:0000947	63.29	gold quality
stromal cell of endometrium	CL:0002255	63.01	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.92	gold quality
lower esophagus	UBERON:0013473	62.89	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.80	gold quality
ascending aorta	UBERON:0001496	62.66	gold quality
thoracic aorta	UBERON:0001515	62.39	gold quality
left uterine tube	UBERON:0001303	61.72	gold quality
buccal mucosa cell	CL:0002336	60.69	silver quality
left testis	UBERON:0004533	60.63	gold quality
uterine cervix	UBERON:0000002	60.28	gold quality
myometrium	UBERON:0001296	60.24	gold quality
testis	UBERON:0000473	59.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.62

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• KCNMA1-AS1 attenuates apoptosis of epithelial ovarian cancer cells and serves as a risk factor for poor prognosis of epithelial ovarian cancer. (PMID:31210304)
• Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis. (PMID:36717952)
• Long noncoding RNA KCNMA1-AS1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the SMAD9 signaling pathway. (PMID:38017487)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.